MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Takabe K et al. | Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. | 2010 | J. Biol. Chem. | pmid:20110355 |
Tao R et al. | High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20061542 |
Pham TH et al. | Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. | 2010 | J. Exp. Med. | pmid:20026661 |
Diab KJ et al. | Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema. | 2010 | Am. J. Respir. Crit. Care Med. | pmid:19965812 |
Claas RF et al. | Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts. | 2010 | Cell. Signal. | pmid:19913094 |
Agudo-López A et al. | Involvement of mitochondria on neuroprotective effect of sphingosine-1-phosphate in cell death in an in vitro model of brain ischemia. | 2010 | Neurosci. Lett. | pmid:20045720 |
Nayak D et al. | Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. | 2010 | Neuroscience | pmid:20036321 |
Danieli-Betto D et al. | Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20042733 |
Hoofnagle AN et al. | HDL lipids and insulin resistance. | 2010 | Curr. Diab. Rep. | pmid:20425071 |
Su SC et al. | Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity. | 2010 | J. Biol. Chem. | pmid:20947498 |
Chi XX and Nicol GD | The sphingosine 1-phosphate receptor, S1PRâ‚, plays a prominent but not exclusive role in enhancing the excitability of sensory neurons. | 2010 | J. Neurophysiol. | pmid:20844107 |
Józefowski S et al. | Ceramide and ceramide 1-phosphate are negative regulators of TNF-α production induced by lipopolysaccharide. | 2010 | J. Immunol. | pmid:21041721 |
Chumanevich AA et al. | Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase. | 2010 | Carcinogenesis | pmid:20688834 |
Bourquin F et al. | Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism. | 2010 | Structure | pmid:20696404 |
De Luca T et al. | Reciprocal relationship between cytosolic NADH and ENOX2 inhibition triggers sphingolipid-induced apoptosis in HeLa cells. | 2010 | J. Cell. Biochem. | pmid:20518072 |
Kilbey A et al. | Runx regulation of sphingolipid metabolism and survival signaling. | 2010 | Cancer Res. | pmid:20587518 |
Frias MA et al. | Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosis. | 2010 | Cardiovasc. Res. | pmid:19700468 |
Francis-Goforth KN et al. | Normalization of diabetic wound healing. | 2010 | Surgery | pmid:19703697 |
Canals D et al. | Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane. | 2010 | J. Biol. Chem. | pmid:20679347 |
Ishii M et al. | Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo. | 2010 | J. Exp. Med. | pmid:21135136 |
Ratner M | Novartis eyes oral MS drug as potential blockbuster. | 2010 | Nat. Biotechnol. | pmid:21057464 |
Morishige J et al. | A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag. | 2010 | Rapid Commun. Mass Spectrom. | pmid:20213695 |
Ponnusamy S et al. | Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance. | 2010 | Future Oncol | pmid:21062159 |
Howard C et al. | Dental pulp stem cell migration. | 2010 | J Endod | pmid:21092813 |
Chao HH et al. | L-Carnitine attenuates angiotensin II-induced proliferation of cardiac fibroblasts: role of NADPH oxidase inhibition and decreased sphingosine-1-phosphate generation. | 2010 | J. Nutr. Biochem. | pmid:19447019 |
Müller R et al. | Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells. | 2010 | Tumour Biol. | pmid:20480410 |
Chen JH et al. | Sphingosine kinase regulates oxidized low density lipoprotein-mediated calcium oscillations and macrophage survival. | 2010 | J. Lipid Res. | pmid:19965613 |
Shea BS et al. | Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. | 2010 | Am. J. Respir. Cell Mol. Biol. | pmid:20081052 |
Dubin AE et al. | Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. | 2010 | J. Neurosci. | pmid:20505096 |
He X et al. | Deregulation of sphingolipid metabolism in Alzheimer's disease. | 2010 | Neurobiol. Aging | pmid:18547682 |
Scott EA et al. | Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. | 2010 | Acta Biomater | pmid:19607945 |
Okae H and Iwakura Y | Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice. | 2010 | Dev. Dyn. | pmid:20186915 |
Blachnio-Zabielska A et al. | Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle. | 2010 | J. Cell. Physiol. | pmid:20568228 |
Long JS et al. | Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells. | 2010 | J. Biol. Chem. | pmid:20837468 |
Nam JH et al. | Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells. | 2010 | Mol. Cells | pmid:20069383 |
Deshpande GP et al. | Effects of sphingosine-1-phosphate on acute contractile heart failure (ACHF). | 2010 | Cardiovasc Drugs Ther | pmid:20838867 |
Gil PR et al. | Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P₠and S1P₃ and Smad-signalling. | 2010 | Cytoskeleton (Hoboken) | pmid:20857421 |
Dudek SM et al. | Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function. | 2010 | Mol. Biol. Cell | pmid:20861316 |
Strub GM et al. | Extracellular and intracellular actions of sphingosine-1-phosphate. | 2010 | Adv. Exp. Med. Biol. | pmid:20919652 |
Oskouian B and Saba JD | Cancer treatment strategies targeting sphingolipid metabolism. | 2010 | Adv. Exp. Med. Biol. | pmid:20919655 |
Wang F et al. | Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice. | 2010 | J. Clin. Invest. | pmid:20978351 |
Sun HY et al. | Sphingosine-1-phosphate induces human endothelial VEGF and MMP-2 production via transcription factor ZNF580: novel insights into angiogenesis. | 2010 | Biochem. Biophys. Res. Commun. | pmid:20382120 |
Siow DL et al. | Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate. | 2010 | J. Lipid Res. | pmid:20386061 |
Harvey KA et al. | Role of Rho kinase in sphingosine 1-phosphate-mediated endothelial and smooth muscle cell migration and differentiation. | 2010 | Mol. Cell. Biochem. | pmid:20401628 |
Qin J et al. | Neurons and oligodendrocytes recycle sphingosine 1-phosphate to ceramide: significance for apoptosis and multiple sclerosis. | 2010 | J. Biol. Chem. | pmid:20215115 |
Sensken SC et al. | Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia. | 2010 | J. Immunol. | pmid:20220090 |
Haghikia A and Gold R | Sphingosine-1-phosphate and its receptors as a possible therapeutic target in autoimmune diseases of the nervous system. | 2010 | J. Neuroimmunol. | pmid:19879005 |
Greco E et al. | Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells. | 2010 | Immunology | pmid:19878354 |
Rolin J et al. | FTY720 and SEW2871 reverse the inhibitory effect of S1P on natural killer cell mediated lysis of K562 tumor cells and dendritic cells but not on cytokine release. | 2010 | Cancer Immunol. Immunother. | pmid:19823820 |
Serra M and Saba JD | Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function. | 2010 | Adv. Enzyme Regul. | pmid:19914275 |
Yamamoto Y et al. | Increased expression of enzymes for sphingosine 1-phosphate turnover and signaling in human decidua during late pregnancy. | 2010 | Biol. Reprod. | pmid:20007411 |
Wang S et al. | A polysaccharide, MDG-1, induces S1P1 and bFGF expression and augments survival and angiogenesis in the ischemic heart. | 2010 | Glycobiology | pmid:20008963 |
McDonald RA et al. | The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. | 2010 | Br. J. Pharmacol. | pmid:20015089 |
Herzog C et al. | Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury. | 2010 | Mediators Inflamm. | pmid:21274265 |
Bonnaud S et al. | Sphingosine-1-phosphate activates the AKT pathway to protect small intestines from radiation-induced endothelial apoptosis. | 2010 | Cancer Res. | pmid:21118968 |
Tawa H et al. | Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis. | 2010 | Circ. Res. | pmid:20413783 |
Bolli MH et al. | 2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists. | 2010 | J. Med. Chem. | pmid:20446681 |
Bucki R et al. | Plasma gelsolin modulates cellular response to sphingosine 1-phosphate. | 2010 | Am. J. Physiol., Cell Physiol. | pmid:20810916 |
Bankovich AJ et al. | CD69 suppresses sphingosine 1-phosophate receptor-1 (S1P1) function through interaction with membrane helix 4. | 2010 | J. Biol. Chem. | pmid:20463015 |
Liu Z et al. | Mechanical tugging force regulates the size of cell-cell junctions. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20463286 |
Komatsu I et al. | Dupuytren's fibroblast contractility by sphingosine-1-phosphate is mediated through non-muscle myosin II. | 2010 | J Hand Surg Am | pmid:20888494 |
Evindar G et al. | Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20304639 |
Watson C et al. | High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. | 2010 | Am. J. Pathol. | pmid:20889557 |
Kim M et al. | Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. | 2010 | Am. J. Nephrol. | pmid:20234131 |
Suhaiman L et al. | Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis. | 2010 | J. Biol. Chem. | pmid:20236935 |
Lee CW et al. | Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis. | 2010 | Arch. Pharm. Res. | pmid:21052934 |
Martin R | Multiple sclerosis: closing in on an oral treatment. | 2010 | Nature | pmid:20237554 |
Di A et al. | A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury. | 2010 | J. Biol. Chem. | pmid:20299461 |
Cutignano A et al. | UPLC-MS/MS method for analysis of sphingosine 1-phosphate in biological samples. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20601074 |
Ohno T et al. | The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling. | 2010 | Biopharm Drug Dispos | pmid:20623701 |
Gurgui M et al. | Dual action of sphingosine 1-phosphate in eliciting proinflammatory responses in primary cultured rat intestinal smooth muscle cells. | 2010 | Cell. Signal. | pmid:20624458 |
He X et al. | Sphingosine-1-phosphate mediates proliferation maintaining the multipotency of human adult bone marrow and adipose tissue-derived stem cells. | 2010 | J Mol Cell Biol | pmid:20584786 |
Thangada S et al. | Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. | 2010 | J. Exp. Med. | pmid:20584883 |
Baker DA et al. | Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis. | 2010 | J. Immunol. | pmid:20644167 |
Lan T et al. | Berberine ameliorates renal injury in diabetic C57BL/6 mice: Involvement of suppression of SphK-S1P signaling pathway. | 2010 | Arch. Biochem. Biophys. | pmid:20646989 |
Adamson RH et al. | Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels. | 2010 | Cardiovasc. Res. | pmid:20542878 |
Abrahan CE et al. | Synthesis of sphingosine is essential for oxidative stress-induced apoptosis of photoreceptors. | 2010 | Invest. Ophthalmol. Vis. Sci. | pmid:19797232 |
Seo J et al. | Sphingosine-1-phosphate signaling in human submandibular cells. | 2010 | J. Dent. Res. | pmid:20651091 |
Sattler KJ et al. | Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease. | 2010 | Basic Res. Cardiol. | pmid:20652276 |
Kelly RF et al. | Ethanolamine is a novel STAT-3 dependent cardioprotective agent. | 2010 | Basic Res. Cardiol. | pmid:20938668 |
Incorvaia C et al. | Anaphylaxis: an update on its understanding and management. | 2010 | Recent Pat Inflamm Allergy Drug Discov | pmid:20100165 |
Maeda Y et al. | Sphingosine 1-phosphate receptor type 1 regulates egress of mature T cells from mouse bone marrow. | 2010 | Int. Immunol. | pmid:20497959 |
Prakash H et al. | Sphingosine kinase-1 (SphK-1) regulates Mycobacterium smegmatis infection in macrophages. | 2010 | PLoS ONE | pmid:20498849 |
Bergelin N et al. | S1P1 and VEGFR-2 form a signaling complex with extracellularly regulated kinase 1/2 and protein kinase C-alpha regulating ML-1 thyroid carcinoma cell migration. | 2010 | Endocrinology | pmid:20501673 |
Gräler MH | Targeting sphingosine 1-phosphate (S1P) levels and S1P receptor functions for therapeutic immune interventions. | 2010 | Cell. Physiol. Biochem. | pmid:20502007 |
de Souza JA et al. | Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A-I. | 2010 | J. Cell. Mol. Med. | pmid:19243471 |
Lucke S and Levkau B | Endothelial functions of sphingosine-1-phosphate. | 2010 | Cell. Physiol. Biochem. | pmid:20502008 |
Chiba Y et al. | Downregulation of sphingosine-1-phosphate receptors in bronchial smooth muscle of mouse experimental asthma. | 2010 | Pharmacol. Res. | pmid:20554039 |
Murohara T | Printing a tissue: a new engineering strategy for cardiovascular regeneration. | 2010 | Arterioscler. Thromb. Vasc. Biol. | pmid:20554948 |
Pyne NJ and Pyne S | Sphingosine 1-phosphate and cancer. | 2010 | Nat. Rev. Cancer | pmid:20555359 |
Fyrst H and Saba JD | An update on sphingosine-1-phosphate and other sphingolipid mediators. | 2010 | Nat. Chem. Biol. | pmid:20559316 |
Valentine WJ et al. | (S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity. | 2010 | Cell. Signal. | pmid:20566326 |
Zhou Y et al. | Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway. | 2010 | Stroke | pmid:20508187 |
Pchejetski D et al. | Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer. | 2010 | Breast Cancer Res. Treat. | pmid:20535545 |
Leong WI and Saba JD | S1P metabolism in cancer and other pathological conditions. | 2010 | Biochimie | pmid:20167244 |
Ma B et al. | Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20188554 |
Gangoiti P et al. | Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. | 2010 | Prog. Lipid Res. | pmid:20193711 |
Zabielski P et al. | The effect of high-fat diet on the sphingolipid pathway of signal transduction in regenerating rat liver. | 2010 | Prostaglandins Other Lipid Mediat. | pmid:20599517 |
Tölle M et al. | Relevance of sphingolipids in the pleiotropic protective effects of high-density lipoproteins. | 2010 | Curr. Pharm. Des. | pmid:20196741 |
Weigert A et al. | Cleavage of sphingosine kinase 2 by caspase-1 provokes its release from apoptotic cells. | 2010 | Blood | pmid:20197547 |