MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Watson L et al. | Increased serum concentration of sphingosine-1-phosphate in juvenile-onset systemic lupus erythematosus. | 2012 | J. Clin. Immunol. | pmid:22648459 |
Sato C et al. | Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22659743 |
Farahat WA et al. | Ensemble analysis of angiogenic growth in three-dimensional microfluidic cell cultures. | 2012 | PLoS ONE | pmid:22662145 |
Nijnik A et al. | The role of sphingosine-1-phosphate transporter Spns2 in immune system function. | 2012 | J. Immunol. | pmid:22664872 |
Kunisawa J and Kiyono H | Immunological function of sphingosine 1-phosphate in the intestine. | 2012 | Nutrients | pmid:22666543 |
Yang J et al. | Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling. | 2012 | Circulation | pmid:22668972 |
Li C et al. | Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor. | 2012 | J. Neurophysiol. | pmid:22673325 |
Takuwa Y et al. | Sphingosine-1-phosphate signaling in physiology and diseases. | 2012 Sep-Oct | Biofactors | pmid:22674845 |
Shmyrev VI et al. | [Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature]. | 2012 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:22677684 |
Lee SH et al. | Higher circulating sphingosine 1-phosphate levels are associated with lower bone mineral density and higher bone resorption marker in humans. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22679064 |
Ishii M and Kikuta J | Sphingosine-1-phosphate signaling controlling osteoclasts and bone homeostasis. | 2013 | Biochim. Biophys. Acta | pmid:22691949 |
Krishna SM et al. | Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. | 2012 | Am. J. Pathol. | pmid:22698985 |
Ponnusamy S et al. | Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. | 2012 | EMBO Mol Med | pmid:22707406 |
GarcÃa-Bernal D et al. | Sphingosine-1-phosphate activates chemokine-promoted myeloma cell adhesion and migration involving α4β1 integrin function. | 2013 | J. Pathol. | pmid:22711564 |
Testai FD et al. | Changes in the cerebrospinal fluid ceramide profile after subarachnoid hemorrhage. | 2012 | Stroke | pmid:22713492 |
GarcÃa-Merino JA and Sánchez AJ | [Basic mechanisms of action of fingolimod in relation to multiple sclerosis]. | 2012 | Rev Neurol | pmid:22718407 |
Hisano Y et al. | Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells. | 2012 | PLoS ONE | pmid:22723910 |
Upadhyaya P et al. | The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22727907 |
Chiba K and Yoshii N | [Pharmacological properties and clinical efficacy of fingolimod hydrochloride (Imusera®/Gilenya®) for the treatment of multiple sclerosis]. | 2012 | Nippon Yakurigaku Zasshi | pmid:22728990 |
Linke B et al. | Analysis of sphingolipid and prostaglandin synthesis during zymosan-induced inflammation. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22732087 |
Yokoyama K et al. | Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. | 2012 | Clin. Nephrol. | pmid:22732343 |
Ohotski J et al. | Identification of novel functional and spatial associations between sphingosine kinase 1, sphingosine 1-phosphate receptors and other signaling proteins that affect prognostic outcome in estrogen receptor-positive breast cancer. | 2013 | Int. J. Cancer | pmid:22733311 |
Takuwa Y et al. | Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases. | 2013 | Biochim. Biophys. Acta | pmid:22735357 |
Olivera A et al. | Shaping the landscape: metabolic regulation of S1P gradients. | 2013 | Biochim. Biophys. Acta | pmid:22735358 |
Karliner JS | Sphingosine kinase and sphingosine 1-phosphate in the heart: a decade of progress. | 2013 | Biochim. Biophys. Acta | pmid:22735359 |
Che W et al. | Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. | 2012 | Biochim. Biophys. Acta | pmid:22743041 |
Kharel Y et al. | Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. | 2012 | Biochem. J. | pmid:22747486 |
Saba JD and de la Garza-Rodea AS | S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. | 2013 | Biochim. Biophys. Acta | pmid:22750505 |
Zhang BL et al. | Sphingosine 1-phosphate acts as an activator for the porcine Gpr3 of constitutively active G protein-coupled receptors. | 2012 | J Zhejiang Univ Sci B | pmid:22761247 |
Kotelevets N et al. | Targeting sphingosine kinase 1 in carcinoma cells decreases proliferation and survival by compromising PKC activity and cytokinesis. | 2012 | PLoS ONE | pmid:22761740 |
Nakahara T et al. | Sphingosine-1-phosphate inhibits H2O2-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway. | 2012 | Fertil. Steril. | pmid:22763095 |
Czarnota GJ et al. | Tumor radiation response enhancement by acoustical stimulation of the vasculature. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22778441 |
Brizuela L et al. | First evidence of sphingosine 1-phosphate lyase protein expression and activity downregulation in human neoplasm: implication for resistance to therapeutics in prostate cancer. | 2012 | Mol. Cancer Ther. | pmid:22784711 |
Chan H and Pitson SM | Post-translational regulation of sphingosine kinases. | 2013 | Biochim. Biophys. Acta | pmid:22801036 |
Orr Gandy KA and Obeid LM | Targeting the sphingosine kinase/sphingosine 1-phosphate pathway in disease: review of sphingosine kinase inhibitors. | 2013 | Biochim. Biophys. Acta | pmid:22801037 |
Pyne NJ et al. | Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis. | 2013 | Biochim. Biophys. Acta | pmid:22801038 |
Shea BS and Tager AM | Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis. | 2012 | Proc Am Thorac Soc | pmid:22802282 |
Boussommier-Calleja A et al. | Pharmacologic manipulation of conventional outflow facility in ex vivo mouse eyes. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:22807298 |
Iwaki S et al. | Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22819712 |
Knapp M et al. | Myocardial infarction changes sphingolipid metabolism in the uninfarcted ventricular wall of the rat. | 2012 | Lipids | pmid:22833182 |
Pitman MR et al. | Molecular targets of FTY720 (fingolimod). | 2012 | Curr. Mol. Med. | pmid:22834825 |
Liu Q et al. | Inhibition of sphingosine kinase-2 suppresses inflammation and attenuates graft injury after liver transplantation in rats. | 2012 | PLoS ONE | pmid:22848628 |
Yu FX et al. | Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. | 2012 | Cell | pmid:22863277 |
Curry FE et al. | Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22865384 |
Donati C et al. | New insights into the role of sphingosine 1-phosphate and lysophosphatidic acid in the regulation of skeletal muscle cell biology. | 2013 | Biochim. Biophys. Acta | pmid:22877992 |
Kim BJ et al. | Plasma sphingosine 1-phosphate levels and the risk of vertebral fracture in postmenopausal women. | 2012 | J. Clin. Endocrinol. Metab. | pmid:22879631 |
Miller E et al. | Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. | 2012 | Chem. Biol. | pmid:22884261 |
Asghar MY et al. | Sphingosine 1-phosphate and human ether-a'-go-go-related gene potassium channels modulate migration in human anaplastic thyroid cancer cells. | 2012 | Endocr. Relat. Cancer | pmid:22889737 |
Schwalm S et al. | Sphingosine-1-phosphate: a Janus-faced mediator of fibrotic diseases. | 2013 | Biochim. Biophys. Acta | pmid:22889995 |
Masuko K et al. | Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis. | 2012 | Int J Rheum Dis | pmid:22898216 |
Schmitz EI et al. | Sphingosine 1-phosphate protects primary human keratinocytes from apoptosis via nitric oxide formation through the receptor subtype S1P₃. | 2012 | Mol. Cell. Biochem. | pmid:22899173 |
Egom EE | A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1. | 2012 | Ther Adv Cardiovasc Dis | pmid:22902834 |
Ihlefeld K et al. | Evidence for a link between histone deacetylation and Ca²+ homoeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts. | 2012 | Biochem. J. | pmid:22908849 |
Kimizuka K et al. | Sphingosine 1-phosphate (S1P) induces S1P2 receptor-dependent tonic contraction in murine iliac lymph vessels. | 2013 | Microcirculation | pmid:22913344 |
He S et al. | Self-amplification mechanisms of mast cell activation: a new look in allergy. | 2012 | Curr. Mol. Med. | pmid:22920722 |
Hisano Y et al. | The functional roles of S1P in immunity. | 2012 | J. Biochem. | pmid:22923732 |
Wang ZY et al. | [Effect of sphingosine 1-phosphate/sphingosine 1-phosphate receptor signal pathway on function of neutrophils]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22931670 |
Price MM et al. | A specific sphingosine kinase 1 inhibitor attenuates airway hyperresponsiveness and inflammation in a mast cell-dependent murine model of allergic asthma. | 2013 | J. Allergy Clin. Immunol. | pmid:22939756 |
Jin YX et al. | A strategy for enrichment of the bioactive sphingoid base-1-phosphates produced by Hypericum perforatum L. in a balloon type airlift reactor. | 2012 | Bioresour. Technol. | pmid:22940331 |
Snider AJ et al. | Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22940715 |
Cannon RE et al. | Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22949658 |
Richerioux N et al. | Rho-ROCK and Rac-PAK signaling pathways have opposing effects on the cell-to-cell spread of Marek's Disease Virus. | 2012 | PLoS ONE | pmid:22952878 |
Knapp M et al. | Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. | 2012 | Basic Res. Cardiol. | pmid:22961594 |
Taub DD et al. | Distinct energy requirements for human memory CD4 T-cell homeostatic functions. | 2013 | FASEB J. | pmid:22972918 |
Ratajczak MZ et al. | An emerging link in stem cell mobilization between activation of the complement cascade and the chemotactic gradient of sphingosine-1-phosphate. | 2013 Jul-Aug | Prostaglandins Other Lipid Mediat. | pmid:22981511 |
Aoyagi T et al. | The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. | 2012 | Lymphat Res Biol | pmid:22984905 |
Xiang SY et al. | Lysophospholipid receptor activation of RhoA and lipid signaling pathways. | 2013 | Biochim. Biophys. Acta | pmid:22986288 |
Patel SA et al. | Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. | 2012 | Endocrinology | pmid:22989629 |
Moon MH et al. | Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes. | 2012 | Int. J. Mol. Med. | pmid:22992945 |
Park TS and Goldberg IJ | Sphingolipids, lipotoxic cardiomyopathy, and cardiac failure. | 2012 | Heart Fail Clin | pmid:22999245 |
Taniguchi M et al. | Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. | 2012 | J. Biol. Chem. | pmid:23035115 |
Kawashima T et al. | Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts. | 2012 | Eur. J. Pharmacol. | pmid:23041148 |
Brewer JW | Phospholipids: "greasing the wheels" of humoral immunity. | 2013 | Biochim. Biophys. Acta | pmid:23051607 |
Di Menna L et al. | Fingolimod protects cultured cortical neurons against excitotoxic death. | 2013 | Pharmacol. Res. | pmid:23073075 |
Sorci-Thomas MG and Thomas MJ | High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:23077142 |
Véret J et al. | Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival. | 2013 | Biochim. Biophys. Acta | pmid:23085009 |
Fernández-Pisonero I et al. | Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells. | 2012 | J. Immunol. | pmid:23089395 |
Ma Y et al. | Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (Hâ‚‚Oâ‚‚) levels in guard cells in Vicia faba. | 2012 | Sci China Life Sci | pmid:23090064 |
Mendoza A et al. | The transporter Spns2 is required for secretion of lymph but not plasma sphingosine-1-phosphate. | 2012 | Cell Rep | pmid:23103166 |
Gandy KA et al. | Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins. | 2013 | Biochem. J. | pmid:23106337 |
Huang J et al. | Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway. | 2013 | Mol. Cell. Endocrinol. | pmid:23127801 |
Wilkerson BA et al. | Sphingosine 1-phosphate (S1P) carrier-dependent regulation of endothelial barrier: high density lipoprotein (HDL)-S1P prolongs endothelial barrier enhancement as compared with albumin-S1P via effects on levels, trafficking, and signaling of S1P1. | 2012 | J. Biol. Chem. | pmid:23135269 |
Tar L and Vécsei L | [Fingolimod therapy in multiple sclerosis--the issue of the pathomechanism]. | 2012 | Ideggyogy Sz | pmid:23136726 |
Japtok L et al. | Sphingosine 1-phosphate modulates antigen capture by murine Langerhans cells via the S1P2 receptor subtype. | 2012 | PLoS ONE | pmid:23145172 |
Zhang L et al. | A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis. | 2012 | J. Exp. Med. | pmid:23148237 |
Qiao Y et al. | Sphingosine 1-phosphate elicits proinflammatory responses in ARPE-19 cells. | 2012 | Invest. Ophthalmol. Vis. Sci. | pmid:23150617 |
Pantoja M et al. | Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila. | 2013 | Development | pmid:23154413 |
Hla T et al. | S1P and the birth of platelets. | 2012 | J. Exp. Med. | pmid:23166370 |
Cartwright TA et al. | Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers. | 2013 | J. Cereb. Blood Flow Metab. | pmid:23168528 |
Cuvillier O | [Sphingosine 1-phosphate receptors: from biology to physiopathology]. | 2012 | Med Sci (Paris) | pmid:23171898 |
Kurek K et al. | [Role of sphingolipids in digestive system]. | 2012 | Postepy Hig Med Dosw (Online) | pmid:23175343 |
Takahashi K et al. | Novel therapy for liver regeneration by increasing the number of platelets. | 2013 | Surg. Today | pmid:23180116 |
Lidington D et al. | Capitalizing on diversity: an integrative approach towards the multiplicity of cellular mechanisms underlying myogenic responsiveness. | 2013 | Cardiovasc. Res. | pmid:23180720 |
Nagahashi M et al. | Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network. | 2013 | FASEB J. | pmid:23180825 |
Kager LM et al. | Endogenous protein C has a protective role during Gram-negative pneumosepsis (melioidosis). | 2013 | J. Thromb. Haemost. | pmid:23216621 |
Jiang LI et al. | Regions on adenylyl cyclase VII required for selective regulation by the G13 pathway. | 2013 | Mol. Pharmacol. | pmid:23229509 |
Park K et al. | A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. | 2013 | Mol. Cell. Biol. | pmid:23230267 |
Xu Y et al. | Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis. | 2013 | Am. J. Respir. Cell Mol. Biol. | pmid:23239501 |
Evindar G et al. | Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23245510 |
Billich A et al. | Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. | 2013 | Anal. Biochem. | pmid:23246729 |