MeSH term | MeSH ID | Detail |
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Farber Lipogranulomatosis | D055577 | 1 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Yatomi Y et al. | [Sphingosine 1-phosphate and vascular endothelial cells]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915347 |
Takuwa Y | [Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915348 |
Tsukahara T et al. | [Molecular diversity of sphingosine kinase]. | 2002 | Tanpakushitsu Kakusan Koso | pmid:11915350 |
English D | Do platelet-released phospholipids play a role in cardiovascular malformations and heritable coangulopathies? | 2002 | Teratology | pmid:11877771 |
Egom EE | A therapeutic approach to hyperglycaemia in the setting of acute myocardial infarction: spotlight on glucagon-like peptide 1. | 2012 | Ther Adv Cardiovasc Dis | pmid:22902834 |
Yang Y and Uhlig S | The role of sphingolipids in respiratory disease. | 2011 | Ther Adv Respir Dis | pmid:21900155 |
Guo L et al. | Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development. | 2013 | Theriogenology | pmid:23731666 |
Milara J et al. | Sphingosine-1-phosphate is increased in patients with idiopathic pulmonary fibrosis and mediates epithelial to mesenchymal transition. | 2012 | Thorax | pmid:22106015 |
Provençal M et al. | Tissue factor pathway inhibitor (TFPI) interferes with endothelial cell migration by inhibition of both the Erk pathway and focal adhesion proteins. | 2008 | Thromb. Haemost. | pmid:18327407 |
RodrÃguez C et al. | Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin. | 2009 | Thromb. Haemost. | pmid:19350109 |
Katkade V et al. | Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt. | 2005 | Thromb. Haemost. | pmid:16268479 |
González-DÃez M et al. | Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. | 2008 | Thromb. Haemost. | pmid:18612546 |
Osada M et al. | Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-alpha in vascular endothelial cells. | 2002 | Thromb. Res. | pmid:12590954 |
Onuma T et al. | Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. | 2017 | Thromb. Res. | pmid:28609704 |
Ohmori T et al. | The intracellular action of sphingosine 1-phosphate in GPVI-mediated Ca2+ mobilization in platelets. | 2005 | Thromb. Res. | pmid:15733975 |
Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
Binder BY et al. | Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering. | 2015 | Tissue Eng Part B Rev | pmid:26035484 |
Whisler JA et al. | Control of perfusable microvascular network morphology using a multiculture microfluidic system. | 2014 | Tissue Eng Part C Methods | pmid:24151838 |
Radi ZA and Vogel MW | Gastric parietal cell atrophy and depletion after administration of a sphingosine-1-phosphate 1 inhibitor. | 2014 | Toxicol Pathol | pmid:24178572 |
Cai Q et al. | Validation of fumonisin biomarkers in F344 rats. | 2007 | Toxicol. Appl. Pharmacol. | pmid:17904604 |