| MeSH term | MeSH ID | Detail |
|---|---|---|
| Sarcoma 180 | D012510 | 21 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Dindo D et al. | Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | 2006 | Mol. Cancer Ther. | pmid:16818511 |
| Durand CA et al. | The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | 2006 | Eur. J. Immunol. | pmid:16821235 |
| Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
| Sanna MG et al. | Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. | 2006 | Nat. Chem. Biol. | pmid:16829954 |
| di Villa Bianca Rd et al. | Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16234413 |
| Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
| Inniss K and Moore H | Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate. | 2006 | Stem Cells Dev. | pmid:17253942 |
| Matsuyuki H et al. | Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. | 2006 | Cell. Mol. Immunol. | pmid:17257496 |
| Naetzker S et al. | Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. | 2006 | Genes Cells | pmid:16483315 |
| Jurisicova A et al. | Molecular requirements for doxorubicin-mediated death in murine oocytes. | 2006 | Cell Death Differ. | pmid:16439991 |
| Bassi R et al. | Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. | 2006 | Glia | pmid:16470810 |
| Yatomi Y | Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. | 2006 | Curr. Pharm. Des. | pmid:16472149 |
| Kurobe H et al. | CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. | 2006 | Immunity | pmid:16473829 |
| von Wenckstern H et al. | The role of the lysophospholipid sphingosine 1-phosphate in immune cell biology. | 2006 Jul-Aug | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:16830220 |
| Fujiwara Y et al. | Identification of the hydrophobic ligand binding pocket of the S1P1 receptor. | 2007 | J. Biol. Chem. | pmid:17114791 |
| Ki SH et al. | Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. | 2007 | J. Biol. Chem. | pmid:17098744 |
| Kume H et al. | Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17105828 |
| Brahmbhatt VV et al. | Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. | 2007 | Chem. Phys. Lipids | pmid:17126823 |
| Kunisawa J et al. | Sphingosine 1-phosphate regulates peritoneal B-cell trafficking for subsequent intestinal IgA production. | 2007 | Blood | pmid:17234743 |
| Martino A et al. | Sphingosine 1-phosphate interferes on the differentiation of human monocytes into competent dendritic cells. | 2007 | Scand. J. Immunol. | pmid:17212771 |
| Johnstone ED et al. | Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17913870 |
| Hänel P et al. | Erythrocytes store and release sphingosine 1-phosphate in blood. | 2007 | FASEB J. | pmid:17215483 |
| Siow DL and Wattenberg BW | An assay system for measuring the acute production of sphingosine 1-phosphate in intact monolayers. | 2007 | Anal. Biochem. | pmid:17884005 |
| Gonzalez-Cabrera PJ et al. | Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics. | 2007 | J. Biol. Chem. | pmid:17218309 |
| Igarashi J et al. | Statins induce S1P1 receptors and enhance endothelial nitric oxide production in response to high-density lipoproteins. | 2007 | Br. J. Pharmacol. | pmid:17220911 |
| Maceyka M et al. | Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. | 2007 | Circ. Res. | pmid:17204658 |
| Guo Y et al. | Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. | 2007 | Mol. Cell Proteomics | pmid:17210631 |
| Zhao Y et al. | Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. | 2007 | J. Biol. Chem. | pmid:17379599 |
| Matsuo Y et al. | Newly developed reconstituted high-density lipoprotein containing sphingosine-1-phosphate induces endothelial tube formation. | 2007 | Atherosclerosis | pmid:17118370 |
| Nodai A et al. | Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. | 2007 | Life Sci. | pmid:17382352 |
| Baumruker T et al. | FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. | 2007 | Expert Opin Investig Drugs | pmid:17302523 |
| Baran Y et al. | Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. | 2007 | J. Biol. Chem. | pmid:17303574 |
| Chandru H and Boggaram V | The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | 2007 | Gene | pmid:17306937 |
| Jung ID et al. | Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells. | 2007 | Int. Immunol. | pmid:17307797 |
| Bonnaud S et al. | Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death. | 2007 | Cancer Res. | pmid:17308123 |
| Rosen H et al. | Tipping the gatekeeper: S1P regulation of endothelial barrier function. | 2007 | Trends Immunol. | pmid:17276731 |
| Liao JJ et al. | Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. | 2007 | J. Immunol. | pmid:17442922 |
| Choi CH et al. | Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. | 2007 | Arch. Pharm. Res. | pmid:17489368 |
| Donati C et al. | Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. | 2007 | Stem Cells | pmid:17464089 |
| Naor MM et al. | Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences. | 2007 | J. Mol. Graph. Model. | pmid:17467317 |
| Ito K et al. | Lack of sphingosine 1-phosphate-degrading enzymes in erythrocytes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17418101 |
| Xia P | Letter by Xia regarding article, "High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor". | 2007 | Circulation | pmid:17420358 |
| Suzuki H et al. | Inducible nitric oxide has protective effect on fumonisin B1 hepatotoxicity in mice via modulation of sphingosine kinase. | 2007 | Toxicology | pmid:17095132 |
| Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. | 2007 | Cardiovasc. Res. | pmid:17320845 |
| Roviezzo F et al. | Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17322125 |
| Kajimoto T et al. | Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. | 2007 | Mol. Cell. Biol. | pmid:17325039 |
| Nombela-Arrieta C et al. | A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. | 2007 | J. Exp. Med. | pmid:17325199 |
| Osada M et al. | Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells. | 2007 | J. Biochem. | pmid:17646176 |
| Weigert A et al. | Tumor cell apoptosis polarizes macrophages role of sphingosine-1-phosphate. | 2007 | Mol. Biol. Cell | pmid:17652460 |
| Kimura A et al. | Essential roles of sphingosine 1-phosphate/S1P1 receptor axis in the migration of neural stem cells toward a site of spinal cord injury. | 2007 | Stem Cells | pmid:16990586 |