| MeSH term | MeSH ID | Detail |
|---|---|---|
| Sarcoma 180 | D012510 | 21 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hsia K et al. | Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. | 2017 | Acta Biomater | pmid:28110073 |
| Maiti A et al. | Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival. | 2017 | Cell. Signal. | pmid:28108260 |
| Meissner A et al. | Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension. | 2017 | Cardiovasc. Res. | pmid:28082452 |
| Atkinson D et al. | Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. | 2017 | Neurology | pmid:28077491 |
| Ng ML et al. | The role of sphingolipid signalling in diabetes‑associated pathologies (Review). | 2017 | Int. J. Mol. Med. | pmid:28075451 |
| van der Weyden L et al. | Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. | 2017 | Nature | pmid:28052056 |
| Lima S et al. | Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. | 2017 | J. Biol. Chem. | pmid:28049734 |
| O'Sullivan S and Dev KK | Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. | 2017 | Neuropharmacology | pmid:27825807 |
| Yanagida K and Hla T | Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. | 2017 | Annu. Rev. Physiol. | pmid:27813829 |
| Zhao Z et al. | Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. | 2017 | Acta Haematol. | pmid:27802432 |
| González-Fernández B et al. | Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. | 2017 | Biofactors | pmid:27801960 |
| McLean CJ et al. | Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. | 2017 | J. Lipid Res. | pmid:27784725 |
| Abraham C et al. | Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. | 2017 | Gastroenterology | pmid:27780712 |
| Katsuta E et al. | Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. | 2017 | J. Surg. Res. | pmid:29078883 |
| Anjum I et al. | Enhancement of S1P-induced contractile response in detrusor smooth muscle of rats having cystitis. | 2017 | Eur. J. Pharmacol. | pmid:28882559 |
| Haddadi N et al. | "Dicing and Splicing" Sphingosine Kinase and Relevance to Cancer. | 2017 | Int J Mol Sci | pmid:28869494 |
| Bosteen MH et al. | Effects of apolipoprotein M in uremic atherosclerosis. | 2017 | Atherosclerosis | pmid:28866363 |
| Olesch C et al. | Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. | 2017 | Mediators Inflamm. | pmid:28848247 |
| Egom EE et al. | Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry. | 2017 | Int J Mol Sci | pmid:28820460 |
| Swendeman SL et al. | An engineered S1P chaperone attenuates hypertension and ischemic injury. | 2017 | Sci Signal | pmid:28811382 |
| Syed SN et al. | S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. | 2017 | Mediators Inflamm. | pmid:28804221 |
| Doan NB et al. | Acid ceramidase confers radioresistance to glioblastoma cells. | 2017 | Oncol. Rep. | pmid:28765947 |
| Arish M et al. | Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. | 2017 | J. Recept. Signal Transduct. Res. | pmid:28758826 |
| Polzin A et al. | Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. | 2017 | J. Mol. Cell. Cardiol. | pmid:28709768 |
| Innamorati G et al. | Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. | 2017 | Cell Death Dis | pmid:28703804 |
| Schmidt KG et al. | Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. | 2017 | Front Immunol | pmid:29033951 |
| Alqinyah M et al. | Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. | 2017 | Mol. Pharmacol. | pmid:28031332 |
| Patmanathan SN et al. | Mechanisms of sphingosine 1-phosphate receptor signalling in cancer. | 2017 | Cell. Signal. | pmid:28302566 |
| Li S et al. | Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. | 2017 | Gynecol. Endocrinol. | pmid:28277139 |
| Garnero P | The Utility of Biomarkers in Osteoporosis Management. | 2017 | Mol Diagn Ther | pmid:28271451 |
| Zeng Y | Endothelial glycocalyx as a critical signalling platform integrating the extracellular haemodynamic forces and chemical signalling. | 2017 | J. Cell. Mol. Med. | pmid:28211170 |
| Sun XJ et al. | Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. | 2017 | Nephrol. Dial. Transplant. | pmid:28206609 |
| Janecke AR et al. | Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. | 2017 | Hum. Mutat. | pmid:28181337 |
| Moritz E et al. | Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. | 2017 | Clin. Chim. Acta | pmid:28159438 |
| Winkler MS et al. | Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? | 2017 | Shock | pmid:27922551 |
| Chen T et al. | Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. | 2017 | Front Biosci (Landmark Ed) | pmid:27814635 |
| Feuerborn R et al. | High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. | 2017 | Atherosclerosis | pmid:28038379 |
| Wang M et al. | Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. | 2017 | PLoS ONE | pmid:29136008 |
| Tran HB et al. | Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. | 2017 | PLoS ONE | pmid:29112690 |
| Mensah SA et al. | Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. | 2017 | PLoS ONE | pmid:29023478 |
| Wang X et al. | Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. | 2017 | Exp. Mol. Pathol. | pmid:28986246 |
| Werth S et al. | Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. | 2017 | J. Endocrinol. | pmid:28970286 |
| Du Y et al. | Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. | 2017 | Cell. Physiol. Biochem. | pmid:28934733 |
| Kuchler L et al. | Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. | 2017 | Mol. Immunol. | pmid:28846923 |
| Garbowska M et al. | Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes. | 2017 | J. Cell. Physiol. | pmid:28369933 |
| Turner VM and Mabbott NA | Ageing adversely affects the migration and function of marginal zone B cells. | 2017 | Immunology | pmid:28369800 |
| Müller J et al. | Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. | 2017 | Biomed Res Int | pmid:28367448 |
| King A et al. | Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. | 2017 | Gastroenterology | pmid:28363640 |
| Wollny T et al. | Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. | 2017 | Int J Mol Sci | pmid:28362332 |
| Denimal D et al. | Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:28360087 |
| Gusman DH and Shoemake C | Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. | 2017 | Yale J Biol Med | pmid:28356890 |
| Andrieu G et al. | Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. | 2017 | Sci Signal | pmid:28351953 |
| Becker S et al. | Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. | 2017 | PLoS ONE | pmid:28334008 |
| Karunakaran I and van Echten-Deckert G | Sphingosine 1-phosphate - A double edged sword in the brain. | 2017 | Biochim. Biophys. Acta | pmid:28315304 |
| Navarrete A et al. | A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. | 2017 | J Pharm Biomed Anal | pmid:28314215 |
| Al Fadel F et al. | Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease. | 2016 | Cell. Physiol. Biochem. | pmid:28006772 |
| Bigaud M et al. | Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism. | 2016 | PLoS ONE | pmid:28005953 |
| Surya VN et al. | Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. | 2016 | J R Soc Interface | pmid:27974574 |
| Soltau I et al. | Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. | 2016 | PLoS ONE | pmid:27973607 |
| Al Alam N and Kreydiyyeh SI | FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. | 2016 | Biochem. Cell Biol. | pmid:27501354 |
| Higashi K et al. | Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. | 2016 | Bone | pmid:27612439 |
| Sasset L et al. | Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. | 2016 | Trends Endocrinol. Metab. | pmid:27562337 |
| Roviezzo F et al. | Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. | 2016 | Pharmacol. Res. | pmid:27713021 |
| Hemdan NY et al. | Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. | 2016 | Eur. J. Immunol. | pmid:27683081 |
| Chew WS et al. | To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. | 2016 | Pharmacol. Res. | pmid:27663260 |
| Hashimoto Y et al. | Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. | 2016 | Cell Biol. Int. | pmid:27486054 |
| Viswanathan P et al. | Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27473658 |
| Moruno Manchon JF et al. | SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. | 2016 | Autophagy | pmid:27467777 |
| Nagahashi M et al. | The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. | 2016 | J. Lipid Res. | pmid:27459945 |
| Rumzhum NN et al. | Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26098693 |
| Zhang XE et al. | Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. | 2016 | PLoS ONE | pmid:27187066 |
| Ohtoyo M et al. | Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. | 2016 | Cell Chem Biol | pmid:27185637 |
| Fleming JK et al. | A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. | 2016 | J. Lipid Res. | pmid:27444045 |
| Barnawi J et al. | Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. | 2016 | COPD | pmid:27144721 |
| Jin L et al. | The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. | 2016 | World J Surg Oncol | pmid:27129720 |
| Sanchez T | Sphingosine-1-Phosphate Signaling in Endothelial Disorders. | 2016 | Curr Atheroscler Rep | pmid:27115142 |
| Crespo I et al. | Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. | 2016 | J. Pineal Res. | pmid:27101794 |
| Riganti L et al. | Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. | 2016 | J. Neurosci. | pmid:27098703 |
| Trinh HK et al. | Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease. | 2016 | Sci Rep | pmid:27830727 |
| Tang X et al. | Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate. | 2016 | J. Lipid Res. | pmid:26884614 |
| Uranbileg B et al. | Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. | 2016 | PLoS ONE | pmid:26886371 |
| Chumanevich A et al. | Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. | 2016 | Mediators Inflamm. | pmid:26884643 |
| Ko P et al. | Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. | 2016 | Sci Rep | pmid:26877098 |
| Luo B et al. | Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. | 2016 | Immunity | pmid:26872696 |
| Li J et al. | Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. | 2016 | Tumour Biol. | pmid:26857281 |
| Petrache I and Berdyshev EV | Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. | 2016 | Annu. Rev. Physiol. | pmid:26667073 |
| Delgado A and MartÃnez-Cartro M | Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. | 2016 | Curr. Med. Chem. | pmid:26639095 |
| Yamamoto S et al. | A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). | 2016 | Mol. Biol. Cell | pmid:26631556 |
| Kakazu E et al. | Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. | 2016 | J. Lipid Res. | pmid:26621917 |
| Chen J et al. | Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. | 2016 | Biochim. Biophys. Acta | pmid:26615875 |
| Maczis M et al. | Sphingosine-1-phosphate and estrogen signaling in breast cancer. | 2016 | Adv Biol Regul | pmid:26601898 |
| Gao D et al. | Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26859520 |
| Scotti L et al. | Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. | 2016 | Mol. Hum. Reprod. | pmid:27645281 |
| Neubauer HA et al. | An oncogenic role for sphingosine kinase 2. | 2016 | Oncotarget | pmid:27588496 |
| Zeng Y et al. | Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. | 2016 | Oncotarget | pmid:27556509 |
| Nagahashi M et al. | Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. | 2016 | J Mammary Gland Biol Neoplasia | pmid:27194029 |
| Nigro E et al. | Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation. | 2016 | Pharmacol. Res. | pmid:26462929 |
| Serdar M et al. | Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. | 2016 | Brain Behav. Immun. | pmid:26456693 |
| Arish M et al. | Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. | 2016 | Drug Discov. Today | pmid:26456576 |
| Melnik BC | Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. | 2016 | Acta Derm. Venereol. | pmid:26304030 |