Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Sarcoma 180 D012510 21 associated lipids
Edema D004487 152 associated lipids
Arthritis D001168 41 associated lipids
Heart Failure D006333 36 associated lipids
Pulmonary Edema D011654 23 associated lipids
Coronary Disease D003327 70 associated lipids
Prostatic Neoplasms D011471 126 associated lipids
Hypersensitivity D006967 22 associated lipids
Acne Vulgaris D000152 35 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

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Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Meyer zu Heringdorf D et al. Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. 2001 Eur. J. Pharmacol. pmid:11239914
Blaukat A and Dikic I Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. 2001 Biol. Chem. pmid:11258664
Alderton F et al. G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. 2001 J. Biol. Chem. pmid:11278307
Igarashi J et al. Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. 2001 J. Biol. Chem. pmid:11278407
Morales-Ruiz M et al. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. 2001 J. Biol. Chem. pmid:11278592
Birchwood CJ et al. Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. 2001 J. Biol. Chem. pmid:11278643
Ng CK et al. Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. 2001 Nature pmid:11279499
Repp H et al. Activation of a Ca2+-dependent K+ current in mouse fibroblasts by sphingosine-1-phosphate involves the protein tyrosine kinase c-Src. 2001 Naunyn Schmiedebergs Arch. Pharmacol. pmid:11284444
Ruwisch L et al. An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. 2001 Naunyn Schmiedebergs Arch. Pharmacol. pmid:11284453
Andor A et al. YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. 2001 Cell. Microbiol. pmid:11298653
Kranenburg O and Moolenaar WH Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. 2001 Oncogene pmid:11313900
Yatomi Y et al. Sphingosine 1-phosphate: synthesis and release. 2001 Prostaglandins Other Lipid Mediat. pmid:11324700
Goetzl EJ Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids. 2001 Prostaglandins Other Lipid Mediat. pmid:11324701
Olivera A and Spiegel S Sphingosine kinase: a mediator of vital cellular functions. 2001 Prostaglandins Other Lipid Mediat. pmid:11324702
Hla T Sphingosine 1-phosphate receptors. 2001 Prostaglandins Other Lipid Mediat. pmid:11324703
Mandala SM Sphingosine-1-phosphate phosphatases. 2001 Prostaglandins Other Lipid Mediat. pmid:11324704
Lynch KR and Macdonald TL Structure activity relationships of lysophospholipid mediators. 2001 Prostaglandins Other Lipid Mediat. pmid:11324706
Panetti TS et al. Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. 2001 Prostaglandins Other Lipid Mediat. pmid:11324710
Schwartz BM et al. Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. 2001 Gynecol. Oncol. pmid:11330965
Ammit AJ et al. Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. 2001 FASEB J. pmid:11344091
Alderton F et al. Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. 2001 J. Biol. Chem. pmid:11359779
Takuwa Y et al. Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. 2001 Mol. Cell. Endocrinol. pmid:11377814
Wells CD et al. Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. 2001 J. Biol. Chem. pmid:11384980
Liu F et al. Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. 2001 Am. J. Respir. Cell Mol. Biol. pmid:11415936
Olorundare OE et al. Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists. 2001 Blood pmid:11418470
Osawa Y et al. TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. 2001 J. Immunol. pmid:11418646
Pébay A et al. Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. 2001 Eur. J. Neurosci. pmid:11422447
Kimura T et al. Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. 2001 J. Biol. Chem. pmid:11427538
Ishii I et al. Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. 2001 J. Biol. Chem. pmid:11443127
Boujaoude LC et al. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. 2001 J. Biol. Chem. pmid:11443135
Kralik SF et al. A method for quantitative extraction of sphingosine 1-phosphate into organic solvent. 2001 Anal. Biochem. pmid:11444818
Pébay A et al. Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. 2001 Eur. J. Neurosci. pmid:11467306
Banno Y et al. Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. 2001 J. Biol. Chem. pmid:11468290
Brownlee C Intracellular signalling: sphingosine-1-phosphate branches out. 2001 Curr. Biol. pmid:11470429
Igarashi J and Michel T Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. 2001 J. Biol. Chem. pmid:11470796
Meacci E et al. Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts. 2001 Cell. Signal. pmid:11483412
Osawa Y et al. Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. 2001 Biochem. Biophys. Res. Commun. pmid:11520048
Bischoff A et al. Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. 2001 Naunyn Schmiedebergs Arch. Pharmacol. pmid:11534858
Garcia JG et al. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. 2001 J. Clin. Invest. pmid:11544274
Nadal A et al. Glial cell responses to lipids bound to albumin in serum and plasma. 2001 Prog. Brain Res. pmid:11545003
Robert P et al. EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. 2001 J. Mol. Cell. Cardiol. pmid:11549339
Karliner JS et al. The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. 2001 J. Mol. Cell. Cardiol. pmid:11549349
Marletta MA Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? 2001 Trends Biochem. Sci. pmid:11551775
Erl W and Siess W Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. 2001 Circ. Res. pmid:11557732
Kluk MJ and Hla T Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. 2001 Circ. Res. pmid:11557736
Li G et al. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. 2001 Development pmid:11566853
Lee MJ et al. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. 2001 Mol. Cell pmid:11583630
Wang DA et al. A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors. 2001 J. Biol. Chem. pmid:11604399
Siehler S et al. Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. 2001 J. Biol. Chem. pmid:11673450
Cuvillier O and Levade T Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. 2001 Blood pmid:11675357