| MeSH term | MeSH ID | Detail |
|---|---|---|
| Sarcoma 180 | D012510 | 21 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Coronary Disease | D003327 | 70 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Acne Vulgaris | D000152 | 35 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kulinski JM et al. | Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. | 2016 | Eur. J. Pharmacol. | pmid:25941085 |
| Kasbi-Chadli F et al. | Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. | 2016 | Eur J Nutr | pmid:25787885 |
| Terashita T et al. | Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. | 2016 | Respir. Res. | pmid:27829417 |
| Brait VH et al. | Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. | 2016 | Stroke | pmid:27827329 |
| Zamora-Pineda J et al. | Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. | 2016 | J. Exp. Med. | pmid:27810923 |
| Kobayashi N et al. | Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes. | 2016 | J. Lipid Res. | pmid:27655910 |
| Evangelisti C et al. | Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. | 2016 | Leukemia | pmid:27461062 |
| Stolwijk JA et al. | Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function. | 2016 | J. Biol. Chem. | pmid:27624938 |
| Custódio R et al. | Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei. | 2016 | Mol. Microbiol. | pmid:27632710 |
| Ebenezer DL et al. | Targeting sphingosine-1-phosphate signaling in lung diseases. | 2016 | Pharmacol. Ther. | pmid:27621206 |
| Tsuchida J et al. | Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. | 2016 | J. Surg. Res. | pmid:27621003 |
| Chen W et al. | Sphingosine 1-phosphate in metabolic syndrome (Review). | 2016 | Int. J. Mol. Med. | pmid:27600830 |
| Hamidi Shishavan M et al. | Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. | 2016 | PLoS ONE | pmid:27583547 |
| Gazit SL et al. | Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. | 2016 | Circ. Res. | pmid:27582371 |
| Machida T et al. | Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. | 2016 | J. Pharmacol. Sci. | pmid:27581589 |
| Nagahashi M et al. | High levels of sphingolipids in human breast cancer. | 2016 | J. Surg. Res. | pmid:27565080 |
| Dong T et al. | Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. | 2016 | J Neuroinflammation | pmid:27561600 |
| Chen C et al. | Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. | 2016 | Mol. Cell. Endocrinol. | pmid:26948947 |
| Hernández-Coronado CG et al. | Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. | 2016 | Gen. Comp. Endocrinol. | pmid:27342378 |
| Chakrabarti SS et al. | Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. | 2016 | Curr Alzheimer Res | pmid:27335046 |
| Tsai HC and Han MH | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. | 2016 | Drugs | pmid:27318702 |
| Yang Z et al. | TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. | 2016 | Pharmacol. Res. | pmid:27317945 |
| Cantalupo A and Di Lorenzo A | S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27317800 |
| Juif PE et al. | Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. | 2016 | Expert Opin Drug Metab Toxicol | pmid:27249325 |
| Hollands A et al. | Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. | 2016 | J. Biol. Chem. | pmid:27226531 |
| Mirzaian M et al. | Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. | 2016 | Clin. Chim. Acta | pmid:27221202 |
| Aoki M et al. | Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. | 2016 | Mediators Inflamm. | pmid:26966342 |
| Brinck JW et al. | Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. | 2016 | Arterioscler. Thromb. Vasc. Biol. | pmid:26966278 |
| Chawla S et al. | S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report. | 2016 | IUBMB Life | pmid:26959531 |
| Vito CD et al. | Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications. | 2016 | Platelets | pmid:26950429 |
| Jin J et al. | Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. | 2016 | Sci Rep | pmid:26948042 |
| Guerrero M et al. | Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). | 2016 | Expert Opin Ther Pat | pmid:26947494 |
| Watterson SH et al. | Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. | 2016 | J. Med. Chem. | pmid:26924461 |
| Liu W et al. | Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. | 2016 | Eur. J. Pharmacol. | pmid:26921757 |
| Puli MR et al. | Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. | 2016 | Planta | pmid:27233507 |
| Zhang Y et al. | Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. | 2016 | PLoS ONE | pmid:26788916 |
| Dillmann C et al. | S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. | 2016 | J. Immunol. | pmid:26783340 |
| Ghasemi R et al. | Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage. | 2016 | Pharmacol. Res. | pmid:26772814 |
| Morel S et al. | Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. | 2016 | Cardiovasc. Res. | pmid:26762268 |
| Sundaram K et al. | Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. | 2016 | Biochem. J. | pmid:26747710 |
| Abu Khweek A et al. | The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. | 2016 | PLoS ONE | pmid:26741365 |
| Deniz U et al. | A systematic methodology for large scale compound screening: A case study on the discovery of novel S1PL inhibitors. | 2016 | J. Mol. Graph. Model. | pmid:26724452 |
| Beach JA et al. | Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer. | 2016 | Oncotarget | pmid:26716409 |
| Deutsch G et al. | Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. | 2016 | Gene | pmid:26707209 |
| Kim YH and Tabata Y | Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure. | 2016 | J Biomed Mater Res A | pmid:26704185 |
| Campos LS et al. | Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. | 2016 | Mol. Cell. Biol. | pmid:26552704 |
| Nagahashi M et al. | DNA damage response and sphingolipid signaling in liver diseases. | 2016 | Surg. Today | pmid:26514817 |
| Liu X et al. | Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells. | 2016 | Exp. Biol. Med. (Maywood) | pmid:26376826 |
| Grammatikos G et al. | Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. | 2016 | Oncotarget | pmid:26933996 |
| Filipenko I et al. | Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. | 2016 | Biochim. Biophys. Acta | pmid:27616330 |