Miller E et al. |
Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. |
2012 |
Chem. Biol. |
pmid:22884261
|
Pan S et al. |
A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. |
2006 |
Chem. Biol. |
pmid:17114004
|
Jo E et al. |
S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. |
2005 |
Chem. Biol. |
pmid:15975516
|
Zhang T et al. |
Apigenin attenuates heart injury in lipopolysaccharide-induced endotoxemic model by suppressing sphingosine kinase 1/sphingosine 1-phosphate signaling pathway. |
2015 |
Chem. Biol. Interact. |
pmid:25557508
|
Kim ES et al. |
A natural piper-amide-like compound NED-135 exhibits a potent inhibitory effect on the invasive breast cancer cells. |
2015 |
Chem. Biol. Interact. |
pmid:25980589
|
Tardieu D et al. |
Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. |
2006 |
Chem. Biol. Interact. |
pmid:16412405
|
Brahmbhatt VV et al. |
Novel carbonyl and nitrile products from reactive chlorinating species attack of lysosphingolipid. |
2007 |
Chem. Phys. Lipids |
pmid:17126823
|
Sharma C et al. |
Inhibition of Ca2+ release channel (ryanodine receptor) activity by sphingolipid bases: mechanism of action. |
2000 |
Chem. Phys. Lipids |
pmid:10660207
|
Camp SM et al. |
Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720. |
2015 |
Chem. Phys. Lipids |
pmid:26272033
|
Reina E et al. |
Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry. |
2012 |
Chem. Phys. Lipids |
pmid:22265672
|
Nussbaumer P et al. |
An efficient, one-pot synthesis of various ceramide 1-phosphates from sphingosine 1-phosphate. |
2008 |
Chem. Phys. Lipids |
pmid:18039471
|
Blaho VA and Hla T |
Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors. |
2011 |
Chem. Rev. |
pmid:21939239
|
Bedia C et al. |
Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity. |
2009 |
Chembiochem |
pmid:19226506
|
Ullrich T et al. |
Synthesis and immobilization of erythro-C14-omega-aminosphingosine-1-phosphate as a potential tool for affinity chromatography. |
2008 |
ChemMedChem |
pmid:18000941
|
Åukomska A et al. |
The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
2017 |
Chemosphere |
pmid:27697711
|
Tibboel J et al. |
Sphingolipids in lung growth and repair. |
2014 |
Chest |
pmid:24394822
|
Deng Y et al. |
Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy. |
2014 |
Chin. Med. J. |
pmid:25131242
|
Moxon JV et al. |
Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease. |
2014 |
Circ Cardiovasc Genet |
pmid:24448739
|
Waeber C and Walther T |
Sphingosine-1-phosphate as a potential target for the treatment of myocardial infarction. |
2014 |
Circ. J. |
pmid:24632793
|
Xu H et al. |
Sphingosine-1-phosphate receptor agonist, FTY720, restores coronary flow reserve in diabetic rats. |
2014 |
Circ. J. |
pmid:25319164
|
Mochizuki N |
Vascular integrity mediated by vascular endothelial cadherin and regulated by sphingosine 1-phosphate and angiopoietin-1. |
2009 |
Circ. J. |
pmid:19838001
|
Tauseef M et al. |
Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. |
2008 |
Circ. Res. |
pmid:18849324
|
Urtz N et al. |
Sphingosine 1-Phosphate Produced by Sphingosine Kinase 2 Intrinsically Controls Platelet Aggregation In Vitro and In Vivo. |
2015 |
Circ. Res. |
pmid:26129975
|
Shimizu T et al. |
Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries. |
2007 |
Circ. Res. |
pmid:17872461
|
Saba JD and Hla T |
Point-counterpoint of sphingosine 1-phosphate metabolism. |
2004 |
Circ. Res. |
pmid:15059942
|
Pchejetski D et al. |
Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. |
2007 |
Circ. Res. |
pmid:17158340
|
Hughes JE et al. |
Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. |
2008 |
Circ. Res. |
pmid:18323526
|
Igarashi J and Michel T |
The enigma of sphingosine 1-phosphate synthesis: a novel role for endothelial sphingosine kinases. |
2008 |
Circ. Res. |
pmid:18369161
|
Hoefer J et al. |
Sphingosine-1-phosphate-dependent activation of p38 MAPK maintains elevated peripheral resistance in heart failure through increased myogenic vasoconstriction. |
2010 |
Circ. Res. |
pmid:20671234
|
Zhao YD et al. |
Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling. |
2009 |
Circ. Res. |
pmid:19696411
|
Gazit SL et al. |
Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. |
2016 |
Circ. Res. |
pmid:27582371
|
Xu SZ et al. |
A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. |
2006 |
Circ. Res. |
pmid:16675717
|
Erl W and Siess W |
Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. |
2001 |
Circ. Res. |
pmid:11557732
|
Kluk MJ and Hla T |
Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. |
2001 |
Circ. Res. |
pmid:11557736
|
Maceyka M et al. |
Shooting the messenger: oxidative stress regulates sphingosine-1-phosphate. |
2007 |
Circ. Res. |
pmid:17204658
|
Ramasamy R et al. |
Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel. |
2006 |
Circ. Res. |
pmid:17008596
|
Tanimoto T et al. |
Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. |
2004 |
Circ. Res. |
pmid:15044318
|
Armulik A et al. |
Endothelial/pericyte interactions. |
2005 |
Circ. Res. |
pmid:16166562
|
Birukov KG et al. |
Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. |
2004 |
Circ. Res. |
pmid:15472119
|
Coussin F et al. |
Comparison of sphingosine 1-phosphate-induced intracellular signaling pathways in vascular smooth muscles: differential role in vasoconstriction. |
2002 |
Circ. Res. |
pmid:12142348
|
Hla T |
Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells. |
2009 |
Circ. Res. |
pmid:19797192
|
Levkau B |
Sphingosine-1-phosphate in the regulation of vascular tone: a finely tuned integration system of S1P sources, receptors, and vascular responsiveness. |
2008 |
Circ. Res. |
pmid:18669929
|
Ryu Y et al. |
Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells. |
2002 |
Circ. Res. |
pmid:11861422
|
Tawa H et al. |
Role of afadin in vascular endothelial growth factor- and sphingosine 1-phosphate-induced angiogenesis. |
2010 |
Circ. Res. |
pmid:20413783
|
Fulton D et al. |
Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83. |
2008 |
Circ. Res. |
pmid:18096817
|
Whetzel AM et al. |
Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. |
2006 |
Circ. Res. |
pmid:16960101
|
Venkataraman K et al. |
Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. |
2008 |
Circ. Res. |
pmid:18258856
|
Theilmeier G et al. |
High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. |
2006 |
Circulation |
pmid:16982942
|
Jin ZQ et al. |
Sphingosine kinase activation mediates ischemic preconditioning in murine heart. |
2004 |
Circulation |
pmid:15451787
|
Yang J et al. |
Proximal cerebral arteries develop myogenic responsiveness in heart failure via tumor necrosis factor-α-dependent activation of sphingosine-1-phosphate signaling. |
2012 |
Circulation |
pmid:22668972
|
Levkau B et al. |
High-density lipoprotein stimulates myocardial perfusion in vivo. |
2004 |
Circulation |
pmid:15545521
|
Nofer JR et al. |
FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. |
2007 |
Circulation |
pmid:17242282
|
Xia P |
Letter by Xia regarding article, "High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor". |
2007 |
Circulation |
pmid:17420358
|
Mann DL |
Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers. |
2012 |
Circulation |
pmid:22534620
|
Meissner A et al. |
Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure. |
2012 |
Circulation |
pmid:22534621
|
Bolz SS et al. |
Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. |
2003 |
Circulation |
pmid:12796138
|
Augé N et al. |
Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. |
2004 |
Circulation |
pmid:15277330
|
Kikuta J et al. |
[Encounter of cancer cells with bone. In vivo imaging of osteoclasts and their precursors in intact bone tissues]. |
2011 |
Clin Calcium |
pmid:21358058
|
Kotani M et al. |
[Bone and calcium update; bone research update. Trafficking of osteoclast precursors visualized by intravital imaging technology]. |
2011 |
Clin Calcium |
pmid:22133828
|
Ohkawa R et al. |
Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects. |
2015 |
Clin. Biochem. |
pmid:25863111
|
Bekpinar S et al. |
The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes. |
2015 |
Clin. Biochem. |
pmid:26255120
|
Murph M et al. |
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer. |
2006 |
Clin. Cancer Res. |
pmid:17121877
|
Zhang L et al. |
Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer. |
2015 |
Clin. Cancer Res. |
pmid:25589614
|
Dickson MA et al. |
A phase I clinical trial of safingol in combination with cisplatin in advanced solid tumors. |
2011 |
Clin. Cancer Res. |
pmid:21257722
|
Beider K et al. |
The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
2017 |
Clin. Cancer Res. |
pmid:27697999
|
Scherer M et al. |
High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry. |
2009 |
Clin. Chem. |
pmid:19325012
|
Ikeda H et al. |
Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C. |
2010 |
Clin. Chim. Acta |
pmid:20188085
|
Ren K et al. |
Apolipoprotein M. |
2015 |
Clin. Chim. Acta |
pmid:25858547
|
Liu X et al. |
ABCA1, ABCG1, and SR-BI: Transit of HDL-associated sphingosine-1-phosphate. |
2012 |
Clin. Chim. Acta |
pmid:22115863
|
Mirzaian M et al. |
Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. |
2016 |
Clin. Chim. Acta |
pmid:27221202
|
Ceglarek U et al. |
Preanalytical standardization of sphingosine-1-phosphate, sphinganine-1-phosphate and sphingosine analysis in human plasma by liquid chromatography-tandem mass spectrometry. |
2014 |
Clin. Chim. Acta |
pmid:24768784
|
Moritz E et al. |
Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. |
2017 |
Clin. Chim. Acta |
pmid:28159438
|
Jing XD et al. |
The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis. |
2015 |
Clin. Chim. Acta |
pmid:25958848
|
Moriue T et al. |
Sphingosine 1-phosphate attenuates peroxide-induced apoptosis in HaCaT cells cultured in vitro. |
2013 |
Clin. Exp. Dermatol. |
pmid:23837937
|
Tanaka K et al. |
Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. |
2014 |
Clin. Exp. Immunol. |
pmid:24028747
|
Benaud CM et al. |
Deregulated activation of matriptase in breast cancer cells. |
2002 |
Clin. Exp. Metastasis |
pmid:12498394
|
Ishizawa S et al. |
Sphingosine-1-phosphate induces differentiation of cultured renal tubular epithelial cells under Rho kinase activation via the S1P2 receptor. |
2014 |
Clin. Exp. Nephrol. |
pmid:24463961
|
Kee TH et al. |
Sphingosine kinase signalling in immune cells. |
2005 |
Clin. Exp. Pharmacol. Physiol. |
pmid:15743396
|
Rana A and Sharma S |
Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore. |
2016 |
Clin. Exp. Pharmacol. Physiol. |
pmid:26582369
|
Yaghobian D et al. |
Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. |
2016 |
Clin. Exp. Pharmacol. Physiol. |
pmid:26414003
|
Garg SK et al. |
Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis? |
2006 |
Clin. Immunol. |
pmid:17049310
|
Mao-Draayer Y et al. |
The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases. |
2017 |
Clin. Immunol. |
pmid:27890706
|
Yokoyama K et al. |
Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. |
2012 |
Clin. Nephrol. |
pmid:22732343
|
Roviezzo F et al. |
Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. |
2014 |
Clin. Sci. |
pmid:24131465
|
Selim S et al. |
Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions. |
2011 |
Clin. Sci. |
pmid:21749329
|
Anderson G and Maes M |
Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions. |
2014 |
CNS Neurol Disord Drug Targets |
pmid:24040808
|
Leo A et al. |
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
2017 |
CNS Neurol Disord Drug Targets |
pmid:27823573
|
Vanoli E et al. |
Vagomimetic effects of fingolimod: physiology and clinical implications. |
2014 |
CNS Neurosci Ther |
pmid:24836740
|
Van Brocklyn JR and Williams JB |
The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: oxidative stress and the seesaw of cell survival and death. |
2012 |
Comp. Biochem. Physiol. B, Biochem. Mol. Biol. |
pmid:22613819
|
Nelson CJ et al. |
Global analysis of circulating metabolites in hibernating ground squirrels. |
2010 |
Comp. Biochem. Physiol. Part D Genomics Proteomics |
pmid:20728417
|
Babahosseini H et al. |
Roles of bioactive sphingolipid metabolites in ovarian cancer cell biomechanics. |
2012 |
Conf Proc IEEE Eng Med Biol Soc |
pmid:23366417
|
Barnawi J et al. |
Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. |
2016 |
COPD |
pmid:27144721
|
Sugiura T et al. |
Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis. |
2012 |
Coron. Artery Dis. |
pmid:22356865
|
Ito S et al. |
TNF-α production in NKT cell hybridoma is regulated by sphingosine-1-phosphate: implications for inflammation in atherosclerosis. |
2014 |
Coron. Artery Dis. |
pmid:24448174
|
Ito S et al. |
Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes. |
2013 |
Coron. Artery Dis. |
pmid:24212262
|
Winkler MS et al. |
Decreased serum concentrations of sphingosine-1-phosphate in sepsis. |
2015 |
Crit Care |
pmid:26498205
|
Egom EE et al. |
Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy. |
2013 May-Jun |
Crit Rev Clin Lab Sci |
pmid:23885725
|
Barth BM et al. |
Gaucher's disease and cancer: a sphingolipid perspective. |
2013 |
Crit Rev Oncog |
pmid:23510065
|
Altay O et al. |
Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice. |
2012 |
Crit. Care Med. |
pmid:22488000
|
Noguchi K and Chun J |
Roles for lysophospholipid S1P receptors in multiple sclerosis. |
2011 |
Crit. Rev. Biochem. Mol. Biol. |
pmid:20979571
|