| MeSH term | MeSH ID | Detail |
|---|---|---|
| Thrombocytopenia | D013921 | 15 associated lipids |
| Vascular Diseases | D014652 | 16 associated lipids |
| Pancreatitis, Acute Necrotizing | D019283 | 18 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Tuberculosis | D014376 | 20 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
| Anemia | D000740 | 21 associated lipids |
| Carcinoma, Lewis Lung | D018827 | 22 associated lipids |
| Hypoxia-Ischemia, Brain | D020925 | 22 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Powell JA et al. | Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. | 2017 | Blood | pmid:27956387 |
| Miyabe C et al. | A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis. | 2017 | Inflamm. Res. | pmid:27942751 |
| Williams PA et al. | Alginate-Chitosan Hydrogels Provide a Sustained Gradient of Sphingosine-1-Phosphate for Therapeutic Angiogenesis. | 2017 | Ann Biomed Eng | pmid:27904998 |
| Mao-Draayer Y et al. | The sphingosine-1-phosphate receptor: A novel therapeutic target for multiple sclerosis and other autoimmune diseases. | 2017 | Clin. Immunol. | pmid:27890706 |
| Lee MH et al. | S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization. | 2017 | J. Lipid Res. | pmid:27881715 |
| Ruiz M et al. | High-Density Lipoprotein-Associated Apolipoprotein M Limits Endothelial Inflammation by Delivering Sphingosine-1-Phosphate to the Sphingosine-1-Phosphate Receptor 1. | 2017 | Arterioscler. Thromb. Vasc. Biol. | pmid:27879252 |
| Barnawi J et al. | Reduced DNA methylation of sphingosine-1 phosphate receptor 5 in alveolar macrophages in COPD: A potential link to failed efferocytosis. | 2017 | Respirology | pmid:27868302 |
| Frias MA et al. | High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia. | 2017 | Eur. J. Clin. Invest. | pmid:27861771 |
| Fang V et al. | Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. | 2017 | Nat. Immunol. | pmid:27841869 |
| Vogt D and Stark H | Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. | 2017 | Med Res Rev | pmid:27480072 |
| Olesch C et al. | Beyond Immune Cell Migration: The Emerging Role of the Sphingosine-1-phosphate Receptor S1PR4 as a Modulator of Innate Immune Cell Activation. | 2017 | Mediators Inflamm. | pmid:28848247 |
| Egom EE et al. | Determination of Sphingosine-1-Phosphate in Human Plasma Using Liquid Chromatography Coupled with Q-Tof Mass Spectrometry. | 2017 | Int J Mol Sci | pmid:28820460 |
| Swendeman SL et al. | An engineered S1P chaperone attenuates hypertension and ischemic injury. | 2017 | Sci Signal | pmid:28811382 |
| Syed SN et al. | S1P Provokes Tumor Lymphangiogenesis via Macrophage-Derived Mediators Such as IL-1 or Lipocalin-2. | 2017 | Mediators Inflamm. | pmid:28804221 |
| Doan NB et al. | Acid ceramidase confers radioresistance to glioblastoma cells. | 2017 | Oncol. Rep. | pmid:28765947 |
| Arish M et al. | Implication of sphingosine-1-phosphate signaling in diseases: molecular mechanism and therapeutic strategies. | 2017 | J. Recept. Signal Transduct. Res. | pmid:28758826 |
| Polzin A et al. | Plasma sphingosine-1-phosphate concentrations are associated with systolic heart failure in patients with ischemic heart disease. | 2017 | J. Mol. Cell. Cardiol. | pmid:28709768 |
| Innamorati G et al. | Pleiotropic effects of sphingosine-1-phosphate signaling to control human chorionic mesenchymal stem cell physiology. | 2017 | Cell Death Dis | pmid:28703804 |
| Bougault C et al. | Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. | 2017 | Bone | pmid:28684192 |
| Tsai CH et al. | Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. | 2017 | Mol Oncol | pmid:28672103 |
| Schmidt KG et al. | Sphingosine-1-Phosphate Receptor 5 Modulates Early-Stage Processes during Fibrogenesis in a Mouse Model of Systemic Sclerosis: A Pilot Study. | 2017 | Front Immunol | pmid:29033951 |
| Xie Z et al. | Targeting sphingosine-1-phosphate signaling for cancer therapy. | 2017 | Sci China Life Sci | pmid:28623546 |
| Yanagida K et al. | Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28396408 |
| Kurano M et al. | Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. | 2017 | PLoS ONE | pmid:28494002 |
| Sun XJ et al. | Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis. | 2017 | Nephrol. Dial. Transplant. | pmid:28206609 |
| Janecke AR et al. | Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications. | 2017 | Hum. Mutat. | pmid:28181337 |
| Moritz E et al. | Reference intervals for serum sphingosine-1-phosphate in the population-based Study of Health in Pomerania. | 2017 | Clin. Chim. Acta | pmid:28159438 |
| Winkler MS et al. | Sphingosine-1-Phosphate: A Potential Biomarker and Therapeutic Target for Endothelial Dysfunction and Sepsis? | 2017 | Shock | pmid:27922551 |
| Al-Jarallah A and Oriowo M | The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. | 2017 | PLoS ONE | pmid:28493876 |
| Chen T et al. | Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. | 2017 | Front Biosci (Landmark Ed) | pmid:27814635 |
| Beider K et al. | The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. | 2017 | Clin. Cancer Res. | pmid:27697999 |
| Thieme M et al. | Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. | 2017 | Exp. Dermatol. | pmid:27574180 |
| Chang CH and Randolph GJ | Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. | 2017 | Dev. Cell | pmid:28633013 |
| Fang R et al. | Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. | 2017 | Arch. Med. Res. | pmid:28625317 |
| Rohrbach T et al. | Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. | 2017 | Crit. Rev. Biochem. Mol. Biol. | pmid:28618839 |
| Vijayan M et al. | Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. | 2017 | J. Immunol. | pmid:28600291 |
| White CR et al. | High-Density Lipoprotein Regulation of Mitochondrial Function. | 2017 | Adv. Exp. Med. Biol. | pmid:28551800 |
| Dany M and Elston D | Gene expression of sphingolipid metabolism pathways is altered in hidradenitis suppurativa. | 2017 | J. Am. Acad. Dermatol. | pmid:28551069 |
| Mendoza A et al. | Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. | 2017 | Nature | pmid:28538737 |
| Ma S et al. | A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. | 2017 | Dev. Cell | pmid:28535372 |
| Meshcheryakova A et al. | Sphingosine 1-phosphate signaling in bone remodeling: multifaceted roles and therapeutic potential. | 2017 | Expert Opin. Ther. Targets | pmid:28524744 |
| Ko J et al. | Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. | 2017 | Invest. Ophthalmol. Vis. Sci. | pmid:28492873 |
| Tafelmeier M et al. | Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. | 2017 | J. Steroid Biochem. Mol. Biol. | pmid:27163393 |
| Serafimidis I et al. | Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. | 2017 | PLoS Biol. | pmid:28248965 |
| Lee HM et al. | Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. | 2017 | J. Pathol. | pmid:28240350 |
| Rieck M et al. | Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. | 2017 | Eur. J. Immunol. | pmid:28198542 |
| Bruno M et al. | Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. | 2017 | Biochim. Biophys. Acta | pmid:28188805 |
| Qi H et al. | Analysis of sphingolipids in human corneal fibroblasts from normal and keratoconus patients. | 2017 | J. Lipid Res. | pmid:28188148 |
| Ren K et al. | ApoA-I/SR-BI modulates S1P/S1PR2-mediated inflammation through the PI3K/Akt signaling pathway in HUVECs. | 2017 | J. Physiol. Biochem. | pmid:28181168 |
| Ruiz M et al. | HDL-associated ApoM is anti-apoptotic by delivering sphingosine 1-phosphate to S1P1 & S1P3 receptors on vascular endothelium. | 2017 | Lipids Health Dis | pmid:28179022 |
| Moruno-Manchon JF et al. | Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. | 2017 | Hum. Mol. Genet. | pmid:28175299 |
| Rojas-Canales D et al. | Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. | 2017 | Diabetes | pmid:28174291 |
| Dela Paz NG et al. | Shear stress induces Gα activation independently of G protein-coupled receptor activation in endothelial cells. | 2017 | Am. J. Physiol., Cell Physiol. | pmid:28148497 |
| Green CL et al. | The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. | 2017 | Aging Cell | pmid:28139067 |
| Vishwakarma S et al. | Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. | 2017 | Cancer Invest. | pmid:28135860 |
| Terashita T et al. | Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. | 2016 | Respir. Res. | pmid:27829417 |
| Brait VH et al. | Selective Sphingosine 1-Phosphate Receptor 1 Agonist Is Protective Against Ischemia/Reperfusion in Mice. | 2016 | Stroke | pmid:27827329 |
| Zamora-Pineda J et al. | Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress. | 2016 | J. Exp. Med. | pmid:27810923 |
| Kobayashi N et al. | Fluorescence-based rapid measurement of sphingosine-1-phosphate transport activity in erythrocytes. | 2016 | J. Lipid Res. | pmid:27655910 |
| Chew WS et al. | To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling. | 2016 | Pharmacol. Res. | pmid:27663260 |
| Wang X et al. | Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. | 2016 | PLoS Pathog. | pmid:27711202 |
| Moruno Manchon JF et al. | SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. | 2016 | Autophagy | pmid:27467777 |
| Nagahashi M et al. | The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. | 2016 | J. Lipid Res. | pmid:27459945 |
| Poissonnier A et al. | CD95-Mediated Calcium Signaling Promotes T Helper 17 Trafficking to Inflamed Organs in Lupus-Prone Mice. | 2016 | Immunity | pmid:27438772 |
| Zhang Q et al. | Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. | 2016 | Am. J. Chin. Med. | pmid:27430910 |
| Adamiak M et al. | Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. | 2016 | Cell Transplant | pmid:27412411 |
| Liu X et al. | ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. | 2016 | J. Physiol. Biochem. | pmid:27377933 |
| Fleming JK et al. | A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. | 2016 | J. Lipid Res. | pmid:27444045 |
| Tong S et al. | Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. | 2016 | J. Biol. Chem. | pmid:27405756 |
| Jin L et al. | The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. | 2016 | World J Surg Oncol | pmid:27129720 |
| Nagura Y et al. | Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. | 2016 | Transfus Med | pmid:27350440 |
| Sanchez T | Sphingosine-1-Phosphate Signaling in Endothelial Disorders. | 2016 | Curr Atheroscler Rep | pmid:27115142 |
| Crespo I et al. | Melatonin inhibits the sphingosine kinase 1/sphingosine-1-phosphate signaling pathway in rabbits with fulminant hepatitis of viral origin. | 2016 | J. Pineal Res. | pmid:27101794 |
| Riganti L et al. | Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. | 2016 | J. Neurosci. | pmid:27098703 |
| Cai Y et al. | FOXF1 maintains endothelial barrier function and prevents edema after lung injury. | 2016 | Sci Signal | pmid:27095594 |
| Castaldi A et al. | Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. | 2016 | Cell. Signal. | pmid:27094722 |
| Anbazhagan AN et al. | Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:27079615 |
| Trinh HK et al. | Exploration of the Sphingolipid Metabolite, Sphingosine-1-phosphate and Sphingosine, as Novel Biomarkers for Aspirin-exacerbated Respiratory Disease. | 2016 | Sci Rep | pmid:27830727 |
| Zhang H et al. | Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening. | 2016 | Sci Rep | pmid:27476912 |
| Luo B et al. | Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. | 2016 | Immunity | pmid:26872696 |
| Li J et al. | Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway. | 2016 | Tumour Biol. | pmid:26857281 |
| Camaré C et al. | The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. | 2016 | Free Radic. Biol. Med. | pmid:26855418 |
| Kim SE et al. | The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:26830367 |
| Messias CV et al. | Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation. | 2016 | PLoS ONE | pmid:26824863 |
| Pászti-Gere E et al. | Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. | 2016 | Oxid Med Cell Longev | pmid:26823955 |
| Chen J et al. | Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. | 2016 | Biochim. Biophys. Acta | pmid:26615875 |
| Maczis M et al. | Sphingosine-1-phosphate and estrogen signaling in breast cancer. | 2016 | Adv Biol Regul | pmid:26601898 |
| Zhang F et al. | Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26589326 |
| Pyne NJ and Tigyi GJ | A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. | 2016 | Prog. Lipid Res. | pmid:26584871 |
| Rana A and Sharma S | Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore. | 2016 | Clin. Exp. Pharmacol. Physiol. | pmid:26582369 |
| Gao D et al. | Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26859520 |
| Zeng Y et al. | Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-β autocrine loop. | 2016 | Oncotarget | pmid:27556509 |
| Nagahashi M et al. | Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. | 2016 | J Mammary Gland Biol Neoplasia | pmid:27194029 |
| Patmanathan SN et al. | Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. | 2016 | Sci Rep | pmid:27160553 |
| Li N and Zhang F | Implication of sphingosin-1-phosphate in cardiovascular regulation. | 2016 | Front Biosci (Landmark Ed) | pmid:27100508 |
| Serdar M et al. | Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. | 2016 | Brain Behav. Immun. | pmid:26456693 |
| Arish M et al. | Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. | 2016 | Drug Discov. Today | pmid:26456576 |
| Zhang L et al. | Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels. | 2016 | Microcirculation | pmid:27015105 |
| Bae SJ et al. | The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study. | 2016 | Osteoporos Int | pmid:26984570 |
| Kurano M et al. | Resveratrol exerts a biphasic effect on apolipoprotein M. | 2016 | Br. J. Pharmacol. | pmid:26445217 |