| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Liver Neoplasms, Experimental | D008114 | 46 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Chemical and Drug Induced Liver Injury | D056486 | 39 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhang Y et al. | Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. | 2014 | J. Clin. Invest. | pmid:24837436 |
| Kurano M et al. | Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. | 2014 | Biochim. Biophys. Acta | pmid:24814049 |
| Arya D et al. | Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells. | 2014 | J. Biomed. Sci. | pmid:24898615 |
| Nagamatsu T et al. | Emerging roles for lysophospholipid mediators in pregnancy. | 2014 | Am. J. Reprod. Immunol. | pmid:24689547 |
| Takeo T et al. | Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. | 2014 | Cryobiology | pmid:24201107 |
| de Assuncao TM et al. | New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. | 2014 | J. Biol. Chem. | pmid:24759103 |
| Sutter I et al. | Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. | 2014 | J. Lipid Res. | pmid:24950692 |
| Rosen H et al. | The organization of the sphingosine 1-phosphate signaling system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728591 |
| Hanson MA and Peach R | Structural biology of the S1P1 receptor. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728592 |
| Kong Y et al. | Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. | 2014 | Mediators Inflamm. | pmid:25147438 |
| Rauch BH | Sphingosine 1-phosphate as a link between blood coagulation and inflammation. | 2014 | Cell. Physiol. Biochem. | pmid:24977491 |
| Sattler K et al. | HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977490 |
| Thuy AV et al. | Sphingosine 1-phosphate in blood: function, metabolism, and fate. | 2014 | Cell. Physiol. Biochem. | pmid:24977489 |
| Hait NC et al. | Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory. | 2014 | Nat. Neurosci. | pmid:24859201 |
| Shin KO et al. | Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. | 2014 | Arch. Pharm. Res. | pmid:24687256 |
| Yu H et al. | Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats. | 2014 | Injury | pmid:24685054 |
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| Baranowski M et al. | Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. | 2014 | Int J Sport Nutr Exerc Metab | pmid:24092763 |
| Fincher J et al. | G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. | 2014 | Dev. Neurosci. | pmid:25138637 |
| Speak AO et al. | Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. | 2014 | Blood | pmid:24235134 |
| Nagahashi M et al. | Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24210073 |
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| Lee H et al. | 4-Deoxypyridoxine improves the viability of isolated pancreatic islets ex vivo. | 2013 May-Jun | Islets | pmid:23756681 |
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| Das A et al. | The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. | 2013 | Biomaterials | pmid:24064148 |
| Taub DD et al. | Distinct energy requirements for human memory CD4 T-cell homeostatic functions. | 2013 | FASEB J. | pmid:22972918 |
| Xiang SY et al. | Lysophospholipid receptor activation of RhoA and lipid signaling pathways. | 2013 | Biochim. Biophys. Acta | pmid:22986288 |
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| Ota K et al. | TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. | 2013 | Endocrinology | pmid:23861379 |
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| Cortez-Retamozo V et al. | Angiotensin II drives the production of tumor-promoting macrophages. | 2013 | Immunity | pmid:23333075 |
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| Bot M et al. | Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice. | 2013 | PLoS ONE | pmid:23700419 |
| Saba JD and de la Garza-Rodea AS | S1P lyase in skeletal muscle regeneration and satellite cell activation: exposing the hidden lyase. | 2013 | Biochim. Biophys. Acta | pmid:22750505 |
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| Yu H et al. | Insulin protects apoptotic cardiomyocytes from hypoxia/reoxygenation injury through the sphingosine kinase/sphingosine 1-phosphate axis. | 2013 | PLoS ONE | pmid:24349009 |
| Walls SM et al. | Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. | 2013 | PLoS Genet. | pmid:24339790 |
| Mierzejewska K et al. | Sphingosine-1-phosphate-mediated mobilization of hematopoietic stem/progenitor cells during intravascular hemolysis requires attenuation of SDF-1-CXCR4 retention signaling in bone marrow. | 2013 | Biomed Res Int | pmid:24490172 |
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| Yasuo M et al. | Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. | 2013 | PLoS ONE | pmid:23326540 |
| Dusaban SS et al. | Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23401561 |
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| Kalhori V et al. | Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma Cells. | 2013 | PLoS ONE | pmid:23824493 |
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| Huang J et al. | Curcumin ameliorates diabetic nephropathy by inhibiting the activation of the SphK1-S1P signaling pathway. | 2013 | Mol. Cell. Endocrinol. | pmid:23127801 |
| Cartwright TA et al. | Mrp1 is essential for sphingolipid signaling to p-glycoprotein in mouse blood-brain and blood-spinal cord barriers. | 2013 | J. Cereb. Blood Flow Metab. | pmid:23168528 |
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| Erkhembaatar LO et al. | Increased expression of sphingosine kinase in the amnion during labor. | 2013 | Placenta | pmid:23462226 |
| Kikuta J et al. | Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23569273 |
| Nguyen DH et al. | Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23569284 |
| Alberg AJ et al. | Plasma sphingolipids and lung cancer: a population-based, nested case-control study. | 2013 | Cancer Epidemiol. Biomarkers Prev. | pmid:23749868 |
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| Tatematsu S et al. | Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. | 2013 | Arterioscler. Thromb. Vasc. Biol. | pmid:23723371 |
| Guo L et al. | Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development. | 2013 | Theriogenology | pmid:23731666 |
| Zhang L et al. | Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P). | 2013 | Blood | pmid:23775711 |
| Park K et al. | Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. | 2013 | J. Invest. Dermatol. | pmid:23856934 |
| Koch A et al. | Sphingosine 1-phosphate in renal diseases. | 2013 | Cell. Physiol. Biochem. | pmid:23736205 |
| Huang LS et al. | Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. | 2013 | FASEB J. | pmid:23315259 |
| Fukuhara S and Mochizuki N | [Lymphocytes mobilization into blood regulated by Spns2, a sphingosine 1-phosphate transporter, expressed on endothelial cells]. | 2013 | Seikagaku | pmid:23717873 |
| Lim SH et al. | Complementary effects of ciclopirox olamine, a prolyl hydroxylase inhibitor and sphingosine 1-phosphate on fibroblasts and endothelial cells in driving capillary sprouting. | 2013 | Integr Biol (Camb) | pmid:24190477 |
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