Soltau I et al. |
Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. |
2016 |
PLoS ONE |
pmid:27973607
|
Machida T et al. |
Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. |
2016 |
J. Pharmacol. Sci. |
pmid:27581589
|
Nagahashi M et al. |
High levels of sphingolipids in human breast cancer. |
2016 |
J. Surg. Res. |
pmid:27565080
|
Dong T et al. |
Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. |
2016 |
J Neuroinflammation |
pmid:27561600
|
Nojima H et al. |
Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. |
2016 |
PLoS ONE |
pmid:27551720
|
Harris CM et al. |
Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. |
2016 |
J. Pharmacol. Exp. Ther. |
pmid:27519818
|
Gstalder C et al. |
FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. |
2016 |
Mol. Cancer Ther. |
pmid:27507852
|
Hollands A et al. |
Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. |
2016 |
J. Biol. Chem. |
pmid:27226531
|
Mirzaian M et al. |
Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. |
2016 |
Clin. Chim. Acta |
pmid:27221202
|
Bao XH et al. |
[Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. |
2016 |
Zhonghua Xin Xue Guan Bing Za Zhi |
pmid:27220580
|
Marfia G et al. |
The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling. |
2016 |
Stem Cells Dev. |
pmid:27217090
|
Versmissen J et al. |
Familial hypercholesterolaemia: cholesterol efflux and coronary disease. |
2016 |
Eur. J. Clin. Invest. |
pmid:27208892
|
Sauvé M et al. |
Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. |
2016 |
Diabetes |
pmid:27207546
|
Guerrero M et al. |
Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). |
2016 |
Expert Opin Ther Pat |
pmid:26947494
|
Watterson SH et al. |
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. |
2016 |
J. Med. Chem. |
pmid:26924461
|
Liu W et al. |
Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. |
2016 |
Eur. J. Pharmacol. |
pmid:26921757
|
Puli MR et al. |
Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. |
2016 |
Planta |
pmid:27233507
|
Yang Y et al. |
Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. |
2016 |
Neurochem. Int. |
pmid:26921668
|
Park K et al. |
ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. |
2016 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:26903652
|
Bien-Möller S et al. |
Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. |
2016 |
Oncotarget |
pmid:26887055
|
Deutsch G et al. |
Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. |
2016 |
Gene |
pmid:26707209
|
Kim YH and Tabata Y |
Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure. |
2016 |
J Biomed Mater Res A |
pmid:26704185
|
Gomez-Muñoz A et al. |
Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate. |
2016 |
Prog. Lipid Res. |
pmid:26703189
|
Ottenlinger F et al. |
Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. |
2016 |
Eur. J. Immunol. |
pmid:26683421
|
Fan A et al. |
Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. |
2016 |
Am. J. Physiol., Cell Physiol. |
pmid:26669941
|
Tan SF et al. |
Acid ceramidase is upregulated in AML and represents a novel therapeutic target. |
2016 |
Oncotarget |
pmid:27825124
|
Li S et al. |
Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
2016 |
Oncotarget |
pmid:27811358
|
Grammatikos G et al. |
Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. |
2016 |
Oncotarget |
pmid:26933996
|
Farnoud AM et al. |
The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway. |
2015 |
Infect. Immun. |
pmid:25895971
|
Chimen M et al. |
Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. |
2015 |
Nat. Med. |
pmid:25894827
|
Pulli I et al. |
A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca²⺠microdomain in the caveolar compartment. |
2015 |
Biochim. Biophys. Acta |
pmid:25892494
|
Zankov DP and Ogita H |
Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. |
2015 |
Biomed Res Int |
pmid:25883953
|
Williams PA et al. |
Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). |
2015 |
PLoS ONE |
pmid:25875493
|
Wang Z et al. |
The Effect of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor on Neutrophil Function and the Relevant Signaling Pathway. |
2015 |
Acta Haematol. |
pmid:25872153
|
Wilson PC et al. |
Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. |
2015 |
Mol. Endocrinol. |
pmid:25871850
|
Jernigan PL et al. |
The role of sphingolipids in endothelial barrier function. |
2015 |
Biol. Chem. |
pmid:25867999
|
Egom EE et al. |
The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue. |
2015 |
J. Cell. Mol. Med. |
pmid:25864579
|
Ohkawa R et al. |
Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects. |
2015 |
Clin. Biochem. |
pmid:25863111
|
Wang L et al. |
Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate. |
2015 |
Microvasc. Res. |
pmid:25862132
|
Kolahdooz Z et al. |
Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism. |
2015 |
Can J Neurol Sci |
pmid:25860537
|
Abdel Hadi L et al. |
Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells. |
2015 |
PLoS ONE |
pmid:26580959
|
Hsu CK et al. |
Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. |
2015 |
J. Cell. Physiol. |
pmid:25201048
|
Lin CC et al. |
Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation. |
2015 |
PLoS ONE |
pmid:25734900
|
Zhang DD et al. |
Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. |
2015 |
Biol. Chem. |
pmid:25720064
|
Schröder M et al. |
Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. |
2015 |
Biol. Chem. |
pmid:25720062
|
Koch A et al. |
Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. |
2015 |
Biol. Chem. |
pmid:25719311
|
Park ES et al. |
Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. |
2015 |
J. Biol. Chem. |
pmid:25716317
|
Rhee SH et al. |
Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall. |
2015 |
J Obstet Gynaecol |
pmid:25692679
|
Ji F et al. |
K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. |
2015 |
Biochem. Biophys. Res. Commun. |
pmid:25680461
|
Breslin JW et al. |
Involvement of local lamellipodia in endothelial barrier function. |
2015 |
PLoS ONE |
pmid:25658915
|
Kalhori V and Törnquist K |
MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. |
2015 |
Mol. Cell. Endocrinol. |
pmid:25643979
|
Sivasubramanian M et al. |
Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. |
2015 |
Neuroscience |
pmid:25637806
|
Zhong Y et al. |
Nephrokeli, a Chinese herbal formula, may improve IgA nephropathy through regulation of the sphingosine-1-phosphate pathway. |
2015 |
PLoS ONE |
pmid:25633986
|
Till KJ et al. |
Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells. |
2015 |
J. Immunol. |
pmid:25632006
|
Liu M et al. |
Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. |
2015 |
J. Biol. Chem. |
pmid:25627684
|
Hwang IY et al. |
An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking. |
2015 |
J. Immunol. |
pmid:25617475
|
Roviezzo F et al. |
S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. |
2015 |
Br. J. Pharmacol. |
pmid:25439580
|
Hashimoto Y et al. |
Sphingosine-1-phosphate inhibits differentiation of C3H10T1/2 cells into adipocyte. |
2015 |
Mol. Cell. Biochem. |
pmid:25445169
|
Carroll B et al. |
Sphingolipids in the DNA damage response. |
2015 |
Adv Biol Regul |
pmid:25434743
|
Xiu L et al. |
Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors. |
2015 |
Am. J. Pathol. |
pmid:25432063
|
Khavandgar Z and Murshed M |
Sphingolipid metabolism and its role in the skeletal tissues. |
2015 |
Cell. Mol. Life Sci. |
pmid:25424644
|
Opal SM and van der Poll T |
Endothelial barrier dysfunction in septic shock. |
2015 |
J. Intern. Med. |
pmid:25418337
|
Frati A et al. |
Role of sphingosine kinase/S1P axis in ECM remodeling of cardiac cells elicited by relaxin. |
2015 |
Mol. Endocrinol. |
pmid:25415609
|
Prüfer N et al. |
The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality. |
2015 |
Biol. Chem. |
pmid:25252751
|
Sorrentino R et al. |
B cell depletion increases sphingosine-1-phosphate-dependent airway inflammation in mice. |
2015 |
Am. J. Respir. Cell Mol. Biol. |
pmid:25250941
|
Hernández-Coronado CG et al. |
Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles. |
2015 |
Animal |
pmid:25245232
|
Czubowicz K et al. |
Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival. |
2015 |
Mol. Neurobiol. |
pmid:25056275
|
Fogarty CE and Bergmann A |
The Sound of Silence: Signaling by Apoptotic Cells. |
2015 |
Curr. Top. Dev. Biol. |
pmid:26431570
|
Abdel-Latif A et al. |
Lysophospholipids in coronary artery and chronic ischemic heart disease. |
2015 |
Curr. Opin. Lipidol. |
pmid:26270808
|
Oskeritzian CA |
Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. |
2015 |
Mol. Immunol. |
pmid:24766823
|
Iwabuchi K et al. |
Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. |
2015 |
Mediators Inflamm. |
pmid:26609196
|
Mahajan-Thakur S et al. |
Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation. |
2015 |
Mediators Inflamm. |
pmid:26604433
|
Binder BY et al. |
Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering. |
2015 |
Tissue Eng Part B Rev |
pmid:26035484
|
Jeong JK et al. |
Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes. |
2015 |
Mol Med Rep |
pmid:26459774
|
Kassmer SH et al. |
Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. |
2015 |
Nat Commun |
pmid:26456232
|
Sutter I et al. |
Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL. |
2015 |
Atherosclerosis |
pmid:26093887
|
Hoffmann FS et al. |
Fingolimod induces neuroprotective factors in human astrocytes. |
2015 |
J Neuroinflammation |
pmid:26419927
|
Le Bihan O et al. |
Visualization of adherent cell monolayers by cryo-electron microscopy: A snapshot of endothelial adherens junctions. |
2015 |
J. Struct. Biol. |
pmid:26470813
|
Li C et al. |
Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. |
2015 |
J Neuroinflammation |
pmid:25880547
|
Cantalupo A et al. |
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure. |
2015 |
Nat. Med. |
pmid:26301690
|
Adamiak M et al. |
Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow. |
2015 |
Oncotarget |
pmid:26299919
|
Mori H et al. |
Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis. |
2015 |
Am. J. Pathol. |
pmid:26272361
|
Camp SM et al. |
Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720. |
2015 |
Chem. Phys. Lipids |
pmid:26272033
|
Galvani S et al. |
HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. |
2015 |
Sci Signal |
pmid:26268607
|
Riley RT et al. |
Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. |
2015 |
Mol Nutr Food Res |
pmid:26264677
|
Attiori Essis S et al. |
GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. |
2015 |
Brain Res. |
pmid:26260438
|
Bekpinar S et al. |
The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes. |
2015 |
Clin. Biochem. |
pmid:26255120
|
Yester JW et al. |
Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. |
2015 |
FASEB J. |
pmid:26246404
|
Kharel Y et al. |
Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. |
2015 |
J. Pharmacol. Exp. Ther. |
pmid:26243740
|
Chen MH et al. |
Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. |
2015 |
Oncotarget |
pmid:26090720
|
Panneer Selvam S et al. |
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. |
2015 |
Sci Signal |
pmid:26082434
|
Malik FA et al. |
Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity. |
2015 |
PLoS ONE |
pmid:26079370
|
Mooren OL et al. |
Role of N-WASP in Endothelial Monolayer Formation and Integrity. |
2015 |
J. Biol. Chem. |
pmid:26070569
|
Blaho VA et al. |
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. |
2015 |
Nature |
pmid:26053123
|
Wang J et al. |
Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis. |
2015 |
Biomaterials |
pmid:26036174
|
Durham JT et al. |
Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? |
2015 |
Invest. Ophthalmol. Vis. Sci. |
pmid:26030100
|
Książek M et al. |
Sources, metabolism, and regulation of circulating sphingosine-1-phosphate. |
2015 |
J. Lipid Res. |
pmid:26014962
|
El-Najjar N et al. |
Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. |
2015 |
PLoS ONE |
pmid:26466367
|
Liu G et al. |
Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumour-derived cytokine and angiogenic factor signalling. |
2015 |
J. Pathol. |
pmid:25988668
|
Zhang JN et al. |
The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction. |
2015 |
Bone |
pmid:25988659
|