| MeSH term | MeSH ID | Detail |
|---|---|---|
| Influenza, Human | D007251 | 11 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Glioblastoma | D005909 | 27 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Dilatation, Pathologic | D004108 | 5 associated lipids |
| Diabetic Nephropathies | D003928 | 39 associated lipids |
| Diabetic Angiopathies | D003925 | 20 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus, Type 1 | D003922 | 56 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pyne S and Pyne N | Sphingosine 1-phosphate signalling via the endothelial differentiation gene family of G-protein-coupled receptors. | 2000 | Pharmacol. Ther. | pmid:11150592 |
| Conway A et al. | Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells. | 2000 | Cell. Signal. | pmid:11152959 |
| Olivera A et al. | Assaying sphingosine kinase activity. | 2000 | Meth. Enzymol. | pmid:10563328 |
| Brindley DN et al. | Analysis of ceramide 1-phosphate and sphingosine-1-phosphate phosphatase activities. | 2000 | Meth. Enzymol. | pmid:10563330 |
| Rümenapp U et al. | Sphingolipid receptor signaling and function in human bladder carcinoma cells: inhibition of LPA- but enhancement of thrombin-stimulated cell motility. | 2000 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:10651140 |
| Lee OH et al. | Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10652210 |
| Kozawa O et al. | Enhancement by sphingosine 1-phosphate in vasopressin-induced phosphoinositide hydrolysis in aortic smooth-muscle cells: involvement of p38 MAP kinase. | 2000 | J. Cell. Biochem. | pmid:11029753 |
| Sato TN | A new role of lipid receptors in vascular and cardiac morphogenesis. | 2000 | J. Clin. Invest. | pmid:11032853 |
| Liu Y et al. | Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. | 2000 | J. Clin. Invest. | pmid:11032855 |
| Xia P et al. | An oncogenic role of sphingosine kinase. | 2000 | Curr. Biol. | pmid:11114522 |
| Okamoto H et al. | Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. | 2000 | Mol. Cell. Biol. | pmid:11094076 |
| Murata N et al. | Interaction of sphingosine 1-phosphate with plasma components, including lipoproteins, regulates the lipid receptor-mediated actions. | 2000 | Biochem. J. | pmid:11104690 |
| Racké K et al. | Potential role of EDG receptors and lysophospholipids as their endogenous ligands in the respiratory tract. | 2000 | Pulm Pharmacol Ther | pmid:10873548 |
| Sugiyama A et al. | Effects of sphingosine 1-phosphate, a naturally occurring biologically active lysophospholipid, on the rat cardiovascular system. | 2000 | Jpn. J. Pharmacol. | pmid:10875754 |
| Spiegel S and Milstien S | Sphingosine-1-phosphate: signaling inside and out. | 2000 | FEBS Lett. | pmid:10878250 |
| Cooke ME et al. | Contraction of collagen matrices mediated by alpha2beta1A and alpha(v)beta3 integrins. | 2000 | J. Cell. Sci. | pmid:10852817 |
| Yanai N et al. | Sphingosine-1-phosphate and lysophosphatidic acid trigger invasion of primitive hematopoietic cells into stromal cell layers. | 2000 | Blood | pmid:10891442 |
| Prieschl EE and Baumruker T | Beyond a structural component: sphingolipids in immunology. | 2000 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:10912620 |
| Nanjundan M and Possmayer F | Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase. | 2000 Jul-Aug | Exp. Lung Res. | pmid:10914334 |
| Osawa Y et al. | TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. | 2001 | J. Immunol. | pmid:11418646 |
| Boujaoude LC et al. | Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. | 2001 | J. Biol. Chem. | pmid:11443135 |
| English D et al. | Platelet-released phospholipids link haemostasis and angiogenesis. | 2001 | Cardiovasc. Res. | pmid:11166272 |
| Radin NS | Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come? | 2001 | Eur. J. Biochem. | pmid:11168352 |
| Karliner JS et al. | The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549349 |
| Siehler S et al. | Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. | 2001 | J. Biol. Chem. | pmid:11673450 |
| Cuvillier O and Levade T | Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. | 2001 | Blood | pmid:11675357 |
| Tigyi G | Selective ligands for lysophosphatidic acid receptor subtypes: gaining control over the endothelial differentiation gene family. | 2001 | Mol. Pharmacol. | pmid:11723220 |
| Castillo SS and Teegarden D | Ceramide conversion to sphingosine-1-phosphate is essential for survival in C3H10T1/2 cells. | 2001 | J. Nutr. | pmid:11694603 |
| Lyons JM and Karin NJ | A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. | 2001 | J. Bone Miner. Res. | pmid:11697799 |
| Hornuss C et al. | Human and rat alveolar macrophages express multiple EDG receptors. | 2001 | Eur. J. Pharmacol. | pmid:11698050 |
| Yoshida A and Ueda H | Neurobiology of the Edg2 lysophosphatidic acid receptor. | 2001 | Jpn. J. Pharmacol. | pmid:11700008 |
| Im DS et al. | Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. | 2001 | Biochemistry | pmid:11705398 |
| Rosenfeldt HM et al. | The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. | 2001 | Biochem. Soc. Trans. | pmid:11709084 |
| Manggau M et al. | 1Alpha,25-dihydroxyvitamin D3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. | 2001 | J. Invest. Dermatol. | pmid:11710939 |
| Sullards MC and Merrill AH | Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. | 2001 | Sci. STKE | pmid:11752637 |
| Okajima F | [Establishment of the method for the measurement of sphingosine-1-phosphate in biological samples and its application for S1P research]. | 2001 | Nippon Yakurigaku Zasshi | pmid:11778456 |
| Tosaka M et al. | Sphingosine 1-phosphate contracts canine basilar arteries in vitro and in vivo: possible role in pathogenesis of cerebral vasospasm. | 2001 | Stroke | pmid:11739995 |
| Alderton F et al. | Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. | 2001 | J. Biol. Chem. | pmid:11359779 |
| Pébay A et al. | Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. | 2001 | Eur. J. Neurosci. | pmid:11422447 |
| Kimura T et al. | Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | 2001 | J. Biol. Chem. | pmid:11427538 |
| Ishii I et al. | Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. | 2001 | J. Biol. Chem. | pmid:11443127 |
| Kralik SF et al. | A method for quantitative extraction of sphingosine 1-phosphate into organic solvent. | 2001 | Anal. Biochem. | pmid:11444818 |
| Wells CD et al. | Identification of potential mechanisms for regulation of p115 RhoGEF through analysis of endogenous and mutant forms of the exchange factor. | 2001 | J. Biol. Chem. | pmid:11384980 |
| Liu F et al. | Differential regulation of sphingosine-1-phosphate- and VEGF-induced endothelial cell chemotaxis. Involvement of G(ialpha2)-linked Rho kinase activity. | 2001 | Am. J. Respir. Cell Mol. Biol. | pmid:11415936 |
| Olorundare OE et al. | Assembly of a fibronectin matrix by adherent platelets stimulated by lysophosphatidic acid and other agonists. | 2001 | Blood | pmid:11418470 |
| Osawa Y et al. | Sphingosine kinase regulates hepatoma cell differentiation: roles of hepatocyte nuclear factor and retinoid receptor. | 2001 | Biochem. Biophys. Res. Commun. | pmid:11520048 |
| Banno Y et al. | Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. | 2001 | J. Biol. Chem. | pmid:11468290 |
| Tilly JL | Emerging technologies to control oocyte apoptosis are finally treading on fertile ground. | 2001 | ScientificWorldJournal | pmid:12805661 |
| Blaukat A and Dikic I | Activation of sphingosine kinase by the bradykinin B2 receptor and its implication in regulation of the ERK/MAP kinase pathway. | 2001 | Biol. Chem. | pmid:11258664 |
| Alemany R et al. | Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. | 2001 | FEBS Lett. | pmid:11741596 |