Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Hammad SM | Blood sphingolipids in homeostasis and pathobiology. | 2011 | Adv. Exp. Med. Biol. | pmid:21910082 |
Rivera J et al. | New insights on mast cell activation via the high affinity receptor for IgE. | 2008 | Adv. Immunol. | pmid:18772004 |
Buehrer BM and Bell RM | Sphingosine kinase: properties and cellular functions. | 1993 | Adv. Lipid Res. | pmid:8397478 |
Silva VR et al. | Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. | 2016 | Aging (Albany NY) | pmid:28039439 |
Green CL et al. | The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. | 2017 | Aging Cell | pmid:28139067 |
Makino Y et al. | Role of sphingosine-1-phosphate inβ-adrenoceptor desensitization via Ca(2+) sensitization in airway smooth muscle. | 2012 | Allergol Int | pmid:22441633 |
Sashio T et al. | Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium. | 2012 | Allergol Int | pmid:22361510 |
Fuerst E et al. | Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. | 2014 | Allergy | pmid:25041788 |
Kleinjan A et al. | Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. | 2013 | Allergy | pmid:23253209 |
Herzinger T et al. | Sphingosine-1-phosphate signaling and the skin. | 2007 | Am J Clin Dermatol | pmid:18039015 |
Deutschman DH et al. | Predicting obstructive coronary artery disease with serum sphingosine-1-phosphate. | 2003 | Am. Heart J. | pmid:12851609 |
Zhang Q et al. | Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. | 2016 | Am. J. Chin. Med. | pmid:27430910 |
Santos-Cortez RL et al. | Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. | 2016 | Am. J. Hum. Genet. | pmid:26805784 |
Kim M et al. | Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. | 2010 | Am. J. Nephrol. | pmid:20234131 |
Sandhu KS et al. | Regional heterogeneity in expression of the sphingosine-1-phosphate pathway in the female rat lower urinary tract. | 2009 | Am. J. Obstet. Gynecol. | pmid:19254791 |
Armstrong SM et al. | Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac. | 2012 | Am. J. Pathol. | pmid:22203054 |
Wang R et al. | Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. | 2017 | Am. J. Pathol. | pmid:27840081 |
Straub AC et al. | Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. | 2009 | Am. J. Pathol. | pmid:19349368 |
Harijith A et al. | Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. | 2013 | Am. J. Pathol. | pmid:23933064 |
Li C et al. | Involvement of sphingosine 1-phosphate (SIP)/S1P3 signaling in cholestasis-induced liver fibrosis. | 2009 | Am. J. Pathol. | pmid:19729475 |
Shimizu Y et al. | Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. | 2014 | Am. J. Pathol. | pmid:24641902 |
Xiu L et al. | Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors. | 2015 | Am. J. Pathol. | pmid:25432063 |
Ishimaru N et al. | CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. | 2012 | Am. J. Pathol. | pmid:22067914 |
Suomalainen L et al. | Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. | 2005 | Am. J. Pathol. | pmid:15743789 |
Krishna SM et al. | Fenofibrate increases high-density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model. | 2012 | Am. J. Pathol. | pmid:22698985 |
Bi Y et al. | Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. | 2014 | Am. J. Pathol. | pmid:25111230 |
Watson C et al. | High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. | 2010 | Am. J. Pathol. | pmid:20889557 |
Mori H et al. | Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis. | 2015 | Am. J. Pathol. | pmid:26272361 |
Simonaro CM et al. | Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases. | 2008 | Am. J. Pathol. | pmid:18079441 |
Im DS et al. | Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes. | 1997 | Am. J. Physiol. | pmid:9176218 |
MacDonell KL et al. | Depression of excitability by sphingosine 1-phosphate in rat ventricular myocytes. | 1998 | Am. J. Physiol. | pmid:9843831 |
Durieux ME et al. | Responses to sphingosine-1-phosphate in X. laevis oocytes: similarities with lysophosphatidic acid signaling. | 1993 | Am. J. Physiol. | pmid:7684565 |
Törnquist K | Sphingosine 1-phosphate stimulates Na+/H+ exchange in thyroid FRTL-5 cells. | 1997 | Am. J. Physiol. | pmid:9124507 |
Jeng YJ et al. | Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences. | 2007 | Am. J. Physiol. Endocrinol. Metab. | pmid:17164439 |
Yang G et al. | Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19435851 |
Anbazhagan AN et al. | Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:27079615 |
Ikeda H et al. | Biological activities of novel lipid mediator sphingosine 1-phosphate in rat hepatic stellate cells. | 2000 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:10915638 |
Ohama T et al. | Sphingosine-1-phosphate enhances IL-1{beta}-induced COX-2 expression in mouse intestinal subepithelial myofibroblasts. | 2008 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:18703638 |
Kang H et al. | Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18805898 |
Zhang G et al. | Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules. | 2010 | Am. J. Physiol. Heart Circ. Physiol. | pmid:20729401 |
Lee JF et al. | Balance of S1P1 and S1P2 signaling regulates peripheral microvascular permeability in rat cremaster muscle vasculature. | 2009 | Am. J. Physiol. Heart Circ. Physiol. | pmid:19011048 |
Egom EE et al. | Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21705677 |
Bandhuvula P et al. | S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the heart. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21335477 |
Adamson RH et al. | Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22427519 |
Means CK et al. | Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17293497 |
Zhang F et al. | Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26589326 |
Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
Jin ZQ et al. | Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12003800 |
Landeen LK et al. | Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18024550 |
Patschan S et al. | Lipid mediators of autophagy in stress-induced premature senescence of endothelial cells. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18203850 |