Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Al Alam N and Kreydiyyeh SI | FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. | 2016 | Biochem. Cell Biol. | pmid:27501354 |
| Fu P et al. | Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. | 2016 | J. Biol. Chem. | pmid:27864331 |
| Dong T et al. | Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. | 2016 | J Neuroinflammation | pmid:27561600 |
| Nojima H et al. | Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. | 2016 | PLoS ONE | pmid:27551720 |
| Harris CM et al. | Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27519818 |
| Gstalder C et al. | FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. | 2016 | Mol. Cancer Ther. | pmid:27507852 |
| Hashimoto Y et al. | Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. | 2016 | Cell Biol. Int. | pmid:27486054 |
| Rumzhum NN et al. | Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26098693 |
| Bao XH et al. | [Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. | 2016 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:27220580 |
| Marfia G et al. | The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling. | 2016 | Stem Cells Dev. | pmid:27217090 |
| Versmissen J et al. | Familial hypercholesterolaemia: cholesterol efflux and coronary disease. | 2016 | Eur. J. Clin. Invest. | pmid:27208892 |
| Sauvé M et al. | Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. | 2016 | Diabetes | pmid:27207546 |
| Zhang XE et al. | Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. | 2016 | PLoS ONE | pmid:27187066 |
| Ohtoyo M et al. | Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. | 2016 | Cell Chem Biol | pmid:27185637 |
| Yang Y et al. | Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. | 2016 | Neurochem. Int. | pmid:26921668 |
| Park K et al. | ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26903652 |
| Bien-Möller S et al. | Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. | 2016 | Oncotarget | pmid:26887055 |
| Uranbileg B et al. | Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. | 2016 | PLoS ONE | pmid:26886371 |
| Chumanevich A et al. | Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. | 2016 | Mediators Inflamm. | pmid:26884643 |
| Gomez-Muñoz A et al. | Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate. | 2016 | Prog. Lipid Res. | pmid:26703189 |
| Ottenlinger F et al. | Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. | 2016 | Eur. J. Immunol. | pmid:26683421 |
| Fan A et al. | Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:26669941 |
| Petrache I and Berdyshev EV | Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. | 2016 | Annu. Rev. Physiol. | pmid:26667073 |
| Delgado A and MartÃnez-Cartro M | Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. | 2016 | Curr. Med. Chem. | pmid:26639095 |
| Tan SF et al. | Acid ceramidase is upregulated in AML and represents a novel therapeutic target. | 2016 | Oncotarget | pmid:27825124 |
| Li S et al. | Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. | 2016 | Oncotarget | pmid:27811358 |
| Scotti L et al. | Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. | 2016 | Mol. Hum. Reprod. | pmid:27645281 |
| Melnik BC | Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. | 2016 | Acta Derm. Venereol. | pmid:26304030 |
| Pulli I et al. | A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca²⺠microdomain in the caveolar compartment. | 2015 | Biochim. Biophys. Acta | pmid:25892494 |
| Zankov DP and Ogita H | Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. | 2015 | Biomed Res Int | pmid:25883953 |
| Williams PA et al. | Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). | 2015 | PLoS ONE | pmid:25875493 |
| Schröder M et al. | Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. | 2015 | Biol. Chem. | pmid:25720062 |
| Koch A et al. | Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. | 2015 | Biol. Chem. | pmid:25719311 |
| Park ES et al. | Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. | 2015 | J. Biol. Chem. | pmid:25716317 |
| Rhee SH et al. | Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall. | 2015 | J Obstet Gynaecol | pmid:25692679 |
| Roviezzo F et al. | S1P-induced airway smooth muscle hyperresponsiveness and lung inflammation in vivo: molecular and cellular mechanisms. | 2015 | Br. J. Pharmacol. | pmid:25439580 |
| Carroll B et al. | Sphingolipids in the DNA damage response. | 2015 | Adv Biol Regul | pmid:25434743 |
| Xiu L et al. | Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors. | 2015 | Am. J. Pathol. | pmid:25432063 |
| Prüfer N et al. | The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality. | 2015 | Biol. Chem. | pmid:25252751 |
| Czubowicz K et al. | Sphingosine-1-phosphate and its effect on glucose deprivation/glucose reload stress: from gene expression to neuronal survival. | 2015 | Mol. Neurobiol. | pmid:25056275 |
| Iwabuchi K et al. | Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. | 2015 | Mediators Inflamm. | pmid:26609196 |
| Jeong JK et al. | Modulation of the expression of sphingosine 1-phosphate 2 receptors regulates the differentiation of pre-adipocytes. | 2015 | Mol Med Rep | pmid:26459774 |
| Li C et al. | Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. | 2015 | J Neuroinflammation | pmid:25880547 |
| Adamiak M et al. | Evidence for the involvement of sphingosine-1-phosphate in the homing and engraftment of hematopoietic stem cells to bone marrow. | 2015 | Oncotarget | pmid:26299919 |
| Mori H et al. | Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis. | 2015 | Am. J. Pathol. | pmid:26272361 |
| Camp SM et al. | Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720. | 2015 | Chem. Phys. Lipids | pmid:26272033 |
| Chen MH et al. | Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. | 2015 | Oncotarget | pmid:26090720 |
| Panneer Selvam S et al. | Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. | 2015 | Sci Signal | pmid:26082434 |
| Malik FA et al. | Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity. | 2015 | PLoS ONE | pmid:26079370 |
| Mooren OL et al. | Role of N-WASP in Endothelial Monolayer Formation and Integrity. | 2015 | J. Biol. Chem. | pmid:26070569 |