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Neurology |
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Nature |
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Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
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Biofactors |
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Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
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Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
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Gastroenterology |
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The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
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Autophagy |
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Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51). |
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DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion. |
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Cell Commun. Signal |
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Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling. |
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Oncotarget |
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In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome. |
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High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
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Atherosclerosis |
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Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. |
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PLoS ONE |
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Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. |
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PLoS ONE |
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Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. |
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PLoS ONE |
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Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
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Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
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Cell. Physiol. Biochem. |
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Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
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Mol. Immunol. |
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Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
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PLoS ONE |
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Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. |
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Diabetes |
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Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. |
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β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. |
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Biomed Res Int |
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Gastroenterology |
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Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. |
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Int J Mol Sci |
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Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. |
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Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. |
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Yale J Biol Med |
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Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
2017 |
Sci Signal |
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Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
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Sphingosine 1-phosphate - A double edged sword in the brain. |
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Biochim. Biophys. Acta |
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A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
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J Pharm Biomed Anal |
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Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
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Glia |
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Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. |
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Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. |
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Trends Mol Med |
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Modulation of sphingosine-1-phosphate in inflammatory bowel disease. |
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Autoimmun Rev |
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Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. |
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J R Soc Interface |
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Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. |
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PLoS ONE |
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Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. |
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Eur J Nutr |
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Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. |
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PLoS ONE |
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Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. |
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High levels of sphingolipids in human breast cancer. |
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Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. |
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J Neuroinflammation |
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Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. |
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PLoS ONE |
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Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. |
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FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. |
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Mol. Cancer Ther. |
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Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. |
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Mol. Cell. Endocrinol. |
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Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization. |
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Am. J. Respir. Cell Mol. Biol. |
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TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. |
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S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. |
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J. Pharmacol. Exp. Ther. |
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Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. |
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Expert Opin Drug Metab Toxicol |
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Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. |
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Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. |
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Clin. Chim. Acta |
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[Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. |
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The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling. |
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Familial hypercholesterolaemia: cholesterol efflux and coronary disease. |
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Eur. J. Clin. Invest. |
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Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. |
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Diabetes |
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Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications. |
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Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. |
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Sci Rep |
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Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). |
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Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. |
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Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. |
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Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. |
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Planta |
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Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. |
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Neurochem. Int. |
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ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. |
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Oncotarget |
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Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. |
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Biochem. J. |
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The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. |
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PLoS ONE |
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A systematic methodology for large scale compound screening: A case study on the discovery of novel S1PL inhibitors. |
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J. Mol. Graph. Model. |
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Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer. |
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Oncotarget |
pmid:26716409
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Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. |
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Gene |
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Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure. |
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J Biomed Mater Res A |
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Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. |
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Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. |
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Am. J. Physiol., Cell Physiol. |
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Acid ceramidase is upregulated in AML and represents a novel therapeutic target. |
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Oncotarget |
pmid:27825124
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Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
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Oncotarget |
pmid:27811358
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DNA damage response and sphingolipid signaling in liver diseases. |
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Surg. Today |
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Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. |
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Oncotarget |
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