| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Huang JS et al. | Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc- and calcium-dependent mechanism in fibroblasts. | 1999 | Arch. Biochem. Biophys. | pmid:10334873 |
| Kozawa O et al. | Sphingosine 1-phosphate regulates heat shock protein 27 induction by a p38 MAP kinase-dependent mechanism in aortic smooth muscle cells. | 1999 | Exp. Cell Res. | pmid:10413591 |
| Augé N et al. | Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. | 1999 | J. Biol. Chem. | pmid:10419457 |
| Igarashi Y | [Recent development of sphingosin 1-phosphate studies as a second messenger or a second agonist in cell signaling]. | 1999 | Tanpakushitsu Kakusan Koso | pmid:10396983 |
| Hisano N et al. | Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. | 1999 | Blood | pmid:10361127 |
| Meacci E et al. | Effect of Rho and ADP-ribosylation factor GTPases on phospholipase D activity in intact human adenocarcinoma A549 cells. | 1999 | J. Biol. Chem. | pmid:10373471 |
| Tolan D et al. | Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model. | 1999 | Cell. Signal. | pmid:10376808 |
| Okamoto H et al. | EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10381367 |
| Edsall LC and Spiegel S | Enzymatic measurement of sphingosine 1-phosphate. | 1999 | Anal. Biochem. | pmid:10405296 |
| Windh RT et al. | Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. | 1999 | J. Biol. Chem. | pmid:10488065 |
| Banno Y et al. | Differential phospholipase D activation by bradykinin and sphingosine 1-phosphate in NIH 3T3 fibroblasts overexpressing gelsolin. | 1999 | J. Biol. Chem. | pmid:10488069 |
| Kozawa O et al. | Sphingosine 1-phosphate induces heat shock protein 27 via p38 mitogen-activated protein kinase activation in osteoblasts. | 1999 | J. Bone Miner. Res. | pmid:10491224 |
| Cavallini L et al. | Ganglioside GM1 protection from apoptosis of rat heart fibroblasts. | 1999 | Arch. Biochem. Biophys. | pmid:10510273 |
| Xia P et al. | High density lipoproteins (HDL) interrupt the sphingosine kinase signaling pathway. A possible mechanism for protection against atherosclerosis by HDL. | 1999 | J. Biol. Chem. | pmid:10551885 |
| Dygas A et al. | Exogenous sphingosine 1-phosphate and sphingosylphosphorylcholine do not stimulate phospholipase D in C6 glioma cells. | 1999 | Acta Biochim. Pol. | pmid:10453985 |
| Wójcik M and Barańska J | Sphingosine, sphingosylphosphorylcholine and sphingosine 1-phosphate modulate phosphatidylserine homeostasis in glioma C6 cells. | 1999 | Acta Biochim. Pol. | pmid:10453988 |
| Waeber C and Chiu ML | In vitro autoradiographic visualization of guanosine-5'-O-(3-[35S]thio)triphosphate binding stimulated by sphingosine 1-phosphate and lysophosphatidic acid. | 1999 | J. Neurochem. | pmid:10461914 |
| Hotchin NA et al. | Differential activation of focal adhesion kinase, Rho and Rac by the ninth and tenth FIII domains of fibronectin. | 1999 | J. Cell. Sci. | pmid:10444388 |
| Kon J et al. | Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells. | 1999 | J. Biol. Chem. | pmid:10446161 |
| Ancellin N and Hla T | Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. | 1999 | J. Biol. Chem. | pmid:10383399 |
| Dallalio G et al. | Inhibition of human erythroid colony formation by ceramide. | 1999 | Exp. Hematol. | pmid:10390188 |
| Hla T et al. | Sphingosine-1-phosphate: extracellular mediator or intracellular second messenger? | 1999 | Biochem. Pharmacol. | pmid:10423159 |
| Prieschl EE et al. | The balance between sphingosine and sphingosine-1-phosphate is decisive for mast cell activation after Fc epsilon receptor I triggering. | 1999 | J. Exp. Med. | pmid:10429665 |
| Sato K et al. | Activation of phospholipase C-Ca2+ system by sphingosine 1-phosphate in CHO cells transfected with Edg-3, a putative lipid receptor. | 1999 | FEBS Lett. | pmid:9928946 |
| Hung WC et al. | Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells. | 1999 | Biochem. J. | pmid:9931312 |
| Zhang G et al. | Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. | 1999 | Gene | pmid:9931453 |
| Xia P et al. | Activation of sphingosine kinase by tumor necrosis factor-alpha inhibits apoptosis in human endothelial cells. | 1999 | J. Biol. Chem. | pmid:10567432 |
| Meyer zu Heringdorf D et al. | Role of sphingosine kinase in Ca(2+) signalling by epidermal growth factor receptor. | 1999 | FEBS Lett. | pmid:10567700 |
| Sabbadini RA et al. | The role of sphingolipids in the control of skeletal muscle function: a review. | 1999 | Ital J Neurol Sci | pmid:10937863 |
| Pyne S et al. | Extracellular actions of sphingosine I-phosphate through endothelial differentiation gene products in mammalian cells: role in regulating proliferation and apoptosis. | 1999 | Biochem. Soc. Trans. | pmid:10917611 |
| Goetzl EJ and An S | A subfamily of G protein-coupled cellular receptors for lysophospholipids and lysosphingolipids. | 1999 | Adv. Exp. Med. Biol. | pmid:10667339 |
| Carpio LC et al. | Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670688 |
| Wang F et al. | Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. | 1999 | Cancer Res. | pmid:10626811 |
| Wang F et al. | Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis. | 1999 | J. Biol. Chem. | pmid:10585401 |
| Alemany R et al. | Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. | 1999 | J. Biol. Chem. | pmid:9933590 |
| Zhang Q et al. | Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. | 1999 | Blood | pmid:10216094 |
| Goetzl EJ et al. | Lysophospholipid enhancement of human T cell sensitivity to diphtheria toxin by increased expression of heparin-binding epidermal growth factor. | 1999 May-Jun | Proc. Assoc. Am. Physicians | pmid:10354366 |
| Pyne S and Pyne NJ | Sphingosine 1-phosphate signalling in mammalian cells. | 2000 | Biochem. J. | pmid:10880336 |
| Spiegel S and Milstien S | Functions of a new family of sphingosine-1-phosphate receptors. | 2000 | Biochim. Biophys. Acta | pmid:10760461 |
| Panetti TS et al. | Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10764666 |
| Boguslawski G et al. | Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10833459 |
| Kimura T et al. | Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. | 2000 | Biochem. J. | pmid:10794715 |
| Meacci E et al. | Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. | 2000 | FEBS Lett. | pmid:11018530 |
| Young KW et al. | Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. | 2000 | J. Biol. Chem. | pmid:10954727 |
| Peyruchaud O and Mosher DF | Differential stimulation of signaling pathways initiated by Edg-2 in response to lysophosphatidic acid or sphingosine-1-phosphate. | 2000 | Cell. Mol. Life Sci. | pmid:10961347 |
| Casper RF and Jurisicova A | Protecting the female germ line from cancer therapy. | 2000 | Nat. Med. | pmid:11017136 |
| Morita Y et al. | Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. | 2000 | Nat. Med. | pmid:11017141 |
| Kozawa O et al. | Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913228 |
| Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
| Takeshita A et al. | Selective stimulation by ceramide of the expression of the alpha isoform of retinoic acid and retinoid X receptors in osteoblastic cells. A role of sphingosine 1-phosphate-mediated AP-1 in the ligand-dependent transcriptional activity of these receptors. | 2000 | J. Biol. Chem. | pmid:10915783 |