Kulinski JM et al. |
Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. |
2016 |
Eur. J. Pharmacol. |
pmid:25941085
|
Silva VR et al. |
Hypothalamic S1P/S1PR1 axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. |
2016 |
Aging (Albany NY) |
pmid:28039439
|
Lei YC et al. |
C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure. |
2016 |
World J. Gastroenterol. |
pmid:28028363
|
Al Fadel F et al. |
Involvement of Sphingosine 1-Phosphate in Palmitate-Induced Non-Alcoholic Fatty Liver Disease. |
2016 |
Cell. Physiol. Biochem. |
pmid:28006772
|
Bigaud M et al. |
Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism. |
2016 |
PLoS ONE |
pmid:28005953
|
Surya VN et al. |
Sphingosine 1-phosphate receptor 1 regulates the directional migration of lymphatic endothelial cells in response to fluid shear stress. |
2016 |
J R Soc Interface |
pmid:27974574
|
Soltau I et al. |
Serum-Sphingosine-1-Phosphate Concentrations Are Inversely Associated with Atherosclerotic Diseases in Humans. |
2016 |
PLoS ONE |
pmid:27973607
|
Kasbi-Chadli F et al. |
Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. |
2016 |
Eur J Nutr |
pmid:25787885
|
Evangelisti C et al. |
Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. |
2016 |
Leukemia |
pmid:27461062
|
Stolwijk JA et al. |
Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function. |
2016 |
J. Biol. Chem. |
pmid:27624938
|
Gharbaran R |
Insights into the molecular roles of heparan sulfate proteoglycans (HSPGs-syndecans) in autocrine and paracrine growth factor signaling in the pathogenesis of Hodgkin's lymphoma. |
2016 |
Tumour Biol. |
pmid:27317256
|
Higashi K et al. |
Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. |
2016 |
Bone |
pmid:27612439
|
Sasset L et al. |
Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis. |
2016 |
Trends Endocrinol. Metab. |
pmid:27562337
|
Roviezzo F et al. |
Disodium cromoglycate inhibits asthma-like features induced by sphingosine-1-phosphate. |
2016 |
Pharmacol. Res. |
pmid:27713021
|
Hemdan NY et al. |
Modulating sphingosine 1-phosphate signaling with DOP or FTY720 alleviates vascular and immune defects in mouse sepsis. |
2016 |
Eur. J. Immunol. |
pmid:27683081
|
Adamiak M et al. |
The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. |
2016 |
Stem Cell Rev |
pmid:27704316
|
Morillon YM et al. |
Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration. |
2016 |
J. Immunol. |
pmid:27694496
|
Lepannetier S et al. |
Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells. |
2016 |
Cell Calcium |
pmid:27638096
|
Kemppainen K et al. |
Sphingosylphosphorylcholine regulates the Hippo signaling pathway in a dual manner. |
2016 |
Cell. Signal. |
pmid:27634386
|
Custódio R et al. |
Characterization of secreted sphingosine-1-phosphate lyases required for virulence and intracellular survival of Burkholderia pseudomallei. |
2016 |
Mol. Microbiol. |
pmid:27632710
|
Ebenezer DL et al. |
Targeting sphingosine-1-phosphate signaling in lung diseases. |
2016 |
Pharmacol. Ther. |
pmid:27621206
|
Tsuchida J et al. |
Breast cancer sphingosine-1-phosphate is associated with phospho-sphingosine kinase 1 and lymphatic metastasis. |
2016 |
J. Surg. Res. |
pmid:27621003
|
Chen W et al. |
Sphingosine 1-phosphate in metabolic syndrome (Review). |
2016 |
Int. J. Mol. Med. |
pmid:27600830
|
Hamidi Shishavan M et al. |
Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. |
2016 |
PLoS ONE |
pmid:27583547
|
Gazit SL et al. |
Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. |
2016 |
Circ. Res. |
pmid:27582371
|
Machida T et al. |
Cellular function and signaling pathways of vascular smooth muscle cells modulated by sphingosine 1-phosphate. |
2016 |
J. Pharmacol. Sci. |
pmid:27581589
|
Nagahashi M et al. |
High levels of sphingolipids in human breast cancer. |
2016 |
J. Surg. Res. |
pmid:27565080
|
Dong T et al. |
Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. |
2016 |
J Neuroinflammation |
pmid:27561600
|
Nojima H et al. |
Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. |
2016 |
PLoS ONE |
pmid:27551720
|
Chen C et al. |
Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. |
2016 |
Mol. Cell. Endocrinol. |
pmid:26948947
|
Liu X et al. |
ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. |
2016 |
J. Physiol. Biochem. |
pmid:27377933
|
Egom EE et al. |
Effect of sphingosine-1-phosphate on L-type calcium current and Ca(2+) transient in rat ventricular myocytes. |
2016 |
Mol. Cell. Biochem. |
pmid:27372350
|
Sanagawa A et al. |
Sphingosine 1‑phosphate induced by hypoxia increases the expression of PAI‑1 in HepG2 cells via HIF‑1α. |
2016 |
Mol Med Rep |
pmid:27357063
|
Tiper IV et al. |
Sphingosine 1-phosphate signaling impacts lymphocyte migration, inflammation and infection. |
2016 |
Pathog Dis |
pmid:27354294
|
Jung M et al. |
Lipocalin 2 from macrophages stimulated by tumor cell-derived sphingosine 1-phosphate promotes lymphangiogenesis and tumor metastasis. |
2016 |
Sci Signal |
pmid:27353364
|
Rodvold JJ and Zanetti M |
Tumor microenvironment on the move and the Aselli connection. |
2016 |
Sci Signal |
pmid:27353363
|
Harijith A et al. |
Hyperoxia-induced p47phox activation and ROS generation is mediated through S1P transporter Spns2, and S1P/S1P1&2 signaling axis in lung endothelium. |
2016 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:27343196
|
Hernández-Coronado CG et al. |
Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. |
2016 |
Gen. Comp. Endocrinol. |
pmid:27342378
|
Chakrabarti SS et al. |
Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. |
2016 |
Curr Alzheimer Res |
pmid:27335046
|
Tsai HC and Han MH |
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. |
2016 |
Drugs |
pmid:27318702
|
Yang Z et al. |
TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. |
2016 |
Pharmacol. Res. |
pmid:27317945
|
Cantalupo A and Di Lorenzo A |
S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. |
2016 |
J. Pharmacol. Exp. Ther. |
pmid:27317800
|
Juif PE et al. |
Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. |
2016 |
Expert Opin Drug Metab Toxicol |
pmid:27249325
|
Hollands A et al. |
Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. |
2016 |
J. Biol. Chem. |
pmid:27226531
|
Mirzaian M et al. |
Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. |
2016 |
Clin. Chim. Acta |
pmid:27221202
|
Bao XH et al. |
[Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. |
2016 |
Zhonghua Xin Xue Guan Bing Za Zhi |
pmid:27220580
|
Koresawa R et al. |
Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma. |
2016 |
Br. J. Haematol. |
pmid:27061580
|
Resop RS et al. |
Sphingosine-1-phosphate/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human TÂ cells from the thymus to the periphery. |
2016 |
J. Allergy Clin. Immunol. |
pmid:27056271
|
Guo J et al. |
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1). |
2016 |
Bioorg. Med. Chem. Lett. |
pmid:27055941
|
Adams DR et al. |
Sphingosine Kinases: Emerging Structure-Function Insights. |
2016 |
Trends Biochem. Sci. |
pmid:27021309
|
Lv M et al. |
Sphingosine kinase 1/sphingosine-1-phosphate regulates the expression of interleukin-17A in activated microglia in cerebral ischemia/reperfusion. |
2016 |
Inflamm. Res. |
pmid:27002656
|
Wang H et al. |
Potential serum biomarkers from a metabolomics study of autism. |
2016 |
J Psychiatry Neurosci |
pmid:26395811
|
Frej C et al. |
Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons. |
2016 |
J. Cell. Mol. Med. |
pmid:26990127
|
Pyne S et al. |
Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances. |
2016 |
Prog. Lipid Res. |
pmid:26970273
|
Aoki M et al. |
Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. |
2016 |
Mediators Inflamm. |
pmid:26966342
|
Brinck JW et al. |
Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. |
2016 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:26966278
|
Chawla S et al. |
S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report. |
2016 |
IUBMB Life |
pmid:26959531
|
Vito CD et al. |
Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications. |
2016 |
Platelets |
pmid:26950429
|
Jin J et al. |
Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. |
2016 |
Sci Rep |
pmid:26948042
|
Guerrero M et al. |
Sphingosine 1-phosphate receptor 1 agonists: a patent review (2013-2015). |
2016 |
Expert Opin Ther Pat |
pmid:26947494
|
Watterson SH et al. |
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. |
2016 |
J. Med. Chem. |
pmid:26924461
|
Liu W et al. |
Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. |
2016 |
Eur. J. Pharmacol. |
pmid:26921757
|
Puli MR et al. |
Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. |
2016 |
Planta |
pmid:27233507
|
Yang Y et al. |
Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. |
2016 |
Neurochem. Int. |
pmid:26921668
|
Wiltshire R et al. |
Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. |
2016 |
Sci Rep |
pmid:26813587
|
Farez MF and Correale J |
Sphingosine 1-phosphate signaling in astrocytes: Implications for progressive multiple sclerosis. |
2016 |
J. Neurol. Sci. |
pmid:26810518
|
Santos-Cortez RL et al. |
Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2. |
2016 |
Am. J. Hum. Genet. |
pmid:26805784
|
Bock S et al. |
Sphingosine 1-phospate differentially modulates maturation and function of human Langerhans-like cells. |
2016 |
J. Dermatol. Sci. |
pmid:26803226
|
Marycz K et al. |
The influence of metal-based biomaterials functionalized with sphingosine-1-phosphate on the cellular response and osteogenic differentaion potenial of human adipose derived mesenchymal stem cells in vitro. |
2016 |
J Biomater Appl |
pmid:26801473
|
Tran HB et al. |
Cigarette smoke inhibits efferocytosis via deregulation of sphingosine kinase signaling: reversal with exogenous S1P and the S1P analogue FTY720. |
2016 |
J. Leukoc. Biol. |
pmid:26792820
|
Chapurlat RD and Confavreux CB |
Novel biological markers of bone: from bone metabolism to bone physiology. |
2016 |
Rheumatology (Oxford) |
pmid:26790456
|
Zhang Y et al. |
Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. |
2016 |
PLoS ONE |
pmid:26788916
|
Dillmann C et al. |
S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. |
2016 |
J. Immunol. |
pmid:26783340
|
Ghasemi R et al. |
Integrated sphingosine-1 phosphate signaling in the central nervous system: From physiological equilibrium to pathological damage. |
2016 |
Pharmacol. Res. |
pmid:26772814
|
Morel S et al. |
Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. |
2016 |
Cardiovasc. Res. |
pmid:26762268
|
Sundaram K et al. |
Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. |
2016 |
Biochem. J. |
pmid:26747710
|
Abu Khweek A et al. |
The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. |
2016 |
PLoS ONE |
pmid:26741365
|
Deniz U et al. |
A systematic methodology for large scale compound screening: A case study on the discovery of novel S1PL inhibitors. |
2016 |
J. Mol. Graph. Model. |
pmid:26724452
|
Beach JA et al. |
Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer. |
2016 |
Oncotarget |
pmid:26716409
|
Deutsch G et al. |
Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. |
2016 |
Gene |
pmid:26707209
|
Kim YH and Tabata Y |
Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure. |
2016 |
J Biomed Mater Res A |
pmid:26704185
|
Gomez-Muñoz A et al. |
Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate. |
2016 |
Prog. Lipid Res. |
pmid:26703189
|
Ottenlinger F et al. |
Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. |
2016 |
Eur. J. Immunol. |
pmid:26683421
|
Yuasa D et al. |
C1q/TNF-related protein-1 functions to protect against acute ischemic injury in the heart. |
2016 |
FASEB J. |
pmid:26578687
|
Realini N et al. |
Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION. |
2016 |
J. Biol. Chem. |
pmid:26553872
|
Campos LS et al. |
Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. |
2016 |
Mol. Cell. Biol. |
pmid:26552704
|
Nagahashi M et al. |
DNA damage response and sphingolipid signaling in liver diseases. |
2016 |
Surg. Today |
pmid:26514817
|
Cheng JC et al. |
Sphingosine-1-phosphate induces COX-2 expression and PGE2 production in human granulosa cells through a S1P1/3-mediated YAP signaling. |
2016 |
Cell. Signal. |
pmid:26994820
|
Ratajczak MZ and Suszynska M |
Emerging Strategies to Enhance Homing and Engraftment of Hematopoietic Stem Cells. |
2016 |
Stem Cell Rev |
pmid:26400757
|
Yaghobian D et al. |
Increased sphingosine 1-phosphate mediates inflammation and fibrosis in tubular injury in diabetic nephropathy. |
2016 |
Clin. Exp. Pharmacol. Physiol. |
pmid:26414003
|
Bae SJ et al. |
The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study. |
2016 |
Osteoporos Int |
pmid:26984570
|
Kalhori V et al. |
FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion. |
2016 |
Endocr. Relat. Cancer |
pmid:26935838
|
Liu X et al. |
Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells. |
2016 |
Exp. Biol. Med. (Maywood) |
pmid:26376826
|
Setoguchi R |
IL-15 boosts the function and migration of human terminally differentiated CD8+ T cells by inducing a unique gene signature. |
2016 |
Int. Immunol. |
pmid:26857736
|
Nojima H et al. |
Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. |
2016 |
J. Hepatol. |
pmid:26254847
|
Kim BJ et al. |
The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient. |
2016 |
J. Endocrinol. Invest. |
pmid:26219613
|
Touat-Hamici Z et al. |
Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function. |
2016 |
Cardiovasc. Res. |
pmid:27694435
|
Medina CB and Ravichandran KS |
Do not let death do us part: 'find-me' signals in communication between dying cells and the phagocytes. |
2016 |
Cell Death Differ. |
pmid:26891690
|
Grammatikos G et al. |
Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. |
2016 |
Oncotarget |
pmid:26933996
|
Filipenko I et al. |
Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. |
2016 |
Biochim. Biophys. Acta |
pmid:27616330
|