Egom EE et al. |
The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue. |
2015 |
J. Cell. Mol. Med. |
pmid:25864579
|
Ohkawa R et al. |
Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects. |
2015 |
Clin. Biochem. |
pmid:25863111
|
Wang L et al. |
Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate. |
2015 |
Microvasc. Res. |
pmid:25862132
|
Abdel Hadi L et al. |
Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells. |
2015 |
PLoS ONE |
pmid:26580959
|
Sivasubramanian M et al. |
Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. |
2015 |
Neuroscience |
pmid:25637806
|
Zhong Y et al. |
Nephrokeli, a Chinese herbal formula, may improve IgA nephropathy through regulation of the sphingosine-1-phosphate pathway. |
2015 |
PLoS ONE |
pmid:25633986
|
Till KJ et al. |
Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells. |
2015 |
J. Immunol. |
pmid:25632006
|
Opal SM and van der Poll T |
Endothelial barrier dysfunction in septic shock. |
2015 |
J. Intern. Med. |
pmid:25418337
|
Frati A et al. |
Role of sphingosine kinase/S1P axis in ECM remodeling of cardiac cells elicited by relaxin. |
2015 |
Mol. Endocrinol. |
pmid:25415609
|
Hernández-Coronado CG et al. |
Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles. |
2015 |
Animal |
pmid:25245232
|
Hoffmann FS et al. |
Fingolimod induces neuroprotective factors in human astrocytes. |
2015 |
J Neuroinflammation |
pmid:26419927
|
Attiori Essis S et al. |
GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. |
2015 |
Brain Res. |
pmid:26260438
|
Bekpinar S et al. |
The effect of nephropathy on plasma sphingosine 1-phosphate concentrations in patients with type 2 diabetes. |
2015 |
Clin. Biochem. |
pmid:26255120
|
Durham JT et al. |
Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? |
2015 |
Invest. Ophthalmol. Vis. Sci. |
pmid:26030100
|
Książek M et al. |
Sources, metabolism, and regulation of circulating sphingosine-1-phosphate. |
2015 |
J. Lipid Res. |
pmid:26014962
|
Liu G et al. |
Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumour-derived cytokine and angiogenic factor signalling. |
2015 |
J. Pathol. |
pmid:25988668
|
Rao PV |
Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. |
2014 Mar-Apr |
J Ocul Pharmacol Ther |
pmid:24283588
|
Nguyen-Tran DH et al. |
Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. |
2014 |
Dis Model Mech |
pmid:24077965
|
Tanaka K et al. |
Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. |
2014 |
Clin. Exp. Immunol. |
pmid:24028747
|
Kihara A |
Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids. |
2014 |
Biochim. Biophys. Acta |
pmid:23994042
|
Roviezzo F et al. |
Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. |
2014 |
Clin. Sci. |
pmid:24131465
|
Qin Z et al. |
Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. |
2014 |
Mol. Cancer Ther. |
pmid:24140934
|
Ryu JM et al. |
Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways. |
2014 |
Stem Cell Res |
pmid:24145189
|
Yu Y et al. |
Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. |
2014 |
Lipids |
pmid:24158769
|
Uhlig S et al. |
Differential regulation of lung endothelial permeability in vitro and in situ. |
2014 |
Cell. Physiol. Biochem. |
pmid:24977477
|
Waeber C and Walther T |
Sphingosine-1-phosphate as a potential target for the treatment of myocardial infarction. |
2014 |
Circ. J. |
pmid:24632793
|
Brünnert D et al. |
Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. |
2014 |
Mol. Hum. Reprod. |
pmid:24994816
|
Willinger T et al. |
Dynamin 2-dependent endocytosis is required for sustained S1PR1 signaling. |
2014 |
J. Exp. Med. |
pmid:24638168
|
Purschke WG et al. |
Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis. |
2014 |
Biochem. J. |
pmid:24832383
|
Karaca I et al. |
Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. |
2014 |
J. Biol. Chem. |
pmid:24808180
|
Fayyaz S et al. |
Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. |
2014 |
Diabetologia |
pmid:24292566
|
Meng Y et al. |
Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice. |
2014 |
Fertil. Steril. |
pmid:24993801
|
Kang JW and Lee SM |
Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury. |
2014 |
Biochem. Biophys. Res. Commun. |
pmid:24997335
|
Nagamatsu T et al. |
Emerging roles for lysophospholipid mediators in pregnancy. |
2014 |
Am. J. Reprod. Immunol. |
pmid:24689547
|
Shimizu Y et al. |
Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. |
2014 |
Am. J. Pathol. |
pmid:24641902
|
Xu M et al. |
FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. |
2014 |
Acta Pharmacol. Sin. |
pmid:25399649
|
Watanabe C et al. |
Antagonism and synergy of single chain sphingolipids sphingosine and sphingosine-1-phosphate toward lipid bilayer properties. Consequences for their role as cell fate regulators. |
2014 |
Langmuir |
pmid:25386673
|
Nakajima C et al. |
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. |
2014 |
Development |
pmid:25377550
|
Barnes J and Dweik RA |
Is pulmonary hypertension a metabolic disease? |
2014 |
Am. J. Respir. Crit. Care Med. |
pmid:25360726
|
Chen J et al. |
Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. |
2014 |
PLoS Genet. |
pmid:25356849
|
Plano D et al. |
Importance of sphingosine kinase (SphK) as a target in developing cancer therapeutics and recent developments in the synthesis of novel SphK inhibitors. |
2014 |
J. Med. Chem. |
pmid:24471412
|
Degagné E et al. |
Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. |
2014 |
J. Clin. Invest. |
pmid:25347472
|
Nakamura H and Murayama T |
Role of sphingolipids in arachidonic acid metabolism. |
2014 |
J. Pharmacol. Sci. |
pmid:24599139
|
Wang F and Ye P |
Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein. |
2014 |
Lipids Health Dis |
pmid:25339382
|
Guo S et al. |
Higher level of plasma bioactive molecule sphingosine 1-phosphate in women is associated with estrogen. |
2014 |
Biochim. Biophys. Acta |
pmid:24603322
|
Keller J et al. |
Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. |
2014 |
Nat Commun |
pmid:25333900
|
Kempf A et al. |
The sphingolipid receptor S1PR2 is a receptor for Nogo-a repressing synaptic plasticity. |
2014 |
PLoS Biol. |
pmid:24453941
|
Lepletier A et al. |
Early double-negative thymocyte export in Trypanosoma cruzi infection is restricted by sphingosine receptors and associated with human chagas disease. |
2014 |
PLoS Negl Trop Dis |
pmid:25330249
|
Tao C et al. |
Regulation of glucose and lipid homeostasis by adiponectin: effects on hepatocytes, pancreatic β cells and adipocytes. |
2014 |
Best Pract. Res. Clin. Endocrinol. Metab. |
pmid:24417945
|
Hamidi S et al. |
TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts. |
2014 |
Biochim. Biophys. Acta |
pmid:24440818
|
Schaper K et al. |
Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. |
2014 |
Mol. Immunol. |
pmid:24434636
|
Kono M et al. |
Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. |
2014 |
J. Clin. Invest. |
pmid:24667638
|
Sasaki H et al. |
Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. |
2014 |
Arch. Biochem. Biophys. |
pmid:24708996
|
Ntranos A et al. |
FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. |
2014 |
J. Neuroimmunol. |
pmid:24680062
|
Liu M et al. |
Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. |
2014 |
J. Biol. Chem. |
pmid:24318881
|
Li F et al. |
Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. |
2014 |
Hum. Reprod. |
pmid:24221908
|
Bigaud M et al. |
Second generation S1P pathway modulators: research strategies and clinical developments. |
2014 |
Biochim. Biophys. Acta |
pmid:24239768
|
Huang YL et al. |
Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. |
2014 |
Cell. Signal. |
pmid:24333325
|
Sutter I et al. |
Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. |
2014 |
J. Lipid Res. |
pmid:24950692
|
Yang W et al. |
Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. |
2014 |
PLoS ONE |
pmid:25188412
|
Chen J et al. |
The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. |
2014 |
Am. J. Respir. Crit. Care Med. |
pmid:25180446
|
Kong Y et al. |
Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. |
2014 |
Mediators Inflamm. |
pmid:25147438
|
Nagahashi M et al. |
Sphingosine-1-phosphate transporters as targets for cancer therapy. |
2014 |
Biomed Res Int |
pmid:25133174
|
Nguyen AV et al. |
STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. |
2014 |
World J. Gastroenterol. |
pmid:25132744
|
Deng Y et al. |
Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy. |
2014 |
Chin. Med. J. |
pmid:25131242
|
Ogle ME et al. |
Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. |
2014 |
Acta Biomater |
pmid:25128750
|
Tong X et al. |
The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus. |
2014 |
Cardiovasc Diabetol |
pmid:24751283
|
Rauch BH |
Sphingosine 1-phosphate as a link between blood coagulation and inflammation. |
2014 |
Cell. Physiol. Biochem. |
pmid:24977491
|
Sattler K et al. |
HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. |
2014 |
Cell. Physiol. Biochem. |
pmid:24977490
|
Thuy AV et al. |
Sphingosine 1-phosphate in blood: function, metabolism, and fate. |
2014 |
Cell. Physiol. Biochem. |
pmid:24977489
|
van Echten-Deckert G et al. |
Sphingosine-1-phosphate: boon and bane for the brain. |
2014 |
Cell. Physiol. Biochem. |
pmid:24977488
|
Fayyaz S et al. |
Divergent role of sphingosine 1-phosphate on insulin resistance. |
2014 |
Cell. Physiol. Biochem. |
pmid:24977487
|
Halmer R et al. |
Sphingolipids: important players in multiple sclerosis. |
2014 |
Cell. Physiol. Biochem. |
pmid:24977485
|
Arlt O et al. |
Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. |
2014 |
Cell. Physiol. Biochem. |
pmid:24977479
|
Don AS et al. |
Re-configuration of sphingolipid metabolism by oncogenic transformation. |
2014 |
Biomolecules |
pmid:24970218
|
Snelder N et al. |
Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation. |
2014 |
Drug Metab. Dispos. |
pmid:24965813
|
BÅ‚ogowski W et al. |
Perioperative release of pro-regenerative biochemical signals from human renal allografts subjected to ischemia-reperfusion injury. |
2014 |
Innate Immun |
pmid:23608824
|
Mahajan-Thakur S et al. |
Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. |
2014 |
J. Leukoc. Biol. |
pmid:24990321
|
Kondo S et al. |
Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. |
2014 |
PLoS ONE |
pmid:24714781
|
Korbelik M et al. |
Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. |
2014 |
Int. Immunopharmacol. |
pmid:24713544
|
Gatfield J et al. |
Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. |
2014 |
Cell. Signal. |
pmid:24704119
|
Shin KO et al. |
Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. |
2014 |
Arch. Pharm. Res. |
pmid:24687256
|
Yu H et al. |
Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats. |
2014 |
Injury |
pmid:24685054
|
Sykes DA et al. |
Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization. |
2014 |
Br. J. Pharmacol. |
pmid:24641481
|
Zhang J and Song J |
Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. |
2014 |
Acta Biomater |
pmid:24631657
|
Priceman SJ et al. |
S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3. |
2014 |
Cell Rep |
pmid:24630990
|
Oizumi A et al. |
Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. |
2014 |
PLoS ONE |
pmid:24586752
|
Guan Z et al. |
Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature. |
2014 |
J. Am. Soc. Nephrol. |
pmid:24578134
|
Borge M et al. |
The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406. |
2014 |
J. Immunol. |
pmid:25127862
|
Blaho VA and Hla T |
An update on the biology of sphingosine 1-phosphate receptors. |
2014 |
J. Lipid Res. |
pmid:24459205
|
Mendes-Braz M et al. |
The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. |
2014 |
Liver Int. |
pmid:24107124
|
Baranowski M et al. |
Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. |
2014 |
Int J Sport Nutr Exerc Metab |
pmid:24092763
|
Egom EE |
Sphingosine-1-phosphate signalling as a therapeutic target for patients with abnormal glucose metabolism and ischaemic heart disease. |
2014 |
J Cardiovasc Med (Hagerstown) |
pmid:23839592
|
Fincher J et al. |
G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. |
2014 |
Dev. Neurosci. |
pmid:25138637
|
Cencetti F et al. |
Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis. |
2014 |
FEBS J. |
pmid:25131845
|
Neuber C et al. |
Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. |
2014 |
Anal. Chem. |
pmid:25137547
|
Nishi T et al. |
Molecular and physiological functions of sphingosine 1-phosphate transporters. |
2014 |
Biochim. Biophys. Acta |
pmid:23921254
|
Xia JY et al. |
The adipokine/ceramide axis: key aspects of insulin sensitization. |
2014 |
Biochimie |
pmid:23969158
|
Albinet V et al. |
Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. |
2014 |
Oncogene |
pmid:23893239
|
Zeng Y et al. |
Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. |
2014 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:24285115
|