| MeSH term | MeSH ID | Detail |
|---|---|---|
| Coronary Disease | D003327 | 70 associated lipids |
| Carcinoma, Non-Small-Cell Lung | D002289 | 72 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
| Diabetes Mellitus, Experimental | D003921 | 85 associated lipids |
| Atherosclerosis | D050197 | 85 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Diabetes Mellitus, Type 2 | D003924 | 87 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Insulin Resistance | D007333 | 99 associated lipids |
| Weight Gain | D015430 | 101 associated lipids |
| Glioma | D005910 | 112 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Colonic Neoplasms | D003110 | 161 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Afrasiabi E et al. | Sphingosylphosphorylcholine enhances calcium entry in thyroid FRO cells by a mechanism dependent on protein kinase C. | 2006 | Cell. Signal. | pmid:16490345 |
| Sabbadini RA | Targeting sphingosine-1-phosphate for cancer therapy. | 2006 | Br. J. Cancer | pmid:17024123 |
| Dragusin M et al. | Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus. | 2006 | FASEB J. | pmid:16877527 |
| Garg SK et al. | Does sphingosine 1-phosphate play a protective role in the course of pulmonary tuberculosis? | 2006 | Clin. Immunol. | pmid:17049310 |
| Mitra P et al. | Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17050692 |
| Yatomi Y | [Elucidation of the functional roles of lysophospholipid mediators and its application in laboratory medicine]. | 2006 | Rinsho Byori | pmid:16913663 |
| Leclercq TM and Pitson SM | Cellular signalling by sphingosine kinase and sphingosine 1-phosphate. | 2006 | IUBMB Life | pmid:16916784 |
| Kohno M et al. | Intracellular role for sphingosine kinase 1 in intestinal adenoma cell proliferation. | 2006 | Mol. Cell. Biol. | pmid:16980623 |
| Theilmeier G et al. | High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. | 2006 | Circulation | pmid:16982942 |
| Murph M et al. | Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer. | 2006 | Clin. Cancer Res. | pmid:17121877 |
| Fisher KE et al. | Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. | 2006 | Mol. Cancer | pmid:17156449 |
| Huwiler A and Pfeilschifter J | Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. | 2006 | Curr. Pharm. Des. | pmid:17168766 |
| Pan S et al. | A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. | 2006 | Chem. Biol. | pmid:17114004 |
| Lee JF et al. | Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. | 2006 | J. Biol. Chem. | pmid:16891661 |
| Zheng DM et al. | Sphingosine 1-phosphate protects rat liver sinusoidal endothelial cells from ethanol-induced apoptosis: Role of intracellular calcium and nitric oxide. | 2006 | Hepatology | pmid:17058266 |
| Kabashima K et al. | Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. | 2006 | J. Exp. Med. | pmid:17101733 |
| Keller M et al. | Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries. | 2006 | FASEB J. | pmid:16476702 |
| Wendler CC and Rivkees SA | Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. | 2006 | Dev. Biol. | pmid:16434032 |
| Wattenberg BW et al. | The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. | 2006 | J. Lipid Res. | pmid:16520486 |
| Czyborra C et al. | Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16521006 |
| Sutherland CM et al. | The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane. | 2006 | J. Biol. Chem. | pmid:16522638 |
| Fieber CB et al. | Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expression of Akt3 in primary endothelial cells. | 2006 | Exp. Cell Res. | pmid:16527273 |
| Berdyshev EV et al. | De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells. | 2006 | Cell. Signal. | pmid:16529909 |
| Schubert R | Sphingosine-1-phosphate in the circulatory system: Cause and therapeutic target for vascular dysfunction? | 2006 | Cardiovasc. Res. | pmid:16542647 |
| Ochi R et al. | Sphingosine-1-phosphate effects on guinea pig atrial myocytes: Alterations in action potentials and K+ currents. | 2006 | Cardiovasc. Res. | pmid:16545787 |
| Betito S and Cuvillier O | Regulation by sphingosine 1-phosphate of Bax and Bad activities during apoptosis in a MEK-dependent manner. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16414356 |
| Lee JF et al. | Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells. | 2006 | Histochem. Cell Biol. | pmid:16416022 |
| Taha TA et al. | Sphingosine kinase: biochemical and cellular regulation and role in disease. | 2006 | J. Biochem. Mol. Biol. | pmid:16584625 |
| Malaplate-Armand C et al. | Soluble oligomers of amyloid-beta peptide induce neuronal apoptosis by activating a cPLA2-dependent sphingomyelinase-ceramide pathway. | 2006 | Neurobiol. Dis. | pmid:16626961 |
| Dindo D et al. | Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells. | 2006 | Mol. Cancer Ther. | pmid:16818511 |
| Durand CA et al. | The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | 2006 | Eur. J. Immunol. | pmid:16821235 |
| Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
| Sanna MG et al. | Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. | 2006 | Nat. Chem. Biol. | pmid:16829954 |
| Veracini L et al. | Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. | 2006 | J. Cell. Sci. | pmid:16787943 |
| Laychock SG et al. | Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells. | 2006 | Endocrinology | pmid:16794003 |
| Oz-Arslan D et al. | IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. | 2006 | J. Leukoc. Biol. | pmid:16769764 |
| Garbers DL et al. | Membrane guanylyl cyclase receptors: an update. | 2006 | Trends Endocrinol. Metab. | pmid:16815030 |
| Yan L et al. | 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16621543 |
| Venkataraman K et al. | Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. | 2006 | Biochem. J. | pmid:16623665 |
| Weigert A et al. | Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. | 2006 | Blood | pmid:16690965 |
| Kim MK et al. | Sphingosine-1-phosphate stimulates rat primary chondrocyte proliferation. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16674917 |
| Xu SZ et al. | A sphingosine-1-phosphate-activated calcium channel controlling vascular smooth muscle cell motility. | 2006 | Circ. Res. | pmid:16675717 |
| Jiang X and Han X | Characterization and direct quantitation of sphingoid base-1-phosphates from lipid extracts: a shotgun lipidomics approach. | 2006 | J. Lipid Res. | pmid:16682747 |
| Zhang YH et al. | Sphingosine-1-phosphate via activation of a G-protein-coupled receptor(s) enhances the excitability of rat sensory neurons. | 2006 | J. Neurophysiol. | pmid:16723416 |
| Zhang YH et al. | Intracellular sphingosine 1-phosphate mediates the increased excitability produced by nerve growth factor in rat sensory neurons. | 2006 | J. Physiol. (Lond.) | pmid:16740613 |
| Hu W et al. | Lentiviral siRNA silencing of sphingosine-1-phosphate receptors S1P1 and S1P2 in smooth muscle. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16574065 |
| Zhi L et al. | Sphingosine kinase 1 regulates pro-inflammatory responses triggered by TNFalpha in primary human monocytes. | 2006 | J. Cell. Physiol. | pmid:16575915 |
| Wacker BK et al. | Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. | 2006 | Biomacromolecules | pmid:16602758 |
| Hemmings DG et al. | Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone. | 2006 | Biol. Reprod. | pmid:16162874 |
| Wong RC et al. | Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16616002 |
| Ozbay T et al. | Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. | 2006 | Endocrinology | pmid:16306078 |
| Kobayashi N et al. | Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner. | 2006 | J. Lipid Res. | pmid:16371645 |
| Kono M et al. | Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. | 2006 | J. Biol. Chem. | pmid:16380386 |
| von Otte S et al. | Follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis. | 2006 | J. Biol. Chem. | pmid:16365044 |
| Alewijnse AE and Michel MC | Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? | 2006 | Br. J. Pharmacol. | pmid:16402045 |
| Mathieson FA and Nixon GF | Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. | 2006 | Br. J. Pharmacol. | pmid:16402047 |
| Chantrain CF et al. | Mechanisms of pericyte recruitment in tumour angiogenesis: a new role for metalloproteinases. | 2006 | Eur. J. Cancer | pmid:16406506 |
| Olivera A et al. | IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses. | 2006 | J. Biol. Chem. | pmid:16316995 |
| Barthomeuf C et al. | Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. | 2006 | Free Radic. Biol. Med. | pmid:16458188 |
| Kawamori T et al. | Sphingosine kinase 1 is up-regulated in colon carcinogenesis. | 2006 | FASEB J. | pmid:16319132 |
| Roviezzo F et al. | Essential requirement for sphingosine kinase activity in eNOS-dependent NO release and vasorelaxation. | 2006 | FASEB J. | pmid:16322129 |
| Der P et al. | Role of lipid rafts in ceramide and nitric oxide signaling in the ischemic and preconditioned hearts. | 2006 | J. Mol. Cell. Cardiol. | pmid:16337960 |
| Ramasamy R et al. | Sphingosine-1-phosphate: waging a battle in the diabetic blood vessel. | 2006 | Circ. Res. | pmid:17008596 |
| Park KS et al. | Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins. | 2006 | Mol. Pharmacol. | pmid:16368894 |
| Gonzalez E et al. | Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. | 2006 | J. Biol. Chem. | pmid:16339142 |
| Dahm F et al. | Distribution and dynamic changes of sphingolipids in blood in response to platelet activation. | 2006 | J. Thromb. Haemost. | pmid:17010150 |
| Gardell SE et al. | Emerging medicinal roles for lysophospholipid signaling. | 2006 | Trends Mol Med | pmid:16406843 |
| di Villa Bianca Rd et al. | Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16234413 |
| Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
| Inniss K and Moore H | Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate. | 2006 | Stem Cells Dev. | pmid:17253942 |
| Matsuyuki H et al. | Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. | 2006 | Cell. Mol. Immunol. | pmid:17257496 |
| Rahaman M et al. | Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia. | 2006 | Am. J. Respir. Cell Mol. Biol. | pmid:16224106 |
| Kang JS et al. | Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. | 2006 | Mol. Pharmacol. | pmid:16354764 |
| Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
| Massberg S and von Andrian UH | Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration. | 2006 | N. Engl. J. Med. | pmid:16971715 |
| Jun DJ et al. | Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. | 2006 | Endocrinology | pmid:16973728 |
| Natarajan J et al. | Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line. | 2006 | BMC Bioinformatics | pmid:16901352 |
| Young N and Van Brocklyn JR | Signal transduction of sphingosine-1-phosphate G protein-coupled receptors. | 2006 | ScientificWorldJournal | pmid:16906327 |
| Hait NC et al. | Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. | 2006 | Biochim. Biophys. Acta | pmid:16996023 |
| Minshall RD and Malik AB | Transport across the endothelium: regulation of endothelial permeability. | 2006 | Handb Exp Pharmacol | pmid:16999218 |
| Smicun Y et al. | S1P regulation of ovarian carcinoma invasiveness. | 2006 | Gynecol. Oncol. | pmid:16956652 |
| Squecco R et al. | Sphingosine 1-phosphate induces myoblast differentiation through Cx43 protein expression: a role for a gap junction-dependent and -independent function. | 2006 | Mol. Biol. Cell | pmid:16957055 |
| Whetzel AM et al. | Sphingosine-1 phosphate prevents monocyte/endothelial interactions in type 1 diabetic NOD mice through activation of the S1P1 receptor. | 2006 | Circ. Res. | pmid:16960101 |
| El-Shewy HM et al. | Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. | 2006 | J. Biol. Chem. | pmid:16926156 |
| Huang WR et al. | [Impact of rhG-CSF on sphingosine 1-phosphate concentration in blood plasma of donors]. | 2006 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:16928321 |
| Meriane M et al. | Cooperation of matrix metalloproteinases with the RhoA/Rho kinase and mitogen-activated protein kinase kinase-1/extracellular signal-regulated kinase signaling pathways is required for the sphingosine-1-phosphate-induced mobilization of marrow-derived stromal cells. | 2006 | Stem Cells | pmid:16931773 |
| Bjursell M et al. | G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice. | 2006 | Biochem. Biophys. Res. Commun. | pmid:16887097 |
| Donati C and Bruni P | Sphingosine 1-phosphate regulates cytoskeleton dynamics: implications in its biological response. | 2006 | Biochim. Biophys. Acta | pmid:16890187 |
| Choueiri TK et al. | Phenoxodiol: isoflavone analog with antineoplastic activity. | 2006 | Curr Oncol Rep | pmid:16507219 |
| Naetzker S et al. | Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. | 2006 | Genes Cells | pmid:16483315 |
| Jurisicova A et al. | Molecular requirements for doxorubicin-mediated death in murine oocytes. | 2006 | Cell Death Differ. | pmid:16439991 |
| Bassi R et al. | Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. | 2006 | Glia | pmid:16470810 |
| Yatomi Y | Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. | 2006 | Curr. Pharm. Des. | pmid:16472149 |
| Kurobe H et al. | CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. | 2006 | Immunity | pmid:16473829 |
| Kitano M et al. | Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. | 2006 | Arthritis Rheum. | pmid:16508938 |
| Hsieh HL et al. | Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells. | 2006 | J. Cell. Physiol. | pmid:16508949 |
| Becciolini L et al. | Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts. | 2006 | Biochim. Biophys. Acta | pmid:16510307 |
| Song HJ et al. | Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells. | 2006 | Mol. Cells | pmid:16511346 |
| Takai S et al. | Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. | 2006 | J. Cell. Biochem. | pmid:16514645 |
| Idzko M et al. | Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. | 2006 | J. Clin. Invest. | pmid:17080194 |