Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kotani T et al. | Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. | 2013 | Biol. Reprod. | pmid:23863409 |
Becker S et al. | Follicular fluid high-density lipoprotein-associated sphingosine 1-phosphate (S1P) promotes human granulosa lutein cell migration via S1P receptor type 3 and small G-protein RAC1. | 2011 | Biol. Reprod. | pmid:20980685 |
Otala M et al. | Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate. | 2004 | Biol. Reprod. | pmid:14613902 |
Roth Z and Hansen PJ | Sphingosine 1-phosphate protects bovine oocytes from heat shock during maturation. | 2004 | Biol. Reprod. | pmid:15317688 |
Wacker BK et al. | Delivery of sphingosine 1-phosphate from poly(ethylene glycol) hydrogels. | 2006 | Biomacromolecules | pmid:16602758 |
Das A et al. | The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. | 2013 | Biomaterials | pmid:24064148 |
Tengood JE et al. | Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis. | 2010 | Biomaterials | pmid:20674008 |
Sefcik LS et al. | Sustained release of sphingosine 1-phosphate for therapeutic arteriogenesis and bone tissue engineering. | 2008 | Biomaterials | pmid:18405965 |
Wang J et al. | Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis. | 2015 | Biomaterials | pmid:26036174 |
Serebrov VIu et al. | [Activity of the sphingomyelin cycle enzymes and concentration of products of sphingomyelin degradation in the rat liver in the course of acute toxic hepatitis]. | 2010 Mar-Apr | Biomed Khim | pmid:21341516 |
Zankov DP and Ogita H | Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. | 2015 | Biomed Res Int | pmid:25883953 |
Carrera I et al. | A comparative evaluation of a novel vaccine in APP/PS1 mouse models of Alzheimer's disease. | 2015 | Biomed Res Int | pmid:25759822 |
Mierzejewska K et al. | Sphingosine-1-phosphate-mediated mobilization of hematopoietic stem/progenitor cells during intravascular hemolysis requires attenuation of SDF-1-CXCR4 retention signaling in bone marrow. | 2013 | Biomed Res Int | pmid:24490172 |
Nagahashi M et al. | Sphingosine-1-phosphate transporters as targets for cancer therapy. | 2014 | Biomed Res Int | pmid:25133174 |
Wang Z et al. | Decreased Splenic CD4(+) T-Lymphocytes in Apolipoprotein M Gene Deficient Mice. | 2015 | Biomed Res Int | pmid:26543853 |
Flávia Nardy A et al. | Modulation of Intrathymic Sphingosine-1-Phosphate Levels Promotes Escape of Immature Thymocytes to the Periphery with a Potential Proinflammatory Role in Chagas Disease. | 2015 | Biomed Res Int | pmid:26347020 |
Müller J et al. | Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. | 2017 | Biomed Res Int | pmid:28367448 |
Jiang Z et al. | Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence. | 2011 | Biomed. Chromatogr. | pmid:20812204 |
Lan T et al. | Determination of sphingosine kinase activity in biological samples by liquid chromatography-tandem mass spectrometry. | 2010 | Biomed. Chromatogr. | pmid:20352614 |
Bassoy EY and Baran Y | Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22326625 |
Don AS et al. | Re-configuration of sphingolipid metabolism by oncogenic transformation. | 2014 | Biomolecules | pmid:24970218 |
Raje MR et al. | Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. | 2012 | Bioorg. Med. Chem. | pmid:22137932 |
Nakamura T et al. | Synthesis and SAR studies of a novel class of S1P1 receptor antagonists. | 2007 | Bioorg. Med. Chem. | pmid:17379528 |
Kim JW et al. | Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases. | 2005 | Bioorg. Med. Chem. | pmid:15848761 |
Qiao L et al. | Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate--caged SPP. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871527 |
Hanessian S et al. | Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17070046 |
Hale JJ et al. | Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15149705 |
Lim HS et al. | Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109640 |
Kurata H et al. | Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22153936 |
Lim HS et al. | Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12482430 |
Pennington LD et al. | Quinolinone-based agonists of S1Pâ‚: use of a N-scan SAR strategy to optimize in vitro and in vivo activity. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22104144 |
Yan L et al. | 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16621543 |
De Jonghe S et al. | Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase. | 1999 | Bioorg. Med. Chem. Lett. | pmid:10560747 |
Evindar G et al. | Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19081720 |
Antoon JW and Beckman BS | Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22366655 |
Foss FW et al. | Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16125386 |
Guo J et al. | Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1). | 2016 | Bioorg. Med. Chem. Lett. | pmid:27055941 |
Evindar G et al. | Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1. | 2013 | Bioorg. Med. Chem. Lett. | pmid:23245510 |
Xiang Y et al. | Discovery of novel sphingosine kinase 1 inhibitors. | 2009 | Bioorg. Med. Chem. Lett. | pmid:19800228 |
Murakami T et al. | Synthesis and biological properties of novel sphingosine derivatives. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15686924 |
Jensen T et al. | The identification of GPR3 inverse agonist AF64394; the first small molecule inhibitor of GPR3 receptor function. | 2014 | Bioorg. Med. Chem. Lett. | pmid:25442311 |
Clemens JJ et al. | Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. | 2003 | Bioorg. Med. Chem. Lett. | pmid:14505636 |
Evindar G et al. | Exploration of amino alcohol derivatives as novel, potent, and highly selective sphingosine-1-phosphate receptor subtype-1 agonists. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20304639 |
Clemens JJ et al. | Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. | 2005 | Bioorg. Med. Chem. Lett. | pmid:15982878 |
Clemens JJ et al. | Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15341948 |
Hakogi T et al. | Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. | 2003 | Bioorg. Med. Chem. Lett. | pmid:12639553 |
Ma B et al. | Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. | 2010 | Bioorg. Med. Chem. Lett. | pmid:20188554 |
Ohno T et al. | The prediction of human response to ONO-4641, a sphingosine 1-phosphate receptor modulator, from preclinical data based on pharmacokinetic-pharmacodynamic modeling. | 2010 | Biopharm Drug Dispos | pmid:20623701 |
Wacker BK et al. | Endothelial cell migration on RGD-peptide-containing PEG hydrogels in the presence of sphingosine 1-phosphate. | 2008 | Biophys. J. | pmid:17827231 |
Arce FT et al. | Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. | 2008 | Biophys. J. | pmid:18408039 |