Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
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Authors | Title | Published | Journal | PubMed Link |
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Higashi K et al. | Sphingosine-1-phosphate/S1PR2-mediated signaling triggers Smad1/5/8 phosphorylation and thereby induces Runx2 expression in osteoblasts. | 2016 | Bone | pmid:27612439 |
Bougault C et al. | Involvement of sphingosine kinase/sphingosine 1-phosphate metabolic pathway in spondyloarthritis. | 2017 | Bone | pmid:28684192 |
Sabbadini RA | Targeting sphingosine-1-phosphate for cancer therapy. | 2006 | Br. J. Cancer | pmid:17024123 |
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Lindner K et al. | Ceramide alters endothelial cell permeability by a nonapoptotic mechanism. | 2005 | Br. J. Pharmacol. | pmid:15735657 |
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Alewijnse AE and Michel MC | Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? | 2006 | Br. J. Pharmacol. | pmid:16402045 |
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Bischoff A et al. | Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. | 2000 | Br. J. Pharmacol. | pmid:10952677 |
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Xin C et al. | Heterologous desensitization of the sphingosine-1-phosphate receptors by purinoceptor activation in renal mesangial cells. | 2004 | Br. J. Pharmacol. | pmid:15466446 |
Brailoiu E et al. | Sphingosine 1-phosphate enhances spontaneous transmitter release at the frog neuromuscular junction. | 2002 | Br. J. Pharmacol. | pmid:12163341 |
McDonald RA et al. | The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia. | 2010 | Br. J. Pharmacol. | pmid:20015089 |
Mair KM et al. | Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery. | 2010 | Br. J. Pharmacol. | pmid:20718749 |
Brinkmann V | FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system. | 2009 | Br. J. Pharmacol. | pmid:19814729 |
Kurano M et al. | Resveratrol exerts a biphasic effect on apolipoprotein M. | 2016 | Br. J. Pharmacol. | pmid:26445217 |
Hsu CK et al. | Mevastatin ameliorates sphingosine 1-phosphate-induced COX-2/PGE2-dependent cell migration via FoxO1 and CREB phosphorylation and translocation. | 2015 | Br. J. Pharmacol. | pmid:26359950 |
Majeed Y et al. | Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids. | 2011 | Br. J. Pharmacol. | pmid:21108630 |
Jongsma M et al. | Different response patterns of several ligands at the sphingosine-1-phosphate receptor subtype 3 (S1P(3)). | 2009 | Br. J. Pharmacol. | pmid:19309361 |
Salomone S et al. | Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools. | 2008 | Br. J. Pharmacol. | pmid:18026125 |
Hemmings DG et al. | Sphingosine 1-phosphate-induced vasoconstriction is elevated in mesenteric resistance arteries from aged female rats. | 2004 | Br. J. Pharmacol. | pmid:15326035 |
Lim KG et al. | Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival. | 2012 | Br. J. Pharmacol. | pmid:22251058 |
Camaré C et al. | Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. | 2015 | Br. J. Pharmacol. | pmid:25176316 |
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Shinpo K et al. | Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons. | 1999 | Brain Res. | pmid:10082875 |
Rao TS et al. | Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. | 2003 | Brain Res. | pmid:14568343 |
Attiori Essis S et al. | GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. | 2015 | Brain Res. | pmid:26260438 |
Sato K et al. | Sphingosine 1-phosphate induces expression of early growth response-1 and fibroblast growth factor-2 through mechanism involving extracellular signal-regulated kinase in astroglial cells. | 1999 | Brain Res. Mol. Brain Res. | pmid:10640689 |
Sato K et al. | Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells. | 2000 | Brain Res. Mol. Brain Res. | pmid:11146117 |
Segura BJ et al. | Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells. | 2005 | Brain Res. Mol. Brain Res. | pmid:15710251 |
Spiegel S et al. | Sphingosine-1-phosphate, a novel second messenger involved in cell growth regulation and signal transduction, affects growth and invasiveness of human breast cancer cells. | 1994 | Breast Cancer Res. Treat. | pmid:7881110 |
Ruckhäberle E et al. | Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. | 2008 | Breast Cancer Res. Treat. | pmid:18058224 |
Pchejetski D et al. | Circulating sphingosine-1-phosphate inversely correlates with chemotherapy-induced weight gain during early breast cancer. | 2010 | Breast Cancer Res. Treat. | pmid:20535545 |
Serebrov VY et al. | Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis. | 2008 | Bull. Exp. Biol. Med. | pmid:19513367 |
Liu X et al. | Effect of sphingosine 1-phosphate on morphological and functional responses in endothelia and venules after scalding injury. | 2009 | Burns | pmid:19520517 |