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2003 |
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Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. |
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Ligand-dependent inhibition of B16 melanoma cell migration and invasion via endogenous S1P2 G protein-coupled receptor. Requirement of inhibition of cellular RAC activity. |
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Emerging technologies to control oocyte apoptosis are finally treading on fertile ground. |
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Inhibition of Akt phosphorylation by thrombin, histamine and lysophosphatidylcholine in endothelial cells. Differential role of protein kinase C. |
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Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. |
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Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of the myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. |
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Circulation |
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Sphingolipid signalling in Arabidopsis guard cells involves heterotrimeric G proteins. |
2003 |
Nature |
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Sphingosine 1-phosphate antagonizes human neutrophil apoptosis via p38 mitogen-activated protein kinase. |
2003 |
Cell. Mol. Life Sci. |
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Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides. |
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Arterioscler. Thromb. Vasc. Biol. |
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Lysophosphatidic acid promotes the proliferation of adult Schwann cells isolated from axotomized sciatic nerve. |
2003 |
J. Neuropathol. Exp. Neurol. |
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Modulation of spontaneous transmitter release from the frog neuromuscular junction by interacting intracellular Ca(2+) stores: critical role for nicotinic acid-adenine dinucleotide phosphate (NAADP). |
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Am. J. Physiol. Heart Circ. Physiol. |
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Synergistic effect of sphingosine 1-phosphate on thrombin-induced tissue factor expression in endothelial cells. |
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Blood |
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The roles of ceramide and complex sphingolipids in neuronal cell function. |
2003 |
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Signaling and biological actions of sphingosine 1-phosphate. |
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[Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. |
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Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation. |
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Sphingosine-1-phosphate inhibits acid sphingomyelinase and blocks apoptosis in macrophages. |
2003 |
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2003 |
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Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing. |
2003 |
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Synthesis of fluorescence-labeled sphingosine and sphingosine 1-phosphate; effective tools for sphingosine and sphingosine 1-phosphate behavior. |
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Cutting edge: Mycobacterium tuberculosis blocks Ca2+ signaling and phagosome maturation in human macrophages via specific inhibition of sphingosine kinase. |
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Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. |
2003 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
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FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. |
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Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. |
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Activation of human monocytic cells by lysophosphatidic acid and sphingosine-1-phosphate. |
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Cell. Signal. |
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Metabolism of sphingosine 1-phosphate and lysophosphatidic acid: a genome wide analysis of gene expression in Drosophila. |
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EphrinA1 inactivates integrin-mediated vascular smooth muscle cell spreading via the Rac/PAK pathway. |
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J. Cell. Sci. |
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Ceramide and sphingosine 1-phosphate in anti-cancer therapies. |
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Cancer Treat. Res. |
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Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. |
2003 |
Prostaglandins Leukot. Essent. Fatty Acids |
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Modulation of sphingosine 1-phosphate/EDG signaling by tumor necrosis factor-alpha in vascular endothelial cells. |
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Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation. |
2003 |
Blood |
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Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate. |
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The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling. |
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Sphingosine-1-phosphate stimulates cortisol secretion. |
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Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5. |
2003 |
Gastroenterology |
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Sphingosine 1-phosphate: a Ca2+ release mediator in the balance. |
2002 Nov-Dec |
Cell Calcium |
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2002 |
Biochim. Biophys. Acta |
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2002 |
Biochim. Biophys. Acta |
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Activation of phospholipase D by bradykinin and sphingosine 1-phosphate in A549 human lung adenocarcinoma cells via different GTP-binding proteins and protein kinase C delta signaling pathways. |
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Biochemistry |
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Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes. |
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Glia |
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Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation. |
2003 |
Biochem. Biophys. Res. Commun. |
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Deregulated activation of matriptase in breast cancer cells. |
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[Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. |
2002 |
Nippon Yakurigaku Zasshi |
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Regulation of oxytocin receptor expression in cultured human myometrial cells by fetal bovine serum and lysophospholipids. |
2003 |
Endocrinology |
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Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. |
2002 |
Arch. Biochem. Biophys. |
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Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation. |
2002 |
Genes Cells |
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2002 |
Arterioscler. Thromb. Vasc. Biol. |
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S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. |
2003 |
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Syntheses of sphingosine-1-phosphate stereoisomers and analogues and their interaction with EDG receptors. |
2003 |
Bioorg. Med. Chem. Lett. |
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Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells. |
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Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function. |
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Biochem. J. |
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Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. |
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FASEB J. |
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The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. |
2002 |
Endocrinology |
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Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. |
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Biochem. Biophys. Res. Commun. |
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Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration. |
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Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. |
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A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. |
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Trends Plant Sci. |
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Ceramide 1-phosphate increases intracellular free calcium concentrations in thyroid FRTL-5 cells: evidence for an effect mediated by inositol 1,4,5-trisphosphate and intracellular sphingosine 1-phosphate. |
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Role of protein kinase C alpha in primary human osteoblast proliferation. |
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Sphingosine-1-phosphate: dual messenger functions. |
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FEBS Lett. |
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Involvement of phospholipase D in insulin-like growth factor-I-induced activation of extracellular signal-regulated kinase, but not phosphoinositide 3-kinase or Akt, in Chinese hamster ovary cells. |
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Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. |
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Development of novel EDG3 antagonists using a 3D database search and their structure-activity relationships. |
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