| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Farnoud AM et al. | The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway. | 2015 | Infect. Immun. | pmid:25895971 |
| Chimen M et al. | Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. | 2015 | Nat. Med. | pmid:25894827 |
| Pulli I et al. | A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca²⺠microdomain in the caveolar compartment. | 2015 | Biochim. Biophys. Acta | pmid:25892494 |
| Zankov DP and Ogita H | Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. | 2015 | Biomed Res Int | pmid:25883953 |
| Williams PA et al. | Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). | 2015 | PLoS ONE | pmid:25875493 |
| Wang Z et al. | The Effect of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor on Neutrophil Function and the Relevant Signaling Pathway. | 2015 | Acta Haematol. | pmid:25872153 |
| Wilson PC et al. | Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. | 2015 | Mol. Endocrinol. | pmid:25871850 |
| Jernigan PL et al. | The role of sphingolipids in endothelial barrier function. | 2015 | Biol. Chem. | pmid:25867999 |
| Egom EE et al. | The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue. | 2015 | J. Cell. Mol. Med. | pmid:25864579 |
| Ohkawa R et al. | Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects. | 2015 | Clin. Biochem. | pmid:25863111 |
| Wang L et al. | Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate. | 2015 | Microvasc. Res. | pmid:25862132 |
| Kolahdooz Z et al. | Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism. | 2015 | Can J Neurol Sci | pmid:25860537 |
| Ren K et al. | Apolipoprotein M. | 2015 | Clin. Chim. Acta | pmid:25858547 |
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| Abdel Hadi L et al. | Sphingosine Kinase 2 and Ceramide Transport as Key Targets of the Natural Flavonoid Luteolin to Induce Apoptosis in Colon Cancer Cells. | 2015 | PLoS ONE | pmid:26580959 |
| Hsu CK et al. | Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. | 2015 | J. Cell. Physiol. | pmid:25201048 |
| Lin CC et al. | Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation. | 2015 | PLoS ONE | pmid:25734900 |
| Zhang DD et al. | Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. | 2015 | Biol. Chem. | pmid:25720064 |
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| Koch A et al. | Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. | 2015 | Biol. Chem. | pmid:25719311 |
| Park ES et al. | Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. | 2015 | J. Biol. Chem. | pmid:25716317 |
| Rhee SH et al. | Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall. | 2015 | J Obstet Gynaecol | pmid:25692679 |
| Ji F et al. | K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25680461 |
| Breslin JW et al. | Involvement of local lamellipodia in endothelial barrier function. | 2015 | PLoS ONE | pmid:25658915 |
| Kalhori V and Törnquist K | MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. | 2015 | Mol. Cell. Endocrinol. | pmid:25643979 |
| Sivasubramanian M et al. | Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. | 2015 | Neuroscience | pmid:25637806 |
| Zhong Y et al. | Nephrokeli, a Chinese herbal formula, may improve IgA nephropathy through regulation of the sphingosine-1-phosphate pathway. | 2015 | PLoS ONE | pmid:25633986 |
| Till KJ et al. | Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells. | 2015 | J. Immunol. | pmid:25632006 |
| Liu M et al. | Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. | 2015 | J. Biol. Chem. | pmid:25627684 |
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| Kurek K et al. | Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia. | 2015 | Lipids | pmid:25595595 |
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| Wysoczynski M et al. | Identification of heme oxygenase 1 (HO-1) as a novel negative regulator of mobilization of hematopoietic stem/progenitor cells. | 2015 | Stem Cell Rev | pmid:25086571 |
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| Galvani S et al. | HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. | 2015 | Sci Signal | pmid:26268607 |
| Riley RT et al. | Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. | 2015 | Mol Nutr Food Res | pmid:26264677 |
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| Yester JW et al. | Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. | 2015 | FASEB J. | pmid:26246404 |
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| Chen MH et al. | Identification of SPHK1 as a therapeutic target and marker of poor prognosis in cholangiocarcinoma. | 2015 | Oncotarget | pmid:26090720 |
| Panneer Selvam S et al. | Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. | 2015 | Sci Signal | pmid:26082434 |
| Malik FA et al. | Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity. | 2015 | PLoS ONE | pmid:26079370 |
| Mooren OL et al. | Role of N-WASP in Endothelial Monolayer Formation and Integrity. | 2015 | J. Biol. Chem. | pmid:26070569 |
| Blaho VA et al. | HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. | 2015 | Nature | pmid:26053123 |
| Wang J et al. | Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis. | 2015 | Biomaterials | pmid:26036174 |
| Durham JT et al. | Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26030100 |
| Książek M et al. | Sources, metabolism, and regulation of circulating sphingosine-1-phosphate. | 2015 | J. Lipid Res. | pmid:26014962 |
| El-Najjar N et al. | Increased Levels of Sphingosylphosphorylcholine (SPC) in Plasma of Metabolic Syndrome Patients. | 2015 | PLoS ONE | pmid:26466367 |
| Liu G et al. | Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumour-derived cytokine and angiogenic factor signalling. | 2015 | J. Pathol. | pmid:25988668 |
| Zhang JN et al. | The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction. | 2015 | Bone | pmid:25988659 |
| Parham KA et al. | Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis. | 2015 | FASEB J. | pmid:25985799 |
| Schweitzer KS et al. | Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25979079 |
| Tian H and Yu Z | Resveratrol induces apoptosis of leukemia cell line K562 by modulation of sphingosine kinase-1 pathway. | 2015 | Int J Clin Exp Pathol | pmid:26045781 |
| Camaré C et al. | Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. | 2015 | Br. J. Pharmacol. | pmid:25176316 |