| MeSH term | MeSH ID | Detail |
|---|---|---|
| Arteriosclerosis | D001161 | 86 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Fibrosis | D005355 | 23 associated lipids |
| Carcinoma, Ductal, Breast | D018270 | 19 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gennero I et al. | Effect of sphingosine-1-phosphate and analogues of lysophosphatidic acid on mesangial cell proliferation. | 2000 | Ann. N. Y. Acad. Sci. | pmid:10818478 |
| Alessenko AV | The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death. | 2000 | Membr Cell Biol | pmid:10779176 |
| Miura Y et al. | Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets. | 2000 | J. Biochem. | pmid:10788802 |
| Im DS et al. | Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. | 2000 | J. Biol. Chem. | pmid:10799507 |
| Goetzl EJ et al. | Cutting edge: differential constitutive expression of functional receptors for lysophosphatidic acid by human blood lymphocytes. | 2000 | J. Immunol. | pmid:10799850 |
| Nava VE et al. | Functional characterization of human sphingosine kinase-1. | 2000 | FEBS Lett. | pmid:10802064 |
| Spiegel S and Milstien S | Functions of a new family of sphingosine-1-phosphate receptors. | 2000 | Biochim. Biophys. Acta | pmid:10760461 |
| Panetti TS et al. | Sphingosine-1-phosphate and lysophosphatidic acid stimulate endothelial cell migration. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:10764666 |
| Meacci E et al. | Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. | 2000 | FEBS Lett. | pmid:11018530 |
| Nugent D and Xu Y | Sphingosine-1-phosphate: characterization of its inhibition of platelet aggregation. | 2000 | Platelets | pmid:10938902 |
| Young KW et al. | Effect of dimethylsphingosine on muscarinic M(3) receptor signalling in SH-SY5Y cells. | 2000 | Eur. J. Pharmacol. | pmid:10940357 |
| Bischoff A et al. | Sphingosine-1-phosphate and sphingosylphosphorylcholine constrict renal and mesenteric microvessels in vitro. | 2000 | Br. J. Pharmacol. | pmid:10952677 |
| Bischoff A et al. | Sphingosine-1-phosphate reduces rat renal and mesenteric blood flow in vivo in a pertussis toxin-sensitive manner. | 2000 | Br. J. Pharmacol. | pmid:10952678 |
| Alemany R et al. | Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation. | 2000 | Mol. Pharmacol. | pmid:10953041 |
| Young KW et al. | Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors. | 2000 | J. Biol. Chem. | pmid:10954727 |
| Peyruchaud O and Mosher DF | Differential stimulation of signaling pathways initiated by Edg-2 in response to lysophosphatidic acid or sphingosine-1-phosphate. | 2000 | Cell. Mol. Life Sci. | pmid:10961347 |
| Sugiyama A et al. | Sphingosine 1-phosphate induces sinus tachycardia and coronary vasoconstriction in the canine heart. | 2000 | Cardiovasc. Res. | pmid:10727660 |
| Okamoto H et al. | Sphingosine 1-phosphate stimulates G(i)- and Rho-mediated vascular endothelial cell spreading and migration. | 2000 | Thromb. Res. | pmid:10942792 |
| Nanjundan M and Possmayer F | Characterization of the pulmonary N-ethylmaleimide-insensitive phosphatidate phosphohydrolase. | 2000 Jul-Aug | Exp. Lung Res. | pmid:10914334 |
| Lampasso JD et al. | Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728164 |
| Hla T et al. | Lysophospholipids--receptor revelations. | 2001 | Science | pmid:11729304 |
| Muraki K and Imaizumi Y | A novel function of sphingosine-1-phosphate to activate a non-selective cation channel in human endothelial cells. | 2001 | J. Physiol. (Lond.) | pmid:11731576 |
| Lee MJ et al. | Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. | 2001 | Mol. Cell | pmid:11583630 |
| Li G et al. | Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. | 2001 | Development | pmid:11566853 |
| Bischoff A et al. | Nifedipine inhibits sphinogosine-1-phosphate-induced renovascular contraction in vitro and in vivo. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11534858 |
| Robert P et al. | EDG1 receptor stimulation leads to cardiac hypertrophy in rat neonatal myocytes. | 2001 | J. Mol. Cell. Cardiol. | pmid:11549339 |
| Marletta MA | Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? | 2001 | Trends Biochem. Sci. | pmid:11551775 |
| Ohmori T et al. | G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. | 2001 | J. Biol. Chem. | pmid:11056155 |
| Erl W and Siess W | Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. | 2001 | Circ. Res. | pmid:11557732 |
| Malek RL et al. | Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. | 2001 | J. Biol. Chem. | pmid:11069896 |
| Kluk MJ and Hla T | Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. | 2001 | Circ. Res. | pmid:11557736 |
| Meacci E et al. | Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts. | 2001 | Cell. Signal. | pmid:11483412 |
| Pébay A et al. | Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. | 2001 | Eur. J. Neurosci. | pmid:11467306 |
| Brownlee C | Intracellular signalling: sphingosine-1-phosphate branches out. | 2001 | Curr. Biol. | pmid:11470429 |
| Alderton F et al. | G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. | 2001 | J. Biol. Chem. | pmid:11278307 |
| Igarashi J et al. | Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278407 |
| Morales-Ruiz M et al. | Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. | 2001 | J. Biol. Chem. | pmid:11278592 |
| Birchwood CJ et al. | Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. | 2001 | J. Biol. Chem. | pmid:11278643 |
| Ng CK et al. | Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. | 2001 | Nature | pmid:11279499 |
| Kranenburg O and Moolenaar WH | Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. | 2001 | Oncogene | pmid:11313900 |
| Schwartz BM et al. | Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. | 2001 | Gynecol. Oncol. | pmid:11330965 |
| Hobson JP et al. | Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. | 2001 | Science | pmid:11230698 |
| Alderton F et al. | Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. | 2001 | J. Biol. Chem. | pmid:11359779 |
| Pébay A et al. | Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. | 2001 | Eur. J. Neurosci. | pmid:11422447 |
| Kimura T et al. | Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. | 2001 | J. Biol. Chem. | pmid:11427538 |
| Ishii I et al. | Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. | 2001 | J. Biol. Chem. | pmid:11443127 |
| Kralik SF et al. | A method for quantitative extraction of sphingosine 1-phosphate into organic solvent. | 2001 | Anal. Biochem. | pmid:11444818 |
| Repp H et al. | Activation of a Ca2+-dependent K+ current in mouse fibroblasts by sphingosine-1-phosphate involves the protein tyrosine kinase c-Src. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11284444 |
| Ruwisch L et al. | An improved high-performance liquid chromatographic method for the determination of sphingosine-1-phosphate in complex biological materials. | 2001 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:11284453 |
| Aas V et al. | Fibronectin promotes calcium signaling by interferon-gamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms. | 2001 | Cell Commun. Adhes. | pmid:11936187 |