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Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma Cells. |
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PLoS ONE |
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Sphingosine kinase-1 inhibition protects primary rat hepatocytes against bile salt-induced apoptosis. |
2013 |
Biochim. Biophys. Acta |
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Tsai YC et al. |
Antiapoptotic agent sphingosine-1-phosphate protects vitrified murine ovarian grafts. |
2014 |
Reprod Sci |
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Targeting the sphingosine kinase/sphingosine 1-phosphate pathway to treat chronic inflammatory kidney diseases. |
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Basic Clin. Pharmacol. Toxicol. |
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Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes. |
2013 |
Endocrinology |
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Zhang L et al. |
Sphingosine kinase 2 (Sphk2) regulates platelet biogenesis by providing intracellular sphingosine 1-phosphate (S1P). |
2013 |
Blood |
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Sphingosine-1-phosphate receptor-2 mediated NFκB activation contributes to tumor necrosis factor-α induced VCAM-1 and ICAM-1 expression in endothelial cells. |
2013 |
Prostaglandins Other Lipid Mediat. |
pmid:23770055
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The structure and function of the S1P1 receptor. |
2013 |
Trends Pharmacol. Sci. |
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Lee H et al. |
4-Deoxypyridoxine improves the viability of isolated pancreatic islets ex vivo. |
2013 May-Jun |
Islets |
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Plasma sphingolipids and lung cancer: a population-based, nested case-control study. |
2013 |
Cancer Epidemiol. Biomarkers Prev. |
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Sphingosine 1-phosphate in renal diseases. |
2013 |
Cell. Physiol. Biochem. |
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Sphingosine-1-phosphate inhibits ceramide-induced apoptosis during murine preimplantation embryonic development. |
2013 |
Theriogenology |
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Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. |
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Arterioscler. Thromb. Vasc. Biol. |
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Fukuhara S and Mochizuki N |
[Lymphocytes mobilization into blood regulated by Spns2, a sphingosine 1-phosphate transporter, expressed on endothelial cells]. |
2013 |
Seikagaku |
pmid:23717873
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Willis MA and Cohen JA |
Fingolimod therapy for multiple sclerosis. |
2013 |
Semin Neurol |
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Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice. |
2013 |
PLoS ONE |
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Treatment with the sphingosine-1-phosphate analogue FTY 720 reduces loss of plasma volume during experimental sepsis in the rat. |
2013 |
Acta Anaesthesiol Scand |
pmid:23683126
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An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer. |
2013 |
J. Cell. Mol. Med. |
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Coronin 1B regulates S1P-induced human lung endothelial cell chemotaxis: role of PLD2, protein kinase C and Rac1 signal transduction. |
2013 |
PLoS ONE |
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Sphingosine 1-phosphate counteracts the effects of interleukin-1β in human chondrocytes. |
2013 |
Arthritis Rheum. |
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Kurano M et al. |
Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M. |
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Atherosclerosis |
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Factor-Xa-induced mitogenesis and migration require sphingosine kinase activity and S1P formation in human vascular smooth muscle cells. |
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Cardiovasc. Res. |
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HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL. |
2013 |
Curr. Opin. Lipidol. |
pmid:23652570
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2013 |
Curr. Opin. Lipidol. |
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A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. |
2013 |
Biochim. Biophys. Acta |
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Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. |
2013 |
J. Dermatol. Sci. |
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Glassy dynamics, cell mechanics, and endothelial permeability. |
2013 |
J Phys Chem B |
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Sphingosine-1-phosphate phosphatase 1 regulates keratinocyte differentiation and epidermal homeostasis. |
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J. Biol. Chem. |
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Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation. |
2013 |
FASEB J. |
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Bioactive lipids S1P and C1P are prometastatic factors in human rhabdomyosarcoma, and their tissue levels increase in response to radio/chemotherapy. |
2013 |
Mol. Cancer Res. |
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Matsuzaki E et al. |
Sphingosine-1-phosphate promotes the nuclear translocation of β-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines. |
2013 |
Bone |
pmid:23612487
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Salmanzadeh A et al. |
Sphingolipid metabolites modulate dielectric characteristics of cells in a mouse ovarian cancer progression model. |
2013 |
Integr Biol (Camb) |
pmid:23609351
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BÅ‚ogowski W et al. |
Perioperative release of pro-regenerative biochemical signals from human renal allografts subjected to ischemia-reperfusion injury. |
2014 |
Innate Immun |
pmid:23608824
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Molecular basis of sphingosine kinase 1 substrate recognition and catalysis. |
2013 |
Structure |
pmid:23602659
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Kroetsch JT and Bolz SS |
The TNF-α/sphingosine-1-phosphate signaling axis drives myogenic responsiveness in heart failure. |
2013 |
J. Vasc. Res. |
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Sphingosine 1-phosphate (S1P) receptor agonists mediate pro-fibrotic responses in normal human lung fibroblasts via S1P2 and S1P3 receptors and Smad-independent signaling. |
2013 |
J. Biol. Chem. |
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Pharmacology of the sphingosine-1-phosphate signalling system. |
2013 |
Handb Exp Pharmacol |
pmid:23579459
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Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23569284
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Kikuta J et al. |
Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23569273
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FTY720 postconditions isolated perfused heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning. |
2013 |
Med Sci Monit Basic Res |
pmid:23567658
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Bruni P and Donati C |
Role of sphingosine 1-phosphate in skeletal muscle cell biology. |
2013 |
Handb Exp Pharmacol |
pmid:23563671
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Gandy KA and Obeid LM |
Regulation of the sphingosine kinase/sphingosine 1-phosphate pathway. |
2013 |
Handb Exp Pharmacol |
pmid:23563662
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Abbasi T and Garcia JG |
Sphingolipids in lung endothelial biology and regulation of vascular integrity. |
2013 |
Handb Exp Pharmacol |
pmid:23563658
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Levkau B |
Cardiovascular effects of sphingosine-1-phosphate (S1P). |
2013 |
Handb Exp Pharmacol |
pmid:23563656
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Jiang XC and Liu J |
Sphingolipid metabolism and atherosclerosis. |
2013 |
Handb Exp Pharmacol |
pmid:23563655
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Pyne S and Pyne NJ |
New perspectives on the role of sphingosine 1-phosphate in cancer. |
2013 |
Handb Exp Pharmacol |
pmid:23563651
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Selvam SP and Ogretmen B |
Sphingosine kinase/sphingosine 1-phosphate signaling in cancer therapeutics and drug resistance. |
2013 |
Handb Exp Pharmacol |
pmid:23563649
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Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro. |
2013 |
Exp. Cell Res. |
pmid:23562655
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An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway. |
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J. Neurosci. |
pmid:23554499
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Cytokine IL-6 secretion by trophoblasts regulated via sphingosine-1-phosphate receptor 2 involving Rho/Rho-kinase and Rac1 signaling pathways. |
2013 |
Mol. Hum. Reprod. |
pmid:23538947
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Morozov VI et al. |
Sphingosine-1-phosphate: distribution, metabolism and role in the regulation of cellular functions. |
2013 Jan-Feb |
Ukr Biokhim Zh (1999) |
pmid:23534286
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Matheu MP et al. |
Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. |
2013 |
PLoS ONE |
pmid:23533579
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Arce FT et al. |
Heterogeneous elastic response of human lung microvascular endothelial cells to barrier modulating stimuli. |
2013 |
Nanomedicine |
pmid:23523769
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Oncogenic properties of sphingosine kinases in haematological malignancies. |
2013 |
Br. J. Haematol. |
pmid:23521541
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[Anti-angiogenic effect of bioactive lipid antagonists]. |
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Nippon Rinsho |
pmid:23513926
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Gaucher's disease and cancer: a sphingolipid perspective. |
2013 |
Crit Rev Oncog |
pmid:23510065
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Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. |
2013 |
Curr. Opin. Hematol. |
pmid:23507960
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Assay to measure the secretion of sphingosine-1-phosphate from cells induced by S1P lyase inhibitors. |
2013 |
Biochem. Biophys. Res. Commun. |
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HDL and endothelial protection. |
2013 |
Br. J. Pharmacol. |
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Sphingosine kinase/sphingosine 1-phosphate (S1P)/S1P receptor axis is involved in liver fibrosis-associated angiogenesis. |
2013 |
J. Hepatol. |
pmid:23466305
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Increased expression of sphingosine kinase in the amnion during labor. |
2013 |
Placenta |
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Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury. |
2013 |
Am. J. Respir. Cell Mol. Biol. |
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A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. |
2013 |
EMBO J. |
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Phosphatidic acid metabolism in rat liver cell nuclei. |
2013 |
FEBS Lett. |
pmid:23439070
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Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. |
2013 |
Acta Physiol (Oxf) |
pmid:23432924
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Kawahara S et al. |
Sphingosine kinase 1 plays a role in the upregulation of CD44 expression through extracellular signal-regulated kinase signaling in human colon cancer cells. |
2013 |
Anticancer Drugs |
pmid:23426175
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Acid ceramidase as a therapeutic target in metastatic prostate cancer. |
2013 |
J. Lipid Res. |
pmid:23423838
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Mudd JC et al. |
Impaired T-cell responses to sphingosine-1-phosphate in HIV-1 infected lymph nodes. |
2013 |
Blood |
pmid:23422746
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Sphingosine 1-phosphate release from platelets during clot formation: close correlation between platelet count and serum sphingosine 1-phosphate concentration. |
2013 |
Lipids Health Dis |
pmid:23418753
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Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. |
2013 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:23401561
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Screening β-arrestin recruitment for the identification of natural ligands for orphan G-protein-coupled receptors. |
2013 |
J Biomol Screen |
pmid:23396314
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Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor. |
2013 |
J. Neurosci. |
pmid:23392686
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Fluorescent lipids as probes for sphingosine kinase activity by capillary electrophoresis. |
2013 |
Methods Mol. Biol. |
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Sphingosine-1-phosphate protects against bisphosphonate‑induced HUVEC cell death via regulation of c-Jun‑N‑terminal kinase signaling. |
2013 |
Int. J. Mol. Med. |
pmid:23381659
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Chang CH et al. |
Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. |
2013 |
Acta Pharmacol. Sin. |
pmid:23377549
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[Sphingosine-1-phosphate--molecular maestro]. |
2012 |
Postepy Biochem. |
pmid:23373414
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Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism. |
2013 |
PLoS ONE |
pmid:23372844
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Babahosseini H et al. |
Roles of bioactive sphingolipid metabolites in ovarian cancer cell biomechanics. |
2012 |
Conf Proc IEEE Eng Med Biol Soc |
pmid:23366417
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Tong X et al. |
High-density lipoprotein of patients with type 2 diabetes mellitus upregulates cyclooxgenase-2 expression and prostacyclin I-2 release in endothelial cells: relationship with HDL-associated sphingosine-1-phosphate. |
2013 |
Cardiovasc Diabetol |
pmid:23360427
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Dillahunt SE et al. |
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined. |
2013 |
J. Immunol. |
pmid:23359503
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Sharma N et al. |
Sphingosine-1-phosphate suppresses TLR-induced CXCL8 secretion from human T cells. |
2013 |
J. Leukoc. Biol. |
pmid:23345392
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Cortez-Retamozo V et al. |
Angiotensin II drives the production of tumor-promoting macrophages. |
2013 |
Immunity |
pmid:23333075
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Yasuo M et al. |
Fenretinide causes emphysema, which is prevented by sphingosine 1-phoshate. |
2013 |
PLoS ONE |
pmid:23326540
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Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation. |
2013 |
J. Clin. Invest. |
pmid:23321671
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Class II phosphoinositide 3-kinases contribute to endothelial cells morphogenesis. |
2013 |
PLoS ONE |
pmid:23320105
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Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. |
2013 |
Trends Pharmacol. Sci. |
pmid:23318139
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Targeting sphingosine kinase 1 attenuates bleomycin-induced pulmonary fibrosis. |
2013 |
FASEB J. |
pmid:23315259
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The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. |
2013 |
Cell. Signal. |
pmid:23314175
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Effects of sphingosine-1-phosphate on pacemaker activity of interstitial cells of Cajal from mouse small intestine. |
2013 |
Mol. Cells |
pmid:23307289
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Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. |
2013 |
J. Clin. Invest. |
pmid:23298833
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Sphingosine kinase 1 in cancer. |
2013 |
Adv. Cancer Res. |
pmid:23290781
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Therapeutic potential of targeting SK1 in human cancers. |
2013 |
Adv. Cancer Res. |
pmid:23290780
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Hypoxia, therapeutic resistance, and sphingosine 1-phosphate. |
2013 |
Adv. Cancer Res. |
pmid:23290779
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Karapetyan AV et al. |
Bioactive lipids and cationic antimicrobial peptides as new potential regulators for trafficking of bone marrow-derived stem cells in patients with acute myocardial infarction. |
2013 |
Stem Cells Dev. |
pmid:23282236
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Liang J et al. |
Sphingosine-1-phosphate links persistent STAT3 activation, chronic intestinal inflammation, and development of colitis-associated cancer. |
2013 |
Cancer Cell |
pmid:23273921
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Kleinjan A et al. |
Topical treatment targeting sphingosine-1-phosphate and sphingosine lyase abrogates experimental allergic rhinitis in a murine model. |
2013 |
Allergy |
pmid:23253209
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Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. |
2013 |
Anal. Biochem. |
pmid:23246729
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Exploring amino acids derivatives as potent, selective, and direct agonists of sphingosine-1-phosphate receptor subtype-1. |
2013 |
Bioorg. Med. Chem. Lett. |
pmid:23245510
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Low sphingosine-1-phosphate impairs lung dendritic cells in cystic fibrosis. |
2013 |
Am. J. Respir. Cell Mol. Biol. |
pmid:23239501
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A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. |
2013 |
Mol. Cell. Biol. |
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