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Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. |
2005 |
Diabetes |
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GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine. |
2005 |
FASEB J. |
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2005 |
FEBS Lett. |
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The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. |
2005 |
Blood |
pmid:15870184
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Wu WT et al. |
Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells. |
2005 |
Endocrinology |
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Takeshita A et al. |
Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. |
2005 |
J Oral Sci |
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Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. |
2005 |
Pharmazie |
pmid:15881612
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Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. |
2005 |
J. Biol. Chem. |
pmid:15883165
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The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate. |
2005 |
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Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. |
2005 |
Biochem. Pharmacol. |
pmid:15907808
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Yin F and Watsky MA |
LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance. |
2005 |
Invest. Ophthalmol. Vis. Sci. |
pmid:15914605
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Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. |
2005 |
Respir. Res. |
pmid:15927078
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Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. |
2005 |
Genes Cells |
pmid:15938718
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Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. |
2005 |
J. Biol. Chem. |
pmid:15946935
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Premature ovarian aging in mice deficient for Gpr3. |
2005 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:15956199
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Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools. |
2005 |
Biochem. J. |
pmid:15960610
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Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:15967165
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Off the shelf but not mass produced. |
2005 |
Chem. Biol. |
pmid:15975506
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S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate. |
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Chem. Biol. |
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Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. |
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Bioorg. Med. Chem. Lett. |
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Sphingosine-1-phosphate induces a PDGFR-dependent cell detachment via inhibiting beta1 integrin in HEK293 cells. |
2005 |
FEBS Lett. |
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Inhibition of gene expression in vivo using multiplex siRNA. |
2005 |
Methods Mol. Biol. |
pmid:15990401
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Sphingosine-1-phosphate inhibition of placental trophoblast differentiation through a G(i)-coupled receptor response. |
2005 |
J. Lipid Res. |
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Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network. |
2005 |
Nat. Rev. Immunol. |
pmid:15999095
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Differential regulation of NPR-B/GC-B by protein kinase c and calcium. |
2005 |
Biochem. Pharmacol. |
pmid:16005434
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Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. |
2005 |
Oncogene |
pmid:16007180
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A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection. |
2005 |
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. |
pmid:16023899
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Regulation of vascular reactivity by established and emerging GPCRs. |
2005 |
Trends Pharmacol. Sci. |
pmid:16054240
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Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets. |
2005 |
J. Lipid Res. |
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Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. |
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Stem Cells |
pmid:16081668
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Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. |
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J. Biol. Chem. |
pmid:16093248
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Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:16099387
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Lysophospholipids in the nervous system. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:16099390
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Rosen H |
Chemical approaches to the lysophospholipid receptors. |
2005 |
Prostaglandins Other Lipid Mediat. |
pmid:16099402
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Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. |
2005 |
J. Immunol. |
pmid:16116177
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Sphingosine-1-phosphate mediates migration of mature dendritic cells. |
2005 |
J. Immunol. |
pmid:16116182
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The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. |
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J. Biol. Chem. |
pmid:16118221
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Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. |
2005 |
Bioorg. Med. Chem. Lett. |
pmid:16125386
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Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. |
2005 |
J. Biol. Chem. |
pmid:16126722
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[Effects of sphingosine 1-phosphate on functions of T cell - review]. |
2005 |
Zhongguo Shi Yan Xue Ye Xue Za Zhi |
pmid:16129068
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Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor. |
2005 |
Ann Biomed Eng |
pmid:16133909
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[Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. |
2005 |
Tanpakushitsu Kakusan Koso |
pmid:16146193
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Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. |
2005 |
FASEB J. |
pmid:16148028
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Hla T |
Immunology. Dietary factors and immunological consequences. |
2005 |
Science |
pmid:16150998
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Schwab SR et al. |
Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. |
2005 |
Science |
pmid:16151014
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Hemmings DG et al. |
Sphingosine-1-phosphate acts via rho-associated kinase and nitric oxide to regulate human placental vascular tone. |
2006 |
Biol. Reprod. |
pmid:16162874
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Armulik A et al. |
Endothelial/pericyte interactions. |
2005 |
Circ. Res. |
pmid:16166562
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Yamashita H et al. |
Sphingosine 1-phosphate receptor expression profile in human gastric cancer cells: differential regulation on the migration and proliferation. |
2006 |
J. Surg. Res. |
pmid:16183075
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Ceramide decreases surfactant protein B gene expression via downregulation of TTF-1 DNA binding activity. |
2006 |
Am. J. Physiol. Lung Cell Mol. Physiol. |
pmid:16183668
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Urata Y et al. |
Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase. |
2005 |
Kobe J Med Sci |
pmid:16199931
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