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Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. |
2015 |
Hepatology |
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A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. |
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FASEB J. |
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The Arabidopsis alkaline ceramidase TOD1 is a key turgor pressure regulator in plant cells. |
2015 |
Nat Commun |
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Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer. |
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Clin. Cancer Res. |
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S1PR1 Tyr143 phosphorylation downregulates endothelial cell surface S1PR1 expression and responsiveness. |
2015 |
J. Cell. Sci. |
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Ca2+ mobilization assays in GPCR drug discovery. |
2015 |
Methods Mol. Biol. |
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Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate. |
2015 |
J. Formos. Med. Assoc. |
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Inhibition of Ceramide De Novo Synthesis Ameliorates Diet Induced Skeletal Muscles Insulin Resistance. |
2015 |
J Diabetes Res |
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Quantification of sphingosine 1-phosphate by validated LC-MS/MS method revealing strong correlation with apolipoprotein M in plasma but not in serum due to platelet activation during blood coagulation. |
2015 |
Anal Bioanal Chem |
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Sphingosine-1-Phosphate Induces the Migration and Angiogenesis of Epcs Through the Akt Signaling Pathway via Sphingosine-1-Phosphate Receptor 3/Platelet-Derived Growth Factor Receptor-β. |
2015 |
Cell. Mol. Biol. Lett. |
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Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing. |
2015 |
Mol. Cell Proteomics |
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Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli? |
2015 |
PLoS ONE |
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The relationship between the high-density lipoprotein (HDL)-associated sphingosine-1-phosphate (S1P) and coronary in-stent restenosis. |
2015 |
Clin. Chim. Acta |
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Endothelial sphingosine kinase/SPNS2 axis is critical for vessel-like formation by human mesoangioblasts. |
2015 |
J. Mol. Med. |
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Secretion of PDGF isoforms during osteoclastogenesis and its modulation by anti-osteoclast drugs. |
2015 |
Biochem. Biophys. Res. Commun. |
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Rao PV |
Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. |
2014 Mar-Apr |
J Ocul Pharmacol Ther |
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Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. |
2014 |
Clin. Sci. |
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Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. |
2014 |
Mol. Cancer Ther. |
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Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways. |
2014 |
Stem Cell Res |
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Differential regulation of lung endothelial permeability in vitro and in situ. |
2014 |
Cell. Physiol. Biochem. |
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Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice. |
2014 |
Fertil. Steril. |
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Kang JW and Lee SM |
Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury. |
2014 |
Biochem. Biophys. Res. Commun. |
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Chen J et al. |
Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. |
2014 |
PLoS Genet. |
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Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. |
2014 |
J. Clin. Invest. |
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Wang F and Ye P |
Improving heart function by modulating myocardiocyte autophagy: a possible novel mechanism for cardiovascular protection of high-density lipoprotein. |
2014 |
Lipids Health Dis |
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Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts. |
2014 |
Nat Commun |
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Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. |
2014 |
Arch. Biochem. Biophys. |
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FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. |
2014 |
J. Neuroimmunol. |
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Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. |
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J. Biol. Chem. |
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Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. |
2014 |
Hum. Reprod. |
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2014 |
Biochim. Biophys. Acta |
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STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. |
2014 |
World J. Gastroenterol. |
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Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy. |
2014 |
Chin. Med. J. |
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Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. |
2014 |
Acta Biomater |
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Tong X et al. |
The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus. |
2014 |
Cardiovasc Diabetol |
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Sphingolipids: important players in multiple sclerosis. |
2014 |
Cell. Physiol. Biochem. |
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Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. |
2014 |
Cell. Physiol. Biochem. |
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Re-configuration of sphingolipid metabolism by oncogenic transformation. |
2014 |
Biomolecules |
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Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation. |
2014 |
Drug Metab. Dispos. |
pmid:24965813
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Zhang J and Song J |
Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. |
2014 |
Acta Biomater |
pmid:24631657
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Priceman SJ et al. |
S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3. |
2014 |
Cell Rep |
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Oizumi A et al. |
Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. |
2014 |
PLoS ONE |
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Guan Z et al. |
Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature. |
2014 |
J. Am. Soc. Nephrol. |
pmid:24578134
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Borge M et al. |
The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406. |
2014 |
J. Immunol. |
pmid:25127862
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Egom EE |
Sphingosine-1-phosphate signalling as a therapeutic target for patients with abnormal glucose metabolism and ischaemic heart disease. |
2014 |
J Cardiovasc Med (Hagerstown) |
pmid:23839592
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Cencetti F et al. |
Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis. |
2014 |
FEBS J. |
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Xia JY et al. |
The adipokine/ceramide axis: key aspects of insulin sensitization. |
2014 |
Biochimie |
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Albinet V et al. |
Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. |
2014 |
Oncogene |
pmid:23893239
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Zeng Y et al. |
Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. |
2014 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:24285115
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