| MeSH term | MeSH ID | Detail |
|---|---|---|
| Neoplasm Invasiveness | D009361 | 23 associated lipids |
| Neoplasms, Hormone-Dependent | D009376 | 23 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Pancreatic Neoplasms | D010190 | 77 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wilson PC et al. | Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. | 2015 | Mol. Endocrinol. | pmid:25871850 |
| Jernigan PL et al. | The role of sphingolipids in endothelial barrier function. | 2015 | Biol. Chem. | pmid:25867999 |
| Egom EE et al. | The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue. | 2015 | J. Cell. Mol. Med. | pmid:25864579 |
| Breslin JW et al. | Involvement of local lamellipodia in endothelial barrier function. | 2015 | PLoS ONE | pmid:25658915 |
| Kalhori V and Törnquist K | MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. | 2015 | Mol. Cell. Endocrinol. | pmid:25643979 |
| Sivasubramanian M et al. | Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. | 2015 | Neuroscience | pmid:25637806 |
| Opal SM and van der Poll T | Endothelial barrier dysfunction in septic shock. | 2015 | J. Intern. Med. | pmid:25418337 |
| Hernández-Coronado CG et al. | Sphingosine-1-phosphate and ceramide are associated with health and atresia of bovine ovarian antral follicles. | 2015 | Animal | pmid:25245232 |
| Fogarty CE and Bergmann A | The Sound of Silence: Signaling by Apoptotic Cells. | 2015 | Curr. Top. Dev. Biol. | pmid:26431570 |
| Oskeritzian CA | Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. | 2015 | Mol. Immunol. | pmid:24766823 |
| Binder BY et al. | Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering. | 2015 | Tissue Eng Part B Rev | pmid:26035484 |
| Hoffmann FS et al. | Fingolimod induces neuroprotective factors in human astrocytes. | 2015 | J Neuroinflammation | pmid:26419927 |
| Galvani S et al. | HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. | 2015 | Sci Signal | pmid:26268607 |
| Riley RT et al. | Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. | 2015 | Mol Nutr Food Res | pmid:26264677 |
| Attiori Essis S et al. | GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P. | 2015 | Brain Res. | pmid:26260438 |
| Durham JT et al. | Pericyte chemomechanics and the angiogenic switch: insights into the pathogenesis of proliferative diabetic retinopathy? | 2015 | Invest. Ophthalmol. Vis. Sci. | pmid:26030100 |
| Rao PV | Bioactive lysophospholipids: role in regulation of aqueous humor outflow and intraocular pressure in the context of pathobiology and therapy of glaucoma. | 2014 Mar-Apr | J Ocul Pharmacol Ther | pmid:24283588 |
| Radi ZA and Vogel MW | Gastric parietal cell atrophy and depletion after administration of a sphingosine-1-phosphate 1 inhibitor. | 2014 | Toxicol Pathol | pmid:24178572 |
| Yu Y et al. | Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. | 2014 | Lipids | pmid:24158769 |
| Giannouli CC et al. | Visualizing S1P-directed cellular egress by intravital imaging. | 2014 | Biochim. Biophys. Acta | pmid:24090699 |
| Zhang Y et al. | Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. | 2014 | J. Clin. Invest. | pmid:24837436 |
| Kurano M et al. | Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. | 2014 | Biochim. Biophys. Acta | pmid:24814049 |
| Arya D et al. | Sphingosine-1-phosphate promotes the differentiation of adipose-derived stem cells into endothelial nitric oxide synthase (eNOS) expressing endothelial-like cells. | 2014 | J. Biomed. Sci. | pmid:24898615 |
| Maceyka M and Spiegel S | Sphingolipid metabolites in inflammatory disease. | 2014 | Nature | pmid:24899305 |
| Nagata Y et al. | Sphingosine-1-phosphate mediates epidermal growth factor-induced muscle satellite cell activation. | 2014 | Exp. Cell Res. | pmid:24960577 |
| Ceccom J et al. | [Sphingosine 1-phosphate as a biomarker for Alzheimer's disease?]. | 2014 | Med Sci (Paris) | pmid:24939530 |
| Uhlig S et al. | Differential regulation of lung endothelial permeability in vitro and in situ. | 2014 | Cell. Physiol. Biochem. | pmid:24977477 |
| Brünnert D et al. | Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. | 2014 | Mol. Hum. Reprod. | pmid:24994816 |
| Nagamatsu T et al. | Emerging roles for lysophospholipid mediators in pregnancy. | 2014 | Am. J. Reprod. Immunol. | pmid:24689547 |
| Shimizu Y et al. | Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin. | 2014 | Am. J. Pathol. | pmid:24641902 |
| Ohotski J et al. | Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. | 2014 | Cell. Signal. | pmid:24486401 |
| Takeo T et al. | Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. | 2014 | Cryobiology | pmid:24201107 |
| de Assuncao TM et al. | New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. | 2014 | J. Biol. Chem. | pmid:24759103 |
| Tibboel J et al. | Sphingolipids in lung growth and repair. | 2014 | Chest | pmid:24394822 |
| Huang K et al. | AP-1 regulates sphingosine kinase 1 expression in a positive feedback manner in glomerular mesangial cells exposed to high glucose. | 2014 | Cell. Signal. | pmid:24342046 |
| Gomes L et al. | Sphingosine 1-phosphate in acute dengue infection. | 2014 | PLoS ONE | pmid:25409037 |
| Xu M et al. | FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. | 2014 | Acta Pharmacol. Sin. | pmid:25399649 |
| Watanabe C et al. | Antagonism and synergy of single chain sphingolipids sphingosine and sphingosine-1-phosphate toward lipid bilayer properties. Consequences for their role as cell fate regulators. | 2014 | Langmuir | pmid:25386673 |
| Nakajima C et al. | The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. | 2014 | Development | pmid:25377550 |
| Barnes J and Dweik RA | Is pulmonary hypertension a metabolic disease? | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25360726 |
| Chen J et al. | Spinster homolog 2 (spns2) deficiency causes early onset progressive hearing loss. | 2014 | PLoS Genet. | pmid:25356849 |
| Degagné E et al. | Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs. | 2014 | J. Clin. Invest. | pmid:25347472 |
| Bigaud M et al. | Second generation S1P pathway modulators: research strategies and clinical developments. | 2014 | Biochim. Biophys. Acta | pmid:24239768 |
| Huang YL et al. | Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. | 2014 | Cell. Signal. | pmid:24333325 |
| Emery SM et al. | Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. | 2014 | J. Pharmacol. Exp. Ther. | pmid:24259678 |
| Sutter I et al. | Apolipoprotein M modulates erythrocyte efflux and tubular reabsorption of sphingosine-1-phosphate. | 2014 | J. Lipid Res. | pmid:24950692 |
| Adamson RH et al. | Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24531813 |
| Rosen H et al. | The organization of the sphingosine 1-phosphate signaling system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728591 |
| Hanson MA and Peach R | Structural biology of the S1P1 receptor. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728592 |
| Cahalan SM | Chemical and genetic tools to explore S1P biology. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728593 |
| Goñi FM et al. | Biophysical properties of sphingosine, ceramides and other simple sphingolipids. | 2014 | Biochem. Soc. Trans. | pmid:25233422 |
| Arnon TI and Cyster JG | Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728595 |
| Yagoub D et al. | Sphingosine kinase 1 isoform-specific interactions in breast cancer. | 2014 | Mol. Endocrinol. | pmid:25216046 |
| Oldstone MB and Rosen H | Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728596 |
| Yang W et al. | Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. | 2014 | PLoS ONE | pmid:25188412 |
| Martin R and Sospedra M | Sphingosine-1 phosphate and central nervous system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728597 |
| Chen J et al. | The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. | 2014 | Am. J. Respir. Crit. Care Med. | pmid:25180446 |
| Kong Y et al. | Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. | 2014 | Mediators Inflamm. | pmid:25147438 |
| Nagahashi M et al. | Sphingosine-1-phosphate transporters as targets for cancer therapy. | 2014 | Biomed Res Int | pmid:25133174 |
| Nguyen AV et al. | STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer. | 2014 | World J. Gastroenterol. | pmid:25132744 |
| Kim EY et al. | Role of sphingosine kinase 1 and sphingosine-1-phosphate in CD40 signaling and IgE class switching. | 2014 | FASEB J. | pmid:25002116 |
| Hao J et al. | The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation. | 2014 | Arthritis Res. Ther. | pmid:25000985 |
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| Rauch BH | Sphingosine 1-phosphate as a link between blood coagulation and inflammation. | 2014 | Cell. Physiol. Biochem. | pmid:24977491 |
| Sattler K et al. | HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977490 |
| Thuy AV et al. | Sphingosine 1-phosphate in blood: function, metabolism, and fate. | 2014 | Cell. Physiol. Biochem. | pmid:24977489 |
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| Fayyaz S et al. | Divergent role of sphingosine 1-phosphate on insulin resistance. | 2014 | Cell. Physiol. Biochem. | pmid:24977487 |
| Rahman MM et al. | Sphingosine 1-phosphate induces neutrophil chemoattractant IL-8: repression by steroids. | 2014 | PLoS ONE | pmid:24647471 |
| Halmer R et al. | Sphingolipids: important players in multiple sclerosis. | 2014 | Cell. Physiol. Biochem. | pmid:24977485 |
| Park SM et al. | Sphingosine-1-phosphate lyase is expressed by CD68+ cells on the parenchymal side of marginal reticular cells in human lymph nodes. | 2014 | Eur. J. Immunol. | pmid:24825162 |
| Arlt O et al. | Sphingosine-1-phosphate modulates dendritic cell function: focus on non-migratory effects in vitro and in vivo. | 2014 | Cell. Physiol. Biochem. | pmid:24977479 |
| Simmons S and Ishii M | Sphingosine-1-phosphate: a master regulator of lymphocyte egress and immunity. | 2014 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:24276789 |
| Mahajan-Thakur S et al. | Sphingosine-1-phosphate induces thrombin receptor PAR-4 expression to enhance cell migration and COX-2 formation in human monocytes. | 2014 | J. Leukoc. Biol. | pmid:24990321 |
| Jesko H et al. | Sphingosine kinases modulate the secretion of amyloid β precursor protein from SH-SY5Y neuroblastoma cells: the role of α-synuclein. | 2014 | Folia Neuropathol | pmid:24729344 |
| Zhu Y et al. | Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation. | 2014 | Mol. Neurobiol. | pmid:24722820 |
| Kondo S et al. | Memo has a novel role in S1P signaling and is [corrected] crucial for vascular development. | 2014 | PLoS ONE | pmid:24714781 |
| Korbelik M et al. | Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. | 2014 | Int. Immunopharmacol. | pmid:24713544 |
| Gatfield J et al. | Sphingosine-1-phosphate (S1P) displays sustained S1P1 receptor agonism and signaling through S1P lyase-dependent receptor recycling. | 2014 | Cell. Signal. | pmid:24704119 |
| Shin KO et al. | Ginsenoside compound K inhibits angiogenesis via regulation of sphingosine kinase-1 in human umbilical vein endothelial cells. | 2014 | Arch. Pharm. Res. | pmid:24687256 |
| Yu H et al. | Sphingosine kinase 1 improves cutaneous wound healing in diabetic rats. | 2014 | Injury | pmid:24685054 |
| Sykes DA et al. | Investigating the molecular mechanisms through which FTY720-P causes persistent S1P1 receptor internalization. | 2014 | Br. J. Pharmacol. | pmid:24641481 |
| Zhang J and Song J | Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. | 2014 | Acta Biomater | pmid:24631657 |
| Priceman SJ et al. | S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3. | 2014 | Cell Rep | pmid:24630990 |
| Oizumi A et al. | Pseudomonas-derived ceramidase induces production of inflammatory mediators from human keratinocytes via sphingosine-1-phosphate. | 2014 | PLoS ONE | pmid:24586752 |
| Blaho VA and Hla T | An update on the biology of sphingosine 1-phosphate receptors. | 2014 | J. Lipid Res. | pmid:24459205 |
| Whisler JA et al. | Control of perfusable microvascular network morphology using a multiculture microfluidic system. | 2014 | Tissue Eng Part C Methods | pmid:24151838 |
| Mendes-Braz M et al. | The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. | 2014 | Liver Int. | pmid:24107124 |
| Baranowski M et al. | Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. | 2014 | Int J Sport Nutr Exerc Metab | pmid:24092763 |
| Egom EE | Sphingosine-1-phosphate signalling as a therapeutic target for patients with abnormal glucose metabolism and ischaemic heart disease. | 2014 | J Cardiovasc Med (Hagerstown) | pmid:23839592 |
| Fincher J et al. | G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. | 2014 | Dev. Neurosci. | pmid:25138637 |
| Cencetti F et al. | Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis. | 2014 | FEBS J. | pmid:25131845 |
| Neuber C et al. | Method to simultaneously determine the sphingosine 1-phosphate breakdown product (2E)-hexadecenal and its fatty acid derivatives using isotope-dilution HPLC-electrospray ionization-quadrupole/time-of-flight mass spectrometry. | 2014 | Anal. Chem. | pmid:25137547 |
| Zeng Y et al. | Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. | 2014 | Am. J. Physiol. Heart Circ. Physiol. | pmid:24285115 |
| Speak AO et al. | Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. | 2014 | Blood | pmid:24235134 |
| Nagahashi M et al. | Sphingosine-1-phosphate in chronic intestinal inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24210073 |
| Ratajczak MZ et al. | The role of sphingosine-1 phosphate and ceramide-1 phosphate in trafficking of normal stem cells and cancer cells. | 2014 | Expert Opin. Ther. Targets | pmid:24188167 |
| Chawla S et al. | Exogenous sphingosine 1-phosphate protects murine splenocytes against hypoxia-induced injury. | 2014 | Lipids | pmid:24190514 |