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HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. |
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(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. |
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S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells. |
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FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma. |
2008 |
Blood |
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An assay system for measuring the acute production of sphingosine 1-phosphate in intact monolayers. |
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Biochim. Biophys. Acta |
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Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. |
2007 |
Expert Rev Mol Med |
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2007 Sep-Oct |
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Biochim. Biophys. Acta |
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Synthesis and immobilization of erythro-C14-omega-aminosphingosine-1-phosphate as a potential tool for affinity chromatography. |
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ChemMedChem |
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Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. |
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Diabetes |
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Bezafibrate decreases growth stimulatory action of the sphingomyelin signaling pathway in regenerating rat liver. |
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Prostaglandins Other Lipid Mediat. |
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Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes. |
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Finding a way out: lymphocyte egress from lymphoid organs. |
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Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools. |
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Discrete influx events refill depleted Ca2+ stores in a chick retinal neuron. |
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Sphingosine-1-phosphate signaling and the skin. |
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Chem. Phys. Lipids |
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Sphingosine-1-phosphate and endothelin-1 induce the expression of rgs16 protein in cardiac myocytes by transcriptional activation of the rgs16 gene. |
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Naunyn Schmiedebergs Arch. Pharmacol. |
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Anti-apoptotic effect of sphingosine-1-phosphate and platelet-derived growth factor in human embryonic stem cells. |
2007 |
Stem Cells Dev. |
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Microarray analysis of altered sphingolipid metabolism reveals prognostic significance of sphingosine kinase 1 in breast cancer. |
2008 |
Breast Cancer Res. Treat. |
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Multifaceted roles of sphingosine-1-phosphate: how does this bioactive sphingolipid fit with acute neurological injury? |
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J. Neurosci. Res. |
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Effects of sphingosine-1-phosphate and sphingosylphosphorylcholine on intracellular Ca2+ and cell death in prostate cancer cell lines. |
2007 |
Auton Autacoid Pharmacol |
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A role for S1P signalling in axon guidance in the Xenopus visual system. |
2008 |
Development |
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Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases. |
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Am. J. Pathol. |
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[Regulation of immunity by sphingosine 1-phosphate and its G protein-coupled receptors--review]. |
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S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. |
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Biochem. Biophys. Res. Commun. |
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Circ. Res. |
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Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. |
2008 |
Biochim. Biophys. Acta |
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Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells. |
2008 |
FEBS Lett. |
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Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. |
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Prostaglandins Other Lipid Mediat. |
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Sphingosine 1-phosphate inhibits nitric oxide production induced by interleukin-1beta in rat vascular smooth muscle cells. |
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J. Invest. Dermatol. |
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Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. |
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Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. |
2008 |
Blood |
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The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice. |
2008 |
Cardiovasc. Res. |
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Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1. |
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Mol. Cell. Endocrinol. |
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Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids. |
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Characterization of an antiproliferative effect of imidazoline receptor ligands on PC12 cells. |
2007 Nov-Dec |
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Determination of sphingosine kinase activity for cellular signaling studies. |
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Tug of war at the exit door. |
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Immunity |
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Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. |
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Blood |
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Am. J. Physiol. Heart Circ. Physiol. |
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Sphingosine 1-phosphate 1 and TLR4 mediate IFN-beta expression in human gingival epithelial cells. |
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