MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Walls SM et al. | Identification of sphingolipid metabolites that induce obesity via misregulation of appetite, caloric intake and fat storage in Drosophila. | 2013 | PLoS Genet. | pmid:24339790 |
Kusch A et al. | Novel signalling mechanisms and targets in renal ischaemia and reperfusion injury. | 2013 | Acta Physiol (Oxf) | pmid:23432924 |
Billich A et al. | Cellular assay for the characterization of sphingosine-1-phosphate lyase inhibitors. | 2013 | Anal. Biochem. | pmid:23246729 |
Kalhori V et al. | Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma Cells. | 2013 | PLoS ONE | pmid:23824493 |
Kikuta J et al. | Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23569273 |
Takuwa Y et al. | Sphingosine-1-phosphate signaling in physiology and diseases. | 2012 Sep-Oct | Biofactors | pmid:22674845 |
Iwaki S et al. | Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells. | 2012 Nov-Dec | Biochim. Biophys. Acta | pmid:22819712 |
Fournie P et al. | Sphingosine-1 phosphate prevents ethanol-induced corneal epithelial apoptosis. | 2012 Mar-Apr | Indian J Ophthalmol | pmid:22446906 |
Tse KW et al. | Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells. | 2012 Jan-Feb | Cell. Immunol. | pmid:22507871 |
Yu FX et al. | Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. | 2012 | Cell | pmid:22863277 |
Miller E et al. | Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP. | 2012 | Chem. Biol. | pmid:22884261 |
Aoyagi T et al. | The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. | 2012 | Lymphat Res Biol | pmid:22984905 |
Koch A et al. | Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells. | 2012 | Br. J. Pharmacol. | pmid:22221312 |
Taylor S et al. | The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists. | 2012 | Xenobiotica | pmid:22225501 |
Majumdar I and Mastrandrea LD | Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome. | 2012 | Endocrine | pmid:22228496 |
Wang S et al. | A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression. | 2012 | Int. J. Biol. Macromol. | pmid:22197795 |
Armstrong SM et al. | Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac. | 2012 | Am. J. Pathol. | pmid:22203054 |
Bode C and Gräler MH | Immune regulation by sphingosine 1-phosphate and its receptors. | 2012 | Arch. Immunol. Ther. Exp. (Warsz.) | pmid:22159476 |
Cyster JG and Schwab SR | Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs. | 2012 | Annu. Rev. Immunol. | pmid:22149932 |
Kurata H et al. | Structure-activity relationship studies of S1P agonists with a dihydronaphthalene scaffold. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22153936 |
Calise S et al. | Sphingosine 1-phosphate stimulates proliferation and migration of satellite cells: role of S1P receptors. | 2012 | Biochim. Biophys. Acta | pmid:22178384 |
Balczerski B et al. | Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. | 2012 | Dev. Biol. | pmid:22185793 |
Witt W et al. | Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves. | 2012 | Cardiovasc. Res. | pmid:22232739 |
Madhunapantula SV et al. | Targeting sphingosine kinase-1 to inhibit melanoma. | 2012 | Pigment Cell Melanoma Res | pmid:22236408 |
Che W et al. | Sphingosine 1-phosphate induces MKP-1 expression via p38 MAPK- and CREB-mediated pathways in airway smooth muscle cells. | 2012 | Biochim. Biophys. Acta | pmid:22743041 |
Shmyrev VI et al. | [Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature]. | 2012 | Zh Nevrol Psikhiatr Im S S Korsakova | pmid:22677684 |
Upadhyaya P et al. | The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22727907 |
Nijnik A et al. | The role of sphingosine-1-phosphate transporter Spns2 in immune system function. | 2012 | J. Immunol. | pmid:22664872 |
Duru EA et al. | Role of S-1-P receptors and human vascular smooth muscle cell migration in diabetes and metabolic syndrome. | 2012 | J. Surg. Res. | pmid:22480845 |
Moberly JB et al. | Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. | 2012 | J. Neuroimmunol. | pmid:22465063 |
Li Q et al. | The reduction of allograft arteriosclerosis in intestinal transplant is associated with sphingosine kinase 1/sphingosine-1-phosphate signaling after fish oil treatment. | 2012 | Transplantation | pmid:22466786 |
von Bismarck P et al. | IKK NBD peptide inhibits LPS induced pulmonary inflammation and alters sphingolipid metabolism in a murine model. | 2012 | Pulm Pharmacol Ther | pmid:22469869 |
El-Shewy HM et al. | Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. | 2012 | Mol. Endocrinol. | pmid:22422617 |
Eisenhoffer GT et al. | Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia. | 2012 | Nature | pmid:22504183 |
Ishimaru N et al. | CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. | 2012 | Am. J. Pathol. | pmid:22067914 |
Peng P et al. | [Effect of sphingosine-1-phosphate on chemotherapy-induced ovarian damage and on the efficacy of chemotherapy in mice bearing S180 tumor]. | 2012 | Nan Fang Yi Ke Da Xue Xue Bao | pmid:22445989 |
Podbielska M et al. | Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. | 2012 | Neurochem. Res. | pmid:22451227 |
Lucki NC et al. | Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. | 2012 | Mol. Cell. Endocrinol. | pmid:21864647 |
Shi Y et al. | Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion. | 2012 | J. Hepatol. | pmid:21756852 |
Kim CH et al. | Conditioning for hematopoietic transplantation activates the complement cascade and induces a proteolytic environment in bone marrow: a novel role for bioactive lipids and soluble C5b-C9 as homing factors. | 2012 | Leukemia | pmid:21769103 |
Schnute ME et al. | Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. | 2012 | Biochem. J. | pmid:22397330 |
Beech DJ | Integration of transient receptor potential canonical channels with lipids. | 2012 | Acta Physiol (Oxf) | pmid:21624095 |
Bachmaier K et al. | Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin. | 2012 | PLoS ONE | pmid:22355325 |
Sugiura T et al. | Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis. | 2012 | Coron. Artery Dis. | pmid:22356865 |
Sashio T et al. | Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium. | 2012 | Allergol Int | pmid:22361510 |
Antoon JW and Beckman BS | Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer. | 2012 | Bioorg. Med. Chem. Lett. | pmid:22366655 |
Kipp M and Amor S | FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination. | 2012 | Mult. Scler. | pmid:22383435 |
Fujii Y et al. | Blocking S1P interaction with S1Pâ‚ receptor by a novel competitive S1Pâ‚-selective antagonist inhibits angiogenesis. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22387544 |
Cantrell Stanford J et al. | Sphingosine 1-phosphate (S1P) regulates glucose-stimulated insulin secretion in pancreatic beta cells. | 2012 | J. Biol. Chem. | pmid:22389505 |
Liu W et al. | S1P2 receptor mediates sphingosine-1-phosphate-induced fibronectin expression via MAPK signaling pathway in mesangial cells under high glucose condition. | 2012 | Exp. Cell Res. | pmid:22406263 |
Fukuhara S et al. | The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. | 2012 | J. Clin. Invest. | pmid:22406534 |
Yang F et al. | Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. | 2012 | Cancer Biol. Ther. | pmid:22406995 |
Kwak HI et al. | Calpain-mediated vimentin cleavage occurs upstream of MT1-MMP membrane translocation to facilitate endothelial sprout initiation. | 2012 | Angiogenesis | pmid:22407449 |
Singh AT et al. | Sphingosine-sphingosine-1-phosphate pathway regulates trophoblast differentiation and syncytialization. | 2012 | Reprod. Biomed. Online | pmid:22197131 |
Pitman MR et al. | Molecular targets of FTY720 (fingolimod). | 2012 | Curr. Mol. Med. | pmid:22834825 |
Karmouty-Quintana H et al. | Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure. | 2012 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:22287614 |
Bassoy EY and Baran Y | Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. | 2012 | Biomed. Pharmacother. | pmid:22326625 |
Törnquist K | Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells. | 2012 | Acta Physiol (Oxf) | pmid:21338471 |
Wilkerson BA et al. | Sphingosine 1-phosphate (S1P) carrier-dependent regulation of endothelial barrier: high density lipoprotein (HDL)-S1P prolongs endothelial barrier enhancement as compared with albumin-S1P via effects on levels, trafficking, and signaling of S1P1. | 2012 | J. Biol. Chem. | pmid:23135269 |
Tar L and Vécsei L | [Fingolimod therapy in multiple sclerosis--the issue of the pathomechanism]. | 2012 | Ideggyogy Sz | pmid:23136726 |
Hla T et al. | S1P and the birth of platelets. | 2012 | J. Exp. Med. | pmid:23166370 |
Cuvillier O | [Sphingosine 1-phosphate receptors: from biology to physiopathology]. | 2012 | Med Sci (Paris) | pmid:23171898 |
Patel SA et al. | Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. | 2012 | Endocrinology | pmid:22989629 |
Fernández-Pisonero I et al. | Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells. | 2012 | J. Immunol. | pmid:23089395 |
Ma Y et al. | Sphingosine-1-phosphate (S1P) mediates darkness-induced stomatal closure through raising cytosol pH and hydrogen peroxide (Hâ‚‚Oâ‚‚) levels in guard cells in Vicia faba. | 2012 | Sci China Life Sci | pmid:23090064 |
Taniguchi M et al. | Regulation of autophagy and its associated cell death by "sphingolipid rheostat": reciprocal role of ceramide and sphingosine 1-phosphate in the mammalian target of rapamycin pathway. | 2012 | J. Biol. Chem. | pmid:23035115 |
Kawashima T et al. | Contrary effects of sphingosine-1-phosphate on expression of α-smooth muscle actin in transforming growth factor β1-stimulated lung fibroblasts. | 2012 | Eur. J. Pharmacol. | pmid:23041148 |
Sorci-Thomas MG and Thomas MJ | High density lipoprotein biogenesis, cholesterol efflux, and immune cell function. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:23077142 |
Medlin MD et al. | Quantifying sphingosine-1-phosphate-dependent activation of the RhoGTPases. | 2012 | Methods Mol. Biol. | pmid:22528442 |
Belmonte SA and Suhaiman L | Optimized protocols to analyze sphingosine-1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm. | 2012 | Methods Mol. Biol. | pmid:22528443 |
Ishii T et al. | Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis. | 2012 | Methods Mol. Biol. | pmid:22528444 |
Meacci E et al. | Sphingosine-1-phosphate signaling in skeletal muscle cells. | 2012 | Methods Mol. Biol. | pmid:22528446 |
Wong RC et al. | Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor. | 2012 | Methods Mol. Biol. | pmid:22528447 |
Bieberich E | Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. | 2012 | Methods Mol. Biol. | pmid:22528448 |
Callihan P and Hooks SB | Sphingosine-1-phosphate signaling in neural progenitors. | 2012 | Methods Mol. Biol. | pmid:22528449 |
Su SC and Bayless KJ | Utilizing sphingosine-1-phosphate to stimulate sprouting angiogenesis. | 2012 | Methods Mol. Biol. | pmid:22528450 |
Lim M et al. | The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. | 2012 | PLoS ONE | pmid:22532844 |
Lynch KR | Building a better sphingosine kinase-1 inhibitor. | 2012 | Biochem. J. | pmid:22533672 |
Mann DL | Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers. | 2012 | Circulation | pmid:22534620 |
Ding R et al. | Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase. | 2012 | Inflammation | pmid:21302134 |
Meissner A et al. | Tumor necrosis factor-α-mediated downregulation of the cystic fibrosis transmembrane conductance regulator drives pathological sphingosine-1-phosphate signaling in a mouse model of heart failure. | 2012 | Circulation | pmid:22534621 |
Callihan P et al. | Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. | 2012 | Neuropharmacology | pmid:22016110 |
Knapp M et al. | Myocardial infarction differentially alters sphingolipid levels in plasma, erythrocytes and platelets of the rat. | 2012 | Basic Res. Cardiol. | pmid:22961594 |
Shea BS and Tager AM | Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis. | 2012 | Proc Am Thorac Soc | pmid:22802282 |
Nakahara K et al. | The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. | 2012 | Mol. Cell | pmid:22633490 |
Dakroub Z and Kreydiyyeh SI | Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells. | 2012 | J. Cell. Biochem. | pmid:22271589 |
Santulli P et al. | Sphingosine pathway deregulation in endometriotic tissues. | 2012 | Fertil. Steril. | pmid:22277765 |
Lim KG et al. | Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival. | 2012 | Br. J. Pharmacol. | pmid:22251058 |
Golan K et al. | S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. | 2012 | Blood | pmid:22279055 |
Jiang H et al. | Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription. | 2012 | J Sep Sci | pmid:22282408 |
Takeshita H et al. | Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis. | 2012 | Biochem. Biophys. Res. Commun. | pmid:22326262 |
Shannon LA et al. | CCR7/CCL19 controls expression of EDG-1 in T cells. | 2012 | J. Biol. Chem. | pmid:22334704 |
Nunes J et al. | Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. | 2012 | Br. J. Cancer | pmid:22315056 |
Shimizu T et al. | Sphingosine-1-phosphate receptor 3 promotes neointimal hyperplasia in mouse iliac-femoral arteries. | 2012 | Arterioscler. Thromb. Vasc. Biol. | pmid:22308044 |
Canals D et al. | Protein phosphatase 1α mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase. | 2012 | J. Biol. Chem. | pmid:22311981 |
Knapp M et al. | Decreased free sphingoid base concentration in the plasma of patients with chronic systolic heart failure. | 2012 | Adv Med Sci | pmid:22296975 |
Nagahashi M et al. | Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. | 2012 | Cancer Res. | pmid:22298596 |
Ratajczak J et al. | A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient. | 2012 | Leukemia | pmid:22343521 |
Mascall KS et al. | Sphingosine-1-phosphate-induced release of TIMP-2 from vascular smooth muscle cells inhibits angiogenesis. | 2012 | J. Cell. Sci. | pmid:22344262 |
Hsu A et al. | Sphingosine-1-phosphate receptor-3 signaling up-regulates epidermal growth factor receptor and enhances epidermal growth factor receptor-mediated carcinogenic activities in cultured lung adenocarcinoma cells. | 2012 | Int. J. Oncol. | pmid:22344462 |