MeSH term | MeSH ID | Detail |
---|---|---|
Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
---|
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Siow D and Wattenberg B | The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21864225 |
Gault CR and Obeid LM | Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy. | 2011 | Crit. Rev. Biochem. Mol. Biol. | pmid:21787121 |
Rohrbach T et al. | Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. | 2017 | Crit. Rev. Biochem. Mol. Biol. | pmid:28618839 |
Pulkoski-Gross MJ et al. | Sphingosine-1-phosphate metabolism: A structural perspective. | 2015 | Crit. Rev. Biochem. Mol. Biol. | pmid:25923252 |
Huwiler A and Zangemeister-Wittke U | Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. | 2007 | Crit. Rev. Oncol. Hematol. | pmid:17560117 |
Takeo T et al. | Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. | 2014 | Cryobiology | pmid:24201107 |
Chakrabarti SS et al. | Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. | 2016 | Curr Alzheimer Res | pmid:27335046 |
Sanchez T | Sphingosine-1-Phosphate Signaling in Endothelial Disorders. | 2016 | Curr Atheroscler Rep | pmid:27115142 |
Herr DR and Chun J | Effects of LPA and S1P on the nervous system and implications for their involvement in disease. | 2007 | Curr Drug Targets | pmid:17266539 |
Zeidan YH et al. | Molecular targeting of acid ceramidase: implications to cancer therapy. | 2008 | Curr Drug Targets | pmid:18691012 |
Jacobson JR and Garcia JG | Novel therapies for microvascular permeability in sepsis. | 2007 | Curr Drug Targets | pmid:17430121 |
Cuvillier O et al. | Activation of sphingosine kinase-1 in cancer: implications for therapeutic targeting. | 2010 | Curr Mol Pharmacol | pmid:20302564 |
Choueiri TK et al. | Phenoxodiol: isoflavone analog with antineoplastic activity. | 2006 | Curr Oncol Rep | pmid:16507219 |
Peavy RD and Metcalfe DD | Understanding the mechanisms of anaphylaxis. | 2008 | Curr Opin Allergy Clin Immunol | pmid:18596587 |
Black JL and Johnson PR | Factors controlling smooth muscle proliferation and airway remodelling. | 2002 | Curr Opin Allergy Clin Immunol | pmid:11964750 |
Rosen H and Liao J | Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. | 2003 | Curr Opin Chem Biol | pmid:12941420 |
Cusack KP and Stoffel RH | S1P(1) receptor agonists: Assessment of selectivity and current clinical activity. | 2010 | Curr Opin Drug Discov Devel | pmid:20597031 |
Hinkovska-Galcheva V et al. | The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis. | 2008 | Curr Opin Investig Drugs | pmid:18951299 |
Chatterjee S et al. | The role of the phospholipid sphingomyelin in heart disease. | 2006 | Curr Opin Investig Drugs | pmid:16555682 |
Elices MJ | Editorial overview: Tie me up, tie me down: immunosuppressive therapies for the 21st century. | 2004 | Curr Opin Investig Drugs | pmid:15573862 |
Kennedy S et al. | Targeting sphingosine-1-phosphate signalling for cardioprotection. | 2009 | Curr Opin Pharmacol | pmid:19070545 |
Peters SL and Alewijnse AE | Sphingosine-1-phosphate signaling in the cardiovascular system. | 2007 | Curr Opin Pharmacol | pmid:17280869 |
Brinkmann V and Baumruker T | Pulmonary and vascular pharmacology of sphingosine 1-phosphate. | 2006 | Curr Opin Pharmacol | pmid:16563863 |
Bolli MH et al. | Synthetic sphingosine 1-phosphate receptor modulators--opportunities and potential pitfalls. | 2011 | Curr Top Med Chem | pmid:21261590 |
Osborne N et al. | The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. | 2008 | Curr. Biol. | pmid:19062281 |
Slattum G et al. | Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. | 2014 | Curr. Biol. | pmid:24361067 |
Brownlee C | Intracellular signalling: sphingosine-1-phosphate branches out. | 2001 | Curr. Biol. | pmid:11470429 |
Xia P et al. | An oncogenic role of sphingosine kinase. | 2000 | Curr. Biol. | pmid:11114522 |
Hoofnagle AN et al. | HDL lipids and insulin resistance. | 2010 | Curr. Diab. Rep. | pmid:20425071 |
Delgado A and MartÃnez-Cartro M | Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. | 2016 | Curr. Med. Chem. | pmid:26639095 |
He S et al. | Self-amplification mechanisms of mast cell activation: a new look in allergy. | 2012 | Curr. Mol. Med. | pmid:22920722 |
Pitman MR et al. | Molecular targets of FTY720 (fingolimod). | 2012 | Curr. Mol. Med. | pmid:22834825 |
Weiner OD | Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. | 2002 | Curr. Opin. Cell Biol. | pmid:11891119 |
Bendall LJ and Basnett J | Role of sphingosine 1-phosphate in trafficking and mobilization of hematopoietic stem cells. | 2013 | Curr. Opin. Hematol. | pmid:23507960 |
Borup A et al. | Apolipoprotein M in lipid metabolism and cardiometabolic diseases. | 2015 | Curr. Opin. Lipidol. | pmid:25551802 |
Christoffersen C and Nielsen LB | Apolipoprotein M: bridging HDL and endothelial function. | 2013 | Curr. Opin. Lipidol. | pmid:23652568 |
Egom EE et al. | HDL quality or cholesterol cargo: what really matters--spotlight on sphingosine-1-phosphate-rich HDL. | 2013 | Curr. Opin. Lipidol. | pmid:23652570 |
Abdel-Latif A et al. | Lysophospholipids in coronary artery and chronic ischemic heart disease. | 2015 | Curr. Opin. Lipidol. | pmid:26270808 |
Jessup W | Lipid metabolism: sources and stability of plasma sphingosine-1-phosphate. | 2008 | Curr. Opin. Lipidol. | pmid:18769238 |
Tamama K and Okajima F | Sphingosine 1-phosphate signaling in atherosclerosis and vascular biology. | 2002 | Curr. Opin. Lipidol. | pmid:12352012 |
Huwiler A and Pfeilschifter J | Altering the sphingosine-1-phosphate/ceramide balance: a promising approach for tumor therapy. | 2006 | Curr. Pharm. Des. | pmid:17168766 |
Yatomi Y | Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. | 2006 | Curr. Pharm. Des. | pmid:16472149 |
Tölle M et al. | Relevance of sphingolipids in the pleiotropic protective effects of high-density lipoproteins. | 2010 | Curr. Pharm. Des. | pmid:20196741 |
Fogarty CE and Bergmann A | The Sound of Silence: Signaling by Apoptotic Cells. | 2015 | Curr. Top. Dev. Biol. | pmid:26431570 |
Rosen H et al. | The organization of the sphingosine 1-phosphate signaling system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728591 |
Hanson MA and Peach R | Structural biology of the S1P1 receptor. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728592 |
Cahalan SM | Chemical and genetic tools to explore S1P biology. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728593 |
Arnon TI and Cyster JG | Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728595 |
Oldstone MB and Rosen H | Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728596 |
Martin R and Sospedra M | Sphingosine-1 phosphate and central nervous system. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728597 |
Xiong Y and Hla T | S1P control of endothelial integrity. | 2014 | Curr. Top. Microbiol. Immunol. | pmid:24728594 |
Xia P and Wadham C | Sphingosine 1-phosphate, a key mediator of the cytokine network: juxtacrine signaling. | 2011 | Cytokine Growth Factor Rev. | pmid:21051273 |
Hirahara K et al. | Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. | 2010 | Cytokine Growth Factor Rev. | pmid:21084214 |
Gil PR et al. | Sphingosine 1-phosphate mediates chemotaxis of human primary fibroblasts via the S1P-receptor subtypes S1P₠and S1P₃ and Smad-signalling. | 2010 | Cytoskeleton (Hoboken) | pmid:20857421 |
Balczerski B et al. | Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. | 2012 | Dev. Biol. | pmid:22185793 |
Phan VH et al. | Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. | 2007 | Dev. Biol. | pmid:17706961 |
Wendler CC and Rivkees SA | Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. | 2006 | Dev. Biol. | pmid:16434032 |
Boyce BF | Sphingosine-1 phosphate: a new player in osteoimmunology. | 2009 | Dev. Cell | pmid:19289077 |
Fukui H et al. | S1P-Yap1 signaling regulates endoderm formation required for cardiac precursor cell migration in zebrafish. | 2014 | Dev. Cell | pmid:25313964 |
Chang CH and Randolph GJ | Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. | 2017 | Dev. Cell | pmid:28633013 |
Ma S et al. | A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. | 2017 | Dev. Cell | pmid:28535372 |
Okae H and Iwakura Y | Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice. | 2010 | Dev. Dyn. | pmid:20186915 |
Ohuchi H et al. | Expression patterns of the lysophospholipid receptor genes during mouse early development. | 2008 | Dev. Dyn. | pmid:18924241 |
MacLennan AJ et al. | Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth. | 2000 | Dev. Neurosci. | pmid:10965150 |
Fincher J et al. | G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate. | 2014 | Dev. Neurosci. | pmid:25138637 |
Nakajima C et al. | The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development. | 2014 | Development | pmid:25377550 |
Li G et al. | Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. | 2001 | Development | pmid:11566853 |
Mendelson K et al. | Sphingosine 1-phosphate signalling. | 2014 | Development | pmid:24346695 |
Edsbagge J et al. | Vascular function and sphingosine-1-phosphate regulate development of the dorsal pancreatic mesenchyme. | 2005 | Development | pmid:15689381 |
Pantoja M et al. | Genetic elevation of sphingosine 1-phosphate suppresses dystrophic muscle phenotypes in Drosophila. | 2013 | Development | pmid:23154413 |
Strochlic L et al. | A role for S1P signalling in axon guidance in the Xenopus visual system. | 2008 | Development | pmid:18077591 |
Laychock SG et al. | Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. | 2003 | Diabetes | pmid:12882914 |
Sauvé M et al. | Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. | 2016 | Diabetes | pmid:27207546 |
Mastrandrea LD et al. | Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. | 2005 | Diabetes | pmid:15855330 |
Lee SY et al. | Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. | 2017 | Diabetes | pmid:28698261 |
Srinivasan S et al. | Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. | 2008 | Diabetes | pmid:18003758 |
Rojas-Canales D et al. | Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. | 2017 | Diabetes | pmid:28174291 |
Bautista-Pérez R et al. | Sphingosine-1-phosphate induced vasoconstriction is increased in the isolated perfused kidneys of diabetic rats. | 2011 | Diabetes Res. Clin. Pract. | pmid:21775010 |
Fayyaz S et al. | Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. | 2014 | Diabetologia | pmid:24292566 |
Greenspon J et al. | Sphingosine-1-phosphate protects intestinal epithelial cells from apoptosis through the Akt signaling pathway. | 2009 | Dig. Dis. Sci. | pmid:18654850 |
Greenspon J et al. | Sphingosine-1-phosphate regulates the expression of adherens junction protein E-cadherin and enhances intestinal epithelial cell barrier function. | 2011 | Dig. Dis. Sci. | pmid:20936358 |
Nguyen-Tran DH et al. | Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. | 2014 | Dis Model Mech | pmid:24077965 |
Pattanaik D and Postlethwaite AE | A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis. | 2010 | Discov Med | pmid:20807477 |
Gao Y et al. | Sphingosine kinase 1 as an anticancer therapeutic target. | 2015 | Drug Des Devel Ther | pmid:26150697 |
Arish M et al. | Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. | 2016 | Drug Discov. Today | pmid:26456576 |
Snelder N et al. | Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation. | 2014 | Drug Metab. Dispos. | pmid:24965813 |
Ryan JJ and Spiegel S | The role of sphingosine-1-phosphate and its receptors in asthma. | 2008 | Drug News Perspect. | pmid:18389100 |
Waeber C et al. | Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors. | 2004 Jul-Aug | Drug News Perspect. | pmid:15334188 |
Tsai HC and Han MH | Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. | 2016 | Drugs | pmid:27318702 |
Sensken SC and Gräler MH | [Sphingolipids and their medical impact]. | 2009 | Dtsch. Med. Wochenschr. | pmid:19180419 |
Yangyuoru PM et al. | Determination of sphingosine kinase 2 activity using fluorescent sphingosine by capillary electrophoresis. | 2011 | Electrophoresis | pmid:21706498 |
Ryu J et al. | Sphingosine 1-phosphate as a regulator of osteoclast differentiation and osteoclast-osteoblast coupling. | 2006 | EMBO J. | pmid:17124500 |
Stam JC et al. | Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling. | 1998 | EMBO J. | pmid:9670021 |
Reichardt P et al. | A role for LFA-1 in delaying T-lymphocyte egress from lymph nodes. | 2013 | EMBO J. | pmid:23443048 |
Meyer zu Heringdorf D et al. | Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. | 1998 | EMBO J. | pmid:9582276 |
Postma FR et al. | Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. | 1996 | EMBO J. | pmid:8665846 |
Bünemann M et al. | A novel membrane receptor with high affinity for lysosphingomyelin and sphingosine 1-phosphate in atrial myocytes. | 1996 | EMBO J. | pmid:8896446 |
Pierre SC et al. | PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. | 2004 | EMBO J. | pmid:15257286 |
Ponnusamy S et al. | Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis. | 2012 | EMBO Mol Med | pmid:22707406 |
Burnett C and Howard K | Fly and mammalian lipid phosphate phosphatase isoforms differ in activity both in vitro and in vivo. | 2003 | EMBO Rep. | pmid:12856002 |