MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Wang W et al. | Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells. | 2004 | FASEB J. | pmid:15084513 |
Dudek SM et al. | Pulmonary endothelial cell barrier enhancement by sphingosine 1-phosphate: roles for cortactin and myosin light chain kinase. | 2004 | J. Biol. Chem. | pmid:15056655 |
Saba JD and Hla T | Point-counterpoint of sphingosine 1-phosphate metabolism. | 2004 | Circ. Res. | pmid:15059942 |
Miura Y et al. | Independence of tumor necrosis factor-alpha-induced adhesion molecule expression from sphingosine 1-phosphate signaling in vascular endothelial cells. | 2004 | J. Thromb. Haemost. | pmid:15140149 |
Garg SK et al. | Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo. | 2004 | J. Infect. Dis. | pmid:15143482 |
Hale JJ et al. | Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15149705 |
Oshima Y et al. | Intraocular gutless adenoviral-vectored VEGF stimulates anterior segment but not retinal neovascularization. | 2004 | J. Cell. Physiol. | pmid:15095287 |
Meacci E et al. | Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | 2004 | Biochem. J. | pmid:15109308 |
Lim HS et al. | Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109640 |
Cui J et al. | Role of ceramide in ischemic preconditioning. | 2004 | J. Am. Coll. Surg. | pmid:15110811 |
Jolly PS et al. | Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. | 2004 | J. Exp. Med. | pmid:15067032 |
Segura BJ et al. | Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells. | 2004 | J. Surg. Res. | pmid:14732348 |
Sanna MG et al. | Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. | 2004 | J. Biol. Chem. | pmid:14732717 |
Forrest M et al. | Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14747617 |
Peng X et al. | Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15020292 |
Kohno T and Igarashi Y | Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells. | 2004 | Glycoconj. J. | pmid:15750791 |
Ochi S et al. | Clostridium perfringens alpha-toxin activates the sphingomyelin metabolism system in sheep erythrocytes. | 2004 | J. Biol. Chem. | pmid:14702348 |
Hammer S et al. | Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation. | 2004 | J. Cell. Biochem. | pmid:14991774 |
Tokuda H et al. | Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. | 2004 | J. Cell. Biochem. | pmid:15034939 |
Bhattacharya J | Lung injury: sphingosine-1-phosphate to the rescue. | 2004 | Am. J. Respir. Crit. Care Med. | pmid:15504814 |
Hedemann J et al. | Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. | 2004 | Auton Autacoid Pharmacol | pmid:15541015 |
Kumar A et al. | Sphingosine-1-phosphate plays a role in the suppression of lateral pseudopod formation during Dictyostelium discoideum cell migration and chemotaxis. | 2004 | Cell Motil. Cytoskeleton | pmid:15476260 |
Sun C and Bittman R | An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with alpha-lithiated alkylphosphonic esters. | 2004 | J. Org. Chem. | pmid:15497998 |
Wang FX et al. | mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15498114 |
Nakamura H et al. | Effects of synthetic sphingosine-1-phosphate analogs on arachidonic acid metabolism and cell death. | 2004 | Biochem. Pharmacol. | pmid:15498509 |
Billich A and Ettmayer P | Fluorescence-based assay of sphingosine kinases. | 2004 | Anal. Biochem. | pmid:14769343 |
Amano S et al. | Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids. | 2004 | Br. J. Dermatol. | pmid:15541073 |
Butler J et al. | Functional characterization of sphingosine 1-phosphate receptor agonist in human endothelial cells. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165029 |
Chae SS et al. | Constitutive expression of the S1P1 receptor in adult tissues. | 2004 | Prostaglandins Other Lipid Mediat. | pmid:15165038 |
Geoffroy K et al. | Bimodal effect of advanced glycation end products on mesangial cell proliferation is mediated by neutral ceramidase regulation and endogenous sphingolipids. | 2004 | J. Biol. Chem. | pmid:15184394 |
Xin C et al. | Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses. | 2004 | J. Biol. Chem. | pmid:15192102 |
Baudhuin LM et al. | S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). | 2004 | FASEB J. | pmid:14657000 |
Otala M et al. | Protection from radiation-induced male germ cell loss by sphingosine-1-phosphate. | 2004 | Biol. Reprod. | pmid:14613902 |
Kelley GG et al. | Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. | 2004 | Biochem. J. | pmid:14567755 |
Sutphen R et al. | Lysophospholipids are potential biomarkers of ovarian cancer. | 2004 | Cancer Epidemiol. Biomarkers Prev. | pmid:15247129 |
Sauer B et al. | Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. | 2004 | J. Biol. Chem. | pmid:15247277 |
Roviezzo F et al. | Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15254297 |
Hla T | Physiological and pathological actions of sphingosine 1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271296 |
Payne SG et al. | Modulation of adaptive immune responses by sphingosine-1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271297 |
Oskouian B and Saba JD | Death and taxis: what non-mammalian models tell us about sphingosine-1-phosphate. | 2004 | Semin. Cell Dev. Biol. | pmid:15271298 |
Matsushita K et al. | Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273282 |
Augé N et al. | Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation. | 2004 | Circulation | pmid:15277330 |
Chavakis T et al. | Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis. | 2004 | FASEB J. | pmid:15208269 |
Xu CB et al. | Sphingosine signaling and atherogenesis. | 2004 | Acta Pharmacol. Sin. | pmid:15210056 |
Yokoo E et al. | Sphingosine 1-phosphate inhibits migration of RBL-2H3 cells via S1P2: cross-talk between platelets and mast cells. | 2004 | J. Biochem. | pmid:15213242 |
Pierre SC et al. | PAM mediates sustained inhibition of cAMP signaling by sphingosine-1-phosphate. | 2004 | EMBO J. | pmid:15257286 |
McVerry BJ and Garcia JG | Endothelial cell barrier regulation by sphingosine 1-phosphate. | 2004 | J. Cell. Biochem. | pmid:15258893 |
Karliner JS | Mechanisms of cardioprotection by lysophospholipids. | 2004 | J. Cell. Biochem. | pmid:15258895 |
Goetzl EJ et al. | Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system. | 2004 | J. Cell. Biochem. | pmid:15258896 |
Deretic D et al. | Phosphoinositides, ezrin/moesin, and rac1 regulate fusion of rhodopsin transport carriers in retinal photoreceptors. | 2004 | Mol. Biol. Cell | pmid:13679519 |