MeSH term | MeSH ID | Detail |
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Lung Neoplasms | D008175 | 171 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Rieken S et al. | Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11). | 2006 | J. Biol. Chem. | pmid:17023430 |
Murph M et al. | Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer. | 2006 | Clin. Cancer Res. | pmid:17121877 |
Fisher KE et al. | Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling. | 2006 | Mol. Cancer | pmid:17156449 |
Pan S et al. | A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. | 2006 | Chem. Biol. | pmid:17114004 |
Lee JF et al. | Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. | 2006 | J. Biol. Chem. | pmid:16891661 |
Zheng DM et al. | Sphingosine 1-phosphate protects rat liver sinusoidal endothelial cells from ethanol-induced apoptosis: Role of intracellular calcium and nitric oxide. | 2006 | Hepatology | pmid:17058266 |
Kabashima K et al. | Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. | 2006 | J. Exp. Med. | pmid:17101733 |
Keller M et al. | Sphingosine kinase functionally links elevated transmural pressure and increased reactive oxygen species formation in resistance arteries. | 2006 | FASEB J. | pmid:16476702 |
Wendler CC and Rivkees SA | Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. | 2006 | Dev. Biol. | pmid:16434032 |
Wattenberg BW et al. | The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function. | 2006 | J. Lipid Res. | pmid:16520486 |
Czyborra C et al. | Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine. | 2006 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16521006 |
Lin CI et al. | Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism. | 2006 | J. Cell. Biochem. | pmid:16795034 |
Durand CA et al. | The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | 2006 | Eur. J. Immunol. | pmid:16821235 |
Giussani P et al. | Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. | 2006 | Mol. Cell. Biol. | pmid:16782891 |
Sanna MG et al. | Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. | 2006 | Nat. Chem. Biol. | pmid:16829954 |
Veracini L et al. | Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles. | 2006 | J. Cell. Sci. | pmid:16787943 |
Laychock SG et al. | Sphingosine 1-phosphate affects cytokine-induced apoptosis in rat pancreatic islet beta-cells. | 2006 | Endocrinology | pmid:16794003 |
Oz-Arslan D et al. | IL-6 and IL-8 release is mediated via multiple signaling pathways after stimulating dendritic cells with lysophospholipids. | 2006 | J. Leukoc. Biol. | pmid:16769764 |
Garbers DL et al. | Membrane guanylyl cyclase receptors: an update. | 2006 | Trends Endocrinol. Metab. | pmid:16815030 |
Yan L et al. | 2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors. | 2006 | Bioorg. Med. Chem. Lett. | pmid:16621543 |
Venkataraman K et al. | Extracellular export of sphingosine kinase-1a contributes to the vascular S1P gradient. | 2006 | Biochem. J. | pmid:16623665 |
Weigert A et al. | Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. | 2006 | Blood | pmid:16690965 |
Ozbay T et al. | Cyclic adenosine 5'-monophosphate-dependent sphingosine-1-phosphate biosynthesis induces human CYP17 gene transcription by activating cleavage of sterol regulatory element binding protein 1. | 2006 | Endocrinology | pmid:16306078 |
Kobayashi N et al. | Sphingosine 1-phosphate is released from the cytosol of rat platelets in a carrier-mediated manner. | 2006 | J. Lipid Res. | pmid:16371645 |
Kono M et al. | Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids. | 2006 | J. Biol. Chem. | pmid:16380386 |
von Otte S et al. | Follicular fluid high density lipoprotein-associated sphingosine 1-phosphate is a novel mediator of ovarian angiogenesis. | 2006 | J. Biol. Chem. | pmid:16365044 |
Alewijnse AE and Michel MC | Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? | 2006 | Br. J. Pharmacol. | pmid:16402045 |
Mathieson FA and Nixon GF | Sphingolipids differentially regulate mitogen-activated protein kinases and intracellular Ca2+ in vascular smooth muscle: effects on CREB activation. | 2006 | Br. J. Pharmacol. | pmid:16402047 |
di Villa Bianca Rd et al. | Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16234413 |
Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
Matsuyuki H et al. | Involvement of sphingosine 1-phosphate (S1P) receptor type 1 and type 4 in migratory response of mouse T cells toward S1P. | 2006 | Cell. Mol. Immunol. | pmid:17257496 |
Schmidt H et al. | LC-MS/MS-analysis of sphingosine-1-phosphate and related compounds in plasma samples. | 2006 | Prostaglandins Other Lipid Mediat. | pmid:17085324 |
Massberg S and von Andrian UH | Fingolimod and sphingosine-1-phosphate--modifiers of lymphocyte migration. | 2006 | N. Engl. J. Med. | pmid:16971715 |
Jun DJ et al. | Sphingosine-1-phosphate modulates both lipolysis and leptin production in differentiated rat white adipocytes. | 2006 | Endocrinology | pmid:16973728 |
Natarajan J et al. | Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line. | 2006 | BMC Bioinformatics | pmid:16901352 |
Young N and Van Brocklyn JR | Signal transduction of sphingosine-1-phosphate G protein-coupled receptors. | 2006 | ScientificWorldJournal | pmid:16906327 |
Hait NC et al. | Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. | 2006 | Biochim. Biophys. Acta | pmid:16996023 |
Minshall RD and Malik AB | Transport across the endothelium: regulation of endothelial permeability. | 2006 | Handb Exp Pharmacol | pmid:16999218 |
Smicun Y et al. | S1P regulation of ovarian carcinoma invasiveness. | 2006 | Gynecol. Oncol. | pmid:16956652 |
Naetzker S et al. | Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. | 2006 | Genes Cells | pmid:16483315 |
Jurisicova A et al. | Molecular requirements for doxorubicin-mediated death in murine oocytes. | 2006 | Cell Death Differ. | pmid:16439991 |
Bassi R et al. | Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. | 2006 | Glia | pmid:16470810 |
Yatomi Y | Sphingosine 1-phosphate in vascular biology: possible therapeutic strategies to control vascular diseases. | 2006 | Curr. Pharm. Des. | pmid:16472149 |
Kurobe H et al. | CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. | 2006 | Immunity | pmid:16473829 |
Kitano M et al. | Sphingosine 1-phosphate/sphingosine 1-phosphate receptor 1 signaling in rheumatoid synovium: regulation of synovial proliferation and inflammatory gene expression. | 2006 | Arthritis Rheum. | pmid:16508938 |
Hsieh HL et al. | Sphingosine-1-phosphate induces COX-2 expression via PI3K/Akt and p42/p44 MAPK pathways in rat vascular smooth muscle cells. | 2006 | J. Cell. Physiol. | pmid:16508949 |
Becciolini L et al. | Sphingosine 1-phosphate inhibits cell migration in C2C12 myoblasts. | 2006 | Biochim. Biophys. Acta | pmid:16510307 |
Song HJ et al. | Sphingosine 1-phosphate-induced signal transduction in cat esophagus smooth muscle cells. | 2006 | Mol. Cells | pmid:16511346 |
Takai S et al. | Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. | 2006 | J. Cell. Biochem. | pmid:16514645 |
Idzko M et al. | Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function. | 2006 | J. Clin. Invest. | pmid:17080194 |