MeSH term | MeSH ID | Detail |
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Farber Lipogranulomatosis | D055577 | 1 associated lipids |
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Pathway name | Related literatures |
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Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Kang H et al. | Fluid shear stress modulates endothelial cell invasion into three-dimensional collagen matrices. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18805898 |
Wymann MP and Schneiter R | Lipid signalling in disease. | 2008 | Nat. Rev. Mol. Cell Biol. | pmid:18216772 |
Schüppel M et al. | Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype. | 2008 | J. Invest. Dermatol. | pmid:18219276 |
Tauseef M et al. | Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. | 2008 | Circ. Res. | pmid:18849324 |
Hinkovska-Galcheva V et al. | The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis. | 2008 | Curr Opin Investig Drugs | pmid:18951299 |
Sensken SC et al. | Selective activation of G alpha i mediated signalling of S1P3 by FTY720-phosphate. | 2008 | Cell. Signal. | pmid:18313900 |
Kunisawa J et al. | Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. | 2008 | Blood | pmid:18292290 |
Nicol GD | Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. | 2008 | Sheng Li Xue Bao | pmid:18958367 |
Park HY et al. | K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin. | 2008 | Exp. Dermatol. | pmid:18341573 |
Sabourdy F et al. | Functions of sphingolipid metabolism in mammals--lessons from genetic defects. | 2008 | Biochim. Biophys. Acta | pmid:18294974 |
Gorshkova I et al. | Protein kinase C-epsilon regulates sphingosine 1-phosphate-mediated migration of human lung endothelial cells through activation of phospholipase D2, protein kinase C-zeta, and Rac1. | 2008 | J. Biol. Chem. | pmid:18296444 |
Means CK et al. | S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. | 2008 | J. Biol. Chem. | pmid:18296752 |
Dyatlovitskaya EV | Sphingolipid receptors. | 2008 | Biochemistry Mosc. | pmid:18298366 |
Leclercq TM et al. | Eukaryotic elongation factor 1A interacts with sphingosine kinase and directly enhances its catalytic activity. | 2008 | J. Biol. Chem. | pmid:18263879 |
Moriue T et al. | Sphingosine 1-phosphate attenuates H2O2-induced apoptosis in endothelial cells. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18267109 |
Malchinkhuu E et al. | S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18088600 |
Meacci E et al. | Sphingosine kinase activity is required for myogenic differentiation of C2C12 myoblasts. | 2008 | J. Cell. Physiol. | pmid:17654519 |
Fortier S et al. | Silencing of the MT1-MMP/ G6PT axis suppresses calcium mobilization by sphingosine-1-phosphate in glioblastoma cells. | 2008 | FEBS Lett. | pmid:18267120 |
Kim HL et al. | Characterization of N,N,-dimethyl-D-erythro-sphingosine-induced apoptosis and signaling in U937 cells: independence of sphingosine kinase inhibition. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18316219 |
Huwiler A and Pfeilschifter J | New players on the center stage: sphingosine 1-phosphate and its receptors as drug targets. | 2008 | Biochem. Pharmacol. | pmid:18321471 |
Jo SK et al. | Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. | 2008 | Kidney Int. | pmid:18322542 |
Hughes JE et al. | Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. | 2008 | Circ. Res. | pmid:18323526 |
Li X et al. | Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1. | 2008 | Blood | pmid:18199826 |
Lichte K et al. | Lysophospholipid receptor-mediated calcium signaling in human keratinocytes. | 2008 | J. Invest. Dermatol. | pmid:18172456 |
Hong JH et al. | K6PC-5, a direct activator of sphingosine kinase 1, promotes epidermal differentiation through intracellular Ca2+ signaling. | 2008 | J. Invest. Dermatol. | pmid:18385762 |
Lebman DA and Spiegel S | Cross-talk at the crossroads of sphingosine-1-phosphate, growth factors, and cytokine signaling. | 2008 | J. Lipid Res. | pmid:18387885 |
Nishiuma T et al. | Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. | 2008 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:18359884 |
Liu HB et al. | Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis. | 2008 | Pancreas | pmid:18362832 |
Yatomi Y | [Physiologically active substances derived from activated platelets: overview in clinical medicine]. | 2008 | Nippon Naika Gakkai Zasshi | pmid:18363212 |
Dueñas AI et al. | Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate. | 2008 | Cardiovasc. Res. | pmid:18411230 |
Hashimoto M et al. | Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor. | 2008 | Am. J. Respir. Cell Mol. Biol. | pmid:18367729 |
Ryan JJ and Spiegel S | The role of sphingosine-1-phosphate and its receptors in asthma. | 2008 | Drug News Perspect. | pmid:18389100 |
Bansal G et al. | RGS13 controls g protein-coupled receptor-evoked responses of human mast cells. | 2008 | J. Immunol. | pmid:19017978 |
Pasquaré SJ et al. | Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments. | 2008 | Neurochem. Res. | pmid:18288612 |
Lai WQ et al. | Anti-inflammatory effects of sphingosine kinase modulation in inflammatory arthritis. | 2008 | J. Immunol. | pmid:19017993 |
Jiang H et al. | Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices. | 2008 | FASEB J. | pmid:18272655 |
Valentine WJ et al. | Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors. | 2008 | J. Biol. Chem. | pmid:18316373 |
Rivera-Lopez CM et al. | Lysophosphatidic acid (LPA) and angiogenesis. | 2008 | Angiogenesis | pmid:18504643 |
Serebrov VY et al. | Functional activity of sphingomyelin cycle in rat liver in chronic toxic hepatitis. | 2008 | Bull. Exp. Biol. Med. | pmid:19513367 |
Li MH et al. | Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. | 2008 | Mol. Cancer Res. | pmid:18922980 |
Devine KM et al. | S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac. | 2008 | Gynecol. Oncol. | pmid:18513786 |
Kimura A et al. | Antagonism of sphingosine 1-phosphate receptor-2 enhances migration of neural progenitor cells toward an area of brain. | 2008 | Stroke | pmid:18757288 |
Yoon CM et al. | Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways. | 2008 | Blood | pmid:18541717 |
Melendez AJ | Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets. | 2008 | Biochim. Biophys. Acta | pmid:17913601 |
Hsieh HL et al. | Sphingosine 1-phosphate induces EGFR expression via Akt/NF-kappaB and ERK/AP-1 pathways in rat vascular smooth muscle cells. | 2008 | J. Cell. Biochem. | pmid:17902169 |
Murakami M et al. | Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18466763 |
Wang D et al. | S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells. | 2008 | Mol. Cancer Ther. | pmid:18645009 |
Takuwa Y et al. | Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. | 2008 | Biochim. Biophys. Acta | pmid:18472021 |
Takabe K et al. | "Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets. | 2008 | Pharmacol. Rev. | pmid:18552276 |
Facchinetti MM et al. | Stratification of sphingosine kinase-1 expression and activity in rat kidney. | 2008 | Cells Tissues Organs (Print) | pmid:18552482 |
Hla T et al. | The vascular S1P gradient-cellular sources and biological significance. | 2008 | Biochim. Biophys. Acta | pmid:18674637 |
Kono M et al. | Sphingosine-1-phosphate regulation of mammalian development. | 2008 | Biochim. Biophys. Acta | pmid:18675379 |
Tanaka R et al. | Cell-culture-dependent change of Ca2+ response of rat aortic myocytes to sphingosine-1-phosphate. | 2008 | J. Pharmacol. Sci. | pmid:18678983 |
Alvero AB et al. | Anti-tumor activity of phenoxodiol: from bench to clinic. | 2008 | Future Oncol | pmid:18684059 |
Swaney JS et al. | Sphingosine-1-phosphate (S1P) is a novel fibrotic mediator in the eye. | 2008 | Exp. Eye Res. | pmid:18687328 |
Shida D et al. | Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. | 2008 | Cancer Res. | pmid:18701480 |
Zeidan YH et al. | Molecular targeting of acid ceramidase: implications to cancer therapy. | 2008 | Curr Drug Targets | pmid:18691012 |
Argraves KM et al. | High density lipoprotein-associated sphingosine 1-phosphate promotes endothelial barrier function. | 2008 | J. Biol. Chem. | pmid:18606817 |
González-DÃez M et al. | Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. | 2008 | Thromb. Haemost. | pmid:18612546 |
Jin YZ et al. | Reciprocal function of Galphai2 and Galphai3 in graft-versus-host disease. | 2008 | Eur. J. Immunol. | pmid:18521956 |
Pyne NJ and Pyne S | Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination. | 2008 | Biochim. Biophys. Acta | pmid:18558100 |
Lynch KR and Macdonald TL | Sphingosine 1-phosphate chemical biology. | 2008 | Biochim. Biophys. Acta | pmid:18638568 |
Igarashi J and Michel T | S1P and eNOS regulation. | 2008 | Biochim. Biophys. Acta | pmid:18638569 |
Machesky NJ et al. | Human cytomegalovirus regulates bioactive sphingolipids. | 2008 | J. Biol. Chem. | pmid:18644793 |
Löf C et al. | Overexpression of TRPC3 reduces the content of intracellular calcium stores in HEK-293 cells. | 2008 | J. Cell. Physiol. | pmid:18431718 |
Kihara A and Igarashi Y | Production and release of sphingosine 1-phosphate and the phosphorylated form of the immunomodulator FTY720. | 2008 | Biochim. Biophys. Acta | pmid:18555808 |
Worrall D et al. | Involvement of sphingosine kinase in plant cell signalling. | 2008 | Plant J. | pmid:18557834 |
Heller R et al. | Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. | 2008 | Cardiovasc. Res. | pmid:18558630 |
Levkau B | Sphingosine-1-phosphate in the regulation of vascular tone: a finely tuned integration system of S1P sources, receptors, and vascular responsiveness. | 2008 | Circ. Res. | pmid:18669929 |
Bollag WB | Potential role of sphingosine 1-phosphate in the pathogenesis of rheumatoid arthritis. | 2008 | J. Lipid Res. | pmid:18669980 |
Yan G et al. | Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids. | 2008 | Cardiovasc. Res. | pmid:18192241 |
Vessey DA et al. | Combined sphingosine, S1P and ischemic postconditioning rescue the heart after protracted ischemia. | 2008 | Biochem. Biophys. Res. Commun. | pmid:18706887 |
Ryser MF et al. | S1P(1) overexpression stimulates S1P-dependent chemotaxis of human CD34+ hematopoietic progenitor cells but strongly inhibits SDF-1/CXCR4-dependent migration and in vivo homing. | 2008 | Mol. Immunol. | pmid:18760838 |
Gude DR et al. | Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. | 2008 | FASEB J. | pmid:18362204 |
Lucki NC and Sewer MB | Multiple roles for sphingolipids in steroid hormone biosynthesis. | 2008 | Subcell. Biochem. | pmid:18751920 |
Saddoughi SA et al. | Roles of bioactive sphingolipids in cancer biology and therapeutics. | 2008 | Subcell. Biochem. | pmid:18751921 |
Billich A and Baumruker T | Sphingolipid metabolizing enzymes as novel therapeutic targets. | 2008 | Subcell. Biochem. | pmid:18751924 |
Ullrich T et al. | Synthesis and immobilization of erythro-C14-omega-aminosphingosine-1-phosphate as a potential tool for affinity chromatography. | 2008 | ChemMedChem | pmid:18000941 |
Fulton D et al. | Agonist-stimulated endothelial nitric oxide synthase activation and vascular relaxation. Role of eNOS phosphorylation at Tyr83. | 2008 | Circ. Res. | pmid:18096817 |
Strochlic L et al. | A role for S1P signalling in axon guidance in the Xenopus visual system. | 2008 | Development | pmid:18077591 |
Simonaro CM et al. | Mechanism of glycosaminoglycan-mediated bone and joint disease: implications for the mucopolysaccharidoses and other connective tissue diseases. | 2008 | Am. J. Pathol. | pmid:18079441 |
Zabielski P et al. | Bezafibrate decreases growth stimulatory action of the sphingomyelin signaling pathway in regenerating rat liver. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18024222 |
Ohuchi H et al. | Expression patterns of the lysophospholipid receptor genes during mouse early development. | 2008 | Dev. Dyn. | pmid:18924241 |
Landeen LK et al. | Mechanisms of the negative inotropic effects of sphingosine-1-phosphate on adult mouse ventricular myocytes. | 2008 | Am. J. Physiol. Heart Circ. Physiol. | pmid:18024550 |
Sekiguchi M et al. | Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. | 2008 | J. Immunol. | pmid:18209090 |
Brunati AM et al. | Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. | 2008 | Biochim. Biophys. Acta | pmid:18157950 |
Gingras D et al. | Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells. | 2008 | FEBS Lett. | pmid:18164686 |
Laviad EL et al. | Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate. | 2008 | J. Biol. Chem. | pmid:18165233 |
Hammad SM et al. | Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. | 2008 | Prostaglandins Other Lipid Mediat. | pmid:18166496 |
Tan W et al. | An essential role for Rac1 in endothelial cell function and vascular development. | 2008 | FASEB J. | pmid:18245172 |
Wang L et al. | Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells. | 2008 | Histochem. Cell Biol. | pmid:18247041 |
Venkataraman K et al. | Vascular endothelium as a contributor of plasma sphingosine 1-phosphate. | 2008 | Circ. Res. | pmid:18258856 |
Hadizadeh S et al. | Sphingosine-1-phosphate regulates the expression of the liver receptor homologue-1. | 2008 | Mol. Cell. Endocrinol. | pmid:18191017 |
van der Giet M et al. | Relevance and potential of sphingosine-1-phosphate in vascular inflammatory disease. | 2008 | Biol. Chem. | pmid:18925828 |
Lee KJ et al. | Determination of sphingosine kinase activity for cellular signaling studies. | 2008 | Anal. Chem. | pmid:18197698 |
Dustin ML and Chakraborty AK | Tug of war at the exit door. | 2008 | Immunity | pmid:18199414 |
Severinson E | WASp stings mature lymphocytes. | 2008 | Blood | pmid:18988873 |
Onions VJ et al. | Ovarian tissue viability following whole ovine ovary cryopreservation: assessing the effects of sphingosine-1-phosphate inclusion. | 2008 | Hum. Reprod. | pmid:18216042 |
Coste O et al. | Sphingosine 1-phosphate modulates spinal nociceptive processing. | 2008 | J. Biol. Chem. | pmid:18805787 |
Hannun YA and Obeid LM | Principles of bioactive lipid signalling: lessons from sphingolipids. | 2008 | Nat. Rev. Mol. Cell Biol. | pmid:18216770 |