| MeSH term | MeSH ID | Detail |
|---|---|---|
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Herr DR and Chun J | Effects of LPA and S1P on the nervous system and implications for their involvement in disease. | 2007 | Curr Drug Targets | pmid:17266539 |
| Huwiler A and Zangemeister-Wittke U | Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. | 2007 | Crit. Rev. Oncol. Hematol. | pmid:17560117 |
| Pchejetski D et al. | Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. | 2007 | Circ. Res. | pmid:17158340 |
| Omori K et al. | Edaravone mimics sphingosine-1-phosphate-induced endothelial barrier enhancement in human microvascular endothelial cells. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17686998 |
| Keul P et al. | The sphingosine-1-phosphate analogue FTY720 reduces atherosclerosis in apolipoprotein E-deficient mice. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17158351 |
| Walter DH et al. | Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17158356 |
| Phan VH et al. | Disruption of sphingolipid metabolism elicits apoptosis-associated reproductive defects in Drosophila. | 2007 | Dev. Biol. | pmid:17706961 |
| Mechtcheriakova D et al. | Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. | 2007 | Cell. Signal. | pmid:17113265 |
| Fujiwara Y et al. | Identification of the hydrophobic ligand binding pocket of the S1P1 receptor. | 2007 | J. Biol. Chem. | pmid:17114791 |
| Ki SH et al. | Galpha12 specifically regulates COX-2 induction by sphingosine 1-phosphate. Role for JNK-dependent ubiquitination and degradation of IkappaBalpha. | 2007 | J. Biol. Chem. | pmid:17098744 |
| Formigli L et al. | Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts. | 2007 | J. Cell. Physiol. | pmid:17295211 |
| Barthomeuf C | Inhibition of S1P-induced angiogenesis, metastasis and inflammation by dietary polyphenols. | 2007 | Free Radic. Biol. Med. | pmid:17189837 |
| Currie JC et al. | MT1-MMP down-regulates the glucose 6-phosphate transporter expression in marrow stromal cells: a molecular link between pro-MMP-2 activation, chemotaxis, and cell survival. | 2007 | J. Biol. Chem. | pmid:17229722 |
| Johnstone ED et al. | Epidermal growth factor and sphingosine-1-phosphate stimulate Na+/H+ exchanger activity in the human placental syncytiotrophoblast. | 2007 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:17913870 |
| Koh E et al. | Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors. | 2007 | Cancer Lett. | pmid:17189669 |
| Masuko K et al. | Sphingosine-1-phosphate attenuates proteoglycan aggrecan expression via production of prostaglandin E2 from human articular chondrocytes. | 2007 | BMC Musculoskelet Disord | pmid:17374154 |
| Young N and Van Brocklyn JR | Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness. | 2007 | Exp. Cell Res. | pmid:17376432 |
| Nakamura T et al. | Synthesis and SAR studies of a novel class of S1P1 receptor antagonists. | 2007 | Bioorg. Med. Chem. | pmid:17379528 |
| Zhao Y et al. | Intracellular generation of sphingosine 1-phosphate in human lung endothelial cells: role of lipid phosphate phosphatase-1 and sphingosine kinase 1. | 2007 | J. Biol. Chem. | pmid:17379599 |
| Nodai A et al. | Sphingosine 1-phosphate induces cyclooxygenase-2 via Ca2+-dependent, but MAPK-independent mechanism in rat vascular smooth muscle cells. | 2007 | Life Sci. | pmid:17382352 |
| Baumruker T et al. | FTY720, an immunomodulatory sphingolipid mimetic: translation of a novel mechanism into clinical benefit in multiple sclerosis. | 2007 | Expert Opin Investig Drugs | pmid:17302523 |
| Baran Y et al. | Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia cells. | 2007 | J. Biol. Chem. | pmid:17303574 |
| Chandru H and Boggaram V | The role of sphingosine 1-phosphate in the TNF-alpha induction of IL-8 gene expression in lung epithelial cells. | 2007 | Gene | pmid:17306937 |
| Jung ID et al. | Sphingosine kinase inhibitor suppresses a Th1 polarization via the inhibition of immunostimulatory activity in murine bone marrow-derived dendritic cells. | 2007 | Int. Immunol. | pmid:17307797 |
| Molderings GJ et al. | S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. | 2007 | Neurochem. Int. | pmid:17559976 |
| Baranowski M et al. | PPARalpha agonist induces the accumulation of ceramide in the heart of rats fed high-fat diet. | 2007 | J. Physiol. Pharmacol. | pmid:17440226 |
| Kimura T et al. | [Measurement of sphingosine 1-phosphate as a biomarker of atherosclerosis]. | 2007 | Rinsho Byori | pmid:17511266 |
| Baranowski M et al. | Pioglitazone induces de novo ceramide synthesis in the rat heart. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17259076 |
| Aoki S et al. | Fluid shear stress enhances the sphingosine 1-phosphate responses in cell-cell interactions between platelets and endothelial cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17512899 |
| Huang MC et al. | Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice. | 2007 | J. Immunol. | pmid:17513728 |
| Kontush A et al. | Preferential sphingosine-1-phosphate enrichment and sphingomyelin depletion are key features of small dense HDL3 particles: relevance to antiapoptotic and antioxidative activities. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17569880 |
| Rosen H et al. | Tipping the gatekeeper: S1P regulation of endothelial barrier function. | 2007 | Trends Immunol. | pmid:17276731 |
| Liao JJ et al. | Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate. | 2007 | J. Immunol. | pmid:17442922 |
| Choi CH et al. | Sphingosine 1-phosphate and sphingosine kinase activity during chicken embryonic development. | 2007 | Arch. Pharm. Res. | pmid:17489368 |
| Donati C et al. | Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. | 2007 | Stem Cells | pmid:17464089 |
| Naor MM et al. | Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences. | 2007 | J. Mol. Graph. Model. | pmid:17467317 |
| Jin ZQ et al. | A sphingosine kinase 1 mutation sensitizes the myocardium to ischemia/reperfusion injury. | 2007 | Cardiovasc. Res. | pmid:17610857 |
| Karahatay S et al. | Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. | 2007 | Cancer Lett. | pmid:17619081 |
| Oskeritzian CA et al. | Sphingosine-1-phosphate in allergic responses, asthma and anaphylaxis. | 2007 | Pharmacol. Ther. | pmid:17669501 |
| Xu M et al. | Sphingosine 1-phosphate rapidly increases endothelial barrier function independently of VE-cadherin but requires cell spreading and Rho kinase. | 2007 | Am. J. Physiol., Cell Physiol. | pmid:17670896 |
| Santucci MB et al. | Sphingosine 1-phosphate promotes antigen processing and presentation to CD4+ T cells in Mycobacterium tuberculosis-infected monocytes. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17673170 |
| Tao R et al. | Deletion of the sphingosine kinase-1 gene influences cell fate during hypoxia and glucose deprivation in adult mouse cardiomyocytes. | 2007 | Cardiovasc. Res. | pmid:17320845 |
| Roviezzo F et al. | Sphingosine-1-phosphate/sphingosine kinase pathway is involved in mouse airway hyperresponsiveness. | 2007 | Am. J. Respir. Cell Mol. Biol. | pmid:17322125 |
| Kajimoto T et al. | Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. | 2007 | Mol. Cell. Biol. | pmid:17325039 |
| Nombela-Arrieta C et al. | A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress. | 2007 | J. Exp. Med. | pmid:17325199 |
| Osada M et al. | Involvement of sphingosine 1-phosphate, a platelet-derived bioactive lipid, in contraction of mesangium cells. | 2007 | J. Biochem. | pmid:17646176 |
| Lin CI et al. | Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17331465 |
| Koh E et al. | Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation. | 2007 | Cell. Signal. | pmid:17307336 |
| Torkhovskaya TI et al. | Lysophospholipid receptors in cell signaling. | 2007 | Biochemistry Mosc. | pmid:17367289 |
| Soares R and Azevedo I | Inhibition of S1P by polyphenols prevents inflammation and angiogenesis: NFkappaB, a downstream effector? | 2007 | Free Radic. Biol. Med. | pmid:17189836 |