| MeSH term | MeSH ID | Detail |
|---|---|---|
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Williams PA et al. | Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). | 2015 | PLoS ONE | pmid:25875493 |
| Engel N et al. | Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. | 2017 | PLoS ONE | pmid:28125641 |
| Mair N et al. | Genetic evidence for involvement of neuronally expressed S1Pâ‚ receptor in nociceptor sensitization and inflammatory pain. | 2011 | PLoS ONE | pmid:21359147 |
| Vogel P et al. | Incomplete inhibition of sphingosine 1-phosphate lyase modulates immune system function yet prevents early lethality and non-lymphoid lesions. | 2009 | PLoS ONE | pmid:19119317 |
| Matheu MP et al. | Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy. | 2013 | PLoS ONE | pmid:23533579 |
| Malik FA et al. | Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity. | 2015 | PLoS ONE | pmid:26079370 |
| Wang X et al. | Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. | 2016 | PLoS Pathog. | pmid:27711202 |
| Salata D et al. | [Sphingosine-1-phosphate--molecular maestro]. | 2012 | Postepy Biochem. | pmid:23373414 |
| Kurek K et al. | [The role of sphingolipids in selected cardiovascular diseases]. | 2013 | Postepy Hig Med Dosw (Online) | pmid:24088546 |
| Kurek K et al. | [Role of sphingolipids in digestive system]. | 2012 | Postepy Hig Med Dosw (Online) | pmid:23175343 |
| Shea BS and Tager AM | Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis. | 2012 | Proc Am Thorac Soc | pmid:22802282 |
| Goetzl EJ et al. | Lysophospholipid enhancement of human T cell sensitivity to diphtheria toxin by increased expression of heparin-binding epidermal growth factor. | 1999 May-Jun | Proc. Assoc. Am. Physicians | pmid:10354366 |
| Mitra P et al. | Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. | 2006 | Proc. Natl. Acad. Sci. U.S.A. | pmid:17050692 |
| Cannon RE et al. | Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22949658 |
| Czarnota GJ et al. | Tumor radiation response enhancement by acoustical stimulation of the vasculature. | 2012 | Proc. Natl. Acad. Sci. U.S.A. | pmid:22778441 |
| Ito K et al. | Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:24516133 |
| Pederson L et al. | Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. | 2008 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19075223 |
| Yanagida K et al. | Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. | 2017 | Proc. Natl. Acad. Sci. U.S.A. | pmid:28396408 |
| Park K et al. | ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26903652 |
| Mandala SM et al. | Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. | 2000 | Proc. Natl. Acad. Sci. U.S.A. | pmid:10859351 |
| Browne CD et al. | SHEP1 partners with CasL to promote marginal zone B-cell maturation. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20956287 |
| Mandala SM et al. | Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9419344 |
| Xia P et al. | Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9826677 |
| Bouma HR et al. | Low body temperature governs the decline of circulating lymphocytes during hibernation through sphingosine-1-phosphate. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21245336 |
| Sadahira Y et al. | Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness. | 1992 | Proc. Natl. Acad. Sci. U.S.A. | pmid:1409683 |
| Dusaban SS et al. | Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23401561 |
| Wojciak JM et al. | The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19815502 |
| Liu Z et al. | Mechanical tugging force regulates the size of cell-cell junctions. | 2010 | Proc. Natl. Acad. Sci. U.S.A. | pmid:20463286 |
| Ledent C et al. | Premature ovarian aging in mice deficient for Gpr3. | 2005 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15956199 |
| Christoffersen C et al. | Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M. | 2011 | Proc. Natl. Acad. Sci. U.S.A. | pmid:21606363 |
| Kikuta J et al. | Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23569273 |
| Nguyen DH et al. | Biomimetic model to reconstitute angiogenic sprouting morphogenesis in vitro. | 2013 | Proc. Natl. Acad. Sci. U.S.A. | pmid:23569284 |
| Roviezzo F et al. | Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15254297 |
| Matsushita K et al. | Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15273282 |
| Egom EE et al. | Cardioprotection in ischemia/reperfusion injury: spotlight on sphingosine-1-phosphate and bradykinin signalling. | 2010 | Prog. Biophys. Mol. Biol. | pmid:20080123 |
| Nadal A et al. | Glial cell responses to lipids bound to albumin in serum and plasma. | 2001 | Prog. Brain Res. | pmid:11545003 |
| Pyne S et al. | Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances. | 2016 | Prog. Lipid Res. | pmid:26970273 |
| Gomez-Muñoz A et al. | Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate. | 2016 | Prog. Lipid Res. | pmid:26703189 |
| Pyne NJ and Tigyi GJ | A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. | 2016 | Prog. Lipid Res. | pmid:26584871 |
| Kihara A et al. | Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. | 2007 | Prog. Lipid Res. | pmid:17449104 |
| Watterson K et al. | Pleiotropic actions of sphingosine-1-phosphate. | 2003 | Prog. Lipid Res. | pmid:12790117 |
| Gangoiti P et al. | Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease. | 2010 | Prog. Lipid Res. | pmid:20193711 |
| Liu H et al. | Sphingosine kinases: a novel family of lipid kinases. | 2002 | Prog. Nucleic Acid Res. Mol. Biol. | pmid:12102559 |
| Dziak R et al. | Effects of sphingosine-1-phosphate and lysophosphatidic acid on human osteoblastic cells. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12591009 |
| Lampasso JD et al. | Sphingosine-1-phosphate effects on PKC isoform expression in human osteoblastic cells. | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11728164 |
| Son DJ et al. | Enhanced release of sphingosine-1-phosphate from hypercholesterolemic platelets: role in development of hypercholesterolemic atherosclerosis. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18571912 |
| Carpio LC et al. | Sphingolipids stimulate cell growth via MAP kinase activation in osteoblastic cells. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10670688 |
| Kozawa O et al. | Sphingosine 1-phosphate amplifies phosphoinositide hydrolysis stimulated by prostaglandin f2 alpha in osteoblasts: involvement of p38MAP kinase. | 2000 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10913228 |
| Zabielski P et al. | Partial hepatectomy activates production of the pro-mitotic intermediates of the sphingomyelin signal transduction pathway in the rat liver. | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17499747 |
| Lee YM et al. | A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). | 2007 | Prostaglandins Other Lipid Mediat. | pmid:17991617 |