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Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. |
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Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. |
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Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. |
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Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function. |
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Targeting sphingosine-1-phosphate signaling in lung diseases. |
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Differential Effects of Long Term FTY720 Treatment on Endothelial versus Smooth Muscle Cell Signaling to S1P in Rat Mesenteric Arteries. |
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PLoS ONE |
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Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but Both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. |
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Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. |
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J Neuroinflammation |
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Polydatin attenuates AGEs-induced upregulation of fibronectin and ICAM-1 in rat glomerular mesangial cells and db/db diabetic mice kidneys by inhibiting the activation of the SphK1-S1P signaling pathway. |
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Mol. Cell. Endocrinol. |
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Sphingosine-1-phosphate, regulated by FSH and VEGF, stimulates granulosa cell proliferation. |
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Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer's Disease. |
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Curr Alzheimer Res |
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Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation. |
2016 |
Drugs |
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TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells. |
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Pharmacol. Res. |
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S1P Signaling and De Novo Biosynthesis in Blood Pressure Homeostasis. |
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J. Pharmacol. Exp. Ther. |
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Clinical pharmacology, efficacy, and safety aspects of sphingosine-1-phosphate receptor modulators. |
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Expert Opin Drug Metab Toxicol |
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Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. |
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Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. |
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Clin. Chim. Acta |
pmid:27221202
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Sphingosine-1-Phosphate Signaling in Immune Cells and Inflammation: Roles and Therapeutic Potential. |
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Mediators Inflamm. |
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Diabetes Mellitus Is Associated With Reduced High-Density Lipoprotein Sphingosine-1-Phosphate Content and Impaired High-Density Lipoprotein Cardiac Cell Protection. |
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Arterioscler. Thromb. Vasc. Biol. |
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S1P prophylaxis mitigates acute hypobaric hypoxia-induced molecular, biochemical, and metabolic disturbances: A preclinical report. |
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IUBMB Life |
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Platelet-derived sphingosine-1-phosphate and inflammation: from basic mechanisms to clinical implications. |
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Platelets |
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Aldo-keto Reductase Family 1 Member B 10 Mediates Liver Cancer Cell Proliferation through Sphingosine-1-Phosphate. |
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Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series. |
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Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. |
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Eur. J. Pharmacol. |
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Stomatal closure induced by phytosphingosine-1-phosphate and sphingosine-1-phosphate depends on nitric oxide and pH of guard cells in Pisum sativum. |
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Planta |
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Ceramide Production Mediates Aldosterone-Induced Human Umbilical Vein Endothelial Cell (HUVEC) Damages. |
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PLoS ONE |
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S1PR4 Signaling Attenuates ILT 7 Internalization To Limit IFN-α Production by Human Plasmacytoid Dendritic Cells. |
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Sphingosine-1-phosphate reduces ischaemia-reperfusion injury by phosphorylating the gap junction protein Connexin43. |
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Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death. |
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The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages. |
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PLoS ONE |
pmid:26741365
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A systematic methodology for large scale compound screening: A case study on the discovery of novel S1PL inhibitors. |
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J. Mol. Graph. Model. |
pmid:26724452
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Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer. |
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Oncotarget |
pmid:26716409
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Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis. |
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Gene |
pmid:26707209
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Recruitment of mesenchymal stem cells and macrophages by dual release of stromal cell-derived factor-1 and a macrophage recruitment agent enhances wound closure. |
2016 |
J Biomed Mater Res A |
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Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-κB Activation in Melanoma Cells by Inhibition of Akt Signaling. |
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Mol. Cell. Biol. |
pmid:26552704
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DNA damage response and sphingolipid signaling in liver diseases. |
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Surg. Today |
pmid:26514817
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Transforming growth factor-β-sphingosine kinase 1/S1P signaling upregulates microRNA-21 to promote fibrosis in renal tubular epithelial cells. |
2016 |
Exp. Biol. Med. (Maywood) |
pmid:26376826
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Serum sphingolipidomic analyses reveal an upregulation of C16-ceramide and sphingosine-1-phosphate in hepatocellular carcinoma. |
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Oncotarget |
pmid:26933996
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Upregulation of the S1P3 receptor in metastatic breast cancer cells increases migration and invasion by induction of PGE2 and EP2/EP4 activation. |
2016 |
Biochim. Biophys. Acta |
pmid:27616330
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