Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Heart Failure D006333 36 associated lipids
Diabetic Nephropathies D003928 39 associated lipids
Chemical and Drug Induced Liver Injury D056486 39 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Adenoma D000236 40 associated lipids
Arthritis D001168 41 associated lipids
Hyperalgesia D006930 42 associated lipids
Hypersensitivity, Delayed D006968 43 associated lipids
Liver Neoplasms, Experimental D008114 46 associated lipids
Coronary Artery Disease D003324 47 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

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Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

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Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Kihara A Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids. 2014 Biochim. Biophys. Acta pmid:23994042
Roviezzo F et al. Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate. 2014 Clin. Sci. pmid:24131465
Qin Z et al. Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma. 2014 Mol. Cancer Ther. pmid:24140934
Ryu JM et al. Sphingosine-1-phosphate-induced Flk-1 transactivation stimulates mouse embryonic stem cell proliferation through S1P1/S1P3-dependent β-arrestin/c-Src pathways. 2014 Stem Cell Res pmid:24145189
Yu Y et al. Phospholipid transfer protein deficiency decreases the content of S1P in HDL via the loss of its transfer capability. 2014 Lipids pmid:24158769
Giannouli CC et al. Visualizing S1P-directed cellular egress by intravital imaging. 2014 Biochim. Biophys. Acta pmid:24090699
Zhang Y et al. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. 2014 J. Clin. Invest. pmid:24837436
Kurano M et al. Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate. 2014 Biochim. Biophys. Acta pmid:24814049
Brünnert D et al. Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells. 2014 Mol. Hum. Reprod. pmid:24994816
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Purschke WG et al. Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis. 2014 Biochem. J. pmid:24832383
Karaca I et al. Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein. 2014 J. Biol. Chem. pmid:24808180
Fayyaz S et al. Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype. 2014 Diabetologia pmid:24292566
Meng Y et al. Sphingosine-1-phosphate suppresses cyclophosphamide induced follicle apoptosis in human fetal ovarian xenografts in nude mice. 2014 Fertil. Steril. pmid:24993801
Kang JW and Lee SM Impaired expression of caveolin-1 contributes to hepatic ischemia and reperfusion injury. 2014 Biochem. Biophys. Res. Commun. pmid:24997335
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Ohotski J et al. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor-4. 2014 Cell. Signal. pmid:24486401
Takeo T et al. Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. 2014 Cryobiology pmid:24201107
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Callihan P et al. Convergent regulation of neuronal differentiation and Erk and Akt kinases in human neural progenitor cells by lysophosphatidic acid, sphingosine 1-phosphate, and LIF: specific roles for the LPA1 receptor. 2014 ASN Neuro pmid:25424429
Kułakowska A et al. Increased levels of sphingosine-1-phosphate in cerebrospinal fluid of patients diagnosed with tick-borne encephalitis. 2014 J Neuroinflammation pmid:25421616
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Xu M et al. FTY720 inhibits tubulointerstitial inflammation in albumin overload-induced nephropathy of rats via the Sphk1 pathway. 2014 Acta Pharmacol. Sin. pmid:25399649
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Hamidi S et al. TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts. 2014 Biochim. Biophys. Acta pmid:24440818
Park K et al. The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. 2014 J. Nutr. Biochem. pmid:24768661
Schaper K et al. Sphingosine-1-phosphate differently regulates the cytokine production of IL-12, IL-23 and IL-27 in activated murine bone marrow derived dendritic cells. 2014 Mol. Immunol. pmid:24434636
Kono M et al. Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo. 2014 J. Clin. Invest. pmid:24667638
Sasaki H et al. Regulation of alkaline ceramidase activity by the c-Src-mediated pathway. 2014 Arch. Biochem. Biophys. pmid:24708996
Ntranos A et al. FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. 2014 J. Neuroimmunol. pmid:24680062
Sassoli C et al. Mesenchymal stromal cell secreted sphingosine 1-phosphate (S1P) exerts a stimulatory effect on skeletal myoblast proliferation. 2014 PLoS ONE pmid:25264785
Liu M et al. Hepatic apolipoprotein M (apoM) overexpression stimulates formation of larger apoM/sphingosine 1-phosphate-enriched plasma high density lipoprotein. 2014 J. Biol. Chem. pmid:24318881
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Li F et al. Sphingosine-1-phosphate prevents chemotherapy-induced human primordial follicle death. 2014 Hum. Reprod. pmid:24221908
Hirata N et al. Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. 2014 Nat Commun pmid:25254944
Bigaud M et al. Second generation S1P pathway modulators: research strategies and clinical developments. 2014 Biochim. Biophys. Acta pmid:24239768
Iino J et al. Platelet-derived sphingosine 1-phosphate induces migration of Jurkat T cells. 2014 Lipids Health Dis pmid:25253303
Huang YL et al. Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. 2014 Cell. Signal. pmid:24333325
Emery SM et al. Combined antiproliferative effects of the aminoalkylindole WIN55,212-2 and radiation in breast cancer cells. 2014 J. Pharmacol. Exp. Ther. pmid:24259678
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Adamson RH et al. Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:24531813
Xiong Y et al. Erythrocyte-derived sphingosine 1-phosphate is essential for vascular development. 2014 J. Clin. Invest. pmid:25250575
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Tan SJ et al. Targeted anti-apoptosis activity for ovarian protection against chemotherapy-induced ovarian gonadotoxicity. 2014 Reprod. Biomed. Online pmid:25246113
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Yang W et al. Sphingosine-1-phosphate promotes extravillous trophoblast cell invasion by activating MEK/ERK/MMP-2 signaling pathways via S1P/S1PR1 axis activation. 2014 PLoS ONE pmid:25188412
Chen J et al. The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension. 2014 Am. J. Respir. Crit. Care Med. pmid:25180446
Kong Y et al. Sphingosine-1-phosphate/S1P receptors signaling modulates cell migration in human bone marrow-derived mesenchymal stem cells. 2014 Mediators Inflamm. pmid:25147438
Belvitch P et al. Proline-rich region of non-muscle myosin light chain kinase modulates kinase activity and endothelial cytoskeletal dynamics. 2014 Microvasc. Res. pmid:25072537
Mendes-da-Cruz DA et al. Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. 2014 PLoS ONE pmid:25068647
Moon MH et al. Sphingosine-1-phosphate inhibits the adipogenic differentiation of 3T3-L1 preadipocytes. 2014 Int. J. Mol. Med. pmid:25050633
Wakashima T et al. Dual functions of the trans-2-enoyl-CoA reductase TER in the sphingosine 1-phosphate metabolic pathway and in fatty acid elongation. 2014 J. Biol. Chem. pmid:25049234
Marfia G et al. Autocrine/paracrine sphingosine-1-phosphate fuels proliferative and stemness qualities of glioblastoma stem cells. 2014 Glia pmid:25042636
Fuerst E et al. Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells. 2014 Allergy pmid:25041788
Tong X et al. The compensatory enrichment of sphingosine -1- phosphate harbored on glycated high-density lipoprotein restores endothelial protective function in type 2 diabetes mellitus. 2014 Cardiovasc Diabetol pmid:24751283
Murakami M et al. Controlled release of sphingosine-1-phosphate agonist with gelatin hydrogels for macrophage recruitment. 2014 Acta Biomater pmid:25038462
Park SJ et al. Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4. 2014 Cell. Signal. pmid:25035231
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Sattler K et al. HDL-bound sphingosine 1-phosphate (S1P) predicts the severity of coronary artery atherosclerosis. 2014 Cell. Physiol. Biochem. pmid:24977490
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Zhu Y et al. Vitamin D therapy in experimental allergic encephalomyelitis could be limited by opposing effects of sphingosine 1-phosphate and gelsolin dysregulation. 2014 Mol. Neurobiol. pmid:24722820
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Korbelik M et al. Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure. 2014 Int. Immunopharmacol. pmid:24713544
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Chen JJ et al. Non-genomic rapid responses via progesterone in human peripheral T cells are not indirectly mimicked by sphingosine 1-phosphate. 2014 Steroids pmid:24269742
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Mendes-Braz M et al. The effects of glucose and lipids in steatotic and non-steatotic livers in conditions of partial hepatectomy under ischaemia-reperfusion. 2014 Liver Int. pmid:24107124
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Xia JY et al. The adipokine/ceramide axis: key aspects of insulin sensitization. 2014 Biochimie pmid:23969158
Albinet V et al. Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. 2014 Oncogene pmid:23893239
Zeng Y et al. Sphingosine-1-phosphate protects endothelial glycocalyx by inhibiting syndecan-1 shedding. 2014 Am. J. Physiol. Heart Circ. Physiol. pmid:24285115
Speak AO et al. Altered distribution and function of natural killer cells in murine and human Niemann-Pick disease type C1. 2014 Blood pmid:24235134
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