| MeSH term | MeSH ID | Detail |
|---|---|---|
| Pregnancy, Ectopic | D011271 | 5 associated lipids |
| Prostatic Neoplasms | D011471 | 126 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Psoriasis | D011565 | 47 associated lipids |
| Pulmonary Edema | D011654 | 23 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Respiratory Distress Syndrome, Adult | D012128 | 15 associated lipids |
| Retinal Detachment | D012163 | 10 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Sarcoma 180 | D012510 | 21 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Li Y et al. | Interaction of cortactin and Arp2/3 complex is required for sphingosine-1-phosphate-induced endothelial cell remodeling. | 2004 | Exp. Cell Res. | pmid:15242766 |
| Takeya H | ['Vegetable wasps and plant worms' and G-protein-coupled receptors]. | 2004 | J. UOEH | pmid:15244075 |
| Miura Y et al. | Independence of tumor necrosis factor-alpha-induced adhesion molecule expression from sphingosine 1-phosphate signaling in vascular endothelial cells. | 2004 | J. Thromb. Haemost. | pmid:15140149 |
| Garg SK et al. | Sphingosine 1-phosphate induces antimicrobial activity both in vitro and in vivo. | 2004 | J. Infect. Dis. | pmid:15143482 |
| Hale JJ et al. | Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15149705 |
| Oshima Y et al. | Intraocular gutless adenoviral-vectored VEGF stimulates anterior segment but not retinal neovascularization. | 2004 | J. Cell. Physiol. | pmid:15095287 |
| Meacci E et al. | Sphingosine kinase activity is required for sphingosine-mediated phospholipase D activation in C2C12 myoblasts. | 2004 | Biochem. J. | pmid:15109308 |
| Lim HS et al. | Syntheses of sphingosine-1-phosphate analogues and their interaction with EDG/S1P receptors. | 2004 | Bioorg. Med. Chem. Lett. | pmid:15109640 |
| Cui J et al. | Role of ceramide in ischemic preconditioning. | 2004 | J. Am. Coll. Surg. | pmid:15110811 |
| Jolly PS et al. | Transactivation of sphingosine-1-phosphate receptors by FcepsilonRI triggering is required for normal mast cell degranulation and chemotaxis. | 2004 | J. Exp. Med. | pmid:15067032 |
| Segura BJ et al. | Sphingosine-1-phosphate mediates calcium signaling in guinea pig enteroglial cells. | 2004 | J. Surg. Res. | pmid:14732348 |
| Sanna MG et al. | Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate. | 2004 | J. Biol. Chem. | pmid:14732717 |
| Forrest M et al. | Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14747617 |
| Yue J et al. | Mice with transgenic overexpression of lipid phosphate phosphatase-1 display multiple organotypic deficits without alteration in circulating lysophosphatidate level. | 2004 | Cell. Signal. | pmid:14687668 |
| Harada J et al. | Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells. | 2004 | J. Neurochem. | pmid:14756825 |
| Matloubian M et al. | Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. | 2004 | Nature | pmid:14737169 |
| Monick MM et al. | Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. | 2004 | Am. J. Respir. Cell Mol. Biol. | pmid:14742298 |
| Kim DS et al. | Sphingosine-1-phosphate inhibits human keratinocyte proliferation via Akt/protein kinase B inactivation. | 2004 | Cell. Signal. | pmid:14607279 |
| Panetti TS et al. | Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid. | 2004 | J. Thromb. Haemost. | pmid:15333043 |
| Kang YC et al. | Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation. | 2004 | Cell Death Differ. | pmid:15297884 |
| Holdsworth G et al. | A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. | 2004 | BMC Biochem. | pmid:15298705 |
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| Levkau B et al. | High-density lipoprotein stimulates myocardial perfusion in vivo. | 2004 | Circulation | pmid:15545521 |
| Hale JJ et al. | A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists. | 2004 | J. Med. Chem. | pmid:15615513 |
| Hammer S et al. | Glucocorticoids mediate differential anti-apoptotic effects in human fibroblasts and keratinocytes via sphingosine-1-phosphate formation. | 2004 | J. Cell. Biochem. | pmid:14991774 |
| Tokuda H et al. | Interleukin (IL)-17 enhances tumor necrosis factor-alpha-stimulated IL-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. | 2004 | J. Cell. Biochem. | pmid:15034939 |
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| Hedemann J et al. | Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries. | 2004 | Auton Autacoid Pharmacol | pmid:15541015 |
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| Wang FX et al. | mitochondrial ceramidase overexpression up-regulates Bcl-2 protein level in K562 cells, probably through its metabolite sphingosine-1-phosphate. | 2004 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15498114 |
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| Liu S et al. | Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. | 2004 | J. Biol. Chem. | pmid:15466414 |
| Birukov KG et al. | Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. | 2004 | Circ. Res. | pmid:15472119 |
| Amano S et al. | Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids. | 2004 | Br. J. Dermatol. | pmid:15541073 |
| Nosi D et al. | Effects of S1P on myoblastic cell contraction: possible involvement of Ca-independent mechanisms. | 2004 | Cells Tissues Organs (Print) | pmid:15655330 |
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| Baudhuin LM et al. | S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). | 2004 | FASEB J. | pmid:14657000 |
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| Kelley GG et al. | Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. | 2004 | Biochem. J. | pmid:14567755 |
| Yu N et al. | Characterization of lysophosphatidic acid and sphingosine-1-phosphate-mediated signal transduction in rat cortical oligodendrocytes. | 2004 | Glia | pmid:14648542 |
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| Kariya Y et al. | Products by the sphingosine kinase/sphingosine 1-phosphate (S1P) lyase pathway but not S1P stimulate mitogenesis. | 2005 | Genes Cells | pmid:15938718 |
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