| MeSH term | MeSH ID | Detail |
|---|---|---|
| Influenza, Human | D007251 | 11 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Glioma | D005910 | 112 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pan CY et al. | Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells. | 2007 | J. Neurochem. | pmid:17630986 |
| Shimizu T et al. | Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries. | 2007 | Circ. Res. | pmid:17872461 |
| Kunisawa J et al. | Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. | 2007 | J. Exp. Med. | pmid:17875673 |
| Klingenberg R et al. | Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17761943 |
| Argraves KM and Argraves WS | HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. | 2007 | J. Lipid Res. | pmid:17698855 |
| Min J et al. | (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. | 2007 | Mol. Cancer Res. | pmid:17699106 |
| Herr DR and Chun J | Effects of LPA and S1P on the nervous system and implications for their involvement in disease. | 2007 | Curr Drug Targets | pmid:17266539 |
| Tani M et al. | Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity. | 2007 | FEBS Lett. | pmid:17825823 |
| Hanessian S et al. | Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17070046 |
| Chun J | Immunology. The sources of a lipid conundrum. | 2007 | Science | pmid:17431159 |
| Liao JJ et al. | Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. | 2007 | J. Biol. Chem. | pmid:17121832 |
| Sanchez T et al. | Induction of vascular permeability by the sphingosine-1-phosphate receptor-2 (S1P2R) and its downstream effectors ROCK and PTEN. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17431187 |
| Jang S et al. | Cytochemical alterations in the rat retina by LPS administration. | 2007 | Neurochem. Res. | pmid:17160463 |
| Harvey KA et al. | Diverse signaling pathways regulate fibroblast differentiation and transformation through Rho kinase activation. | 2007 | J. Cell. Physiol. | pmid:17167780 |
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| Huwiler A and Zangemeister-Wittke U | Targeting the conversion of ceramide to sphingosine 1-phosphate as a novel strategy for cancer therapy. | 2007 | Crit. Rev. Oncol. Hematol. | pmid:17560117 |
| Formigli L et al. | Cytoskeleton/stretch-activated ion channel interaction regulates myogenic differentiation of skeletal myoblasts. | 2007 | J. Cell. Physiol. | pmid:17295211 |
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| Chilton L et al. | Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. | 2007 | J. Physiol. (Lond.) | pmid:17569734 |
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| Hinson JS et al. | Smooth muscle cell-specific transcription is regulated by nuclear localization of the myocardin-related transcription factors. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:16997888 |
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| Walzer T et al. | Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor. | 2007 | Nat. Immunol. | pmid:17965716 |
| Yang Q | Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival. | 2007 | Cardiovasc. Res. | pmid:17331485 |
| Landeen LK et al. | Sphingosine-1-phosphate receptor expression in cardiac fibroblasts is modulated by in vitro culture conditions. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17337593 |
| Maeda Y et al. | Migration of CD4 T cells and dendritic cells toward sphingosine 1-phosphate (S1P) is mediated by different receptor subtypes: S1P regulates the functions of murine mature dendritic cells via S1P receptor type 3. | 2007 | J. Immunol. | pmid:17339438 |
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| Means CK et al. | Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. | 2007 | Am. J. Physiol. Heart Circ. Physiol. | pmid:17293497 |
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| Herr DR et al. | Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2. | 2007 | J. Neurosci. | pmid:17287522 |
| Molderings GJ et al. | S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands. | 2007 | Neurochem. Int. | pmid:17559976 |
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| Levine YC et al. | Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway. | 2007 | J. Biol. Chem. | pmid:17519230 |
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| Park KS et al. | S1P stimulates chemotactic migration and invasion in OVCAR3 ovarian cancer cells. | 2007 | Biochem. Biophys. Res. Commun. | pmid:17349972 |
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| Kunisawa J et al. | Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells. | 2008 | Blood | pmid:18292290 |
| Nicol GD | Nerve growth factor, sphingomyelins, and sensitization in sensory neurons. | 2008 | Sheng Li Xue Bao | pmid:18958367 |
| Park HY et al. | K6PC-5, a novel sphingosine kinase activator, improves long-term ultraviolet light-exposed aged murine skin. | 2008 | Exp. Dermatol. | pmid:18341573 |
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| Liu HB et al. | Sphingosine-1-phosphate and its analogue FTY720 diminish acute pulmonary injury in rats with acute necrotizing pancreatitis. | 2008 | Pancreas | pmid:18362832 |
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| Shida D et al. | Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion. | 2008 | Cancer Res. | pmid:18701480 |
| Worrall D et al. | Involvement of sphingosine kinase in plant cell signalling. | 2008 | Plant J. | pmid:18557834 |
| Heller R et al. | Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells. | 2008 | Cardiovasc. Res. | pmid:18558630 |
| Levkau B | Sphingosine-1-phosphate in the regulation of vascular tone: a finely tuned integration system of S1P sources, receptors, and vascular responsiveness. | 2008 | Circ. Res. | pmid:18669929 |
| Ohuchi H et al. | Expression patterns of the lysophospholipid receptor genes during mouse early development. | 2008 | Dev. Dyn. | pmid:18924241 |
| Sekiguchi M et al. | Role of sphingosine 1-phosphate in the pathogenesis of Sjögren's syndrome. | 2008 | J. Immunol. | pmid:18209090 |
| Brunati AM et al. | Cross-talk between PDGF and S1P signalling elucidates the inhibitory effect and potential antifibrotic action of the immunomodulator FTY720 in activated HSC-cultures. | 2008 | Biochim. Biophys. Acta | pmid:18157950 |
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