| MeSH term | MeSH ID | Detail |
|---|---|---|
| Influenza, Human | D007251 | 11 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Hyperalgesia | D006930 | 42 associated lipids |
| Carcinoma, Hepatocellular | D006528 | 140 associated lipids |
| Hemolysis | D006461 | 131 associated lipids |
| Heart Failure | D006333 | 36 associated lipids |
| Glioma | D005910 | 112 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| De Luca T et al. | NAD+/NADH and/or CoQ/CoQH2 ratios from plasma membrane electron transport may determine ceramide and sphingosine-1-phosphate levels accompanying G1 arrest and apoptosis. | 2005 | Biofactors | pmid:16873929 |
| Perez GI et al. | A central role for ceramide in the age-related acceleration of apoptosis in the female germline. | 2005 | FASEB J. | pmid:15728664 |
| Ikeda M et al. | Sphingolipid-to-glycerophospholipid conversion in SPL-null cells implies the existence of an alternative isozyme. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15737611 |
| Yabu T et al. | Thalidomide-induced antiangiogenic action is mediated by ceramide through depletion of VEGF receptors, and is antagonized by sphingosine-1-phosphate. | 2005 | Blood | pmid:15741222 |
| Kee TH et al. | Sphingosine kinase signalling in immune cells. | 2005 | Clin. Exp. Pharmacol. Physiol. | pmid:15743396 |
| Suomalainen L et al. | Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. | 2005 | Am. J. Pathol. | pmid:15743789 |
| Pilorget A et al. | Inhibition of angiogenic properties of brain endothelial cells by platelet-derived sphingosine-1-phosphate. | 2005 | J. Cereb. Blood Flow Metab. | pmid:15829917 |
| Bolick DT et al. | Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. | 2005 | Arterioscler. Thromb. Vasc. Biol. | pmid:15761190 |
| Blom T et al. | Enhancement of intracellular sphingosine-1-phosphate production by inositol 1,4,5-trisphosphate-evoked calcium mobilisation in HEK-293 cells: endogenous sphingosine-1-phosphate as a modulator of the calcium response. | 2005 | Cell. Signal. | pmid:15763425 |
| Im YJ et al. | Study on action mode of sphingosine 1-phosphate in rat hepatocytes. | 2005 | J. Pharmacol. Sci. | pmid:15764837 |
| Oberst MD et al. | HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15800053 |
| Cyster JG | Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. | 2005 | Annu. Rev. Immunol. | pmid:15771568 |
| Church LD et al. | TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx. | 2005 | J. Leukoc. Biol. | pmid:15817701 |
| Tamama K et al. | High-density lipoprotein inhibits migration of vascular smooth muscle cells through its sphingosine 1-phosphate component. | 2005 | Atherosclerosis | pmid:15585196 |
| Zhang B et al. | Correlation of high density lipoprotein (HDL)-associated sphingosine 1-phosphate with serum levels of HDL-cholesterol and apolipoproteins. | 2005 | Atherosclerosis | pmid:15585219 |
| Hojjati MR et al. | Effect of myriocin on plasma sphingolipid metabolism and atherosclerosis in apoE-deficient mice. | 2005 | J. Biol. Chem. | pmid:15590644 |
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| Lee MS et al. | Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15590895 |
| Kihara A et al. | [Function and metabolism of the bioactive lipid molecule sphingosine 1-phosphate]. | 2005 | Tanpakushitsu Kakusan Koso | pmid:16146193 |
| Watterson KR et al. | The role of sphingosine-1-phosphate in smooth muscle contraction. | 2005 | Cell. Signal. | pmid:15567060 |
| Fieger CB et al. | Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines. | 2005 | FASEB J. | pmid:16148028 |
| Hla T | Immunology. Dietary factors and immunological consequences. | 2005 | Science | pmid:16150998 |
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| Donati C et al. | Sphingosine 1-phosphate regulates myogenic differentiation: a major role for S1P2 receptor. | 2005 | FASEB J. | pmid:15625079 |
| Urata Y et al. | Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase. | 2005 | Kobe J Med Sci | pmid:16199931 |
| Hughes SK et al. | Fluid shear stress modulates cell migration induced by sphingosine 1-phosphate and vascular endothelial growth factor. | 2005 | Ann Biomed Eng | pmid:16133909 |
| Foss FW et al. | Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. | 2005 | Bioorg. Med. Chem. Lett. | pmid:16125386 |
| van Meeteren LA et al. | Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate. | 2005 | J. Biol. Chem. | pmid:15769751 |
| Tani M et al. | Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu. | 2005 | J. Biol. Chem. | pmid:16126722 |
| Shida D et al. | Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15649431 |
| Katkade V et al. | Domain 5 of cleaved high molecular weight kininogen inhibits endothelial cell migration through Akt. | 2005 | Thromb. Haemost. | pmid:16268479 |
| Wei SH et al. | Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary T cells to lymphatic sinuses. | 2005 | Nat. Immunol. | pmid:16273098 |
| Lee HS et al. | Antigen-induced Ca2+ mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production. | 2005 | Cell Calcium | pmid:16219349 |
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| Itagaki K et al. | Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. | 2005 | J. Leukoc. Biol. | pmid:15522918 |
| McVerry BJ and Garcia JG | In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. | 2005 | Cell. Signal. | pmid:15494205 |
| Waters CM et al. | c-Src is involved in regulating signal transmission from PDGFbeta receptor-GPCR(s) complexes in mammalian cells. | 2005 | Cell. Signal. | pmid:15494217 |
| Butter JJ et al. | A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection. | 2005 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:16023899 |
| Maguire JJ and Davenport AP | Regulation of vascular reactivity by established and emerging GPCRs. | 2005 | Trends Pharmacol. Sci. | pmid:16054240 |
| Yopp AC et al. | Sphingosine 1-phosphate receptors regulate chemokine-driven transendothelial migration of lymph node but not splenic T cells. | 2005 | J. Immunol. | pmid:16116177 |
| Czeloth N et al. | Sphingosine-1-phosphate mediates migration of mature dendritic cells. | 2005 | J. Immunol. | pmid:16116182 |
| Bandhuvula P et al. | The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. | 2005 | J. Biol. Chem. | pmid:16118221 |
| Kharel Y et al. | Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. | 2005 | J. Biol. Chem. | pmid:16093248 |
| Maceyka M et al. | Sphingosine kinases, sphingosine-1-phosphate and sphingolipidomics. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099387 |
| Danieli-Betto D et al. | Sphingosine 1-phosphate protects mouse extensor digitorum longus skeletal muscle during fatigue. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15659717 |
| Roth Z and Hansen PJ | Disruption of nuclear maturation and rearrangement of cytoskeletal elements in bovine oocytes exposed to heat shock during maturation. | 2005 | Reproduction | pmid:15695618 |
| Tanski WJ et al. | Sphingosine-1-phosphate-induced smooth muscle cell migration involves the mammalian target of rapamycin. | 2005 | J. Vasc. Surg. | pmid:15696050 |
| Björklund S et al. | Effects of sphingosine 1-phosphate on calcium signaling, proliferation and S1P2 receptor expression in PC Cl3 rat thyroid cells. | 2005 | Mol. Cell. Endocrinol. | pmid:15713536 |
| Anelli V et al. | Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes. | 2005 | J. Neurochem. | pmid:15715670 |
| Minnear FL et al. | Sphingosine 1-phosphate prevents platelet-activating factor-induced increase in hydraulic conductivity in rat mesenteric venules: pertussis toxin sensitive. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15778280 |
| Hsiao SH et al. | Effects of exogenous sphinganine, sphingosine, and sphingosine-1-phosphate on relaxation and contraction of porcine thoracic aortic and pulmonary arterial rings. | 2005 | Toxicol. Sci. | pmid:15829618 |
| Geoffroy K et al. | Glomerular proliferation during early stages of diabetic nephropathy is associated with local increase of sphingosine-1-phosphate levels. | 2005 | FEBS Lett. | pmid:15710421 |
| Budnik LT and Brunswig-Spickenheier B | Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor. | 2005 | J. Lipid Res. | pmid:15716590 |
| Takashiro Y et al. | Involvement of p38 MAP kinase-mediated cytochrome c release on sphingosine-1-phosphate (S1P)- and N-monomethyl-S1P-induced cell death of PC12 cells. | 2005 | Biochem. Pharmacol. | pmid:15907808 |
| Halin C et al. | The S1P-analog FTY720 differentially modulates T-cell homing via HEV: T-cell-expressed S1P1 amplifies integrin activation in peripheral lymph nodes but not in Peyer patches. | 2005 | Blood | pmid:15870184 |
| Takeshita A et al. | Sphingosine 1-phosphate acts as a signal molecule in ceramide signal transduction of TNF-alpha-induced activator protein-1 in osteoblastic cell line MC3T3-E1 cells. | 2005 | J Oral Sci | pmid:15881228 |
| Yin Z and Watsky MA | Chloride channel activity in human lung fibroblasts and myofibroblasts. | 2005 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15681397 |
| Sauer B et al. | Sphingosine 1-phosphate is involved in cytoprotective actions of calcitriol in human fibroblasts and enhances the intracellular Bcl-2/Bax rheostat. | 2005 | Pharmazie | pmid:15881612 |
| Ma Y et al. | Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. | 2005 | J. Biol. Chem. | pmid:15883165 |
| Radeke HH et al. | Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52. | 2005 | J. Immunol. | pmid:15728487 |
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| Kawata T et al. | Sphingosine 1-phosphate inhibits migration and RANTES production in human bronchial smooth muscle cells. | 2005 | Biochem. Biophys. Res. Commun. | pmid:15850807 |
| Pfaff M et al. | Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. | 2005 | Respir. Res. | pmid:15927078 |
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| Mastrandrea LD et al. | Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. | 2005 | Diabetes | pmid:15855330 |
| Segura BJ et al. | Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells. | 2005 | Brain Res. Mol. Brain Res. | pmid:15710251 |
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| Malchinkhuu E et al. | Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells. | 2005 | Oncogene | pmid:16007180 |
| Pébay A et al. | Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. | 2005 Nov-Dec | Stem Cells | pmid:16081668 |
| Seol GH et al. | Sphingosine-1-phosphate-induced intracellular Ca2+ mobilization in human endothelial cells. | 2005 Sep-Dec | Endothelium | pmid:16410226 |
| Pan S et al. | A monoselective sphingosine-1-phosphate receptor-1 agonist prevents allograft rejection in a stringent rat heart transplantation model. | 2006 | Chem. Biol. | pmid:17114004 |
| Durand CA et al. | The Rap GTPases mediate CXCL13- and sphingosine1-phosphate-induced chemotaxis, adhesion, and Pyk2 tyrosine phosphorylation in B lymphocytes. | 2006 | Eur. J. Immunol. | pmid:16821235 |
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| Park KS et al. | Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins. | 2006 | Mol. Pharmacol. | pmid:16368894 |
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| di Villa Bianca Rd et al. | Sphingosine 1-phosphate induces endothelial nitric-oxide synthase activation through phosphorylation in human corpus cavernosum. | 2006 | J. Pharmacol. Exp. Ther. | pmid:16234413 |
| Bu S et al. | Dihydrosphingosine 1-phosphate stimulates MMP1 gene expression via activation of ERK1/2-Ets1 pathway in human fibroblasts. | 2006 | FASEB J. | pmid:16278291 |
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| Kang JS et al. | Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. | 2006 | Mol. Pharmacol. | pmid:16354764 |
| Tardieu D et al. | Effects of fumonisins on liver and kidney sphinganine and the sphinganine to sphingosine ratio during chronic exposure in ducks. | 2006 | Chem. Biol. Interact. | pmid:16412405 |
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| Bassi R et al. | Sphingosine-1-phosphate is released by cerebellar astrocytes in response to bFGF and induces astrocyte proliferation through Gi-protein-coupled receptors. | 2006 | Glia | pmid:16470810 |
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| Kurobe H et al. | CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central tolerance. | 2006 | Immunity | pmid:16473829 |