| MeSH term | MeSH ID | Detail |
|---|---|---|
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Cardiomyopathies | D009202 | 10 associated lipids |
| Shock, Hemorrhagic | D012771 | 4 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Vascular Diseases | D014652 | 16 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Anemia | D000740 | 21 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Pan CY et al. | Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells. | 2007 | J. Neurochem. | pmid:17630986 |
| Shimizu T et al. | Sphingosine 1-phosphate receptor 2 negatively regulates neointimal formation in mouse arteries. | 2007 | Circ. Res. | pmid:17872461 |
| Kunisawa J et al. | Sphingosine 1-phosphate dependence in the regulation of lymphocyte trafficking to the gut epithelium. | 2007 | J. Exp. Med. | pmid:17875673 |
| Klingenberg R et al. | Sphingosine-1-phosphate analogue FTY720 causes lymphocyte redistribution and hypercholesterolemia in ApoE-deficient mice. | 2007 | Arterioscler. Thromb. Vasc. Biol. | pmid:17761943 |
| Argraves KM and Argraves WS | HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. | 2007 | J. Lipid Res. | pmid:17698855 |
| Min J et al. | (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. | 2007 | Mol. Cancer Res. | pmid:17699106 |
| Tani M et al. | Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity. | 2007 | FEBS Lett. | pmid:17825823 |
| Hanessian S et al. | Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors. | 2007 | Bioorg. Med. Chem. Lett. | pmid:17070046 |
| Liao JJ et al. | Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors. | 2007 | J. Biol. Chem. | pmid:17121832 |
| Kume H et al. | Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated myosin phosphatase inactivation. | 2007 | J. Pharmacol. Exp. Ther. | pmid:17105828 |
| Smicun Y et al. | S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells. | 2007 | Gynecol. Oncol. | pmid:17716713 |
| Chilton L et al. | Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts. | 2007 | J. Physiol. (Lond.) | pmid:17569734 |
| Mitra P et al. | A rapid and sensitive method to measure secretion of sphingosine-1-phosphate. | 2007 | Meth. Enzymol. | pmid:17954252 |
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| Guo Y et al. | Quantitative proteomics analysis of human endothelial cell membrane rafts: evidence of MARCKS and MRP regulation in the sphingosine 1-phosphate-induced barrier enhancement. | 2007 | Mol. Cell Proteomics | pmid:17210631 |
| Nofer JR et al. | FTY720, a synthetic sphingosine 1 phosphate analogue, inhibits development of atherosclerosis in low-density lipoprotein receptor-deficient mice. | 2007 | Circulation | pmid:17242282 |
| Alemany R et al. | Regulation and functional roles of sphingosine kinases. | 2007 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:17242884 |
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| Lavieu G et al. | Is autophagy the key mechanism by which the sphingolipid rheostat controls the cell fate decision? | 2007 Jan-Feb | Autophagy | pmid:17035732 |
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| Provençal M et al. | Tissue factor pathway inhibitor (TFPI) interferes with endothelial cell migration by inhibition of both the Erk pathway and focal adhesion proteins. | 2008 | Thromb. Haemost. | pmid:18327407 |
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| Arce FT et al. | Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin. | 2008 | Biophys. J. | pmid:18408039 |
| Chung FY et al. | Signaling mechanisms of sphingosine 1-phosphate-induced ERK1/2 activation in cultured feline esophageal smooth muscle cells. | 2008 | Arch. Pharm. Res. | pmid:19023540 |
| Osborne N et al. | The spinster homolog, two of hearts, is required for sphingosine 1-phosphate signaling in zebrafish. | 2008 | Curr. Biol. | pmid:19062281 |
| Szczepaniak WS et al. | Sphingosine 1-phosphate rescues canine LPS-induced acute lung injury and alters systemic inflammatory cytokine production in vivo. | 2008 | Transl Res | pmid:19010292 |
| Rapizzi E et al. | Sphingosine 1-phosphate differentially regulates proliferation of C2C12 reserve cells and myoblasts. | 2008 | Mol. Cell. Biochem. | pmid:18454302 |
| Son DJ et al. | Enhanced release of sphingosine-1-phosphate from hypercholesterolemic platelets: role in development of hypercholesterolemic atherosclerosis. | 2008 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18571912 |
| Peavy RD and Metcalfe DD | Understanding the mechanisms of anaphylaxis. | 2008 | Curr Opin Allergy Clin Immunol | pmid:18596587 |
| Huang WR et al. | [SphK-1/S1P signal pathway in CML cells]. | 2008 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:18718048 |
| Serrano-Sanchez M et al. | Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2. | 2008 | Endocrinology | pmid:18723875 |
| Srinivasan S et al. | Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. | 2008 | Diabetes | pmid:18003758 |
| Johann AM et al. | Apoptotic cell-derived sphingosine-1-phosphate promotes HuR-dependent cyclooxygenase-2 mRNA stabilization and protein expression. | 2008 | J. Immunol. | pmid:18178864 |
| Oskeritzian CA et al. | Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions. | 2008 | Blood | pmid:18178871 |
| Oyama O et al. | The lysophospholipid mediator sphingosine-1-phosphate promotes angiogenesis in vivo in ischaemic hindlimbs of mice. | 2008 | Cardiovasc. Res. | pmid:18187460 |