| MeSH term | MeSH ID | Detail |
|---|---|---|
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Cardiomyopathies | D009202 | 10 associated lipids |
| Shock, Hemorrhagic | D012771 | 4 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Vascular Diseases | D014652 | 16 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Anemia | D000740 | 21 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Benesch MG et al. | Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate. | 2015 | J. Lipid Res. | pmid:25896349 |
| Farnoud AM et al. | The Granuloma Response Controlling Cryptococcosis in Mice Depends on the Sphingosine Kinase 1-Sphingosine 1-Phosphate Pathway. | 2015 | Infect. Immun. | pmid:25895971 |
| Chimen M et al. | Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. | 2015 | Nat. Med. | pmid:25894827 |
| Pulli I et al. | A novel chimeric aequorin fused with caveolin-1 reveals a sphingosine kinase 1-regulated Ca²⺠microdomain in the caveolar compartment. | 2015 | Biochim. Biophys. Acta | pmid:25892494 |
| Zankov DP and Ogita H | Actin-tethered junctional complexes in angiogenesis and lymphangiogenesis in association with vascular endothelial growth factor. | 2015 | Biomed Res Int | pmid:25883953 |
| Li C et al. | Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. | 2015 | J Neuroinflammation | pmid:25880547 |
| Williams PA et al. | Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). | 2015 | PLoS ONE | pmid:25875493 |
| Wang Z et al. | The Effect of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor on Neutrophil Function and the Relevant Signaling Pathway. | 2015 | Acta Haematol. | pmid:25872153 |
| Wilson PC et al. | Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. | 2015 | Mol. Endocrinol. | pmid:25871850 |
| Jernigan PL et al. | The role of sphingolipids in endothelial barrier function. | 2015 | Biol. Chem. | pmid:25867999 |
| Egom EE et al. | The effect of the sphingosine-1-phosphate analogue FTY720 on atrioventricular nodal tissue. | 2015 | J. Cell. Mol. Med. | pmid:25864579 |
| Ohkawa R et al. | Possible involvement of sphingomyelin in the regulation of the plasma sphingosine 1-phosphate level in human subjects. | 2015 | Clin. Biochem. | pmid:25863111 |
| Wang L et al. | Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate. | 2015 | Microvasc. Res. | pmid:25862132 |
| Kolahdooz Z et al. | Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism. | 2015 | Can J Neurol Sci | pmid:25860537 |
| Ren K et al. | Apolipoprotein M. | 2015 | Clin. Chim. Acta | pmid:25858547 |
| Molinari G | Is hydrogen ion (H(+)) the real second messenger in calcium signalling? | 2015 | Cell. Signal. | pmid:25843778 |
| Riley RT et al. | A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. | 2015 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess | pmid:25833119 |
| Nussbaum C et al. | Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. | 2015 | Nat Commun | pmid:25832730 |
| Proia RL and Hla T | Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapy. | 2015 | J. Clin. Invest. | pmid:25831442 |
| Lee SY et al. | Activation of sphingosine kinase 2 by endoplasmic reticulum stress ameliorates hepatic steatosis and insulin resistance in mice. | 2015 | Hepatology | pmid:25808625 |
| Salama MF et al. | A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma. | 2015 | FASEB J. | pmid:25805832 |
| Potì F et al. | SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet. | 2015 | Atherosclerosis | pmid:25801013 |
| Castillo-Badillo JA et al. | α1B-adrenergic receptors differentially associate with Rab proteins during homologous and heterologous desensitization. | 2015 | PLoS ONE | pmid:25799564 |
| Kasbi-Chadli F et al. | Direct and maternal n-3 long-chain polyunsaturated fatty acid supplementation improved triglyceridemia and glycemia through the regulation of hepatic and muscle sphingolipid synthesis in offspring hamsters fed a high-fat diet. | 2016 | Eur J Nutr | pmid:25787885 |
| Brulhart-Meynet MC et al. | Improving reconstituted HDL composition for efficient post-ischemic reduction of ischemia reperfusion injury. | 2015 | PLoS ONE | pmid:25781943 |
| Nojima H et al. | Sphingolipids in liver injury, repair and regeneration. | 2015 | Biol. Chem. | pmid:25781682 |
| Newton J et al. | Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy. | 2015 | Exp. Cell Res. | pmid:25770011 |
| Muñoz-Sáez E et al. | Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y). | 2015 | Neurosci. Lett. | pmid:25769802 |
| Kang H et al. | The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension. | 2015 | Stem Cells Dev. | pmid:25761906 |
| Carrera I et al. | A comparative evaluation of a novel vaccine in APP/PS1 mouse models of Alzheimer's disease. | 2015 | Biomed Res Int | pmid:25759822 |
| Ueda N | Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate. | 2015 | Int J Mol Sci | pmid:25751724 |
| Zhao S and Li J | Sphingosine-1-phosphate induces the migration of thyroid follicular carcinoma cells through the microRNA-17/PTK6/ERK1/2 pathway. | 2015 | PLoS ONE | pmid:25748447 |
| Moolenaar WH | Introduction to the ECR special issue on lysophospholipids in biology. | 2015 | Exp. Cell Res. | pmid:25746723 |
| Lin CC et al. | Sphingosine-1-phosphate mediates ICAM-1-dependent monocyte adhesion through p38 MAPK and p42/p44 MAPK-dependent Akt activation. | 2015 | PLoS ONE | pmid:25734900 |
| Zhang DD et al. | Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors. | 2015 | Biol. Chem. | pmid:25720064 |
| Schröder M et al. | Subcellular distribution of FTY720 and FTY720-phosphate in immune cells - another aspect of Fingolimod action relevant for therapeutic application. | 2015 | Biol. Chem. | pmid:25720062 |
| Koch A et al. | Downregulation of sphingosine 1-phosphate (S1P) receptor 1 by dexamethasone inhibits S1P-induced mesangial cell migration. | 2015 | Biol. Chem. | pmid:25719311 |
| Park ES et al. | Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. | 2015 | J. Biol. Chem. | pmid:25716317 |
| Rhee SH et al. | Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall. | 2015 | J Obstet Gynaecol | pmid:25692679 |
| Cheng Y et al. | Actin polymerization-enhancing drugs promote ovarian follicle growth mediated by the Hippo signaling effector YAP. | 2015 | FASEB J. | pmid:25690654 |
| Ji F et al. | K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. | 2015 | Biochem. Biophys. Res. Commun. | pmid:25680461 |
| Breslin JW et al. | Involvement of local lamellipodia in endothelial barrier function. | 2015 | PLoS ONE | pmid:25658915 |
| Kalhori V and Törnquist K | MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells. | 2015 | Mol. Cell. Endocrinol. | pmid:25643979 |
| Sivasubramanian M et al. | Sphingosine kinase 2 and sphingosine-1-phosphate promotes mitochondrial function in dopaminergic neurons of mouse model of Parkinson's disease and in MPP+ -treated MN9D cells in vitro. | 2015 | Neuroscience | pmid:25637806 |
| Zhong Y et al. | Nephrokeli, a Chinese herbal formula, may improve IgA nephropathy through regulation of the sphingosine-1-phosphate pathway. | 2015 | PLoS ONE | pmid:25633986 |
| Till KJ et al. | Expression of functional sphingosine-1 phosphate receptor-1 is reduced by B cell receptor signaling and increased by inhibition of PI3 kinase δ but not SYK or BTK in chronic lymphocytic leukemia cells. | 2015 | J. Immunol. | pmid:25632006 |
| Liu M et al. | Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. | 2015 | J. Biol. Chem. | pmid:25627684 |
| Hwang IY et al. | An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking. | 2015 | J. Immunol. | pmid:25617475 |
| Mikłosz A et al. | Hyperthyroidism evokes myocardial ceramide accumulation. | 2015 | Cell. Physiol. Biochem. | pmid:25613909 |
| Kurek K et al. | Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia. | 2015 | Lipids | pmid:25595595 |