| MeSH term | MeSH ID | Detail |
|---|---|---|
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Niemann-Pick Diseases | D009542 | 25 associated lipids |
| Cardiomyopathies | D009202 | 10 associated lipids |
| Shock, Hemorrhagic | D012771 | 4 associated lipids |
| Adenoma | D000236 | 40 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Vascular Diseases | D014652 | 16 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
| Anemia | D000740 | 21 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Yuan S et al. | Lipid receptor S1Pâ‚ activation scheme concluded from microsecond all-atom molecular dynamics simulations. | 2013 | PLoS Comput. Biol. | pmid:24098103 |
| Baranowski M et al. | Ultramarathon run markedly reduces plasma sphingosine-1-phosphate concentration. | 2014 | Int J Sport Nutr Exerc Metab | pmid:24092763 |
| Giannouli CC et al. | Visualizing S1P-directed cellular egress by intravital imaging. | 2014 | Biochim. Biophys. Acta | pmid:24090699 |
| Kurek K et al. | [The role of sphingolipids in selected cardiovascular diseases]. | 2013 | Postepy Hig Med Dosw (Online) | pmid:24088546 |
| Xiong Y et al. | Sphingosine kinases are not required for inflammatory responses in macrophages. | 2013 | J. Biol. Chem. | pmid:24081141 |
| Nguyen-Tran DH et al. | Molecular mechanism of sphingosine-1-phosphate action in Duchenne muscular dystrophy. | 2014 | Dis Model Mech | pmid:24077965 |
| Garris CS et al. | Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation. | 2013 | Nat. Immunol. | pmid:24076635 |
| Pyne NJ et al. | The role of sphingosine 1-phosphate in inflammation and cancer. | 2014 | Adv Biol Regul | pmid:24070975 |
| Völzke A et al. | Sphingosine 1-phosphate (S1P) induces COX-2 expression and PGE2 formation via S1P receptor 2 in renal mesangial cells. | 2014 | Biochim. Biophys. Acta | pmid:24064301 |
| Zhang W et al. | ETS-1-mediated transcriptional up-regulation of CD44 is required for sphingosine-1-phosphate receptor subtype 3-stimulated chemotaxis. | 2013 | J. Biol. Chem. | pmid:24064218 |
| Das A et al. | The promotion of mandibular defect healing by the targeting of S1P receptors and the recruitment of alternatively activated macrophages. | 2013 | Biomaterials | pmid:24064148 |
| Babahosseini H et al. | Bioactive sphingolipid metabolites modulate ovarian cancer cell structural mechanics. | 2013 | Integr Biol (Camb) | pmid:24056950 |
| Anderson G and Maes M | Reconceptualizing adult neurogenesis: role for sphingosine-1-phosphate and fibroblast growth factor-1 in co-ordinating astrocyte-neuronal precursor interactions. | 2014 | CNS Neurol Disord Drug Targets | pmid:24040808 |
| Kowalski GM et al. | Plasma sphingosine-1-phosphate is elevated in obesity. | 2013 | PLoS ONE | pmid:24039766 |
| Chang N et al. | Sphingosine 1-phosphate receptors negatively regulate collagen type I/III expression in human bone marrow-derived mesenchymal stem cell. | 2014 | J. Cell. Biochem. | pmid:24038457 |
| Sar JI et al. | Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate. | 2015 | J. Formos. Med. Assoc. | pmid:24035571 |
| Che W et al. | Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1. | 2014 | Am. J. Respir. Cell Mol. Biol. | pmid:24032470 |
| Tanaka K et al. | Anti-interleukin-6 receptor antibody prevents systemic bone mass loss via reducing the number of osteoclast precursors in bone marrow in a collagen-induced arthritis model. | 2014 | Clin. Exp. Immunol. | pmid:24028747 |
| Dave JM et al. | Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK). | 2013 | J. Biol. Chem. | pmid:24005669 |
| Dziak R | The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells. | 2013 | Immunol. Invest. | pmid:24004055 |
| Herr DR et al. | Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. | 2013 | J. Biol. Chem. | pmid:24003216 |
| Zhang J et al. | Sphingosine signalling regulates decidual NK cell angiogenic phenotype and trophoblast migration. | 2013 | Hum. Reprod. | pmid:24001716 |
| Herzog BH et al. | Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. | 2013 | Nature | pmid:23995678 |
| Kihara A | Sphingosine 1-phosphate is a key metabolite linking sphingolipids to glycerophospholipids. | 2014 | Biochim. Biophys. Acta | pmid:23994042 |
| Del Galdo S et al. | The activation of RhoC in vascular endothelial cells is required for the S1P receptor type 2-induced inhibition of angiogenesis. | 2013 | Cell. Signal. | pmid:23993968 |
| Zhang O et al. | Sphingosine kinase A is a pleiotropic and essential enzyme for Leishmania survival and virulence. | 2013 | Mol. Microbiol. | pmid:23980754 |
| Kihara A | [Complete metabolic pathway of sphingosine 1-phosphate and its importance as a metabolic intermediate]. | 2013 | Seikagaku | pmid:23980469 |
| Xia JY et al. | The adipokine/ceramide axis: key aspects of insulin sensitization. | 2014 | Biochimie | pmid:23969158 |
| Kim ES et al. | Inflammatory lipid sphingosine-1-phosphate upregulates C-reactive protein via C/EBPβ and potentiates breast cancer progression. | 2014 | Oncogene | pmid:23955082 |
| Kunkel GT et al. | Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond. | 2013 | Nat Rev Drug Discov | pmid:23954895 |
| Morad SA et al. | Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. | 2013 | Biochim. Biophys. Acta | pmid:23939396 |
| Weichand B et al. | Apoptotic cells enhance sphingosine-1-phosphate receptor 1 dependent macrophage migration. | 2013 | Eur. J. Immunol. | pmid:23934754 |
| Harijith A et al. | Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins. | 2013 | Am. J. Pathol. | pmid:23933064 |
| Nishi T et al. | Molecular and physiological functions of sphingosine 1-phosphate transporters. | 2014 | Biochim. Biophys. Acta | pmid:23921254 |
| Sun X et al. | Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. | 2013 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:23911438 |
| Koch A et al. | PPARγ agonists upregulate sphingosine 1-phosphate (S1P) receptor 1 expression, which in turn reduces S1P-induced [Ca(2+)]i increases in renal mesangial cells. | 2013 | Biochim. Biophys. Acta | pmid:23906789 |
| Olivera A et al. | Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. | 2013 | J. Leukoc. Biol. | pmid:23904439 |
| Albinet V et al. | Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. | 2014 | Oncogene | pmid:23893239 |
| Gorshkova IA et al. | Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest. | 2013 | Life Sci. | pmid:23892195 |
| Egom EE et al. | Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy. | 2013 May-Jun | Crit Rev Clin Lab Sci | pmid:23885725 |
| Gao X et al. | Aberrant sphingolipid metabolism in the human fallopian tube with ectopic pregnancy. | 2013 | Lipids | pmid:23881382 |
| Adada M et al. | Sphingosine-1-phosphate receptor 2. | 2013 | FEBS J. | pmid:23879641 |
| Zhao CG et al. | Sphingosine-1-phosphate is a possible fibrogenic factor in gluteal muscle fibrosis. | 2013 | Physiol Res | pmid:23869887 |
| Kotani T et al. | Altered expression of enzymes regulating the activity of endothelin-1 in the lower segment of the human amnion during labor. | 2013 | Biol. Reprod. | pmid:23863409 |
| Ota K et al. | TGF-β induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. | 2013 | Endocrinology | pmid:23861379 |
| Park K et al. | Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. | 2013 | J. Invest. Dermatol. | pmid:23856934 |
| Liu Y et al. | Hepatopoietin Cn reduces ethanol-induced hepatoxicity via sphingosine kinase 1 and sphingosine 1-phosphate receptors. | 2013 | J. Pathol. | pmid:23839903 |
| Egom EE | Sphingosine-1-phosphate signalling as a therapeutic target for patients with abnormal glucose metabolism and ischaemic heart disease. | 2014 | J Cardiovasc Med (Hagerstown) | pmid:23839592 |
| Moriue T et al. | Sphingosine 1-phosphate attenuates peroxide-induced apoptosis in HaCaT cells cultured in vitro. | 2013 | Clin. Exp. Dermatol. | pmid:23837937 |
| Riccitelli E et al. | Extracellular sphingosine-1-phosphate: a novel actor in human glioblastoma stem cell survival. | 2013 | PLoS ONE | pmid:23826381 |