Sphingosine 1-phosphate

Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.

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Introduction

To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Sphingosine 1-phosphate?

Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate

MeSH term MeSH ID Detail
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Rhabdomyosarcoma D012208 7 associated lipids
Niemann-Pick Diseases D009542 25 associated lipids
Cardiomyopathies D009202 10 associated lipids
Shock, Hemorrhagic D012771 4 associated lipids
Adenoma D000236 40 associated lipids
Mycobacterium Infections, Nontuberculous D009165 8 associated lipids
Vascular Diseases D014652 16 associated lipids
Ovarian Diseases D010049 5 associated lipids
Anemia D000740 21 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Sphingosine 1-phosphate

Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.

Related references are published most in these journals:

Pathway name Related literatures
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PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Sphingosine 1-phosphate?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Sphingosine 1-phosphate?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Sphingosine 1-phosphate?

Knock-out

Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).

Mouse Model

Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).

Transgenic Model

Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Sphingosine 1-phosphate

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Per page 10 20 50 100 | Total 2896
Authors Title Published Journal PubMed Link
Aoyagi T et al. The role of sphingosine-1-phosphate in breast cancer tumor-induced lymphangiogenesis. 2012 Lymphat Res Biol pmid:22984905
Koch A et al. Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells. 2012 Br. J. Pharmacol. pmid:22221312
Taylor S et al. The utility of pharmacokinetic-pharmacodynamic modeling in the discovery and optimization of selective S1P(1) agonists. 2012 Xenobiotica pmid:22225501
Majumdar I and Mastrandrea LD Serum sphingolipids and inflammatory mediators in adolescents at risk for metabolic syndrome. 2012 Endocrine pmid:22228496
Wang S et al. A polysaccharides MDG-1 augments survival in the ischemic heart by inducing S1P release and S1P1 expression. 2012 Int. J. Biol. Macromol. pmid:22197795
Armstrong SM et al. Co-regulation of transcellular and paracellular leak across microvascular endothelium by dynamin and Rac. 2012 Am. J. Pathol. pmid:22203054
Bode C and Gräler MH Immune regulation by sphingosine 1-phosphate and its receptors. 2012 Arch. Immunol. Ther. Exp. (Warsz.) pmid:22159476
Shmyrev VI et al. [Sphingosine-1-phosphate signaling system and the innovative mechanism of action of fingolimod in treatment of multiple sclerosis: review of foreign literature]. 2012 Zh Nevrol Psikhiatr Im S S Korsakova pmid:22677684
Upadhyaya P et al. The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA. 2012 Biochem. Biophys. Res. Commun. pmid:22727907
Sun DF et al. Sphingosine 1-phosphate antagonizes the effect of all-trans retinoic acid (ATRA) in a human colon cancer cell line by modulation of RARβ expression. 2012 Cancer Lett. pmid:22261335
Nijnik A et al. The role of sphingosine-1-phosphate transporter Spns2 in immune system function. 2012 J. Immunol. pmid:22664872
Duru EA et al. Role of S-1-P receptors and human vascular smooth muscle cell migration in diabetes and metabolic syndrome. 2012 J. Surg. Res. pmid:22480845
Moberly JB et al. Pharmacological effects of CS-0777, a selective sphingosine 1-phosphate receptor-1 modulator: results from a 12-week, open-label pilot study in multiple sclerosis patients. 2012 J. Neuroimmunol. pmid:22465063
Ishimaru N et al. CCR7 with S1P1 signaling through AP-1 for migration of Foxp3+ regulatory T-cells controls autoimmune exocrinopathy. 2012 Am. J. Pathol. pmid:22067914
Lucki NC et al. Sphingosine-1-phosphate rapidly increases cortisol biosynthesis and the expression of genes involved in cholesterol uptake and transport in H295R adrenocortical cells. 2012 Mol. Cell. Endocrinol. pmid:21864647
Schnute ME et al. Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1. 2012 Biochem. J. pmid:22397330
Bachmaier K et al. Sphingosine kinase 1 mediation of expression of the anaphylatoxin receptor C5L2 dampens the inflammatory response to endotoxin. 2012 PLoS ONE pmid:22355325
Sugiura T et al. Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis. 2012 Coron. Artery Dis. pmid:22356865
Sashio T et al. Possible Involvement of Sphingosine-1-Phosphate/G(i)/RhoA pathways in adherence of eosinophils to pulmonary endothelium. 2012 Allergol Int pmid:22361510
Antoon JW and Beckman BS Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer. 2012 Bioorg. Med. Chem. Lett. pmid:22366655
Kipp M and Amor S FTY720 on the way from the base camp to the summit of the mountain: relevance for remyelination. 2012 Mult. Scler. pmid:22383435
Fujii Y et al. Blocking S1P interaction with S1P₁ receptor by a novel competitive S1P₁-selective antagonist inhibits angiogenesis. 2012 Biochem. Biophys. Res. Commun. pmid:22387544
Karmouty-Quintana H et al. Treatment with a sphingosine-1-phosphate analog inhibits airway remodeling following repeated allergen exposure. 2012 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:22287614
Bassoy EY and Baran Y Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. 2012 Biomed. Pharmacother. pmid:22326625
Adamson RH et al. Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible. 2012 Am. J. Physiol. Heart Circ. Physiol. pmid:22427519
Korbelik M et al. Monitoring ceramide and sphingosine-1-phosphate levels in cancer cells and macrophages from tumours treated by photodynamic therapy. 2012 Photochem. Photobiol. Sci. pmid:22354109
Wilkerson BA et al. Sphingosine 1-phosphate (S1P) carrier-dependent regulation of endothelial barrier: high density lipoprotein (HDL)-S1P prolongs endothelial barrier enhancement as compared with albumin-S1P via effects on levels, trafficking, and signaling of S1P1. 2012 J. Biol. Chem. pmid:23135269
Tar L and Vécsei L [Fingolimod therapy in multiple sclerosis--the issue of the pathomechanism]. 2012 Ideggyogy Sz pmid:23136726
Hla T et al. S1P and the birth of platelets. 2012 J. Exp. Med. pmid:23166370
Cuvillier O [Sphingosine 1-phosphate receptors: from biology to physiopathology]. 2012 Med Sci (Paris) pmid:23171898
Giacomini MM et al. Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force. 2012 Exp. Cell Res. pmid:22309779
Patel SA et al. Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity. 2012 Endocrinology pmid:22989629
Fernández-Pisonero I et al. Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells. 2012 J. Immunol. pmid:23089395
Medlin MD et al. Quantifying sphingosine-1-phosphate-dependent activation of the RhoGTPases. 2012 Methods Mol. Biol. pmid:22528442
Belmonte SA and Suhaiman L Optimized protocols to analyze sphingosine-1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm. 2012 Methods Mol. Biol. pmid:22528443
Ishii T et al. Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis. 2012 Methods Mol. Biol. pmid:22528444
Meacci E et al. Sphingosine-1-phosphate signaling in skeletal muscle cells. 2012 Methods Mol. Biol. pmid:22528446
Wong RC et al. Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor. 2012 Methods Mol. Biol. pmid:22528447
Bieberich E Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation. 2012 Methods Mol. Biol. pmid:22528448
Callihan P and Hooks SB Sphingosine-1-phosphate signaling in neural progenitors. 2012 Methods Mol. Biol. pmid:22528449
Reina E et al. Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry. 2012 Chem. Phys. Lipids pmid:22265672
Ding R et al. Sphingosine-1-phosphate attenuates lung injury induced by intestinal ischemia/reperfusion in mice: role of inducible nitric-oxide synthase. 2012 Inflammation pmid:21302134
Nakahara K et al. The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. 2012 Mol. Cell pmid:22633490
Dakroub Z and Kreydiyyeh SI Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells. 2012 J. Cell. Biochem. pmid:22271589
Santulli P et al. Sphingosine pathway deregulation in endometriotic tissues. 2012 Fertil. Steril. pmid:22277765
Golan K et al. S1P promotes murine progenitor cell egress and mobilization via S1P1-mediated ROS signaling and SDF-1 release. 2012 Blood pmid:22279055
Jiang H et al. Application of ultra-performance liquid chromatography coupled with mass spectrometry to metabonomic study on spontaneously hypertensive rats and intervention effects of Ping Gan prescription. 2012 J Sep Sci pmid:22282408
Takeshita H et al. Sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling regulates receptor activator of NF-κB ligand (RANKL) expression in rheumatoid arthritis. 2012 Biochem. Biophys. Res. Commun. pmid:22326262
Shannon LA et al. CCR7/CCL19 controls expression of EDG-1 in T cells. 2012 J. Biol. Chem. pmid:22334704
Nunes J et al. Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection. 2012 Br. J. Cancer pmid:22315056