Hsia K et al. |
Sphingosine-1-phosphate improves endothelialization with reduction of thrombosis in recellularized human umbilical vein graft by inhibiting syndecan-1 shedding in vitro. |
2017 |
Acta Biomater |
pmid:28110073
|
Maiti A et al. |
Metastatic triple-negative breast cancer is dependent on SphKs/S1P signaling for growth and survival. |
2017 |
Cell. Signal. |
pmid:28108260
|
Meissner A et al. |
Sphingosine-1-phosphate signalling-a key player in the pathogenesis of Angiotensin II-induced hypertension. |
2017 |
Cardiovasc. Res. |
pmid:28082452
|
Atkinson D et al. |
Sphingosine 1-phosphate lyase deficiency causes Charcot-Marie-Tooth neuropathy. |
2017 |
Neurology |
pmid:28077491
|
Ng ML et al. |
The role of sphingolipid signalling in diabetes‑associated pathologies (Review). |
2017 |
Int. J. Mol. Med. |
pmid:28075451
|
van der Weyden L et al. |
Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. |
2017 |
Nature |
pmid:28052056
|
Lima S et al. |
Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking. |
2017 |
J. Biol. Chem. |
pmid:28049734
|
Ogle ME et al. |
Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. |
2017 |
Stem Cells |
pmid:28026131
|
Yung BS et al. |
Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection. |
2017 |
J. Mol. Cell. Cardiol. |
pmid:28017639
|
Frias MA et al. |
High-density lipoprotein-associated sphingosine-1-phosphate activity in heterozygous familial hypercholesterolaemia. |
2017 |
Eur. J. Clin. Invest. |
pmid:27861771
|
Fang V et al. |
Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. |
2017 |
Nat. Immunol. |
pmid:27841869
|
Wang R et al. |
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration. |
2017 |
Am. J. Pathol. |
pmid:27840081
|
O'Sullivan S and Dev KK |
Sphingosine-1-phosphate receptor therapies: Advances in clinical trials for CNS-related diseases. |
2017 |
Neuropharmacology |
pmid:27825807
|
Engel N et al. |
Synergistic Action of Genistein and Calcitriol in Immature Osteosarcoma MG-63 Cells by SGPL1 Up-Regulation. |
2017 |
PLoS ONE |
pmid:28125641
|
Yanagida K and Hla T |
Vascular and Immunobiology of the Circulatory Sphingosine 1-Phosphate Gradient. |
2017 |
Annu. Rev. Physiol. |
pmid:27813829
|
Zhao Z et al. |
Characterization of the Anticoagulant and Antithrombotic Properties of the Sphingosine 1-Phosphate Mimetic FTY720. |
2017 |
Acta Haematol. |
pmid:27802432
|
González-Fernández B et al. |
Inhibition of the SphK1/S1P signaling pathway by melatonin in mice with liver fibrosis and human hepatic stellate cells. |
2017 |
Biofactors |
pmid:27801960
|
McLean CJ et al. |
Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. |
2017 |
J. Lipid Res. |
pmid:27784725
|
Abraham C et al. |
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. |
2017 |
Gastroenterology |
pmid:27780712
|
Pal SK et al. |
A phase 2 study of the sphingosine-1-phosphate antibody sonepcizumab in patients with metastatic renal cell carcinoma. |
2017 |
Cancer |
pmid:27727447
|
Åukomska A et al. |
The effect of low levels of lead (Pb) in the blood on levels of sphingosine-1-phosphate (S1P) and expression of S1P receptor 1 in the brain of the rat in the perinatal period. |
2017 |
Chemosphere |
pmid:27697711
|
Sánchez DI et al. |
Melatonin prevents deregulation of the sphingosine kinase/sphingosine 1-phosphate signaling pathway in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma. |
2017 |
J. Pineal Res. |
pmid:27696512
|
Lim J et al. |
Valproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells. |
2017 |
Int. J. Mol. Med. |
pmid:28677769
|
Katsuta E et al. |
Doxorubicin effect is enhanced by sphingosine-1-phosphate signaling antagonist in breast cancer. |
2017 |
J. Surg. Res. |
pmid:29078883
|
Vogt D and Stark H |
Therapeutic Strategies and Pharmacological Tools Influencing S1P Signaling and Metabolism. |
2017 |
Med Res Rev |
pmid:27480072
|
Mitroi DN et al. |
SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. |
2017 |
Autophagy |
pmid:28521611
|
Tsai CH et al. |
Sphingosine-1-phosphate suppresses chondrosarcoma metastasis by upregulation of tissue inhibitor of metalloproteinase 3 through suppressing miR-101 expression. |
2017 |
Mol Oncol |
pmid:28672103
|
Xie Z et al. |
Targeting sphingosine-1-phosphate signaling for cancer therapy. |
2017 |
Sci China Life Sci |
pmid:28623546
|
Yanagida K et al. |
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1. |
2017 |
Proc. Natl. Acad. Sci. U.S.A. |
pmid:28396408
|
Takahashi C et al. |
Vehicle-dependent Effects of Sphingosine 1-phosphate on Plasminogen Activator Inhibitor-1 Expression. |
2017 |
J. Atheroscler. Thromb. |
pmid:28321011
|
Pierucci F et al. |
Vitamin D protects against Aβ peptide cytotoxicity in differentiated human neuroblastoma SH- SY5Y cells: A role for S1P1/p38MAPK/ATF4 axis. |
2017 |
Neuropharmacology |
pmid:28077289
|
Leo A et al. |
The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. |
2017 |
CNS Neurol Disord Drug Targets |
pmid:27823573
|
Roch L et al. |
High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. |
2017 |
Mol. Neurobiol. |
pmid:27631876
|
Vu TM et al. |
Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets. |
2017 |
Nature |
pmid:29045386
|
Reinhard NR et al. |
The balance between Gα-Cdc42/Rac and Gα/-RhoA pathways determines endothelial barrier regulation by sphingosine-1-phosphate. |
2017 |
Mol. Biol. Cell |
pmid:28954861
|
Natarajan V et al. |
Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. |
2017 |
BMC Genomics |
pmid:28851267
|
Hajny S and Christoffersen C |
A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. |
2017 |
Int J Mol Sci |
pmid:28749426
|
Bertlich M et al. |
Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. |
2017 |
Otol. Neurotol. |
pmid:28742634
|
Koch A et al. |
Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. |
2017 |
Int J Mol Sci |
pmid:28714882
|
Wilkerson JL and Mandal NA |
Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. |
2017 |
Methods Mol. Biol. |
pmid:28660590
|
Kurano M et al. |
Involvement of Band3 in the efflux of sphingosine 1-phosphate from erythrocytes. |
2017 |
PLoS ONE |
pmid:28494002
|
Onuma T et al. |
Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. |
2017 |
Thromb. Res. |
pmid:28609704
|
Azimzadeh K et al. |
Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51). |
2017 |
Microb. Pathog. |
pmid:28533142
|
Alqinyah M et al. |
Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. |
2017 |
Mol. Pharmacol. |
pmid:28031332
|
Oh YT et al. |
DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion. |
2017 |
Cell Commun. Signal |
pmid:28482915
|
Fan Q et al. |
Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling. |
2017 |
Oncotarget |
pmid:28460443
|
Lafargue A et al. |
Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. |
2017 |
Free Radic. Biol. Med. |
pmid:28431961
|
Di Pietro M et al. |
In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome. |
2017 |
Mol. Hum. Reprod. |
pmid:28379469
|
Schumacher F et al. |
The sphingosine 1-phosphate breakdown product, (2)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. |
2017 |
J. Lipid Res. |
pmid:28588048
|
Ebenezer DL et al. |
Epigenetic regulation of pro-inflammatory cytokine secretion by sphingosine 1-phosphate (S1P) in acute lung injury: Role of S1P lyase. |
2017 |
Adv Biol Regul |
pmid:27720306
|
Al-Jarallah A and Oriowo M |
The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis. |
2017 |
PLoS ONE |
pmid:28493876
|
Beider K et al. |
The Sphingosine-1-Phosphate Modulator FTY720 Targets Multiple Myeloma via the CXCR4/CXCL12 Pathway. |
2017 |
Clin. Cancer Res. |
pmid:27697999
|
Feuerborn R et al. |
High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. |
2017 |
Atherosclerosis |
pmid:28038379
|
Thieme M et al. |
Sphingosine-1-phosphate modulators in inflammatory skin diseases - lining up for clinical translation. |
2017 |
Exp. Dermatol. |
pmid:27574180
|
Chang N et al. |
HuR mediates motility of human bone marrow-derived mesenchymal stem cells triggered by sphingosine 1-phosphate in liver fibrosis. |
2017 |
J. Mol. Med. |
pmid:27543493
|
Gudipaty SA and Rosenblatt J |
Epithelial cell extrusion: Pathways and pathologies. |
2017 |
Semin. Cell Dev. Biol. |
pmid:27212253
|
Wang M et al. |
Automated tracking and quantification of angiogenic vessel formation in 3D microfluidic devices. |
2017 |
PLoS ONE |
pmid:29136008
|
Tran HB et al. |
Disrupted epithelial/macrophage crosstalk via Spinster homologue 2-mediated S1P signaling may drive defective macrophage phagocytic function in COPD. |
2017 |
PLoS ONE |
pmid:29112690
|
Mensah SA et al. |
Regeneration of glycocalyx by heparan sulfate and sphingosine 1-phosphate restores inter-endothelial communication. |
2017 |
PLoS ONE |
pmid:29023478
|
Wang X et al. |
Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. |
2017 |
Exp. Mol. Pathol. |
pmid:28986246
|
Werth S et al. |
Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. |
2017 |
J. Endocrinol. |
pmid:28970286
|
Du Y et al. |
Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. |
2017 |
Cell. Physiol. Biochem. |
pmid:28934733
|
Kuchler L et al. |
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. |
2017 |
Mol. Immunol. |
pmid:28846923
|
Nicholas SE et al. |
Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. |
2017 |
PLoS ONE |
pmid:28806736
|
Lee SY et al. |
Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. |
2017 |
Diabetes |
pmid:28698261
|
Ko J et al. |
Sphingosine-1-Phosphate Mediates Fibrosis in Orbital Fibroblasts in Graves' Orbitopathy. |
2017 |
Invest. Ophthalmol. Vis. Sci. |
pmid:28492873
|
Aoyama-Araki Y et al. |
Sphingosine-1-Phosphate (S1P)-Related Response of Human Conjunctival Fibroblasts After Filtration Surgery for Glaucoma. |
2017 |
Invest. Ophthalmol. Vis. Sci. |
pmid:28418499
|
Frej C et al. |
A Shift in ApoM/S1P Between HDL-Particles in Women With Type 1 Diabetes Mellitus Is Associated With Impaired Anti-Inflammatory Effects of the ApoM/S1P Complex. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:28385702
|
Nakajima M et al. |
The role of sphingosine-1-phosphate in the tumor microenvironment and its clinical implications. |
2017 |
Tumour Biol. |
pmid:28381169
|
Garbowska M et al. |
Sphingolipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes. |
2017 |
J. Cell. Physiol. |
pmid:28369933
|
Turner VM and Mabbott NA |
Ageing adversely affects the migration and function of marginal zone B cells. |
2017 |
Immunology |
pmid:28369800
|
Müller J et al. |
Differential S1P Receptor Profiles on M1- and M2-Polarized Macrophages Affect Macrophage Cytokine Production and Migration. |
2017 |
Biomed Res Int |
pmid:28367448
|
King A et al. |
Sphingosine-1-Phosphate Prevents Egress of Hematopoietic Stem Cells From Liver to Reduce Fibrosis. |
2017 |
Gastroenterology |
pmid:28363640
|
Wollny T et al. |
Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease. |
2017 |
Int J Mol Sci |
pmid:28362332
|
Denimal D et al. |
Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS: Correction by S1P Enrichment. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:28360087
|
Gusman DH and Shoemake C |
Evaluation and Optimization of designed Sphingosine-1-Phosphate (S1P) Receptor Subtype 1 Modulators for the Management of Multiple Sclerosis. |
2017 |
Yale J Biol Med |
pmid:28356890
|
Andrieu G et al. |
Sphingosine 1-phosphate signaling through its receptor S1P promotes chromosome segregation and mitotic progression. |
2017 |
Sci Signal |
pmid:28351953
|
Becker S et al. |
Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. |
2017 |
PLoS ONE |
pmid:28334008
|
Karunakaran I and van Echten-Deckert G |
Sphingosine 1-phosphate - A double edged sword in the brain. |
2017 |
Biochim. Biophys. Acta |
pmid:28315304
|
Navarrete A et al. |
A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. |
2017 |
J Pharm Biomed Anal |
pmid:28314215
|
Shirakawa H et al. |
Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. |
2017 |
Glia |
pmid:28300348
|
Dyckman AJ |
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. |
2017 |
J. Med. Chem. |
pmid:28291340
|
Tafelmeier M et al. |
Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles. |
2017 |
J. Steroid Biochem. Mol. Biol. |
pmid:27163393
|
Rojas-Canales D et al. |
Local Sphingosine Kinase 1 Activity Improves Islet Transplantation. |
2017 |
Diabetes |
pmid:28174291
|
Dela Paz NG et al. |
Shear stress induces Gα activation independently of G protein-coupled receptor activation in endothelial cells. |
2017 |
Am. J. Physiol., Cell Physiol. |
pmid:28148497
|
Green CL et al. |
The effects of graded levels of calorie restriction: IX. Global metabolomic screen reveals modulation of carnitines, sphingolipids and bile acids in the liver of C57BL/6 mice. |
2017 |
Aging Cell |
pmid:28139067
|
Vishwakarma S et al. |
Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes. |
2017 |
Cancer Invest. |
pmid:28135860
|
Kurano M et al. |
Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions. |
2017 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:28126827
|
Wang Y et al. |
The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice. |
2017 |
Hepatology |
pmid:28120434
|
Tang HB et al. |
S1P/S1PR3 signaling mediated proliferation of pericytes via Ras/pERK pathway and CAY10444 had beneficial effects on spinal cord injury. |
2018 |
Biochem. Biophys. Res. Commun. |
pmid:29534963
|
Yu FC et al. |
Protective effect of sphingosine-1-phosphate for chronic intermittent hypoxia-induced endothelial cell injury. |
2018 |
Biochem. Biophys. Res. Commun. |
pmid:29550481
|
Nádró B et al. |
[The role of apolipoprotein M and sphingosine 1-phosphate axis in the prevention of atherosclerosis]. |
2018 |
Orv Hetil |
pmid:29376427
|
Deshpande GP et al. |
Sphingosine-1-phosphate (S1P) activates STAT3 to protect against de novo acute heart failure (AHF). |
2018 |
Life Sci. |
pmid:29373815
|
Książek M et al. |
Arteriovenous Sphingosine-1-Phosphate Differences Across Selected Organs of the Rat. |
2018 |
Cell. Physiol. Biochem. |
pmid:29316552
|
Huang Y et al. |
S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense. |
2018 |
Science |
pmid:29302015
|
Ogretmen B |
Sphingolipid metabolism in cancer signalling and therapy. |
2018 |
Nat. Rev. Cancer |
pmid:29147025
|