| MeSH term | MeSH ID | Detail |
|---|---|---|
| Respiratory Distress Syndrome, Adult | D012128 | 15 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Lung Injury | D055370 | 14 associated lipids |
| Osteoarthritis, Knee | D020370 | 13 associated lipids |
| Sciatic Neuropathy | D020426 | 13 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Hepatitis C, Chronic | D019698 | 12 associated lipids |
| Influenza, Human | D007251 | 11 associated lipids |
| Muscular Dystrophy, Duchenne | D020388 | 11 associated lipids |
| Cardiomyopathies | D009202 | 10 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Wang X et al. | Sphingosine 1-Phosphate Activation of EGFR As a Novel Target for Meningitic Escherichia coli Penetration of the Blood-Brain Barrier. | 2016 | PLoS Pathog. | pmid:27711202 |
| Adamiak M et al. | The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells. | 2016 | Stem Cell Rev | pmid:27704316 |
| Zhang Q et al. | Berberine Preconditioning Protects Neurons Against Ischemia via Sphingosine-1-Phosphate and Hypoxia-Inducible Factor-1[Formula: see text]. | 2016 | Am. J. Chin. Med. | pmid:27430910 |
| Adamiak M et al. | Downregulation of Heme Oxygenase 1 (HO-1) Activity in Hematopoietic Cells Enhances Their Engraftment After Transplantation. | 2016 | Cell Transplant | pmid:27412411 |
| Liu X et al. | ApoA-I induces S1P release from endothelial cells through ABCA1 and SR-BI in a positive feedback manner. | 2016 | J. Physiol. Biochem. | pmid:27377933 |
| Tong S et al. | Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane. | 2016 | J. Biol. Chem. | pmid:27405756 |
| Nagura Y et al. | Regulation of the lysophosphatidylserine and sphingosine 1-phosphate levels in autologous whole blood by the pre-storage leukocyte reduction. | 2016 | Transfus Med | pmid:27350440 |
| Riganti L et al. | Sphingosine-1-Phosphate (S1P) Impacts Presynaptic Functions by Regulating Synapsin I Localization in the Presynaptic Compartment. | 2016 | J. Neurosci. | pmid:27098703 |
| Cai Y et al. | FOXF1 maintains endothelial barrier function and prevents edema after lung injury. | 2016 | Sci Signal | pmid:27095594 |
| Castaldi A et al. | Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs. | 2016 | Cell. Signal. | pmid:27094722 |
| Anbazhagan AN et al. | Transcriptional modulation of SLC26A3 (DRA) by sphingosine-1-phosphate. | 2016 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:27079615 |
| Koresawa R et al. | Sphingosine-1-phosphate receptor 1 as a prognostic biomarker and therapeutic target for patients with primary testicular diffuse large B-cell lymphoma. | 2016 | Br. J. Haematol. | pmid:27061580 |
| Zhang H et al. | Binding Characteristics of Sphingosine-1-Phosphate to ApoM hints to Assisted Release Mechanism via the ApoM Calyx-Opening. | 2016 | Sci Rep | pmid:27476912 |
| Camaré C et al. | The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL. | 2016 | Free Radic. Biol. Med. | pmid:26855418 |
| Kim SE et al. | The Role of Sphingosine-1-Phosphate in Adipogenesis of Graves' Orbitopathy. | 2016 | Invest. Ophthalmol. Vis. Sci. | pmid:26830367 |
| Messias CV et al. | Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation. | 2016 | PLoS ONE | pmid:26824863 |
| Pászti-Gere E et al. | Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status. | 2016 | Oxid Med Cell Longev | pmid:26823955 |
| Wiltshire R et al. | Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors. | 2016 | Sci Rep | pmid:26813587 |
| Zhang F et al. | Sphingosine 1-phosphate signaling contributes to cardiac inflammation, dysfunction, and remodeling following myocardial infarction. | 2016 | Am. J. Physiol. Heart Circ. Physiol. | pmid:26589326 |
| Pyne NJ and Tigyi GJ | A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research. | 2016 | Prog. Lipid Res. | pmid:26584871 |
| Rana A and Sharma S | Mechanism of sphingosine-1-phosphate induced cardioprotection against I/R injury in diabetic rat heart: Possible involvement of glycogen synthase kinase 3β and mitochondrial permeability transition pore. | 2016 | Clin. Exp. Pharmacol. Physiol. | pmid:26582369 |
| Nagahashi M et al. | Interstitial Fluid Sphingosine-1-Phosphate in Murine Mammary Gland and Cancer and Human Breast Tissue and Cancer Determined by Novel Methods. | 2016 | J Mammary Gland Biol Neoplasia | pmid:27194029 |
| Patmanathan SN et al. | Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. | 2016 | Sci Rep | pmid:27160553 |
| Li N and Zhang F | Implication of sphingosin-1-phosphate in cardiovascular regulation. | 2016 | Front Biosci (Landmark Ed) | pmid:27100508 |
| Zhang L et al. | Sphingosine-1-phosphate Maintains Normal Vascular Permeability by Preserving Endothelial Surface Glycocalyx in Intact Microvessels. | 2016 | Microcirculation | pmid:27015105 |
| Bae SJ et al. | The circulating sphingosine-1-phosphate level predicts incident fracture in postmenopausal women: a 3.5-year follow-up observation study. | 2016 | Osteoporos Int | pmid:26984570 |
| Kurano M et al. | Resveratrol exerts a biphasic effect on apolipoprotein M. | 2016 | Br. J. Pharmacol. | pmid:26445217 |
| Nojima H et al. | Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate. | 2016 | J. Hepatol. | pmid:26254847 |
| Kolahdooz Z et al. | Sphingosin-1-phosphate Receptor 1: a Potential Target to Inhibit Neuroinflammation and Restore the Sphingosin-1-phosphate Metabolism. | 2015 | Can J Neurol Sci | pmid:25860537 |
| Ren K et al. | Apolipoprotein M. | 2015 | Clin. Chim. Acta | pmid:25858547 |
| Molinari G | Is hydrogen ion (H(+)) the real second messenger in calcium signalling? | 2015 | Cell. Signal. | pmid:25843778 |
| Nussbaum C et al. | Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin. | 2015 | Nat Commun | pmid:25832730 |
| Hsu CK et al. | Sphingosine-1-phosphate mediates COX-2 expression and PGE2 /IL-6 secretion via c-Src-dependent AP-1 activation. | 2015 | J. Cell. Physiol. | pmid:25201048 |
| Liu M et al. | Uncleaved ApoM signal peptide is required for formation of large ApoM/sphingosine 1-phosphate (S1P)-enriched HDL particles. | 2015 | J. Biol. Chem. | pmid:25627684 |
| Hwang IY et al. | An essential role for RGS protein/Gαi2 interactions in B lymphocyte-directed cell migration and trafficking. | 2015 | J. Immunol. | pmid:25617475 |
| Mikłosz A et al. | Hyperthyroidism evokes myocardial ceramide accumulation. | 2015 | Cell. Physiol. Biochem. | pmid:25613909 |
| Kurek K et al. | Sphingolipid metabolism in colorectal adenomas varies depending on histological architecture of polyps and grade of nuclear dysplasia. | 2015 | Lipids | pmid:25595595 |
| Chawla S and Saxena S | Differential modulation of S1PR(1-5) and specific activities of SphK and nSMase in pulmonary and cerebral tissues of rats exposed to hypobaric hypoxia. | 2015 | Lipids | pmid:25398597 |
| Santos WL and Lynch KR | Drugging sphingosine kinases. | 2015 | ACS Chem. Biol. | pmid:25384187 |
| Cuvillier O | [SphingomabTM, an anti-sphingosine 1-phosphate antibody to inhibit hypoxia]. | 2015 | Med Sci (Paris) | pmid:26576602 |
| Moon E et al. | Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling. | 2015 | Mediators Inflamm. | pmid:26576074 |
| Tang H et al. | Expression of Sphingosine-1-phosphate (S1P) on the cerebral vasospasm after subarachnoid hemorrhage in rabbits. | 2015 | Acta Cir Bras | pmid:26560422 |
| Sattler K et al. | Defects of High-Density Lipoproteins in Coronary Artery Disease Caused by Low Sphingosine-1-Phosphate Content: Correction by Sphingosine-1-Phosphate-Loading. | 2015 | J. Am. Coll. Cardiol. | pmid:26403344 |
| Yester JW et al. | Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop. | 2015 | FASEB J. | pmid:26246404 |
| Kharel Y et al. | Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. | 2015 | J. Pharmacol. Exp. Ther. | pmid:26243740 |
| Gao XY et al. | Inhibition of sphingosine-1-phosphate phosphatase 1 promotes cancer cells migration in gastric cancer: Clinical implications. | 2015 | Oncol. Rep. | pmid:26239167 |
| Zhang JN et al. | The role of the sphingosine-1-phosphate signaling pathway in osteocyte mechanotransduction. | 2015 | Bone | pmid:25988659 |
| Parham KA et al. | Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis. | 2015 | FASEB J. | pmid:25985799 |
| Schweitzer KS et al. | Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. | 2015 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:25979079 |
| Lee KP et al. | DJ-1-mediated upregulation of serine palmitoyltransferase 2 controls vascular neointima via S1P autocrine. | 2015 | Int. J. Cardiol. | pmid:25978603 |