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FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. |
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FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. |
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Mol. Cancer Ther. |
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Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. |
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Cell Biol. Int. |
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Familial hypercholesterolaemia: cholesterol efflux and coronary disease. |
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Eur. J. Clin. Invest. |
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Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. |
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Diabetes |
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PLoS ONE |
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Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. |
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Cell Chem Biol |
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Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. |
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ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. |
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Proc. Natl. Acad. Sci. U.S.A. |
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Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. |
2016 |
Oncotarget |
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Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. |
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PLoS ONE |
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Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. |
2016 |
Mediators Inflamm. |
pmid:26884643
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Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. |
2016 |
Sci Rep |
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Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. |
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Am. J. Physiol., Cell Physiol. |
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Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. |
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Annu. Rev. Physiol. |
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Curr. Med. Chem. |
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A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). |
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Mol. Biol. Cell |
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Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. |
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Sphk1 promotes breast epithelial cell proliferation via NF-κB-p65-mediated cyclin D1 expression. |
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Oncotarget |
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Sphingosine-1-phosphate restores endothelial barrier integrity in ovarian hyperstimulation syndrome. |
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Mol. Hum. Reprod. |
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Oncotarget |
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Acta Derm. Venereol. |
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Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P). |
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PLoS ONE |
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The Effect of Sphingosine 1-Phosphate/Sphingosine 1-Phosphate Receptor on Neutrophil Function and the Relevant Signaling Pathway. |
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Acta Haematol. |
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Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. |
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Mol. Endocrinol. |
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Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. |
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Pelvic organ prolapse is associated with alteration of sphingosine-1-phosphate/Rho-kinase signalling pathway in human vaginal wall. |
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J Obstet Gynaecol |
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K6PC-5, a novel sphingosine kinase 1 (SphK1) activator, alleviates dexamethasone-induced damages to osteoblasts through activating SphK1-Akt signaling. |
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Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors. |
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Am. J. Pathol. |
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Sphingolipid metabolism and its role in the skeletal tissues. |
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Cell. Mol. Life Sci. |
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The role of serum amyloid A and sphingosine-1-phosphate on high-density lipoprotein functionality. |
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Biol. Chem. |
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B cell depletion increases sphingosine-1-phosphate-dependent airway inflammation in mice. |
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Am. J. Respir. Cell Mol. Biol. |
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Lysophospholipids in coronary artery and chronic ischemic heart disease. |
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Curr. Opin. Lipidol. |
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Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer. |
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Mol. Immunol. |
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Role of Ceramide from Glycosphingolipids and Its Metabolites in Immunological and Inflammatory Responses in Humans. |
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Mediators Inflamm. |
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Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation. |
2015 |
Mediators Inflamm. |
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Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. |
2015 |
Nat Commun |
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Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3. |
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J Neuroinflammation |
pmid:25880547
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Smad3 deficiency leads to mandibular condyle degradation via the sphingosine 1-phosphate (S1P)/S1P3 signaling axis. |
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Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720. |
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Chem. Phys. Lipids |
pmid:26272033
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HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation. |
2015 |
Sci Signal |
pmid:26268607
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Sphingosine-1-Phosphate Is a Novel Regulator of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity. |
2015 |
PLoS ONE |
pmid:26079370
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Role of N-WASP in Endothelial Monolayer Formation and Integrity. |
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J. Biol. Chem. |
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HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation. |
2015 |
Nature |
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