Cummings RJ et al. |
Phospholipase D activation by sphingosine 1-phosphate regulates interleukin-8 secretion in human bronchial epithelial cells. |
2002 |
J. Biol. Chem. |
pmid:12039947
|
Yun JK and Kester M |
Regulatory role of sphingomyelin metabolites in hypoxia-induced vascular smooth muscle cell proliferation. |
2002 |
Arch. Biochem. Biophys. |
pmid:12485605
|
Hirafuji M et al. |
[Modulation of sphingosine 1-phosphate, a new lipid mediator, on nitric oxide production by vascular smooth muscle cells]. |
2002 |
Nippon Yakurigaku Zasshi |
pmid:12491784
|
Muraki K et al. |
[Effects of sphingosine-1-phosphate, a lipid mediator, in cardiovascular tissues]. |
2002 |
Nippon Yakurigaku Zasshi |
pmid:12491795
|
Graeler M and Goetzl EJ |
Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. |
2002 |
FASEB J. |
pmid:12468451
|
Tanski W et al. |
Sphingosine-1-phosphate induces G(alphai)-coupled, PI3K/ras-dependent smooth muscle cell migration. |
2002 |
J. Surg. Res. |
pmid:12443721
|
Osada M et al. |
Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist. |
2002 |
Biochem. Biophys. Res. Commun. |
pmid:12445827
|
Grey A et al. |
The phospholipids sphingosine-1-phosphate and lysophosphatidic acid prevent apoptosis in osteoblastic cells via a signaling pathway involving G(i) proteins and phosphatidylinositol-3 kinase. |
2002 |
Endocrinology |
pmid:12446603
|
Ghelli A et al. |
Phospholipase D1 is threonine-phosphorylated in human-airway epithelial cells stimulated by sphingosine-1-phosphate by a mechanism involving Src tyrosine kinase and protein kinase Cdelta. |
2002 |
Biochem. J. |
pmid:12014986
|
Auge N et al. |
Oxidized LDL-induced smooth muscle cell proliferation involves the EGF receptor/PI-3 kinase/Akt and the sphingolipid signaling pathways. |
2002 |
Arterioscler. Thromb. Vasc. Biol. |
pmid:12482824
|
Nava VE et al. |
Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. |
2002 |
Exp. Cell Res. |
pmid:12441135
|
Chin TY et al. |
Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma X glioma cells. |
2002 |
Mol. Pharmacol. |
pmid:11854428
|
Idzko M et al. |
Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. |
2002 |
FASEB J. |
pmid:11919175
|
Mandala S et al. |
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. |
2002 |
Science |
pmid:11923495
|
Ancellin N et al. |
Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation. |
2002 |
J. Biol. Chem. |
pmid:11741921
|
Benaud C et al. |
Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. |
2002 |
J. Biol. Chem. |
pmid:11792696
|
Wang J et al. |
Receptor-mediated activation of a Cl(-) current by LPA and S1P in cultured corneal keratocytes. |
2002 |
Invest. Ophthalmol. Vis. Sci. |
pmid:12356825
|
Van Brocklyn J et al. |
Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase beta. |
2002 |
Cancer Lett. |
pmid:12175535
|
Birbes H et al. |
Mitochondria and ceramide: intertwined roles in regulation of apoptosis. |
2002 |
Adv. Enzyme Regul. |
pmid:12123710
|
Johnson KR et al. |
PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). |
2002 |
J. Biol. Chem. |
pmid:12124383
|
Thamilselvan V et al. |
Sphingosine-1-phosphate stimulates human Caco-2 intestinal epithelial proliferation via p38 activation and activates ERK by an independent mechanism. |
2002 |
In Vitro Cell. Dev. Biol. Anim. |
pmid:12197778
|
Spiegel S and Milstien S |
Sphingosine 1-phosphate, a key cell signaling molecule. |
2002 |
J. Biol. Chem. |
pmid:12011102
|
Kihara A and Igarashi Y |
[Sphingosine 1-phosphate in yeast]. |
2002 |
Tanpakushitsu Kakusan Koso |
pmid:11915338
|
Okazaki T and Ito M |
[Signal transduction of ceramide]. |
2002 |
Tanpakushitsu Kakusan Koso |
pmid:11915339
|
Jin ZQ et al. |
Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts. |
2002 |
Am. J. Physiol. Heart Circ. Physiol. |
pmid:12003800
|
Igarashi Y |
[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]. |
2002 |
Tanpakushitsu Kakusan Koso |
pmid:11915345
|
Black JL and Johnson PR |
Factors controlling smooth muscle proliferation and airway remodelling. |
2002 |
Curr Opin Allergy Clin Immunol |
pmid:11964750
|
Okajima F |
[Distribution of sphingosine 1-phosphate in plasma lipoproteins and its role in the regulation of the vascular cell functions]. |
2002 |
Tanpakushitsu Kakusan Koso |
pmid:11915346
|
Brinkmann V et al. |
The immune modulator FTY720 targets sphingosine 1-phosphate receptors. |
2002 |
J. Biol. Chem. |
pmid:11967257
|
Yatomi Y et al. |
[Sphingosine 1-phosphate and vascular endothelial cells]. |
2002 |
Tanpakushitsu Kakusan Koso |
pmid:11915347
|
Liu H et al. |
Sphingosine kinases: a novel family of lipid kinases. |
2002 |
Prog. Nucleic Acid Res. Mol. Biol. |
pmid:12102559
|
Takuwa Y |
[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]. |
2002 |
Tanpakushitsu Kakusan Koso |
pmid:11915348
|
Morales M |
[Participation of the phosphatidylinositol-3-kinase/Akt/endothelial-nitric-oxide synthase signaling in the processes of angiogenesis and vascular remodeling]. |
2002 |
Nefrologia |
pmid:12107910
|
Kim DS et al. |
Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes. |
2002 |
Cell. Signal. |
pmid:12034359
|
Pyne S |
Cellular signaling by sphingosine and sphingosine 1-phosphate. Their opposing roles in apoptosis. |
2002 |
Subcell. Biochem. |
pmid:12037985
|
Takuwa Y et al. |
The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities. |
2002 |
J. Biochem. |
pmid:12038970
|
Meacci E et al. |
A role for calcium in sphingosine 1-phosphate-induced phospholipase D activity in C2C12 myoblasts. |
2002 |
FEBS Lett. |
pmid:12067705
|
Le Stunff H et al. |
Sphingosine-1-phosphate and lipid phosphohydrolases. |
2002 |
Biochim. Biophys. Acta |
pmid:12069805
|
Kluk MJ and Hla T |
Signaling of sphingosine-1-phosphate via the S1P/EDG-family of G-protein-coupled receptors. |
2002 |
Biochim. Biophys. Acta |
pmid:12069812
|
Siehler S and Manning DR |
Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. |
2002 |
Biochim. Biophys. Acta |
pmid:12069815
|
Takuwa Y |
Subtype-specific differential regulation of Rho family G proteins and cell migration by the Edg family sphingosine-1-phosphate receptors. |
2002 |
Biochim. Biophys. Acta |
pmid:12069818
|
Pyne S and Pyne NJ |
Sphingosine 1-phosphate signalling and termination at lipid phosphate receptors. |
2002 |
Biochim. Biophys. Acta |
pmid:12069819
|
Okajima F |
Plasma lipoproteins behave as carriers of extracellular sphingosine 1-phosphate: is this an atherogenic mediator or an anti-atherogenic mediator? |
2002 |
Biochim. Biophys. Acta |
pmid:12069820
|
Meyer zu Heringdorf D et al. |
Sphingosylphosphorylcholine-biological functions and mechanisms of action. |
2002 |
Biochim. Biophys. Acta |
pmid:12069827
|
Lampasso JD et al. |
Role of protein kinase C alpha in primary human osteoblast proliferation. |
2002 |
J. Bone Miner. Res. |
pmid:12412804
|
Napier JA et al. |
A new class of lipid desaturase central to sphingolipid biosynthesis and signalling. |
2002 |
Trends Plant Sci. |
pmid:12417141
|
Uhlenbrock K et al. |
Sphingosine 1-phosphate is a ligand of the human gpr3, gpr6 and gpr12 family of constitutively active G protein-coupled receptors. |
2002 |
Cell. Signal. |
pmid:12220620
|
Tanimoto T et al. |
Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). |
2002 |
J. Biol. Chem. |
pmid:12226078
|
Porcelli AM et al. |
Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells. |
2002 |
Cell. Signal. |
pmid:11747992
|
Baudhuin LM et al. |
Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific. |
2002 |
Mol. Pharmacol. |
pmid:12181443
|
Paik JH et al. |
Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. |
2001 |
J. Biol. Chem. |
pmid:11150298
|
Meyer zu Heringdorf D et al. |
Stimulation of intracellular sphingosine-1-phosphate production by G-protein-coupled sphingosine-1-phosphate receptors. |
2001 |
Eur. J. Pharmacol. |
pmid:11239914
|
Young KW and Nahorski SR |
Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release. |
2001 |
Semin. Cell Dev. Biol. |
pmid:11162743
|
English D et al. |
Platelet-released phospholipids link haemostasis and angiogenesis. |
2001 |
Cardiovasc. Res. |
pmid:11166272
|
Radin NS |
Killing cancer cells by poly-drug elevation of ceramide levels: a hypothesis whose time has come? |
2001 |
Eur. J. Biochem. |
pmid:11168352
|
Siehler S et al. |
Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells. |
2001 |
J. Biol. Chem. |
pmid:11673450
|
Cuvillier O and Levade T |
Sphingosine 1-phosphate antagonizes apoptosis of human leukemia cells by inhibiting release of cytochrome c and Smac/DIABLO from mitochondria. |
2001 |
Blood |
pmid:11675357
|
Tigyi G |
Selective ligands for lysophosphatidic acid receptor subtypes: gaining control over the endothelial differentiation gene family. |
2001 |
Mol. Pharmacol. |
pmid:11723220
|
Castillo SS and Teegarden D |
Ceramide conversion to sphingosine-1-phosphate is essential for survival in C3H10T1/2 cells. |
2001 |
J. Nutr. |
pmid:11694603
|
Lyons JM and Karin NJ |
A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. |
2001 |
J. Bone Miner. Res. |
pmid:11697799
|
Hornuss C et al. |
Human and rat alveolar macrophages express multiple EDG receptors. |
2001 |
Eur. J. Pharmacol. |
pmid:11698050
|
Yoshida A and Ueda H |
Neurobiology of the Edg2 lysophosphatidic acid receptor. |
2001 |
Jpn. J. Pharmacol. |
pmid:11700008
|
Im DS et al. |
Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. |
2001 |
Biochemistry |
pmid:11705398
|
Rosenfeldt HM et al. |
The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. |
2001 |
Biochem. Soc. Trans. |
pmid:11709084
|
Ohmori T et al. |
G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. |
2001 |
J. Biol. Chem. |
pmid:11056155
|
Erl W and Siess W |
Sphingosine-1-phosphate and the leading Edg-1 of vascular smooth muscle cells. |
2001 |
Circ. Res. |
pmid:11557732
|
Malek RL et al. |
Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. |
2001 |
J. Biol. Chem. |
pmid:11069896
|
Kluk MJ and Hla T |
Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. |
2001 |
Circ. Res. |
pmid:11557736
|
Meacci E et al. |
Dual regulation of sphingosine 1-phosphate-induced phospholipase D activity through RhoA and protein kinase C-alpha in C2C12 myoblasts. |
2001 |
Cell. Signal. |
pmid:11483412
|
Pébay A et al. |
Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades. |
2001 |
Eur. J. Neurosci. |
pmid:11467306
|
Brownlee C |
Intracellular signalling: sphingosine-1-phosphate branches out. |
2001 |
Curr. Biol. |
pmid:11470429
|
Igarashi J and Michel T |
Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. |
2001 |
J. Biol. Chem. |
pmid:11470796
|
Garcia JG et al. |
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. |
2001 |
J. Clin. Invest. |
pmid:11544274
|
Nadal A et al. |
Glial cell responses to lipids bound to albumin in serum and plasma. |
2001 |
Prog. Brain Res. |
pmid:11545003
|
Sullards MC and Merrill AH |
Analysis of sphingosine 1-phosphate, ceramides, and other bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. |
2001 |
Sci. STKE |
pmid:11752637
|
Okajima F |
[Establishment of the method for the measurement of sphingosine-1-phosphate in biological samples and its application for S1P research]. |
2001 |
Nippon Yakurigaku Zasshi |
pmid:11778456
|
Wang DA et al. |
A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors. |
2001 |
J. Biol. Chem. |
pmid:11604399
|
Andor A et al. |
YopE of Yersinia, a GAP for Rho GTPases, selectively modulates Rac-dependent actin structures in endothelial cells. |
2001 |
Cell. Microbiol. |
pmid:11298653
|
Ammit AJ et al. |
Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma. |
2001 |
FASEB J. |
pmid:11344091
|
Yatomi Y et al. |
Sphingosine 1-phosphate: synthesis and release. |
2001 |
Prostaglandins Other Lipid Mediat. |
pmid:11324700
|
Goetzl EJ |
Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids. |
2001 |
Prostaglandins Other Lipid Mediat. |
pmid:11324701
|
Olivera A and Spiegel S |
Sphingosine kinase: a mediator of vital cellular functions. |
2001 |
Prostaglandins Other Lipid Mediat. |
pmid:11324702
|
Hla T |
Sphingosine 1-phosphate receptors. |
2001 |
Prostaglandins Other Lipid Mediat. |
pmid:11324703
|
Mandala SM |
Sphingosine-1-phosphate phosphatases. |
2001 |
Prostaglandins Other Lipid Mediat. |
pmid:11324704
|
Lynch KR and Macdonald TL |
Structure activity relationships of lysophospholipid mediators. |
2001 |
Prostaglandins Other Lipid Mediat. |
pmid:11324706
|
Panetti TS et al. |
Modulation of cell interactions with extracellular matrix by lysophosphatidic acid and sphingosine 1-phosphate. |
2001 |
Prostaglandins Other Lipid Mediat. |
pmid:11324710
|
Alderton F et al. |
G-protein-coupled receptor stimulation of the p42/p44 mitogen-activated protein kinase pathway is attenuated by lipid phosphate phosphatases 1, 1a, and 2 in human embryonic kidney 293 cells. |
2001 |
J. Biol. Chem. |
pmid:11278307
|
Igarashi J et al. |
Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. |
2001 |
J. Biol. Chem. |
pmid:11278407
|
Morales-Ruiz M et al. |
Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. |
2001 |
J. Biol. Chem. |
pmid:11278592
|
Birchwood CJ et al. |
Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. |
2001 |
J. Biol. Chem. |
pmid:11278643
|
Ng CK et al. |
Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. |
2001 |
Nature |
pmid:11279499
|
Kranenburg O and Moolenaar WH |
Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonists. |
2001 |
Oncogene |
pmid:11313900
|
Schwartz BM et al. |
Lysophospholipids increase interleukin-8 expression in ovarian cancer cells. |
2001 |
Gynecol. Oncol. |
pmid:11330965
|
Hobson JP et al. |
Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. |
2001 |
Science |
pmid:11230698
|
Alderton F et al. |
Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells. |
2001 |
J. Biol. Chem. |
pmid:11359779
|
Pébay A et al. |
Antiproliferative properties of sphingosine-1-phosphate in human hepatic myofibroblasts. |
2001 |
Eur. J. Neurosci. |
pmid:11422447
|
Kimura T et al. |
Sphingosine 1-phosphate may be a major component of plasma lipoproteins responsible for the cytoprotective actions in human umbilical vein endothelial cells. |
2001 |
J. Biol. Chem. |
pmid:11427538
|
Ishii I et al. |
Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. |
2001 |
J. Biol. Chem. |
pmid:11443127
|
Takuwa Y et al. |
Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator. |
2001 |
Mol. Cell. Endocrinol. |
pmid:11377814
|
Alemany R et al. |
Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate. |
2001 |
FEBS Lett. |
pmid:11741596
|