| MeSH term | MeSH ID | Detail |
|---|---|---|
| Retinal Detachment | D012163 | 10 associated lipids |
| Thrombocythemia, Essential | D013920 | 9 associated lipids |
| Mycobacterium Infections, Nontuberculous | D009165 | 8 associated lipids |
| Teratocarcinoma | D018243 | 7 associated lipids |
| Rhabdomyosarcoma | D012208 | 7 associated lipids |
| Eye Abnormalities | D005124 | 7 associated lipids |
| Multiple Sclerosis, Relapsing-Remitting | D020529 | 7 associated lipids |
| Peripheral Arterial Disease | D058729 | 7 associated lipids |
| Anemia, Aplastic | D000741 | 6 associated lipids |
| Ovarian Diseases | D010049 | 5 associated lipids |
Sphingosine 1-phosphate
Sphingosine 1-phosphate is a lipid of Sphingolipids (SP) class. Sphingosine 1-phosphate is associated with abnormalities such as Infection, Painful Bladder Syndrome, Atherosclerosis, Hyperglycemia and Rheumatoid Arthritis. The involved functions are known as Phosphorylation, Regulation, enzyme activity, Energy Absorption and Vascular Permeability. Sphingosine 1-phosphate often locates in Endothelium, Tissue membrane, Vascular System, Protoplasm and Microfilaments. The associated genes with Sphingosine 1-phosphate are MBTPS1 gene, FBXL15 gene, TEK gene, NTRK1 gene and Gene Family. The related lipids are Promega, Lipopolysaccharides, lysophosphatidic acid, Lysophosphatidylcholines and Lysophospholipids. The related experimental models are Knock-out, Mouse Model, Transgenic Model, Disease model and Experimental Autoimmune Encephalomyelitis.
Cross Reference
Introduction
To understand associated biological information of Sphingosine 1-phosphate, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Sphingosine 1-phosphate?
Sphingosine 1-phosphate is suspected in Lymphopenia, Ischemia, Infection, Atherosclerosis, Multiple Sclerosis, Asthma and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Sphingosine 1-phosphate
PubChem Associated disorders and diseases
What pathways are associated with Sphingosine 1-phosphate
Lipid pathways are not clear in current pathway databases. We organized associated pathways with Sphingosine 1-phosphate through full-text articles, including metabolic pathways or pathways of biological mechanisms.
Related references are published most in these journals:
| Pathway name | Related literatures |
|---|
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PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Sphingosine 1-phosphate?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Sphingosine 1-phosphate?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Sphingosine 1-phosphate?
Knock-out
Knock-out are used in the study 'Sphingosine 1-phosphate-dependent trafficking of peritoneal B cells requires functional NFkappaB-inducing kinase in stromal cells.' (Kunisawa J et al., 2008), Knock-out are used in the study 'Connective tissue growth factor (CTGF/CCN2) mediates angiogenic effect of S1P in human dermal microvascular endothelial cells.' (Markiewicz M et al., 2011), Knock-out are used in the study 'Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival.' (Yang Q, 2007), Knock-out are used in the study 'Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function.' (Idzko M et al., 2006) and Knock-out are used in the study 'Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho.' (Gratzinger D et al., 2003).
Mouse Model
Mouse Model are used in the study 'Regulation of the micromechanical properties of pulmonary endothelium by S1P and thrombin: role of cortactin.' (Arce FT et al., 2008), Mouse Model are used in the study 'Sequential delivery of vascular endothelial growth factor and sphingosine 1-phosphate for angiogenesis.' (Tengood JE et al., 2010), Mouse Model are used in the study 'S1P(5) is required for sphingosine 1-phosphate-induced autophagy in human prostate cancer PC-3 cells.' (Chang CL et al., 2009), Mouse Model are used in the study 'Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages.' (Hughes JE et al., 2008) and Mouse Model are used in the study 'The alliance of sphingosine-1-phosphate and its receptors in immunity.' (Rivera J et al., 2008).
Transgenic Model
Transgenic Model are used in the study 'Role for matrix metalloproteinase-2 in oxidized low-density lipoprotein-induced activation of the sphingomyelin/ceramide pathway and smooth muscle cell proliferation.' (Augé N et al., 2004), Transgenic Model are used in the study 'Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.' (Sabbadini RA, 2011) and Transgenic Model are used in the study 'Still benched on its way to the bedside: sphingosine kinase 1 as an emerging target in cancer chemotherapy.' (Gault CR and Obeid LM, 2011).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Sphingosine 1-phosphate
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ogle ME et al. | Sphingosine-1-Phosphate Receptor-3 Supports Hematopoietic Stem and Progenitor Cell Residence Within the Bone Marrow Niche. | 2017 | Stem Cells | pmid:28026131 |
| Yung BS et al. | Selective coupling of the S1P receptor subtype to S1P-mediated RhoA activation and cardioprotection. | 2017 | J. Mol. Cell. Cardiol. | pmid:28017639 |
| Contaifer D et al. | Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients. | 2017 | J. Lipid Res. | pmid:27993949 |
| Myśliwiec H et al. | Increase in circulating sphingosine-1-phosphate and decrease in ceramide levels in psoriatic patients. | 2017 | Arch. Dermatol. Res. | pmid:27988894 |
| Powell JA et al. | Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia. | 2017 | Blood | pmid:27956387 |
| Miyabe C et al. | A sphingosine 1-phosphate receptor agonist ameliorates animal model of vasculitis. | 2017 | Inflamm. Res. | pmid:27942751 |
| McLean CJ et al. | Characterization of homologous sphingosine-1-phosphate lyase isoforms in the bacterial pathogen Burkholderia pseudomallei. | 2017 | J. Lipid Res. | pmid:27784725 |
| Abraham C et al. | Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases. | 2017 | Gastroenterology | pmid:27780712 |
| Lim J et al. | Valproic acid enforces the priming effect of sphingosine-1 phosphate on human mesenchymal stem cells. | 2017 | Int. J. Mol. Med. | pmid:28677769 |
| Pierucci F et al. | Non-dioxin-like organic toxicant PCB153 modulates sphingolipid metabolism in liver progenitor cells: its role in Cx43-formed gap junction impairment. | 2017 | Arch. Toxicol. | pmid:27318803 |
| Mitroi DN et al. | SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. | 2017 | Autophagy | pmid:28521611 |
| Leo A et al. | The Sphingosine 1-Phosphate Signaling Pathway in Epilepsy: A Possible Role for the Immunomodulator Drug Fingolimod in Epilepsy Treatment. | 2017 | CNS Neurol Disord Drug Targets | pmid:27823573 |
| Roch L et al. | High-Resolution Expression Profiling of Peripheral Blood CD8 Cells in Patients with Multiple Sclerosis Displays Fingolimod-Induced Immune Cell Redistribution. | 2017 | Mol. Neurobiol. | pmid:27631876 |
| Natarajan V et al. | Expression profiling of genes regulated by sphingosine kinase1 signaling in a murine model of hyperoxia induced neonatal bronchopulmonary dysplasia. | 2017 | BMC Genomics | pmid:28851267 |
| Hajny S and Christoffersen C | A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and Neuroinflammation. | 2017 | Int J Mol Sci | pmid:28749426 |
| Bertlich M et al. | Fingolimod (FTY-720) is Capable of Reversing Tumor Necrosis Factor Induced Decreases in Cochlear Blood Flow. | 2017 | Otol. Neurotol. | pmid:28742634 |
| Koch A et al. | Vitamin D Supplementation Enhances C18(dihydro)ceramide Levels in Type 2 Diabetes Patients. | 2017 | Int J Mol Sci | pmid:28714882 |
| Wilkerson JL and Mandal NA | Angiogenesis Model of Cornea to Understand the Role of Sphingosine 1-Phosphate. | 2017 | Methods Mol. Biol. | pmid:28660590 |
| Onuma T et al. | Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. | 2017 | Thromb. Res. | pmid:28609704 |
| Azimzadeh K et al. | Evaluation of plasma sphingosine 1-phosphate, hepcidin and cardiovascular damage biomarkers (cardiac troponin I and homocysteine) in rats infected with brucellosis and vaccinated (Rev-1, RB-51). | 2017 | Microb. Pathog. | pmid:28533142 |
| Alqinyah M et al. | Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity. | 2017 | Mol. Pharmacol. | pmid:28031332 |
| Oh YT et al. | DR5 suppression induces sphingosine-1-phosphate-dependent TRAF2 polyubiquitination, leading to activation of JNK/AP-1 and promotion of cancer cell invasion. | 2017 | Cell Commun. Signal | pmid:28482915 |
| Fan Q et al. | Sphingosine-1-phosphate promotes ovarian cancer cell proliferation by disrupting Hippo signaling. | 2017 | Oncotarget | pmid:28460443 |
| Lafargue A et al. | Ionizing radiation induces long-term senescence in endothelial cells through mitochondrial respiratory complex II dysfunction and superoxide generation. | 2017 | Free Radic. Biol. Med. | pmid:28431961 |
| Di Pietro M et al. | In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome. | 2017 | Mol. Hum. Reprod. | pmid:28379469 |
| Schumacher F et al. | The sphingosine 1-phosphate breakdown product, (2)-hexadecenal, forms protein adducts and glutathione conjugates in vitro. | 2017 | J. Lipid Res. | pmid:28588048 |
| Feuerborn R et al. | High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression. | 2017 | Atherosclerosis | pmid:28038379 |
| Gudipaty SA and Rosenblatt J | Epithelial cell extrusion: Pathways and pathologies. | 2017 | Semin. Cell Dev. Biol. | pmid:27212253 |
| Wang X et al. | Sphingosine 1-phosphate alleviates Coxsackievirus B3-induced myocarditis by increasing invariant natural killer T cells. | 2017 | Exp. Mol. Pathol. | pmid:28986246 |
| Werth S et al. | Obesity-stimulated aldosterone release is not related to an S1P-dependent mechanism. | 2017 | J. Endocrinol. | pmid:28970286 |
| Du Y et al. | Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway. | 2017 | Cell. Physiol. Biochem. | pmid:28934733 |
| Kuchler L et al. | Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis. | 2017 | Mol. Immunol. | pmid:28846923 |
| Nicholas SE et al. | Unravelling the interplay of sphingolipids and TGF-β signaling in the human corneal stroma. | 2017 | PLoS ONE | pmid:28806736 |
| Lee SY et al. | Adipocyte-Specific Deficiency of De Novo Sphingolipid Biosynthesis Leads to Lipodystrophy and Insulin Resistance. | 2017 | Diabetes | pmid:28698261 |
| Hutami IR et al. | Fas/S1P crosstalk via NF-κB activation in osteoclasts controls subchondral bone remodeling in murine TMJ arthritis. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28687489 |
| Cannavo A et al. | β-Blockade Prevents Post-Ischemic Myocardial Decompensation Via βAR-Dependent Protective Sphingosine-1 Phosphate Signaling. | 2017 | J. Am. Coll. Cardiol. | pmid:28683966 |
| Punsawad C and Viriyavejakul P | Reduction in serum sphingosine 1-phosphate concentration in malaria. | 2017 | PLoS ONE | pmid:28666023 |
| Luo J et al. | The effects of berberine on a murine model of multiple sclerosis and the SPHK1/S1P signaling pathway. | 2017 | Biochem. Biophys. Res. Commun. | pmid:28655617 |
| Chang CH and Randolph GJ | Sphingosine-1-Phosphate as the Lymphocyte's Ticket to Ride and Survive. | 2017 | Dev. Cell | pmid:28633013 |
| Fang R et al. | Sphingosine 1-Phosphate Postconditioning Protects Against Myocardial Ischemia/reperfusion Injury in Rats via Mitochondrial Signaling and Akt-Gsk3β Phosphorylation. | 2017 | Arch. Med. Res. | pmid:28625317 |
| Rohrbach T et al. | Sphingosine kinase and sphingosine-1-phosphate in liver pathobiology. | 2017 | Crit. Rev. Biochem. Mol. Biol. | pmid:28618839 |
| Vijayan M et al. | Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection. | 2017 | J. Immunol. | pmid:28600291 |
| Becker S et al. | Low sphingosine-1-phosphate plasma levels are predictive for increased mortality in patients with liver cirrhosis. | 2017 | PLoS ONE | pmid:28334008 |
| Karunakaran I and van Echten-Deckert G | Sphingosine 1-phosphate - A double edged sword in the brain. | 2017 | Biochim. Biophys. Acta | pmid:28315304 |
| Navarrete A et al. | A metabolomic approach shows sphingosine 1-phosphate and lysophospholipids as mediators of the therapeutic effect of liver growth factor in emphysema. | 2017 | J Pharm Biomed Anal | pmid:28314215 |
| Shirakawa H et al. | Sphingosine-1-phosphate induces Ca signaling and CXCL1 release via TRPC6 channel in astrocytes. | 2017 | Glia | pmid:28300348 |
| Dyckman AJ | Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P) Agonists and Future Perspectives. | 2017 | J. Med. Chem. | pmid:28291340 |
| Nielsen OH et al. | Sphingosine-1-Phosphate Signaling in Inflammatory Bowel Disease. | 2017 | Trends Mol Med | pmid:28283249 |
| Peyrin-Biroulet L et al. | Modulation of sphingosine-1-phosphate in inflammatory bowel disease. | 2017 | Autoimmun Rev | pmid:28279838 |
| Miller M et al. | Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate. | 2017 | J. Immunol. | pmid:28275141 |
| Su K et al. | FTY720 Attenuates Angiotensin II-Induced Podocyte Damage via Inhibiting Inflammatory Cytokines. | 2017 | Mediators Inflamm. | pmid:28270699 |
| Serafimidis I et al. | Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling. | 2017 | PLoS Biol. | pmid:28248965 |
| Lee HM et al. | Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. | 2017 | J. Pathol. | pmid:28240350 |
| Rieck M et al. | Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. | 2017 | Eur. J. Immunol. | pmid:28198542 |
| Bruno M et al. | Sphingosine 1-phosphate signaling axis mediates fibroblast growth factor 2-induced proliferation and survival of murine auditory neuroblasts. | 2017 | Biochim. Biophys. Acta | pmid:28188805 |
| Al Alam N and Kreydiyyeh SI | FTY720P inhibits hepatic Na(+)-K(+) ATPase via S1PR2 and PGE2. | 2016 | Biochem. Cell Biol. | pmid:27501354 |
| Fu P et al. | Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium. | 2016 | J. Biol. Chem. | pmid:27864331 |
| Terashita T et al. | Administration of JTE013 abrogates experimental asthma by regulating proinflammatory cytokine production from bronchial epithelial cells. | 2016 | Respir. Res. | pmid:27829417 |
| Dong T et al. | Cortisol-induced immune suppression by a blockade of lymphocyte egress in traumatic brain injury. | 2016 | J Neuroinflammation | pmid:27561600 |
| Nojima H et al. | Chemokine Receptors, CXCR1 and CXCR2, Differentially Regulate Exosome Release in Hepatocytes. | 2016 | PLoS ONE | pmid:27551720 |
| Harris CM et al. | Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats. | 2016 | J. Pharmacol. Exp. Ther. | pmid:27519818 |
| Gstalder C et al. | FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. | 2016 | Mol. Cancer Ther. | pmid:27507852 |
| Hashimoto Y et al. | Sphingosine-1-phosphate-enhanced Wnt5a promotes osteogenic differentiation in C3H10T1/2 cells. | 2016 | Cell Biol. Int. | pmid:27486054 |
| Viswanathan P et al. | Differential elastic responses to barrier-altering agonists in two types of human lung endothelium. | 2016 | Biochem. Biophys. Res. Commun. | pmid:27473658 |
| Moruno Manchon JF et al. | SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells. | 2016 | Autophagy | pmid:27467777 |
| Nagahashi M et al. | The roles of bile acids and sphingosine-1-phosphate signaling in the hepatobiliary diseases. | 2016 | J. Lipid Res. | pmid:27459945 |
| Rumzhum NN et al. | Effect of Sphingosine 1-Phosphate on Cyclo-Oxygenase-2 Expression, Prostaglandin E2 Secretion, and β2-Adrenergic Receptor Desensitization. | 2016 | Am. J. Respir. Cell Mol. Biol. | pmid:26098693 |
| Bao XH et al. | [Role and related mechanism of S1P/S1P1 signal pathway during post conditioning of hypertrophic cardiomyocytes]. | 2016 | Zhonghua Xin Xue Guan Bing Za Zhi | pmid:27220580 |
| Marfia G et al. | The Adipose Mesenchymal Stem Cell Secretome Inhibits Inflammatory Responses of Microglia: Evidence for an Involvement of Sphingosine-1-Phosphate Signalling. | 2016 | Stem Cells Dev. | pmid:27217090 |
| Versmissen J et al. | Familial hypercholesterolaemia: cholesterol efflux and coronary disease. | 2016 | Eur. J. Clin. Invest. | pmid:27208892 |
| Sauvé M et al. | Tumor Necrosis Factor/Sphingosine-1-Phosphate Signaling Augments Resistance Artery Myogenic Tone in Diabetes. | 2016 | Diabetes | pmid:27207546 |
| Zhang XE et al. | Activation of RhoA, but Not Rac1, Mediates Early Stages of S1P-Induced Endothelial Barrier Enhancement. | 2016 | PLoS ONE | pmid:27187066 |
| Ohtoyo M et al. | Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. | 2016 | Cell Chem Biol | pmid:27185637 |
| Fleming JK et al. | A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay. | 2016 | J. Lipid Res. | pmid:27444045 |
| Barnawi J et al. | Pro-phagocytic Effects of Thymoquinone on Cigarette Smoke-exposed Macrophages Occur by Modulation of the Sphingosine-1-phosphate Signalling System. | 2016 | COPD | pmid:27144721 |
| Jin L et al. | The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined. | 2016 | World J Surg Oncol | pmid:27129720 |
| Sanchez T | Sphingosine-1-Phosphate Signaling in Endothelial Disorders. | 2016 | Curr Atheroscler Rep | pmid:27115142 |
| Tang X et al. | Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate. | 2016 | J. Lipid Res. | pmid:26884614 |
| Liu W et al. | Sphingosine-1-phosphate receptor 2 mediates endothelial cells dysfunction by PI3K-Akt pathway under high glucose condition. | 2016 | Eur. J. Pharmacol. | pmid:26921757 |
| Yang Y et al. | Sphingosine kinase inhibition ameliorates chronic hypoperfusion-induced white matter lesions. | 2016 | Neurochem. Int. | pmid:26921668 |
| Park K et al. | ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. | 2016 | Proc. Natl. Acad. Sci. U.S.A. | pmid:26903652 |
| Bien-Möller S et al. | Expression of S1P metabolizing enzymes and receptors correlate with survival time and regulate cell migration in glioblastoma multiforme. | 2016 | Oncotarget | pmid:26887055 |
| Uranbileg B et al. | Increased mRNA Levels of Sphingosine Kinases and S1P Lyase and Reduced Levels of S1P Were Observed in Hepatocellular Carcinoma in Association with Poorer Differentiation and Earlier Recurrence. | 2016 | PLoS ONE | pmid:26886371 |
| Chumanevich A et al. | Sphingosine-1-Phosphate/Sphingosine-1-Phosphate Receptor 2 Axis Can Promote Mouse and Human Primary Mast Cell Angiogenic Potential through Upregulation of Vascular Endothelial Growth Factor-A and Matrix Metalloproteinase-2. | 2016 | Mediators Inflamm. | pmid:26884643 |
| Ko P et al. | Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion. | 2016 | Sci Rep | pmid:26877098 |
| Luo B et al. | Erythropoeitin Signaling in Macrophages Promotes Dying Cell Clearance and Immune Tolerance. | 2016 | Immunity | pmid:26872696 |
| Gomez-Muñoz A et al. | Control of inflammatory responses by ceramide, sphingosine 1-phosphate and ceramide 1-phosphate. | 2016 | Prog. Lipid Res. | pmid:26703189 |
| Ottenlinger F et al. | Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes. | 2016 | Eur. J. Immunol. | pmid:26683421 |
| Fan A et al. | Liver X receptor-α and miR-130a-3p regulate expression of sphingosine 1-phosphate receptor 2 in human umbilical vein endothelial cells. | 2016 | Am. J. Physiol., Cell Physiol. | pmid:26669941 |
| Petrache I and Berdyshev EV | Ceramide Signaling and Metabolism in Pathophysiological States of the Lung. | 2016 | Annu. Rev. Physiol. | pmid:26667073 |
| Delgado A and MartÃnez-Cartro M | Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors. | 2016 | Curr. Med. Chem. | pmid:26639095 |
| Yamamoto S et al. | A role of the sphingosine-1-phosphate (S1P)-S1P receptor 2 pathway in epithelial defense against cancer (EDAC). | 2016 | Mol. Biol. Cell | pmid:26631556 |
| Kakazu E et al. | Hepatocytes release ceramide-enriched pro-inflammatory extracellular vesicles in an IRE1α-dependent manner. | 2016 | J. Lipid Res. | pmid:26621917 |
| Chen J et al. | Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. | 2016 | Biochim. Biophys. Acta | pmid:26615875 |
| Tan SF et al. | Acid ceramidase is upregulated in AML and represents a novel therapeutic target. | 2016 | Oncotarget | pmid:27825124 |
| Gao D et al. | Metabolomics study on the antitumor effect of marine natural compound flexibilide in HCT-116 colon cancer cell line. | 2016 | J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. | pmid:26859520 |
| Nigro E et al. | Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation. | 2016 | Pharmacol. Res. | pmid:26462929 |
| Serdar M et al. | Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. | 2016 | Brain Behav. Immun. | pmid:26456693 |
| Arish M et al. | Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases. | 2016 | Drug Discov. Today | pmid:26456576 |
| Melnik BC | Rosacea: The Blessing of the Celts - An Approach to Pathogenesis Through Translational Research. | 2016 | Acta Derm. Venereol. | pmid:26304030 |